Motif ID: SRY.p2

Z-value: 1.605


Transcription factors associated with SRY.p2:

Gene SymbolEntrez IDGene Name
SRY 6736 sex determining region Y



Activity profile for motif SRY.p2.

activity profile for motif SRY.p2


Sorted Z-values histogram for motif SRY.p2

Sorted Z-values for motif SRY.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SRY.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_152970904 6.669 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr11_-_16380967 4.232 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr1_-_108032645 4.094 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr3_+_173043832 3.732 NM_001164436
TMEM212
transmembrane protein 212
chr11_+_22652957 2.983 GAS2
growth arrest-specific 2
chr11_+_22652894 2.915 NM_005256
GAS2
growth arrest-specific 2
chr14_-_64479198 2.844 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr18_+_3584056 2.828 FLJ35776
hypothetical LOC649446
chr3_+_190990142 2.713 NM_001114980
NM_001114981
NM_001114982
TP63


tumor protein p63


chr6_+_105511615 2.548 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr9_+_126460511 2.545


chr13_-_47885018 2.542 LPAR6
lysophosphatidic acid receptor 6
chr11_+_57285809 2.495 NM_001085458
NM_001085459
NM_001085460
NM_001085461
NM_001085462
NM_001085463
NM_001085464
NM_001085465
NM_001085466
NM_001085467
NM_001085468
NM_001085469
NM_001331
CTNND1












catenin (cadherin-associated protein), delta 1












chr20_+_10363949 2.470 NM_001009608
C20orf94
chromosome 20 open reading frame 94
chr13_-_47885248 2.466 LPAR6
lysophosphatidic acid receptor 6
chr2_+_228386800 2.414 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr10_-_116241572 2.403


chr15_-_32398220 2.311 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr17_-_53847937 2.098 RNF43
ring finger protein 43
chr10_-_105835525 2.027 COL17A1
collagen, type XVII, alpha 1
chr12_+_14429499 1.986 ATF7IP
activating transcription factor 7 interacting protein
chrX_-_19598912 1.982 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr2_+_201756048 1.975 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr10_-_105835609 1.943 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr18_+_53863865 1.892 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr12_-_28016182 1.881 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr3_-_150422474 1.842 NM_000096
CP
ceruloplasmin (ferroxidase)
chr13_-_47885653 1.831 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr10_+_63331018 1.828 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr9_-_129752687 1.815 NM_203305
FAM102A
family with sequence similarity 102, member A
chr20_+_31613800 1.763 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr1_+_61319976 1.730 NM_001145512
NFIA
nuclear factor I/A
chr9_+_674193 1.725


chr4_-_186969041 1.704 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr6_-_116488458 1.699 NM_002031
FRK
fyn-related kinase
chrX_+_107569671 1.644 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr4_+_74491272 1.534 ALB
albumin
chr7_-_104696678 1.506 NM_182691
SRPK2
SRSF protein kinase 2
chr1_+_153366928 1.462 NM_004428
NM_182685
EFNA1

ephrin-A1

chr4_-_74307637 1.414 ANKRD17
ankyrin repeat domain 17
chr2_+_101680594 1.366 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr8_+_22266256 1.340 PIWIL2
piwi-like 2 (Drosophila)
chr3_+_138159396 1.334 NM_144717
IL20RB
interleukin 20 receptor beta
chr6_-_56615544 1.331 NM_001723
NM_015548
DST

dystonin

chr2_+_201755865 1.303 NM_001230
NM_032974
NM_032977
CASP10


caspase 10, apoptosis-related cysteine peptidase


chr4_-_139382672 1.299 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr7_+_116238309 1.292 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr2_+_138438277 1.284 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr1_+_116455898 1.271 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr17_+_34114924 1.241 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr3_-_121884091 1.232 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr2_+_143351536 1.213 NM_001032998
NM_003937
KYNU

kynureninase

chr10_-_123346148 1.212 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr11_+_101488380 1.204 NM_001195045
YAP1
Yes-associated protein 1
chr4_-_186969202 1.203 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr2_-_55090759 1.194 NM_007008
RTN4
reticulon 4
chr6_-_28663045 1.175 NM_052923
SCAND3
SCAN domain containing 3
chr8_+_40130143 1.164 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr2_-_39310176 1.161 NM_001009565
CDKL4
cyclin-dependent kinase-like 4
chr13_-_40491405 1.159 ELF1
E74-like factor 1 (ets domain transcription factor)
chr7_-_158304062 1.143 ESYT2
extended synaptotagmin-like protein 2
chr13_+_75232797 1.139 NM_015842
LMO7
LIM domain 7
chr1_-_171286634 1.137 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr3_-_150569574 1.127 TM4SF1
transmembrane 4 L six family member 1
chr7_+_45894480 1.127 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr14_-_67353046 1.121 NM_015346
ZFYVE26
zinc finger, FYVE domain containing 26
chr14_-_37134050 1.121 FOXA1
forkhead box A1
chr12_+_56114724 1.113 NM_005538
INHBC
inhibin, beta C
chr5_-_98290117 1.111 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr13_-_40491491 1.110 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr13_+_48582389 1.109 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr11_+_20005704 1.106 NAV2
neuron navigator 2
chr1_+_144149794 1.097 NM_006472
TXNIP
thioredoxin interacting protein
chr6_-_138862271 1.090 NM_001144060
NHSL1
NHS-like 1
chr17_+_72795567 1.066 NM_001113492
SEPT9
septin 9
chr6_-_138862273 1.065


chr20_+_19863716 1.060 RIN2
Ras and Rab interactor 2
chr21_+_42492867 1.054 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr18_+_59405513 1.054 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr10_-_73953699 1.044 NM_001195519
CBARA1
calcium binding atopy-related autoantigen 1
chr1_-_21373816 1.043 NM_001198803
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chrX_-_107569256 1.040 NM_001847
COL4A6
collagen, type IV, alpha 6
chr8_-_17797127 1.034 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr4_+_90252990 1.030 NM_145715
TIGD2
tigger transposable element derived 2
chr17_+_69939130 1.028 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr6_-_29752909 1.022 NM_001109809
ZFP57
zinc finger protein 57 homolog (mouse)
chr2_+_120233676 1.003 NM_002830
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr14_+_57964462 0.998 NM_014749
KIAA0586
KIAA0586
chr13_-_40454360 0.996 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr10_+_63331401 0.986 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr17_-_53849888 0.959 RNF43
ring finger protein 43
chr3_-_121883647 0.951 HGD
homogentisate 1,2-dioxygenase
chr1_-_204455269 0.945 NM_001007544
C1orf186
chromosome 1 open reading frame 186
chr10_-_116276560 0.941 ABLIM1
actin binding LIM protein 1
chr12_-_51173238 0.928 NM_005554
KRT6A
keratin 6A
chr5_+_73145098 0.927 RGNEF
190 kDa guanine nucleotide exchange factor
chr7_-_30032649 0.922 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr9_+_27099138 0.921 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr14_-_22825148 0.920 NM_020834
HOMEZ
homeobox and leucine zipper encoding
chr10_+_118177371 0.912 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr4_+_140806536 0.911 MGST2
microsomal glutathione S-transferase 2
chr3_-_137395966 0.901 NM_001145417
MSL2
male-specific lethal 2 homolog (Drosophila)
chr6_+_148705421 0.900 NM_015278
SASH1
SAM and SH3 domain containing 1
chr12_+_50633430 0.895 NM_020327
ACVR1B
activin A receptor, type IB
chr3_+_138132006 0.890 NM_001190796
NCK1
NCK adaptor protein 1
chr1_+_153366559 0.888 EFNA1
ephrin-A1
chr13_-_33148899 0.883 STARD13
StAR-related lipid transfer (START) domain containing 13
chr18_+_7936885 0.874 PTPRM
protein tyrosine phosphatase, receptor type, M
chr2_+_127892459 0.873 NM_000312
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr6_-_130072971 0.870 NM_033515
ARHGAP18
Rho GTPase activating protein 18
chr2_+_127892489 0.869 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr4_+_140806371 0.859 NM_002413
MGST2
microsomal glutathione S-transferase 2
chr3_+_195336631 0.855 HES1
hairy and enhancer of split 1, (Drosophila)
chr16_+_52027020 0.849 RBL2
retinoblastoma-like 2 (p130)
chr17_-_59817456 0.843 PECAM1
platelet/endothelial cell adhesion molecule
chr13_-_74799898 0.843 TBC1D4
TBC1 domain family, member 4
chr4_+_74493918 0.840 ALB
albumin
chr14_+_34583863 0.836 NM_001079519
FAM177A1
family with sequence similarity 177, member A1
chr5_+_145297490 0.832 SH3RF2
SH3 domain containing ring finger 2
chr10_-_116276651 0.831 NM_006720
ABLIM1
actin binding LIM protein 1
chr3_+_39484073 0.828 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr13_+_96672705 0.822 MBNL2
muscleblind-like 2 (Drosophila)
chr10_+_63478974 0.821 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr2_-_218865451 0.818 NM_022152
TMBIM1
transmembrane BAX inhibitor motif containing 1
chr11_+_66764060 0.816 LOC100131150
hypothetical protein LOC100131150
chr5_-_59100194 0.814 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_+_66764064 0.808 KDM2A
lysine (K)-specific demethylase 2A
chr9_+_74956614 0.797 ANXA1
annexin A1
chr5_+_147754467 0.792 FBXO38
F-box protein 38
chr3_-_71376919 0.792 FOXP1
forkhead box P1
chr10_+_5228756 0.783 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr6_+_126143971 0.777 NCOA7
nuclear receptor coactivator 7
chr3_+_133798770 0.775 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr2_-_45691887 0.775 NM_018079
SRBD1
S1 RNA binding domain 1
chr14_-_22825072 0.773 HOMEZ
homeobox and leucine zipper encoding
chr5_+_56507029 0.771 NM_001127235
GPBP1
GC-rich promoter binding protein 1
chr17_+_34115383 0.764 NM_005937
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr2_+_108604111 0.761 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr18_+_27281729 0.751 NM_001944
DSG3
desmoglein 3
chrX_-_85189194 0.747 NM_000390
NM_001145414
CHM

choroideremia (Rab escort protein 1)

chr2_-_162883062 0.742 NM_022168
IFIH1
interferon induced with helicase C domain 1
chr2_-_39201631 0.735 SOS1
son of sevenless homolog 1 (Drosophila)
chr15_+_47249700 0.734 NM_002044
GALK2
galactokinase 2
chr1_-_177106702 0.730 NM_004673
ANGPTL1
angiopoietin-like 1
chr13_+_23042722 0.726 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr8_-_102029997 0.722 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr19_+_53450743 0.719


chr10_-_123347493 0.719 NM_000141
NM_001144917
NM_001144918
NM_001144919
NM_022970
FGFR2




fibroblast growth factor receptor 2




chr11_-_18214891 0.713 NM_006512
SAA4
serum amyloid A4, constitutive
chr11_-_123353607 0.712 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr11_-_114880275 0.710 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr2_-_148495642 0.708 NM_181742
ORC4
origin recognition complex, subunit 4
chr22_+_38770610 0.704 NM_001024843
TNRC6B
trinucleotide repeat containing 6B
chr7_+_113842284 0.695 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr4_-_155731288 0.693 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr4_+_69716298 0.691 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chrX_-_10504852 0.683 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr2_+_17861266 0.683 NM_001105569
MSGN1
mesogenin 1
chr2_-_160181206 0.682 NM_013450
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr11_-_101292462 0.676 NM_178127
ANGPTL5
angiopoietin-like 5
chr9_+_74956494 0.675 NM_000700
ANXA1
annexin A1
chr17_-_59817575 0.672 PECAM1
platelet/endothelial cell adhesion molecule
chr1_+_185064654 0.671 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr8_-_30121741 0.667 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chr9_-_40782062 0.666 NM_033160
ZNF658
zinc finger protein 658
chr14_+_38805251 0.664 NM_203356
CTAGE5
CTAGE family, member 5
chr5_+_34723420 0.663 NM_001145523
RAI14
retinoic acid induced 14
chr10_-_85921703 0.663 LOC642934
hypothetical LOC642934
chr1_+_86785346 0.655 NM_012128
CLCA4
chloride channel accessory 4
chr7_+_113842470 0.654 FOXP2
forkhead box P2
chr1_+_61320213 0.654 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr7_-_41709191 0.653 NM_002192
INHBA
inhibin, beta A
chr19_-_53444733 0.650 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr6_+_114285209 0.647 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr8_-_110689396 0.646 SYBU
syntabulin (syntaxin-interacting)
chr6_+_148705646 0.646 SASH1
SAM and SH3 domain containing 1
chr7_+_113842407 0.646 FOXP2
forkhead box P2
chr6_+_34964999 0.639 NM_015245
ANKS1A
ankyrin repeat and sterile alpha motif domain containing 1A
chr20_+_12937616 0.636 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr3_+_153014550 0.636 NM_001086
AADAC
arylacetamide deacetylase (esterase)
chr2_+_27573206 0.627 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr20_-_18425811 0.626 NM_006606
RBBP9
retinoblastoma binding protein 9
chr18_+_45342398 0.624 NM_006033
LIPG
lipase, endothelial
chr17_+_75366524 0.621 NM_005189
NM_032647
CBX2

chromobox homolog 2

chr17_-_46296376 0.621 NM_005749
TOB1
transducer of ERBB2, 1
chr11_+_129496792 0.619 APLP2
amyloid beta (A4) precursor-like protein 2
chr21_+_39681558 0.618 NM_001146218
WRB
tryptophan rich basic protein
chrX_-_15198093 0.610 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr3_-_180452096 0.606 NM_014407
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr17_-_34262862 0.602 RPL23
ribosomal protein L23
chr17_-_59817722 0.601 NM_000442
PECAM1
platelet/endothelial cell adhesion molecule
chr1_-_12599934 0.601 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr20_+_34635362 0.601 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr19_-_56549853 0.600 NM_001014763
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr11_+_22644732 0.599 NM_001143830
GAS2
growth arrest-specific 2
chr4_+_74500748 0.598 ALB
albumin
chr11_-_33139449 0.598 NM_001033505
NM_001033506
NM_001326
CSTF3


cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa


chr21_+_38550739 0.595 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr17_-_36996611 0.595 NM_000526
KRT14
keratin 14
chr2_-_165133239 0.594 GRB14
growth factor receptor-bound protein 14

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.22 4.34e-06 GO:0044260 cellular macromolecule metabolic process
1.20 1.17e-05 GO:0043170 macromolecule metabolic process
1.16 3.78e-05 GO:0044238 primary metabolic process
1.15 5.63e-04 GO:0044237 cellular metabolic process
1.13 8.82e-04 GO:0008152 metabolic process
1.21 4.26e-03 GO:0071840 cellular component organization or biogenesis
1.26 5.47e-03 GO:0048519 negative regulation of biological process
1.27 5.58e-03 GO:0048523 negative regulation of cellular process
1.30 5.77e-03 GO:0010467 gene expression
1.07 1.52e-02 GO:0009987 cellular process
1.18 1.84e-02 GO:0032502 developmental process
1.19 2.15e-02 GO:0007275 multicellular organismal development
1.57 3.09e-02 GO:0006325 chromatin organization
1.20 3.39e-02 GO:0034641 cellular nitrogen compound metabolic process
1.19 4.12e-02 GO:0006807 nitrogen compound metabolic process
1.49 4.73e-02 GO:0051276 chromosome organization
1.24 4.82e-02 GO:0090304 nucleic acid metabolic process
1.19 4.83e-02 GO:0016043 cellular component organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.41 3.09e-08 GO:0031981 nuclear lumen
1.09 3.52e-08 GO:0005622 intracellular
1.09 1.43e-07 GO:0044424 intracellular part
1.34 1.46e-07 GO:0043233 organelle lumen
1.19 2.05e-07 GO:0005634 nucleus
1.34 2.31e-07 GO:0031974 membrane-enclosed lumen
1.33 6.83e-07 GO:0070013 intracellular organelle lumen
1.34 9.57e-07 GO:0044428 nuclear part
1.12 5.11e-06 GO:0043231 intracellular membrane-bounded organelle
1.12 6.94e-06 GO:0043227 membrane-bounded organelle
1.10 1.36e-05 GO:0043229 intracellular organelle
1.10 1.79e-05 GO:0043226 organelle
1.16 3.13e-05 GO:0044446 intracellular organelle part
1.40 4.27e-05 GO:0005654 nucleoplasm
1.16 7.04e-05 GO:0044422 organelle part
1.53 2.95e-03 GO:0005694 chromosome
1.21 4.25e-03 GO:0043228 non-membrane-bounded organelle
1.21 4.25e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.10 4.81e-03 GO:0005737 cytoplasm
1.70 4.77e-02 GO:0000785 chromatin

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 8.03e-07 GO:0005515 protein binding
1.07 5.99e-04 GO:0005488 binding
1.46 1.10e-03 GO:0003723 RNA binding