Motif ID: SPIB.p2

Z-value: 4.429


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
SPIB 6689 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SPIBchr19_+_556140060.811.2e-04Click!


Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_15005761 10.878 NM_001175
 ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr17_+_44643067 8.063 ABI3
ABI family, member 3
chr6_-_32268267 7.920 GPSM3
G-protein signaling modulator 3
chr17_-_40843530 7.878 ARHGAP27
Rho GTPase activating protein 27
chr19_-_40925151 6.974 NM_024660
 TMEM149
transmembrane protein 149
chr2_-_225519974 6.118 DOCK10
dedicator of cytokinesis 10
chr7_+_128367961 5.943 NM_001098627
 IRF5
interferon regulatory factor 5
chr2_-_175207521 5.743 NM_003387
 WIPF1
WAS/WASL interacting protein family, member 1
chr6_-_11490487 5.496 NM_001142393
 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr11_+_63864263 5.404 NM_032251
 CCDC88B
coiled-coil domain containing 88B
chr14_+_99601498 5.362 NM_016337
 EVL
Enah/Vasp-like
chr14_+_99601517 5.316 EVL
Enah/Vasp-like
chr6_-_32742265 5.312 NM_002123
 HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr17_-_44642934 5.215 NM_001198754
 GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr6_-_32268615 5.205 GPSM3
G-protein signaling modulator 3
chr18_-_65766068 4.955 CD226
CD226 molecule
chr3_-_113701073 4.916 NM_001085357
NM_181780
 BTLA

B and T lymphocyte associated

chr6_-_56824672 4.911 DST
dystonin
chr19_+_3129735 4.564 NM_003775
 S1PR4
sphingosine-1-phosphate receptor 4
chr17_-_18890963 4.532 NM_006613
 GRAP
GRB2-related adaptor protein

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 56 entries
enrichment   p-value GO term description
2.26 2.95e-03 GO:0031294 lymphocyte costimulation
2.26 2.95e-03 GO:0031295 T cell costimulation
2.01 2.85e-07 GO:0051251 positive regulation of lymphocyte activation
2.01 1.31e-02 GO:0019080 viral genome expression
2.01 1.31e-02 GO:0019083 viral transcription
2.00 2.07e-05 GO:0050870 positive regulation of T cell activation
1.98 6.34e-03 GO:0050851 antigen receptor-mediated signaling pathway
1.96 2.76e-07 GO:0050867 positive regulation of cell activation
1.94 7.81e-07 GO:0002696 positive regulation of leukocyte activation
1.91 1.69e-02 GO:0006414 translational elongation
1.89 5.37e-03 GO:0042110 T cell activation
1.85 8.23e-05 GO:0050863 regulation of T cell activation
1.84 4.05e-02 GO:0002768 immune response-regulating cell surface receptor signaling pathway
1.80 1.23e-05 GO:0051249 regulation of lymphocyte activation
1.75 1.89e-05 GO:0002694 regulation of leukocyte activation
1.74 1.55e-05 GO:0050865 regulation of cell activation
1.73 1.05e-03 GO:0046649 lymphocyte activation
1.73 2.29e-03 GO:0002764 immune response-regulating signaling pathway
1.72 4.33e-03 GO:0002757 immune response-activating signal transduction
1.66 7.37e-04 GO:0045321 leukocyte activation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
2.92 1.42e-02 GO:0070603 SWI/SNF-type complex
1.85 2.00e-02 GO:0016585 chromatin remodeling complex
1.56 8.08e-03 GO:0016604 nuclear body
1.40 1.30e-03 GO:0030529 ribonucleoprotein complex
1.28 1.69e-05 GO:0005654 nucleoplasm
1.24 1.70e-05 GO:0031981 nuclear lumen
1.22 1.80e-05 GO:0044428 nuclear part
1.20 2.34e-04 GO:0005829 cytosol
1.18 3.93e-04 GO:0031974 membrane-enclosed lumen
1.18 5.73e-04 GO:0043233 organelle lumen
1.18 8.98e-04 GO:0070013 intracellular organelle lumen
1.13 4.18e-07 GO:0005634 nucleus
1.13 2.52e-03 GO:0032991 macromolecular complex
1.11 3.77e-05 GO:0044446 intracellular organelle part
1.11 4.30e-05 GO:0044422 organelle part
1.08 4.32e-05 GO:0043227 membrane-bounded organelle
1.08 5.21e-05 GO:0043231 intracellular membrane-bounded organelle
1.07 3.57e-05 GO:0043226 organelle
1.07 3.86e-05 GO:0043229 intracellular organelle
1.06 1.28e-06 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
1.43 1.25e-02 GO:0003712 transcription cofactor activity
1.42 1.44e-02 GO:0000988 protein binding transcription factor activity
1.42 1.44e-02 GO:0000989 transcription factor binding transcription factor activity
1.39 9.14e-03 GO:0060589 nucleoside-triphosphatase regulator activity
1.37 2.12e-02 GO:0030695 GTPase regulator activity
1.34 2.11e-04 GO:0003723 RNA binding
1.25 1.74e-02 GO:0001071 nucleic acid binding transcription factor activity
1.25 1.74e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.20 8.58e-08 GO:0003676 nucleic acid binding
1.19 1.41e-04 GO:0003677 DNA binding
1.13 7.14e-12 GO:0005515 protein binding
1.05 2.02e-04 GO:0005488 binding