Motif ID: SREBF1,2.p2

Z-value: 1.095


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
SREBF1 6720 sterol regulatory element binding transcription factor 1
SREBF2 6721 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SREBF1chr17_-_17681013-0.562.4e-02Click!
SREBF2chr22_+_405590830.371.6e-01Click!


Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_112999590 3.013 LAMP1
lysosomal-associated membrane protein 1
chr13_+_112999538 2.963 LAMP1
lysosomal-associated membrane protein 1
chr13_+_112999462 2.596 NM_005561
LAMP1
lysosomal-associated membrane protein 1
chr19_-_52710129 2.094 NM_003827
NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr12_-_47604930 2.090 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr13_+_48582389 1.990 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr17_-_7078446 1.931 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr19_-_52709975 1.890 NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr14_-_67353046 1.860 NM_015346
ZFYVE26
zinc finger, FYVE domain containing 26
chr19_-_52710089 1.782 NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr14_-_93512818 1.760 ASB2
ankyrin repeat and SOCS box containing 2
chr17_-_7078304 1.725 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr17_-_7078399 1.702 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr15_-_71712711 1.702 NM_001161363
NM_001161364
NM_012428
NM_017455
NPTN



neuroplastin



chr18_+_54958095 1.634 NM_033280
SEC11C
SEC11 homolog C (S. cerevisiae)
chr13_-_31900218 1.608 NM_001079691
NM_052818
N4BP2L1

NEDD4 binding protein 2-like 1

chr19_+_54149963 1.587 BAX
BCL2-associated X protein
chr8_-_54918389 1.586 NM_015941
NM_213619
ATP6V1H

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

chr8_-_54918325 1.579 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr10_-_98021144 1.576 NM_001114094
NM_013314
BLNK

B-cell linker

chrX_+_55760774 1.573 NM_006064
NM_016656
RRAGB

Ras-related GTP binding B

chr19_+_54149941 1.571 BAX
BCL2-associated X protein
chr8_-_54918369 1.569 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr15_-_71712605 1.546 NPTN
neuroplastin
chr16_+_28893525 1.537 NM_001142448
NM_001142449
NM_001142450
NM_001142451
NM_032038
SPIN1
SPNS1




spindlin 1
spinster homolog 1 (Drosophila)




chr17_-_3407780 1.508 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr15_-_70455355 1.504 NM_000520
HEXA
hexosaminidase A (alpha polypeptide)
chr6_+_160310118 1.497 NM_000876
IGF2R
insulin-like growth factor 2 receptor
chr8_-_54918099 1.455 NM_213620
ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr19_+_54149843 1.439 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chr13_-_49057707 1.400 NM_018191
RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr13_-_49057629 1.399 RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr12_+_52733927 1.368 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chrX_-_114703273 1.357


chr17_+_75851984 1.353


chr2_+_143603439 1.351 ARHGAP15
Rho GTPase activating protein 15
chr8_+_120289735 1.292 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr15_-_70455153 1.274 HEXA
hexosaminidase A (alpha polypeptide)
chr11_+_120828058 1.272 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr1_+_148521852 1.269 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr1_-_199635057 1.236 LAD1
ladinin 1
chr9_+_6747919 1.219 KDM4C
lysine (K)-specific demethylase 4C
chr11_+_7491789 1.210 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr19_-_15436333 1.206 NM_022904
RASAL3
RAS protein activator like 3
chr11_+_120828275 1.205 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr2_+_241174803 1.204 NM_023083
NM_023085
CAPN10

calpain 10

chr16_-_66827449 1.200 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr11_+_7491576 1.176 NM_003621
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr17_+_39778016 1.164 NM_002087
GRN
granulin
chr10_-_105427898 1.143 SH3PXD2A
SH3 and PX domains 2A
chr7_+_4781784 1.141 NM_014855
KIAA0415
KIAA0415
chr14_+_73621408 1.139 NM_001024674
LIN52
lin-52 homolog (C. elegans)
chr22_+_40724674 1.129 NM_152613
WBP2NL
WBP2 N-terminal like
chr7_-_29995809 1.121 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr16_+_639278 1.100 NM_145294
WDR90
WD repeat domain 90
chr1_-_152797760 1.090 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr2_+_219751207 1.088 FAM134A
family with sequence similarity 134, member A
chr1_-_42694263 1.077 ZMYND12
zinc finger, MYND-type containing 12
chr1_-_152797707 1.075 NM_017582
UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr8_+_98725604 1.069 MTDH
metadherin
chr11_+_9642226 1.067 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr17_+_7152417 1.066 NM_001143762
EIF5A
eukaryotic translation initiation factor 5A
chr17_+_39778153 1.060 GRN
granulin
chr15_-_32398220 1.054 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr6_-_33493640 1.053 CUTA
cutA divalent cation tolerance homolog (E. coli)
chr2_+_169021001 1.052 LASS6
LAG1 homolog, ceramide synthase 6
chr12_-_119826073 1.051 SPPL3
signal peptide peptidase 3
chr2_+_219751192 1.045 FAM134A
family with sequence similarity 134, member A
chr11_+_9642200 1.044 NM_015055
SWAP70
SWAP switching B-cell complex 70kDa subunit
chrX_+_128741578 1.043 SASH3
SAM and SH3 domain containing 3
chr14_-_70345485 1.039 NM_033141
MAP3K9
mitogen-activated protein kinase kinase kinase 9
chr8_+_109525050 1.037 TTC35
tetratricopeptide repeat domain 35
chr17_+_3486753 1.030 CTNS
cystinosis, nephropathic
chr2_+_219751230 1.028 FAM134A
family with sequence similarity 134, member A
chr11_+_9642182 1.028 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr8_-_81246215 1.026 NM_001025253
NM_005079
TPD52

tumor protein D52

chr15_+_86983038 1.026 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr12_-_44949046 1.016 SLC38A1
solute carrier family 38, member 1
chr17_+_39778191 1.011 GRN
granulin
chr6_-_43445103 1.010 NM_014345
ZNF318
zinc finger protein 318
chr1_-_24386324 1.008 NM_170743
NM_173064
NM_173065
IL28RA


interleukin 28 receptor, alpha (interferon, lambda receptor)


chr1_-_152797767 1.002 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr8_+_75066117 0.999 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr8_+_98725505 0.995 NM_178812
MTDH
metadherin
chr19_+_55614006 0.992 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr3_-_113763449 0.991 ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr2_+_169021039 0.987 NM_203463
LASS6
LAG1 homolog, ceramide synthase 6
chr17_+_39778180 0.981 GRN
granulin
chr3_-_49370755 0.976 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chr8_+_109525010 0.975 NM_014673
TTC35
tetratricopeptide repeat domain 35
chr20_-_4743768 0.967 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chrX_+_128741562 0.966 NM_018990
SASH3
SAM and SH3 domain containing 3
chr1_-_152797820 0.960 UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr3_-_49370682 0.954 GPX1
glutathione peroxidase 1
chr18_+_54682261 0.953 ZNF532
zinc finger protein 532
chr2_+_227898163 0.951 MFF
mitochondrial fission factor
chr8_-_143482433 0.950 NM_145003
TSNARE1
t-SNARE domain containing 1
chr14_-_93512647 0.949 ASB2
ankyrin repeat and SOCS box containing 2
chr3_-_113763454 0.944 ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr13_-_32757835 0.943 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr11_-_60475558 0.943 NM_016582
SLC15A3
solute carrier family 15, member 3
chr2_-_55090759 0.942 NM_007008
RTN4
reticulon 4
chr3_-_123995216 0.942 NM_024610
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr7_+_101860958 0.934 NM_001126340
NM_032831
ORAI2

ORAI calcium release-activated calcium modulator 2

chr1_-_197173159 0.932 LOC100131234
familial acute myelogenous leukemia related factor
chr10_+_106018915 0.928 GSTO2
glutathione S-transferase omega 2
chr5_+_68746694 0.925 NM_001038603
MARVELD2
MARVEL domain containing 2
chr1_-_39097904 0.925 NM_022157
RRAGC
Ras-related GTP binding C
chr9_-_139128777 0.924 DPP7
dipeptidyl-peptidase 7
chr10_+_51497716 0.924 FAM21A
family with sequence similarity 21, member A
chr9_-_21984329 0.913 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr2_-_227372574 0.912 IRS1
insulin receptor substrate 1
chr9_-_21984379 0.908 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr6_-_33493792 0.906 CUTA
cutA divalent cation tolerance homolog (E. coli)
chr3_+_113763561 0.902 NM_017945
SLC35A5
solute carrier family 35, member A5
chr4_-_47160476 0.901 COMMD8
COMM domain containing 8
chr11_+_9642229 0.900 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr7_+_101861007 0.894 ORAI2
ORAI calcium release-activated calcium modulator 2
chr17_-_41018291 0.891


chr12_+_56284867 0.889 NM_178502
DTX3
deltex homolog 3 (Drosophila)
chr11_+_59979857 0.885 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr12_-_44948976 0.885 SLC38A1
solute carrier family 38, member 1
chr3_-_113763425 0.878 ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr9_-_21984414 0.878 NM_058195
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr4_-_47160403 0.877 NM_017845
COMMD8
COMM domain containing 8
chr2_+_219751145 0.873 NM_024293
FAM134A
family with sequence similarity 134, member A
chr22_+_38720881 0.873 NM_138435
FAM83F
family with sequence similarity 83, member F
chr12_-_57600564 0.846 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr12_-_57600336 0.832 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr16_-_4528380 0.831 NM_001199054
C16orf5
chromosome 16 open reading frame 5
chr9_-_37566248 0.828 NM_012166
FBXO10
F-box protein 10
chr8_+_95722448 0.824 ESRP1
epithelial splicing regulatory protein 1
chr17_-_7962531 0.816 NM_021628
ALOXE3
arachidonate lipoxygenase 3
chr16_+_1341937 0.814 GNPTG
N-acetylglucosamine-1-phosphate transferase, gamma subunit
chr14_-_34661156 0.813 PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr18_-_45241014 0.811 NM_017653
DYM
dymeclin
chr18_+_58535145 0.809 PHLPP1
PH domain and leucine rich repeat protein phosphatase 1
chr14_-_64040072 0.809 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr7_+_17304707 0.809 NM_001621
AHR
aryl hydrocarbon receptor
chr17_+_1574782 0.808 NM_001163809
WDR81
WD repeat domain 81
chr12_+_102982365 0.806 NM_013320
HCFC2
host cell factor C2
chr4_+_75393053 0.804 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr1_+_152459918 0.802 NM_014847
UBAP2L
ubiquitin associated protein 2-like
chr3_-_113763217 0.796 ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr3_-_126414252 0.781 NM_024628
SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr14_+_20580224 0.775 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr10_-_105442868 0.762 SH3PXD2A
SH3 and PX domains 2A
chr2_-_219750975 0.757 C2orf24
chromosome 2 open reading frame 24
chr6_+_138230045 0.755 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr2_-_166359016 0.750 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr7_+_4781803 0.749 KIAA0415
KIAA0415
chr14_-_91642703 0.749 NM_001127696
NM_001127697
NM_001164774
NM_001164776
NM_001164777
NM_001164778
NM_001164779
NM_001164780
NM_001164781
NM_001164782
NM_004993
NM_030660
ATXN3











ataxin 3











chr14_+_44622916 0.747 NM_017922
PRPF39
PRP39 pre-mRNA processing factor 39 homolog (S. cerevisiae)
chr16_+_80370426 0.746 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr1_-_115060904 0.742 NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr12_+_52618815 0.741 NM_017410
HOXC13
homeobox C13
chr15_-_70455794 0.740 HEXA
hexosaminidase A (alpha polypeptide)
chr19_+_50196526 0.734 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr5_+_122138677 0.734 SNX2
sorting nexin 2
chr14_-_34661190 0.727 NM_017917
PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr3_-_113763049 0.721 NM_022488
ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chr8_+_98725670 0.719 MTDH
metadherin
chr1_+_111544469 0.718


chr12_+_14409875 0.714 NM_018179
ATF7IP
activating transcription factor 7 interacting protein
chr12_-_51912101 0.711 NM_000966
RARG
retinoic acid receptor, gamma
chr22_+_23153529 0.704 NM_000675
ADORA2A
adenosine A2a receptor
chr11_+_125586828 0.704 NM_024556
FAM118B
family with sequence similarity 118, member B
chr14_+_23700261 0.699 NM_006084
IRF9
interferon regulatory factor 9
chr3_+_44878380 0.699 NM_144638
TMEM42
transmembrane protein 42
chr14_-_91642641 0.699 ATXN3
ATXN8
ataxin 3
ataxin 8
chr16_-_15644465 0.696 NM_001184998
NM_001184999
NM_014647
KIAA0430


KIAA0430


chr16_-_66072477 0.695 NM_004691
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr19_+_1018293 0.695 HMHA1
histocompatibility (minor) HA-1
chr17_+_6856521 0.694 NM_001004333
RNASEK-C17ORF49
RNASEK
RNASEK-C17orf49 read-through transcript
ribonuclease, RNase K
chr3_-_11736946 0.694 NM_014667
VGLL4
vestigial like 4 (Drosophila)
chr20_+_43028590 0.693 STK4
serine/threonine kinase 4
chr22_-_36907638 0.692 NM_001004426
NM_003560
PLA2G6

phospholipase A2, group VI (cytosolic, calcium-independent)

chr6_+_139391511 0.690 NM_021243
C6orf115
chromosome 6 open reading frame 115
chr3_+_133619193 0.687 NM_015268
DNAJC13
DnaJ (Hsp40) homolog, subfamily C, member 13
chr17_+_6856676 0.684 RNASEK-C17ORF49
RNASEK
RNASEK-C17orf49 read-through transcript
ribonuclease, RNase K
chr20_+_43028533 0.677 NM_006282
STK4
serine/threonine kinase 4
chr19_+_1018536 0.676 HMHA1
histocompatibility (minor) HA-1
chr9_+_6747636 0.674 NM_001146694
NM_001146695
NM_015061
KDM4C


lysine (K)-specific demethylase 4C


chr3_+_114733907 0.671 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr9_+_114953048 0.670 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chr14_+_44501083 0.669 NM_015091
FAM179B
family with sequence similarity 179, member B
chr12_+_52713098 0.666 NM_018953
HOXC5
homeobox C5
chr5_+_122138636 0.662 NM_003100
SNX2
sorting nexin 2
chr3_+_113763601 0.660 SLC35A5
solute carrier family 35, member A5
chr3_+_87359088 0.659 NM_014043
CHMP2B
chromatin modifying protein 2B
chr12_+_56271259 0.656 PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr17_+_6856697 0.655 RNASEK-C17ORF49
RNASEK-C17orf49 read-through transcript
chr17_+_1574583 0.653 NM_001163811
WDR81
WD repeat domain 81
chr9_-_133574928 0.650 NM_198679
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr5_+_122138661 0.647 SNX2
sorting nexin 2
chr7_-_27149750 0.646 NM_019102
HOXA5
homeobox A5
chr1_+_149437602 0.642 NM_001135636
NM_001135637
NM_001135638
NM_003557
PIP5K1A



phosphatidylinositol-4-phosphate 5-kinase, type I, alpha



chr1_+_42694751 0.634 NM_001077447
NM_024664
PPCS

phosphopantothenoylcysteine synthetase

chr16_+_68353662 0.632 WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr11_-_85457469 0.630 PICALM
phosphatidylinositol binding clathrin assembly protein

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.42 1.35e-05 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.23 4.14e-05 GO:0044237 cellular metabolic process
1.33 6.45e-04 GO:0006807 nitrogen compound metabolic process
1.33 7.84e-04 GO:0034641 cellular nitrogen compound metabolic process
1.11 1.41e-03 GO:0009987 cellular process
1.41 1.49e-03 GO:0090304 nucleic acid metabolic process
1.44 2.72e-03 GO:0010467 gene expression
1.18 3.68e-03 GO:0008152 metabolic process
1.24 8.21e-03 GO:0044260 cellular macromolecule metabolic process
1.17 3.13e-02 GO:0044238 primary metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 1.94e-12 GO:0005622 intracellular
1.16 4.68e-12 GO:0044424 intracellular part
1.22 6.13e-11 GO:0043227 membrane-bounded organelle
1.22 7.35e-11 GO:0043231 intracellular membrane-bounded organelle
1.18 1.32e-09 GO:0043226 organelle
1.31 1.66e-09 GO:0044446 intracellular organelle part
1.18 2.00e-09 GO:0043229 intracellular organelle
1.30 4.85e-09 GO:0044422 organelle part
1.19 2.42e-07 GO:0005737 cytoplasm
1.26 2.39e-06 GO:0005634 nucleus
1.24 2.84e-06 GO:0044444 cytoplasmic part
1.45 7.74e-06 GO:0070013 intracellular organelle lumen
1.44 3.15e-05 GO:0044428 nuclear part
1.42 3.27e-05 GO:0031974 membrane-enclosed lumen
1.42 3.65e-05 GO:0043233 organelle lumen
1.46 9.52e-05 GO:0031981 nuclear lumen
1.55 1.35e-04 GO:0005654 nucleoplasm
1.41 3.82e-04 GO:0005829 cytosol
1.29 3.91e-04 GO:0032991 macromolecular complex
1.65 4.91e-03 GO:0044451 nucleoplasm part
1.97 1.11e-02 GO:0005773 vacuole
1.27 1.26e-02 GO:0043234 protein complex
1.05 2.12e-02 GO:0044464 cell part
1.05 2.17e-02 GO:0005623 cell

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.20 7.30e-06 GO:0005515 protein binding
1.11 3.99e-05 GO:0005488 binding
1.82 4.41e-02 GO:0003712 transcription cofactor activity
1.82 4.70e-02 GO:0000988 protein binding transcription factor activity
1.82 4.70e-02 GO:0000989 transcription factor binding transcription factor activity