Motif ID: TBP.p2

Z-value: 1.945


Transcription factors associated with TBP.p2:

Gene SymbolEntrez IDGene Name
TBP 6908 TATA box binding protein

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TBPchr6_+_1707053450.194.9e-01Click!


Activity profile for motif TBP.p2.

activity profile for motif TBP.p2


Sorted Z-values histogram for motif TBP.p2

Sorted Z-values for motif TBP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBP.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_151052391 3.581 NM_005168
 RND3
Rho family GTPase 3
chr7_+_100557098 3.373 NM_000602
NM_001165413
 SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr9_+_123088217 3.293 GSN
gelsolin
chr5_-_57791544 3.275 NM_006622
 PLK2
polo-like kinase 2
chr21_-_27139143 3.235 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr21_-_27139563 3.086 NM_006988
 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr4_-_75183700 2.894 CXCL2
chemokine (C-X-C motif) ligand 2
chr10_-_62373828 2.879 NM_014836
 RHOBTB1
Rho-related BTB domain containing 1
chr3_+_195336625 2.718 NM_005524
 HES1
hairy and enhancer of split 1, (Drosophila)
chr14_+_74815233 2.661 NM_005252
 FOS
FBJ murine osteosarcoma viral oncogene homolog
chr11_-_2907169 2.655 NM_003311
 PHLDA2
pleckstrin homology-like domain, family A, member 2
chr2_-_216009015 2.576 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
 FN1





fibronectin 1





chr12_+_12935759 2.559 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr8_-_23077392 2.508 NM_003840
 TNFRSF10D
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
chr17_-_36469869 2.491 NM_001165252
 LOC730755
keratin associated protein 2-4-like
chr10_+_53744043 2.487 NM_012242
 DKK1
dickkopf homolog 1 (Xenopus laevis)
chr16_+_55217085 2.307 NM_175617
 MT1E
metallothionein 1E
chr20_-_43410437 2.293 NM_002999
 SDC4
syndecan 4
chr17_+_29606408 2.255 NM_002982
 CCL2
chemokine (C-C motif) ligand 2
chr16_+_55217180 2.241 MT1E
metallothionein 1E

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 43 entries
enrichment   p-value GO term description
12.14 8.28e-07 GO:0070301 cellular response to hydrogen peroxide
12.02 1.46e-03 GO:0042744 hydrogen peroxide catabolic process
10.30 4.58e-08 GO:0034614 cellular response to reactive oxygen species
10.30 9.26e-04 GO:0042743 hydrogen peroxide metabolic process
8.09 1.10e-04 GO:0031424 keratinization
8.01 3.16e-02 GO:0031032 actomyosin structure organization
8.01 3.16e-02 GO:0044243 multicellular organismal catabolic process
7.73 8.72e-07 GO:0034599 cellular response to oxidative stress
7.73 4.10e-02 GO:0032963 collagen metabolic process
6.95 7.07e-03 GO:0072593 reactive oxygen species metabolic process
6.87 2.71e-02 GO:0044236 multicellular organismal metabolic process
6.18 2.23e-04 GO:0042542 response to hydrogen peroxide
5.90 5.41e-06 GO:0000302 response to reactive oxygen species
5.72 1.34e-02 GO:0002526 acute inflammatory response
5.43 1.09e-03 GO:0009913 epidermal cell differentiation
5.31 1.00e-02 GO:0030216 keratinocyte differentiation
4.50 1.87e-03 GO:0008217 regulation of blood pressure
4.23 8.65e-07 GO:0008544 epidermis development
4.02 3.83e-03 GO:0051789 response to protein stimulus
3.76 1.67e-04 GO:0006979 response to oxidative stress

Gene overrepresentation in compartment category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
12.02 1.76e-04 GO:0032982 myosin filament
10.82 1.14e-19 GO:0045095 keratin filament
8.88 4.52e-30 GO:0005882 intermediate filament
7.69 6.64e-27 GO:0045111 intermediate filament cytoskeleton
5.48 8.73e-04 GO:0000786 nucleosome
5.15 2.90e-02 GO:0031674 I band
4.02 4.61e-04 GO:0043292 contractile fiber
4.00 1.03e-03 GO:0030016 myofibril
3.86 2.72e-28 GO:0005615 extracellular space
3.83 3.50e-03 GO:0044449 contractile fiber part
3.52 2.80e-30 GO:0044421 extracellular region part
3.08 4.23e-07 GO:0031012 extracellular matrix
2.94 4.51e-05 GO:0005578 proteinaceous extracellular matrix
2.61 2.53e-30 GO:0005576 extracellular region
2.18 7.19e-08 GO:0044430 cytoskeletal part
2.00 7.21e-09 GO:0005856 cytoskeleton
1.49 3.99e-04 GO:0043228 non-membrane-bounded organelle
1.49 3.99e-04 GO:0043232 intracellular non-membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
24.72 1.89e-03 GO:0046870 cadmium ion binding
23.18 4.72e-02 GO:0015168 glycerol transmembrane transporter activity
15.45 2.45e-02 GO:0015250 water channel activity
13.73 4.29e-02 GO:0005372 water transmembrane transporter activity
11.89 1.29e-02 GO:0005344 oxygen transporter activity
7.19 2.98e-04 GO:0008307 structural constituent of muscle
7.18 2.20e-11 GO:0005179 hormone activity
6.18 4.02e-03 GO:0019825 oxygen binding
6.05 4.85e-03 GO:0008009 chemokine activity
5.45 1.16e-02 GO:0042379 chemokine receptor binding
4.79 5.69e-03 GO:0005200 structural constituent of cytoskeleton
4.64 3.31e-03 GO:0005201 extracellular matrix structural constituent
4.27 1.56e-04 GO:0020037 heme binding
4.25 7.84e-05 GO:0046906 tetrapyrrole binding
4.04 4.84e-07 GO:0005125 cytokine activity
3.51 2.10e-04 GO:0005126 cytokine receptor binding
3.50 1.39e-03 GO:0008083 growth factor activity
3.42 1.09e-03 GO:0001664 G-protein-coupled receptor binding
3.20 3.81e-13 GO:0005198 structural molecule activity
3.13 3.21e-02 GO:0005539 glycosaminoglycan binding