Motif ID: SRF.p3

Z-value: 2.599


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SRFchr6_+_432471790.371.6e-01Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_34603290 7.810 NM_006097
NM_181526
MYL9

myosin, light chain 9, regulatory

chr15_-_32875040 7.808 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr20_+_34603311 7.706 MYL9
myosin, light chain 9, regulatory
chr5_+_137829077 6.682 NM_001964
EGR1
early growth response 1
chr19_-_40939756 5.885 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr17_-_44026042 5.820 NM_002147
HOXB5
homeobox B5
chr11_+_116575249 4.495 NM_001001522
NM_003186
TAGLN

transgelin

chr5_-_33928049 4.006 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr17_-_44026321 3.873 HOXB5
homeobox B5
chr12_+_74160779 3.843 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr5_-_33927724 3.744 NM_030955
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr1_+_221955876 3.624 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr5_-_141981083 3.480 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr10_+_31650069 3.444 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr19_+_2427122 3.150 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr9_+_91409746 3.069 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr5_+_137829065 3.031 EGR1
early growth response 1
chr22_+_29810981 3.000 SMTN
smoothelin
chr1_-_16217025 2.846 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr6_-_109882116 2.766 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr12_+_50731457 2.763 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr3_+_189413414 2.638 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr14_-_52487558 2.558 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr14_-_93512818 2.538 ASB2
ankyrin repeat and SOCS box containing 2
chr10_+_112247614 2.534 NM_004419
DUSP5
dual specificity phosphatase 5
chr10_-_90702490 2.502 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr10_-_64246080 2.496 EGR2
early growth response 2
chr6_+_116939500 2.337 NM_153711
FAM26E
family with sequence similarity 26, member E
chr10_-_64246129 2.205 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr5_-_178983241 2.023 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr17_-_1336073 2.001 MYO1C
myosin IC
chr2_+_88148413 1.974 NM_198274
SMYD1
SET and MYND domain containing 1
chr7_-_5536783 1.920 ACTB
actin, beta
chr17_-_4831644 1.891 NM_001171166
NM_015099
CAMTA2

calmodulin binding transcription activator 2

chr11_-_65424434 1.890 FOSL1
FOS-like antigen 1
chr13_-_98757634 1.874 NM_004951
GPR183
G protein-coupled receptor 183
chr11_-_65424385 1.808 FOSL1
FOS-like antigen 1
chr11_-_65424436 1.771 NM_005438
FOSL1
FOS-like antigen 1
chr9_+_36126667 1.749 GLIPR2
GLI pathogenesis-related 2
chr1_-_227636462 1.717 NM_001100
ACTA1
actin, alpha 1, skeletal muscle
chr9_+_36126710 1.710 NM_022343
GLIPR2
GLI pathogenesis-related 2
chr19_+_59064471 1.621 NM_001020821
NM_001020818
MYADM

myeloid-associated differentiation marker

chr19_+_59064795 1.543 MYADM
myeloid-associated differentiation marker
chr1_+_165866127 1.485 RCSD1
RCSD domain containing 1
chr16_+_55523526 1.454 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr17_+_3326045 1.445 NM_000049
ASPA
aspartoacylase
chr6_+_151603201 1.440 AKAP12
A kinase (PRKA) anchor protein 12
chr6_-_105691675 1.435 BVES
blood vessel epicardial substance
chr15_-_63147350 1.400 NM_016563
RASL12
RAS-like, family 12
chr14_-_93512647 1.398 ASB2
ankyrin repeat and SOCS box containing 2
chr3_+_150675117 1.392 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr7_-_107430566 1.388 NM_002291
LAMB1
laminin, beta 1
chr5_-_178983281 1.385 NM_005520
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr6_+_151602787 1.331 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr1_-_166373434 1.322 GPR161
G protein-coupled receptor 161
chr19_+_977608 1.320 CNN2
calponin 2
chr1_+_165865953 1.310 NM_052862
RCSD1
RCSD domain containing 1
chr2_-_128149112 1.304 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr1_-_89303478 1.281 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible, 67kDa
chr14_-_73296643 1.266 NM_194278
C14orf43
chromosome 14 open reading frame 43
chr17_-_4831388 1.264 NM_001171167
NM_001171168
CAMTA2

calmodulin binding transcription activator 2

chr1_-_31618405 1.202 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr10_-_131652364 1.201 EBF3
early B-cell factor 3
chr7_-_5536704 1.196 NM_001101
ACTB
actin, beta
chr15_+_72006015 1.194 LOXL1
lysyl oxidase-like 1
chr19_+_977601 1.184 CNN2
calponin 2
chr5_+_88220846 1.169


chr20_+_4650499 1.145 NM_012409
PRND
prion protein 2 (dublet)
chr5_+_60663842 1.137 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr19_+_977555 1.133 CNN2
calponin 2
chr5_+_92944680 1.116 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr17_+_29707583 1.095 NM_005408
CCL13
chemokine (C-C motif) ligand 13
chr19_+_977624 1.088 CNN2
calponin 2
chr3_-_101077605 1.081 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr19_+_977582 1.047 CNN2
calponin 2
chr11_-_118799058 1.042 THY1
Thy-1 cell surface antigen
chr4_+_14985272 1.020 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr7_+_94123612 1.007 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr2_-_30883775 0.986 NM_144575
CAPN13
calpain 13
chr20_+_32610161 0.964 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr7_-_94123308 0.946 SGCE
sarcoglycan, epsilon
chr16_+_29984611 0.941 ALDOA
aldolase A, fructose-bisphosphate
chr2_-_160972606 0.932 RBMS1
RNA binding motif, single stranded interacting protein 1
chr17_+_39990124 0.925 NM_001466
FZD2
frizzled homolog 2 (Drosophila)
chr7_+_142788521 0.884 ZYX
zyxin
chr2_-_105421661 0.868 NM_201557
FHL2
four and a half LIM domains 2
chr19_+_977627 0.864 CNN2
calponin 2
chr7_+_142788480 0.859 NM_001010972
NM_003461
ZYX

zyxin

chr1_-_166373351 0.853 GPR161
G protein-coupled receptor 161
chr7_+_142788566 0.851 ZYX
zyxin
chr10_+_88418147 0.850 NM_001171610
LDB3
LIM domain binding 3
chr1_-_166373159 0.846 GPR161
G protein-coupled receptor 161
chr13_-_45640679 0.844 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr10_+_6226909 0.835 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr1_-_152431175 0.832 NM_152263
TPM3
tropomyosin 3
chr4_+_81337663 0.830 NM_001099403
PRDM8
PR domain containing 8
chr10_+_6226884 0.828 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr22_-_35114001 0.824 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr9_-_78710698 0.823 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr16_+_29984591 0.822 ALDOA
aldolase A, fructose-bisphosphate
chr3_-_46879883 0.821 NM_000258
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr7_+_142788569 0.819 ZYX
zyxin
chr3_+_150675169 0.812 TM4SF4
transmembrane 4 L six family member 4
chr17_-_36456949 0.788 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr16_+_29984544 0.774 NM_184041
ALDOA
aldolase A, fructose-bisphosphate
chr16_+_29984621 0.759 ALDOA
aldolase A, fructose-bisphosphate
chr6_+_167445284 0.755 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr7_-_94123362 0.753 SGCE
sarcoglycan, epsilon
chr4_+_24406182 0.747 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr7_-_94123413 0.731 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr7_+_142788517 0.730 ZYX
zyxin
chr17_-_77094375 0.723 NM_001614
ACTG1
actin, gamma 1
chr16_+_29984647 0.699 ALDOA
aldolase A, fructose-bisphosphate
chr3_+_145173329 0.693 NM_173552
C3orf58
chromosome 3 open reading frame 58
chrX_+_153318662 0.693 GDI1
GDP dissociation inhibitor 1
chr1_-_148080888 0.686 NM_001040874
NM_003516
HIST2H2AA4
HIST2H2AA3
histone cluster 2, H2aa4
histone cluster 2, H2aa3
chr7_-_5535726 0.684 ACTB
actin, beta
chr7_+_94123672 0.656 PEG10
paternally expressed 10
chr17_+_16259636 0.643 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr10_+_6226764 0.631 NM_001145443
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr17_-_77094426 0.627 ACTG1
actin, gamma 1
chr14_-_101623097 0.615 HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr11_-_64402629 0.610 NM_006795
EHD1
EH-domain containing 1
chr16_+_30015899 0.610


chr15_-_63147228 0.605 RASL12
RAS-like, family 12
chr7_+_142788579 0.597 ZYX
zyxin
chr3_-_124821868 0.596 MYLK
myosin light chain kinase
chr11_+_46339691 0.586 NM_001105540
DGKZ
diacylglycerol kinase, zeta
chr12_-_46405477 0.582 NM_001172439
NM_001172440
NM_006025
ENDOU


endonuclease, polyU-specific


chr10_+_88418243 0.562 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr2_+_87536106 0.560 NCRNA00152
non-protein coding RNA 152
chr1_-_240228987 0.558 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr15_-_57452361 0.540 NM_004998
MYO1E
myosin IE
chr11_+_74950893 0.536 SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr17_+_16259573 0.534 NM_016113
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr20_-_33706532 0.530 RBM12
RNA binding motif protein 12
chr9_+_18464090 0.530 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr7_-_526005 0.528 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr15_-_57452357 0.521 MYO1E
myosin IE
chr17_+_16259812 0.513 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr12_+_27824429 0.508 NM_020782
KLHDC5
kelch domain containing 5
chr2_+_100545827 0.505 NM_024065
PDCL3
phosducin-like 3
chr8_-_22606653 0.478 NM_004430
EGR3
early growth response 3
chr11_-_8982107 0.475 NM_020645
NRIP3
nuclear receptor interacting protein 3
chr12_-_90029672 0.469 NM_002345
LUM
lumican
chr20_-_61728866 0.467 GMEB2
glucocorticoid modulatory element binding protein 2
chr17_+_30498948 0.464 NM_001033576
NM_173167
UNC45B

unc-45 homolog B (C. elegans)

chr2_-_207739815 0.462 KLF7
Kruppel-like factor 7 (ubiquitous)
chr16_+_31390567 0.460 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr7_+_142788730 0.459 ZYX
zyxin
chr3_+_25445071 0.457 RARB
retinoic acid receptor, beta
chr9_-_4290028 0.457 NM_001042413
GLIS3
GLIS family zinc finger 3
chr14_-_73296387 0.455 C14orf43
chromosome 14 open reading frame 43
chr3_-_124822113 0.455 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr22_+_24468110 0.454 NM_032608
MYO18B
myosin XVIIIB
chr17_-_36181927 0.451 NM_181539
KRT26
keratin 26
chr17_-_1335763 0.450 NM_001080950
MYO1C
myosin IC
chr2_-_225086564 0.439 CUL3
cullin 3
chr19_+_39402167 0.435 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr3_-_158704056 0.431 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr19_-_50975603 0.418 NM_001081563
DMPK
dystrophia myotonica-protein kinase
chr6_-_159386007 0.418 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr1_+_179324458 0.410 IER5
immediate early response 5
chr9_+_115396020 0.403 NM_144489
RGS3
regulator of G-protein signaling 3
chr18_+_9698299 0.395 RAB31
RAB31, member RAS oncogene family
chr2_-_96174502 0.393 DUSP2
dual specificity phosphatase 2
chr2_-_105381855 0.391 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr21_-_27139143 0.376 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr12_+_26239755 0.374 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr9_-_97309301 0.363 NM_001083607
PTCH1
patched 1
chr1_+_144183811 0.359 ANKRD34A
ankyrin repeat domain 34A
chr22_+_38246509 0.357 NM_001675
NM_182810
ATF4

activating transcription factor 4 (tax-responsive enhancer element B67)

chr12_+_8167494 0.349 NM_016184
NM_194447
NM_194448
NM_194450
CLEC4A



C-type lectin domain family 4, member A



chr6_-_132314004 0.346 NM_001901
CTGF
connective tissue growth factor
chr1_-_35097232 0.345 NM_001164824
C1orf212
chromosome 1 open reading frame 212
chr2_-_96174865 0.342 NM_004418
DUSP2
dual specificity phosphatase 2
chr2_-_69033515 0.339 NM_182536
GKN2
gastrokine 2
chr7_+_71937980 0.325 SBDSP1
Shwachman-Bodian-Diamond syndrome pseudogene 1
chr4_+_86918882 0.323 ARHGAP24
Rho GTPase activating protein 24
chr4_+_120276386 0.310 NM_016599
MYOZ2
myozenin 2
chr18_-_42810446 0.309 NM_145653
TCEB3C
transcription elongation factor B polypeptide 3C (elongin A3)
chr7_-_5535432 0.305 ACTB
actin, beta
chr18_-_63333487 0.302 DSEL
dermatan sulfate epimerase-like
chr4_+_156899575 0.298 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr7_+_94123556 0.296 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr22_+_24468168 0.295 MYO18B
myosin XVIIIB
chr15_-_57452345 0.289 MYO1E
myosin IE
chr5_-_111120929 0.286 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr2_+_84986273 0.281 NM_021103
TMSB10
thymosin beta 10
chr1_+_27972269 0.273 NM_177424
STX12
syntaxin 12
chrX_-_11194015 0.261 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr6_+_144654565 0.258 NM_007124
UTRN
utrophin
chr22_-_29694186 0.255 NM_014941
MORC2
MORC family CW-type zinc finger 2
chr5_+_176807931 0.252 NM_001174102
PRR7
proline rich 7 (synaptic)
chr14_+_73775927 0.240 NM_182894
VSX2
visual system homeobox 2
chr18_-_42804531 0.235 NM_145653
TCEB3C
transcription elongation factor B polypeptide 3C (elongin A3)
chr5_-_39461054 0.233 NM_001343
DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr19_-_63550712 0.233 A1BG
alpha-1-B glycoprotein
chr11_+_34029764 0.232 NM_005898
NM_203364
CAPRIN1

cell cycle associated protein 1

chr19_+_40541327 0.231 NM_005304
FFAR3
free fatty acid receptor 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
7.56 7.91e-09 GO:0003012 muscle system process
7.79 1.69e-08 GO:0006936 muscle contraction
4.80 1.82e-05 GO:0030029 actin filament-based process
12.07 4.58e-05 GO:0030048 actin filament-based movement
5.58 8.42e-05 GO:0007517 muscle organ development
1.71 9.55e-05 GO:0032502 developmental process
4.49 2.69e-04 GO:0061061 muscle structure development
1.72 3.04e-04 GO:0007275 multicellular organismal development
1.53 3.26e-04 GO:0032501 multicellular organismal process
12.94 9.07e-04 GO:0030049 muscle filament sliding
12.94 9.07e-04 GO:0033275 actin-myosin filament sliding
12.60 1.10e-03 GO:0070252 actin-mediated cell contraction
8.10 1.56e-03 GO:0007015 actin filament organization
1.43 2.29e-03 GO:0050896 response to stimulus
1.69 3.52e-03 GO:0048856 anatomical structure development
1.35 7.94e-03 GO:0050789 regulation of biological process
1.87 9.15e-03 GO:0030154 cell differentiation
1.32 1.26e-02 GO:0065007 biological regulation
1.82 1.95e-02 GO:0048869 cellular developmental process
1.67 2.36e-02 GO:0048731 system development
1.86 2.56e-02 GO:0048513 organ development
3.80 4.10e-02 GO:0030036 actin cytoskeleton organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.46 2.40e-12 GO:0015629 actin cytoskeleton
8.90 5.71e-09 GO:0043292 contractile fiber
9.08 1.79e-08 GO:0044449 contractile fiber part
8.85 2.62e-08 GO:0030016 myofibril
2.46 1.68e-07 GO:0005856 cytoskeleton
16.58 3.43e-06 GO:0042641 actomyosin
8.38 3.54e-06 GO:0030017 sarcomere
8.29 3.98e-06 GO:0005925 focal adhesion
7.89 6.98e-06 GO:0005924 cell-substrate adherens junction
7.60 1.07e-05 GO:0030055 cell-substrate junction
17.10 2.18e-05 GO:0001725 stress fiber
15.96 3.65e-05 GO:0032432 actin filament bundle
5.97 5.30e-05 GO:0005912 adherens junction
5.39 1.71e-04 GO:0070161 anchoring junction
8.55 7.41e-04 GO:0016459 myosin complex
9.98 1.05e-03 GO:0031674 I band
12.07 1.60e-03 GO:0005884 actin filament
2.18 5.12e-03 GO:0044430 cytoskeletal part
1.64 9.25e-03 GO:0043228 non-membrane-bounded organelle
1.64 9.25e-03 GO:0043232 intracellular non-membrane-bounded organelle
3.59 2.62e-02 GO:0016323 basolateral plasma membrane
2.41 4.99e-02 GO:0030054 cell junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.55 1.73e-06 GO:0003779 actin binding
3.31 3.50e-05 GO:0008092 cytoskeletal protein binding
1.37 2.70e-04 GO:0005515 protein binding
13.68 5.56e-03 GO:0017022 myosin binding
9.54 7.38e-03 GO:0008307 structural constituent of muscle
4.43 4.30e-02 GO:0005516 calmodulin binding
4.40 4.53e-02 GO:0003774 motor activity
1.15 4.97e-02 GO:0005488 binding