Motif ID: STAT2,4,6.p2

Z-value: 1.905


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
STAT2 6773 signal transducer and activator of transcription 2, 113kDa
STAT4 6775 signal transducer and activator of transcription 4
STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
STAT2chr12_-_550401830.448.7e-02Click!
STAT4chr2_-_191724169-0.322.2e-01Click!
STAT6chr12_-_557913880.273.1e-01Click!


Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_188945921 4.300 BCL6
B-cell CLL/lymphoma 6
chr3_-_188946168 2.980 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr17_-_73867748 2.086 NM_003955
SOCS3
suppressor of cytokine signaling 3
chr9_-_116920232 1.958 NM_002160
TNC
tenascin C
chr12_-_92488767 1.935


chr12_+_92488932 1.802 SOCS2
suppressor of cytokine signaling 2
chr19_-_49552638 1.722 NM_001083335
NM_013380
ZFP112

zinc finger protein 112 homolog (mouse)

chr8_+_103889733 1.639 FLJ45248
FLJ45248 protein
chr12_+_51730101 1.543 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr20_+_2743613 1.519 NM_080739
C20orf141
chromosome 20 open reading frame 141
chrX_+_105932536 1.504 NM_017752
NM_198881
TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr7_-_5429702 1.468 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr12_-_51200347 1.462 NM_000424
KRT5
keratin 5
chr3_+_189353502 1.441 LPP
LIM domain containing preferred translocation partner in lipoma
chr5_+_38882017 1.414 OSMR
oncostatin M receptor
chr6_-_35572694 1.410 NM_003214
TEAD3
TEA domain family member 3
chr18_+_59295123 1.309 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr17_+_72827227 1.260 SEPT9
septin 9
chr19_+_49248003 1.208 NM_013361
ZNF223
zinc finger protein 223
chr17_+_72827185 1.175 NM_006640
SEPT9
septin 9
chr10_+_74540215 1.167 NM_015901
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr12_+_54700955 1.148 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr14_+_95792299 1.137 NM_000710
BDKRB1
bradykinin receptor B1
chr10_-_95231933 1.049 NM_013451
NM_133337
MYOF

myoferlin

chr5_+_38881719 1.027 NM_003999
OSMR
oncostatin M receptor
chr5_-_38881636 1.025


chr12_+_51729239 0.977 TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr2_-_178645718 0.977 NM_016953
PDE11A
phosphodiesterase 11A
chr12_+_7038240 0.965 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr10_+_75343352 0.960 PLAU
plasminogen activator, urokinase
chr7_-_13992351 0.956 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr11_-_8788765 0.943 NM_213618
ST5
suppression of tumorigenicity 5
chr19_+_49361054 0.938 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
ZNF226




zinc finger protein 226




chr4_-_89963177 0.924 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr1_+_36462583 0.917 NM_005119
THRAP3
thyroid hormone receptor associated protein 3
chr2_+_69974581 0.910 NM_006857
SNRNP27
small nuclear ribonucleoprotein 27kDa (U4/U6.U5)
chr11_+_57122153 0.899 NM_001032295
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr15_-_41185460 0.895 NM_174916
UBR1
ubiquitin protein ligase E3 component n-recognin 1
chr16_+_4485859 0.883 NM_001127205
HMOX2
heme oxygenase (decycling) 2
chr16_+_88515917 0.873 NM_001197181
TUBB3
tubulin, beta 3
chr12_+_8958397 0.873 NM_004426
PHC1
polyhomeotic homolog 1 (Drosophila)
chr17_+_29606408 0.865 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr7_+_89870707 0.852 CLDN12
claudin 12
chr3_-_48607596 0.842 NM_000094
COL7A1
collagen, type VII, alpha 1
chr11_+_10283171 0.840 NM_001124
ADM
adrenomedullin
chr1_-_20682541 0.832


chr2_-_151052391 0.829 NM_005168
RND3
Rho family GTPase 3
chr7_+_89870647 0.828 NM_001185072
NM_001185073
NM_012129
CLDN12


claudin 12


chr18_+_3437607 0.828 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr5_+_38881716 0.825 NM_001168355
OSMR
oncostatin M receptor
chr20_-_14266200 0.824 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr17_+_55269974 0.821


chr2_-_144994349 0.802 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr3_+_189354167 0.794 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr3_+_11153778 0.785 NM_001098213
HRH1
histamine receptor H1
chr16_+_68516401 0.785 NM_199424
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr19_-_60320592 0.782 NM_017607
PPP1R12C
protein phosphatase 1, regulatory (inhibitor) subunit 12C
chr11_-_11986704 0.755 NM_001018057
DKK3
dickkopf homolog 3 (Xenopus laevis)
chr20_+_19903778 0.755 RIN2
Ras and Rab interactor 2
chr19_+_15079141 0.752 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr1_-_68071635 0.752 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr2_+_159533329 0.744 NM_001145909
NM_033394
TANC1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr14_+_20608179 0.743 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr11_+_113672378 0.740 NNMT
nicotinamide N-methyltransferase
chr4_+_130236731 0.736 NM_001099783
C4orf33
chromosome 4 open reading frame 33
chr7_+_138469029 0.733 NM_001144920
NM_001144923
NM_024926
TTC26


tetratricopeptide repeat domain 26


chr12_+_12829807 0.732 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr1_+_36462625 0.727 THRAP3
thyroid hormone receptor associated protein 3
chr3_+_185537969 0.727 NM_144635
FAM131A
family with sequence similarity 131, member A
chr12_+_56424930 0.724 NM_005981
TSPAN31
tetraspanin 31
chr19_-_54258935 0.717 NM_006179
NTF4
neurotrophin 4
chr8_-_130868315 0.715 NM_031415
GSDMC
gasdermin C
chr17_+_7199178 0.715 NM_198154
TMEM95
transmembrane protein 95
chr8_-_37847095 0.710 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr9_+_131291144 0.708


chr11_+_65027721 0.707


chr11_+_113672407 0.703 NNMT
nicotinamide N-methyltransferase
chr8_-_10550026 0.702 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr7_-_41709191 0.701 NM_002192
INHBA
inhibin, beta A
chr16_+_14187965 0.700 MKL2
MKL/myocardin-like 2
chr17_+_72982919 0.681 NM_001113495
SEPT9
septin 9
chr2_-_144994038 0.680 ZEB2
zinc finger E-box binding homeobox 2
chr16_-_28457728 0.677 NUPR1
nuclear protein, transcriptional regulator, 1
chr1_-_27565923 0.674 NM_004672
MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr12_-_7136147 0.672 NM_001733
C1R
complement component 1, r subcomponent
chr14_+_74815233 0.672 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr12_-_7136189 0.660 C1R
complement component 1, r subcomponent
chr6_-_26393705 0.660 NM_003543
HIST1H4H
histone cluster 1, H4h
chr3_-_64186151 0.656 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr3_+_199171467 0.648 NM_001136049
NM_033029
LMLN

leishmanolysin-like (metallopeptidase M8 family)

chr5_-_64813459 0.647 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr2_+_43854681 0.642 NM_001193464
NM_015522
NM_016008
DYNC2LI1


dynein, cytoplasmic 2, light intermediate chain 1


chr3_-_102888090 0.642 NM_000986
RPL24
ribosomal protein L24
chr2_-_128000315 0.639 NM_017969
IWS1
IWS1 homolog (S. cerevisiae)
chr2_+_17585287 0.637 NM_003385
VSNL1
visinin-like 1
chr16_-_28457825 0.631 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr5_-_138238877 0.628 LRRTM2
leucine rich repeat transmembrane neuronal 2
chr3_-_139315011 0.625 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr9_-_109291130 0.625 KLF4
Kruppel-like factor 4 (gut)
chr1_-_151788341 0.622 NM_002960
S100A3
S100 calcium binding protein A3
chr5_-_140875591 0.620 DIAPH1
diaphanous homolog 1 (Drosophila)
chr12_+_6363482 0.611 NM_002342
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr7_+_134114957 0.606 CALD1
caldesmon 1
chr11_-_119504726 0.604 TRIM29
tripartite motif containing 29
chr22_+_34374358 0.600 NM_030641
APOL6
apolipoprotein L, 6
chr5_-_92982927 0.599


chr3_+_185377341 0.599 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr7_+_134114912 0.597 CALD1
caldesmon 1
chr9_-_133944877 0.596 MED27
mediator complex subunit 27
chr11_+_7574992 0.595 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr19_+_58715988 0.590 NM_018555
ZNF331
zinc finger protein 331
chr9_-_90456824 0.587 NM_001100111
LOC286238
hypothetical protein LOC286238
chr8_-_95343696 0.585 GEM
GTP binding protein overexpressed in skeletal muscle
chr11_+_57121602 0.584 NM_000062
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr1_-_27565412 0.582 MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr8_-_95343716 0.582 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr12_+_52180971 0.581 NM_004178
NM_134323
TARBP2

TAR (HIV-1) RNA binding protein 2

chr14_+_94148466 0.580 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr6_+_54819527 0.579 NM_001010872
FAM83B
family with sequence similarity 83, member B
chr6_-_32206029 0.574 NM_022110
FKBPL
FK506 binding protein like
chr22_+_34374421 0.572 APOL6
apolipoprotein L, 6
chr15_-_53369261 0.572 NM_183235
RAB27A
RAB27A, member RAS oncogene family
chr15_-_69194854 0.571 NM_001102658
CT62
cancer/testis antigen 62
chr1_-_17253073 0.570 NM_003000
SDHB
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
chr14_+_52243645 0.569 NM_002806
PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr8_-_48813236 0.569 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr5_+_52131686 0.569 PELO
pelota homolog (Drosophila)
chr9_+_676640 0.565


chr7_-_83116414 0.565 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr3_+_45042754 0.562 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr5_+_67558217 0.558 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr22_-_30018329 0.557 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr5_+_137542652 0.557 KIF20A
kinesin family member 20A
chr22_-_29833484 0.556 NM_080430
SELM
selenoprotein M
chr11_+_43622348 0.554


chr6_+_32229278 0.553 NM_138717
PPT2
palmitoyl-protein thioesterase 2
chrX_+_73557809 0.552 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr3_-_71376919 0.551 FOXP1
forkhead box P1
chr19_+_1223475 0.549 CIRBP
cold inducible RNA binding protein
chr4_+_128773529 0.548 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr8_-_97316933 0.542 NM_006294
UQCRB
ubiquinol-cytochrome c reductase binding protein
chr1_+_203740391 0.541 CDK18
cyclin-dependent kinase 18
chr12_+_6884157 0.540 NM_001135217
NM_006992
NM_201650
LRRC23


leucine rich repeat containing 23


chr1_+_40769819 0.540 NM_152373
ZNF684
zinc finger protein 684
chr15_+_60838053 0.540 TLN2
talin 2
chr20_-_44746529 0.537 NM_001011554
NM_001193340
SLC13A3

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

chr6_-_152744143 0.535 SYNE1
spectrin repeat containing, nuclear envelope 1
chr15_-_65334022 0.531 NM_024666
AAGAB
alpha- and gamma-adaptin binding protein
chrX_+_109548940 0.528 NM_020769
RGAG1
retrotransposon gag domain containing 1
chr17_-_2250967 0.527 NM_020310
MNT
MAX binding protein
chr19_-_45912817 0.526 ADCK4
aarF domain containing kinase 4
chr11_+_129823667 0.524 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr8_-_48813256 0.523 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr1_+_40769877 0.523 ZNF684
zinc finger protein 684
chr12_+_43972732 0.522 NM_001142678
ANO6
anoctamin 6
chr7_+_129634935 0.522 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr12_+_51777715 0.521 IGFBP6
insulin-like growth factor binding protein 6
chr2_-_166940710 0.518 NM_002977
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr6_-_42218692 0.517 NM_001164446
C6orf132
chromosome 6 open reading frame 132
chr8_-_127639892 0.517 NM_174911
FAM84B
family with sequence similarity 84, member B
chr6_+_32229771 0.514 PPT2-EGFL8
PPT2
PPT2-EGFL8 read-through transcript
palmitoyl-protein thioesterase 2
chr1_+_167604056 0.510 BLZF1
basic leucine zipper nuclear factor 1
chr1_+_170077234 0.509 NM_001136127
NM_015569
DNM3

dynamin 3

chr16_+_55199978 0.509 NM_005953
MT2A
metallothionein 2A
chr12_+_8866416 0.507 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr6_-_28519207 0.506 NM_001012455
ZSCAN23
zinc finger and SCAN domain containing 23
chr1_+_36409277 0.506 MAP7D1
MAP7 domain containing 1
chr12_+_51777684 0.505 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr3_+_38154972 0.505 NM_001172566
NM_001172567
NM_001172568
NM_001172569
NM_002468
MYD88




myeloid differentiation primary response gene (88)




chr1_+_167603817 0.504 NM_003666
BLZF1
basic leucine zipper nuclear factor 1
chr5_-_102926349 0.502 NM_031438
NUDT12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr5_+_148186348 0.501 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr9_+_129900637 0.501 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr20_+_54637714 0.501 NM_003222
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr7_-_13997574 0.499 NM_001163148
ETV1
ets variant 1
chr19_-_45912832 0.499 NM_001142555
ADCK4
aarF domain containing kinase 4
chr19_-_49644470 0.497 NM_014518
ZNF229
zinc finger protein 229
chr9_-_133945064 0.496 NM_004269
CRSP8P
MED27
mediator complex subunit 27 pseudogene
mediator complex subunit 27
chr6_-_84994032 0.494 NM_014895
KIAA1009
KIAA1009
chr5_-_138238891 0.492 CTNNA1
LRRTM2
catenin (cadherin-associated protein), alpha 1, 102kDa
leucine rich repeat transmembrane neuronal 2
chr22_+_19248733 0.489 MED15
mediator complex subunit 15
chr4_-_185632610 0.487 NM_002199
IRF2
interferon regulatory factor 2
chr10_+_114699953 0.485 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr19_+_54837181 0.484 NM_021228
SCAF1
SR-related CTD-associated factor 1
chr1_+_32485404 0.482 NM_032648
FAM167B
family with sequence similarity 167, member B
chr5_+_145296313 0.482 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr16_-_30705707 0.477 NM_001080417
ZNF629
zinc finger protein 629
chr3_+_186483408 0.476 LOC100505749
MAP3K13
hypothetical LOC100505749
mitogen-activated protein kinase kinase kinase 13
chr6_+_32230172 0.476 PPT2
palmitoyl-protein thioesterase 2
chr4_-_152901542 0.476 NM_004564
PET112L
PET112-like (yeast)
chr16_-_73842884 0.476 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr9_-_106730157 0.474 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr10_-_21847126 0.472


chr12_+_12857516 0.469 NM_016355
NM_201224
DDX47

DEAD (Asp-Glu-Ala-Asp) box polypeptide 47

chr20_+_29790564 0.469 NM_012112
TPX2
TPX2, microtubule-associated, homolog (Xenopus laevis)
chr22_+_19248810 0.469 MED15
mediator complex subunit 15
chr1_-_149404954 0.469 NM_212551
NM_001136543
LYSMD1

LysM, putative peptidoglycan-binding, domain containing 1

chr1_+_68070573 0.468


chr2_-_189752575 0.468 NM_000393
COL5A2
collagen, type V, alpha 2
chrX_-_134013644 0.467 NM_001078172
NM_001134321
FAM127B

family with sequence similarity 127, member B


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.38 1.19e-02 GO:0002455 humoral immune response mediated by circulating immunoglobulin
1.22 1.64e-02 GO:0071842 cellular component organization at cellular level
2.05 2.10e-02 GO:0034330 cell junction organization
2.10 2.57e-02 GO:0034329 cell junction assembly
1.20 4.63e-02 GO:0071841 cellular component organization or biogenesis at cellular level

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.08 5.94e-07 GO:0044424 intracellular part
1.08 3.64e-06 GO:0005622 intracellular
1.11 3.17e-05 GO:0005737 cytoplasm
1.10 9.04e-05 GO:0043231 intracellular membrane-bounded organelle
1.10 9.51e-05 GO:0043227 membrane-bounded organelle
1.09 1.44e-04 GO:0043229 intracellular organelle
1.09 1.49e-04 GO:0043226 organelle
2.04 2.12e-03 GO:0005912 adherens junction
1.12 9.71e-03 GO:0005634 nucleus
1.88 1.31e-02 GO:0070161 anchoring junction
2.17 1.45e-02 GO:0005925 focal adhesion
2.06 3.22e-02 GO:0030055 cell-substrate junction
2.06 3.92e-02 GO:0005924 cell-substrate adherens junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.12 2.10e-04 GO:0005515 protein binding