Motif ID: SRF.p3

Z-value: 2.599


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SRFchr6_+_432471790.371.6e-01Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_34603290 7.810 NM_006097
NM_181526
 MYL9

myosin, light chain 9, regulatory

chr15_-_32875040 7.808 NM_005159
 ACTC1
actin, alpha, cardiac muscle 1
chr20_+_34603311 7.706 MYL9
myosin, light chain 9, regulatory
chr5_+_137829077 6.682 NM_001964
 EGR1
early growth response 1
chr19_-_40939756 5.885 NM_144617
 HSPB6
heat shock protein, alpha-crystallin-related, B6
chr17_-_44026042 5.820 NM_002147
 HOXB5
homeobox B5
chr11_+_116575249 4.495 NM_001001522
NM_003186
 TAGLN

transgelin

chr5_-_33928049 4.006 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr17_-_44026321 3.873 HOXB5
homeobox B5
chr12_+_74160779 3.843 NM_006851
 GLIPR1
GLI pathogenesis-related 1
chr5_-_33927724 3.744 NM_030955
 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr1_+_221955876 3.624 NM_001146068
 CAPN2
calpain 2, (m/II) large subunit
chr5_-_141981083 3.480 NM_001144892
 FGF1
fibroblast growth factor 1 (acidic)
chr10_+_31650069 3.444 NM_001128128
NM_001174094
 ZEB1

zinc finger E-box binding homeobox 1

chr19_+_2427122 3.150 NM_015675
 GADD45B
growth arrest and DNA-damage-inducible, beta
chr9_+_91409746 3.069 NM_006705
 GADD45G
growth arrest and DNA-damage-inducible, gamma
chr5_+_137829065 3.031 EGR1
early growth response 1
chr22_+_29810981 3.000 SMTN
smoothelin
chr1_-_16217025 2.846 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr6_-_109882116 2.766 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
12.94 9.07e-04 GO:0030049 muscle filament sliding
12.94 9.07e-04 GO:0033275 actin-myosin filament sliding
12.60 1.10e-03 GO:0070252 actin-mediated cell contraction
12.07 4.58e-05 GO:0030048 actin filament-based movement
8.10 1.56e-03 GO:0007015 actin filament organization
7.79 1.69e-08 GO:0006936 muscle contraction
7.56 7.91e-09 GO:0003012 muscle system process
5.58 8.42e-05 GO:0007517 muscle organ development
4.80 1.82e-05 GO:0030029 actin filament-based process
4.49 2.69e-04 GO:0061061 muscle structure development
3.80 4.10e-02 GO:0030036 actin cytoskeleton organization
1.87 9.15e-03 GO:0030154 cell differentiation
1.86 2.56e-02 GO:0048513 organ development
1.82 1.95e-02 GO:0048869 cellular developmental process
1.72 3.04e-04 GO:0007275 multicellular organismal development
1.71 9.55e-05 GO:0032502 developmental process
1.69 3.52e-03 GO:0048856 anatomical structure development
1.67 2.36e-02 GO:0048731 system development
1.53 3.26e-04 GO:0032501 multicellular organismal process
1.43 2.29e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
17.10 2.18e-05 GO:0001725 stress fiber
16.58 3.43e-06 GO:0042641 actomyosin
15.96 3.65e-05 GO:0032432 actin filament bundle
12.07 1.60e-03 GO:0005884 actin filament
9.98 1.05e-03 GO:0031674 I band
9.08 1.79e-08 GO:0044449 contractile fiber part
8.90 5.71e-09 GO:0043292 contractile fiber
8.85 2.62e-08 GO:0030016 myofibril
8.55 7.41e-04 GO:0016459 myosin complex
8.38 3.54e-06 GO:0030017 sarcomere
8.29 3.98e-06 GO:0005925 focal adhesion
7.89 6.98e-06 GO:0005924 cell-substrate adherens junction
7.60 1.07e-05 GO:0030055 cell-substrate junction
6.46 2.40e-12 GO:0015629 actin cytoskeleton
5.97 5.30e-05 GO:0005912 adherens junction
5.39 1.71e-04 GO:0070161 anchoring junction
3.59 2.62e-02 GO:0016323 basolateral plasma membrane
2.46 1.68e-07 GO:0005856 cytoskeleton
2.41 4.99e-02 GO:0030054 cell junction
2.18 5.12e-03 GO:0044430 cytoskeletal part

Gene overrepresentation in function category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
13.68 5.56e-03 GO:0017022 myosin binding
9.54 7.38e-03 GO:0008307 structural constituent of muscle
4.55 1.73e-06 GO:0003779 actin binding
4.43 4.30e-02 GO:0005516 calmodulin binding
4.40 4.53e-02 GO:0003774 motor activity
3.31 3.50e-05 GO:0008092 cytoskeletal protein binding
1.37 2.70e-04 GO:0005515 protein binding
1.15 4.97e-02 GO:0005488 binding