Motif ID: SREBF1,2.p2

Z-value: 1.095


Transcription factors associated with SREBF1,2.p2:

Gene SymbolEntrez IDGene Name
SREBF1 6720 sterol regulatory element binding transcription factor 1
SREBF2 6721 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SREBF1chr17_-_17681013-0.562.4e-02Click!
SREBF2chr22_+_405590830.371.6e-01Click!


Activity profile for motif SREBF1,2.p2.

activity profile for motif SREBF1,2.p2


Sorted Z-values histogram for motif SREBF1,2.p2

Sorted Z-values for motif SREBF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SREBF1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_112999590 3.013 LAMP1
lysosomal-associated membrane protein 1
chr13_+_112999538 2.963 LAMP1
lysosomal-associated membrane protein 1
chr13_+_112999462 2.596 NM_005561
 LAMP1
lysosomal-associated membrane protein 1
chr19_-_52710129 2.094 NM_003827
 NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr12_-_47604930 2.090 NM_001143781
 FKBP11
FK506 binding protein 11, 19 kDa
chr13_+_48582389 1.990 NM_014923
 FNDC3A
fibronectin type III domain containing 3A
chr17_-_7078446 1.931 NM_004422
 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr19_-_52709975 1.890 NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr14_-_67353046 1.860 NM_015346
 ZFYVE26
zinc finger, FYVE domain containing 26
chr19_-_52710089 1.782 NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr14_-_93512818 1.760 ASB2
ankyrin repeat and SOCS box containing 2
chr17_-_7078304 1.725 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr17_-_7078399 1.702 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr15_-_71712711 1.702 NM_001161363
NM_001161364
NM_012428
NM_017455
 NPTN



neuroplastin



chr18_+_54958095 1.634 NM_033280
 SEC11C
SEC11 homolog C (S. cerevisiae)
chr13_-_31900218 1.608 NM_001079691
NM_052818
 N4BP2L1

NEDD4 binding protein 2-like 1

chr19_+_54149963 1.587 BAX
BCL2-associated X protein
chr8_-_54918389 1.586 NM_015941
NM_213619
 ATP6V1H

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

chr8_-_54918325 1.579 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr10_-_98021144 1.576 NM_001114094
NM_013314
 BLNK

B-cell linker


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
1.44 2.72e-03 GO:0010467 gene expression
1.42 1.35e-05 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.41 1.49e-03 GO:0090304 nucleic acid metabolic process
1.33 6.45e-04 GO:0006807 nitrogen compound metabolic process
1.33 7.84e-04 GO:0034641 cellular nitrogen compound metabolic process
1.24 8.21e-03 GO:0044260 cellular macromolecule metabolic process
1.23 4.14e-05 GO:0044237 cellular metabolic process
1.18 3.68e-03 GO:0008152 metabolic process
1.17 3.13e-02 GO:0044238 primary metabolic process
1.11 1.41e-03 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
1.97 1.11e-02 GO:0005773 vacuole
1.65 4.91e-03 GO:0044451 nucleoplasm part
1.55 1.35e-04 GO:0005654 nucleoplasm
1.46 9.52e-05 GO:0031981 nuclear lumen
1.45 7.74e-06 GO:0070013 intracellular organelle lumen
1.44 3.15e-05 GO:0044428 nuclear part
1.42 3.27e-05 GO:0031974 membrane-enclosed lumen
1.42 3.65e-05 GO:0043233 organelle lumen
1.41 3.82e-04 GO:0005829 cytosol
1.31 1.66e-09 GO:0044446 intracellular organelle part
1.30 4.85e-09 GO:0044422 organelle part
1.29 3.91e-04 GO:0032991 macromolecular complex
1.27 1.26e-02 GO:0043234 protein complex
1.26 2.39e-06 GO:0005634 nucleus
1.24 2.84e-06 GO:0044444 cytoplasmic part
1.22 6.13e-11 GO:0043227 membrane-bounded organelle
1.22 7.35e-11 GO:0043231 intracellular membrane-bounded organelle
1.19 2.42e-07 GO:0005737 cytoplasm
1.18 1.32e-09 GO:0043226 organelle
1.18 2.00e-09 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
1.82 4.41e-02 GO:0003712 transcription cofactor activity
1.82 4.70e-02 GO:0000988 protein binding transcription factor activity
1.82 4.70e-02 GO:0000989 transcription factor binding transcription factor activity
1.20 7.30e-06 GO:0005515 protein binding
1.11 3.99e-05 GO:0005488 binding