Motif ID: SP1.p2

Z-value: 2.023


Transcription factors associated with SP1.p2:

Gene SymbolEntrez IDGene Name
SP1 6667 Sp1 transcription factor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SP1chr12_+_52060191-0.155.7e-01Click!


Activity profile for motif SP1.p2.

activity profile for motif SP1.p2


Sorted Z-values histogram for motif SP1.p2

Sorted Z-values for motif SP1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SP1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_35572694 3.100 NM_003214
 TEAD3
TEA domain family member 3
chr6_+_37245860 2.482 NM_002648
 PIM1
pim-1 oncogene
chr17_+_34114924 2.366 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr16_-_88295595 1.979 NM_152339
 SPATA2L
spermatogenesis associated 2-like
chr22_-_18807805 1.962 PI4KAP2
PI4KAP1
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 2
phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 1
chr5_+_176446425 1.933 NM_002011
NM_213647
 FGFR4

fibroblast growth factor receptor 4

chr19_+_7891193 1.932 NM_003083
 SNAPC2
small nuclear RNA activating complex, polypeptide 2, 45kDa
chr22_+_20101661 1.868 NM_015094
 HIC2
hypermethylated in cancer 2
chr2_+_10101081 1.797 NM_003597
NM_001177716
 KLF11

Kruppel-like factor 11

chr1_+_3679168 1.786 NM_001163724
 LOC388588
hypothetical protein LOC388588
chr1_-_20685314 1.620 NM_018584
 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr9_+_139566129 1.582 NM_032477
 MRPL41
mitochondrial ribosomal protein L41
chr20_-_62151216 1.543 NM_018419
 SOX18
SRY (sex determining region Y)-box 18
chr19_-_7840806 1.541 FLJ22184
hypothetical protein FLJ22184
chr19_+_59064795 1.540 MYADM
myeloid-associated differentiation marker
chr3_-_12983959 1.500 NM_014869
 IQSEC1
IQ motif and Sec7 domain 1
chr16_+_88422354 1.498 NM_032451
 SPIRE2
spire homolog 2 (Drosophila)
chr19_+_38979502 1.491 NM_001129994
NM_001129995
NM_024076
 KCTD15


potassium channel tetramerisation domain containing 15


chr17_+_44429748 1.438 NM_001160423
NM_006546
 IGF2BP1

insulin-like growth factor 2 mRNA binding protein 1

chr14_-_37134191 1.421 NM_004496
 FOXA1
forkhead box A1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 125 entries
enrichment   p-value GO term description
1.99 3.63e-02 GO:0006476 protein deacetylation
1.61 2.53e-02 GO:0006475 internal protein amino acid acetylation
1.59 3.74e-09 GO:0016569 covalent chromatin modification
1.59 4.80e-09 GO:0016570 histone modification
1.53 4.89e-02 GO:0018205 peptidyl-lysine modification
1.53 4.89e-02 GO:0043392 negative regulation of DNA binding
1.48 1.77e-12 GO:0016568 chromatin modification
1.48 4.33e-02 GO:0051100 negative regulation of binding
1.33 8.55e-07 GO:0006325 chromatin organization
1.32 1.88e-03 GO:0051098 regulation of binding
1.32 1.15e-02 GO:0051101 regulation of DNA binding
1.31 6.06e-03 GO:0051329 interphase of mitotic cell cycle
1.31 4.95e-02 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
1.30 8.82e-03 GO:0051325 interphase
1.29 6.88e-07 GO:0010558 negative regulation of macromolecule biosynthetic process
1.29 8.70e-07 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.29 1.70e-02 GO:0060284 regulation of cell development
1.28 3.46e-06 GO:0051276 chromosome organization
1.28 3.56e-05 GO:0045892 negative regulation of transcription, DNA-dependent
1.28 6.80e-05 GO:0051253 negative regulation of RNA metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 50 entries
enrichment   p-value GO term description
1.70 1.45e-03 GO:0034708 methyltransferase complex
1.70 1.45e-03 GO:0035097 histone methyltransferase complex
1.57 1.90e-02 GO:0000123 histone acetyltransferase complex
1.55 9.29e-04 GO:0016585 chromatin remodeling complex
1.50 3.21e-03 GO:0005925 focal adhesion
1.46 8.90e-03 GO:0030055 cell-substrate junction
1.45 1.72e-02 GO:0005924 cell-substrate adherens junction
1.41 4.78e-03 GO:0000151 ubiquitin ligase complex
1.35 1.04e-03 GO:0016323 basolateral plasma membrane
1.34 4.46e-02 GO:0070161 anchoring junction
1.33 1.74e-02 GO:0030135 coated vesicle
1.33 3.17e-02 GO:0031252 cell leading edge
1.31 2.90e-11 GO:0044451 nucleoplasm part
1.31 1.20e-03 GO:0005874 microtubule
1.31 1.46e-02 GO:0016604 nuclear body
1.30 1.15e-02 GO:0005667 transcription factor complex
1.30 4.03e-02 GO:0000228 nuclear chromosome
1.26 6.34e-15 GO:0005654 nucleoplasm
1.25 2.88e-20 GO:0031981 nuclear lumen
1.25 1.35e-06 GO:0015630 microtubule cytoskeleton

Gene overrepresentation in function category:

Showing 1 to 20 of 32 entries
enrichment   p-value GO term description
1.44 5.45e-05 GO:0003682 chromatin binding
1.31 7.82e-03 GO:0003702 RNA polymerase II transcription factor activity
1.30 1.48e-05 GO:0019904 protein domain specific binding
1.29 3.61e-03 GO:0016563 transcription activator activity
1.29 6.49e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.26 1.08e-07 GO:0019899 enzyme binding
1.26 4.52e-02 GO:0016564 transcription repressor activity
1.24 2.78e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.23 6.51e-03 GO:0030695 GTPase regulator activity
1.22 2.97e-02 GO:0016874 ligase activity
1.21 2.87e-06 GO:0030528 transcription regulator activity
1.21 1.03e-02 GO:0008092 cytoskeletal protein binding
1.17 1.11e-03 GO:0001071 nucleic acid binding transcription factor activity
1.17 1.11e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.16 2.25e-09 GO:0003677 DNA binding
1.16 1.01e-02 GO:0030234 enzyme regulator activity
1.16 2.38e-02 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.16 4.18e-02 GO:0016301 kinase activity
1.14 1.32e-38 GO:0005515 protein binding
1.12 8.36e-09 GO:0003676 nucleic acid binding