Motif ID: TCF4_dimer.p2

Z-value: 3.927


Transcription factors associated with TCF4_dimer.p2:

Gene SymbolEntrez IDGene Name
TCF4 6925 transcription factor 4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF4chr18_-_514063590.601.4e-02Click!


Activity profile for motif TCF4_dimer.p2.

activity profile for motif TCF4_dimer.p2


Sorted Z-values histogram for motif TCF4_dimer.p2

Sorted Z-values for motif TCF4_dimer.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF4_dimer.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_49996353 11.938 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr17_+_36493927 9.042 NM_033061
KRTAP4-7
keratin associated protein 4-7
chr16_-_30983909 7.996 NM_001172669
NM_001172670
ZNF668

zinc finger protein 668

chr15_+_72006015 7.094 LOXL1
lysyl oxidase-like 1
chr3_-_87122936 6.972 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr1_+_46151845 6.966 MAST2
microtubule associated serine/threonine kinase 2
chr9_-_35679799 6.478 TPM2
tropomyosin 2 (beta)
chr9_-_35679902 6.084 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr11_-_6298284 6.003 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr1_+_181259317 6.001


chr15_-_46725087 5.980 NM_000138
FBN1
fibrillin 1
chr8_-_41641881 5.978 NM_001142445
NM_020478
NM_020480
ANK1


ankyrin 1, erythrocytic


chr2_-_175337386 5.927 NM_000079
NM_001039523
CHRNA1

cholinergic receptor, nicotinic, alpha 1 (muscle)

chr2_+_33213111 5.884 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr1_-_143643064 5.848 PDE4DIP
phosphodiesterase 4D interacting protein
chr22_-_20235372 5.455 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr1_+_221955876 5.387 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr2_+_219991342 5.375 NM_001927
DES
desmin
chr2_+_85834111 5.311 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr11_-_47427263 5.099 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr3_-_87122958 5.092 VGLL3
vestigial like 3 (Drosophila)
chr4_-_40911212 5.091 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr7_+_115953582 5.079 NM_001172896
NM_001172897
CAV1

caveolin 1, caveolae protein, 22kDa

chr13_+_30378311 4.994 NM_032849
C13orf33
chromosome 13 open reading frame 33
chr19_+_10597167 4.772 NM_020428
SLC44A2
solute carrier family 44, member 2
chr15_-_40537002 4.766 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr12_-_107745455 4.672 NM_001161331
SSH1
slingshot homolog 1 (Drosophila)
chr22_+_20068039 4.428 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr1_-_39871226 4.404 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr2_+_205118801 4.222 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr2_+_205118961 4.162 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr2_+_223625105 4.143 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr6_-_75972286 4.108 NM_004370
NM_080645
COL12A1

collagen, type XII, alpha 1

chr19_+_43446937 4.088 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr6_-_75972473 4.041 COL12A1
collagen, type XII, alpha 1
chr1_-_154205675 4.000 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr1_+_24614831 3.949 NM_020448
NIPAL3
NIPA-like domain containing 3
chr4_-_177427252 3.928 NM_080874
ASB5
ankyrin repeat and SOCS box containing 5
chr15_+_72005839 3.923 NM_005576
LOXL1
lysyl oxidase-like 1
chr19_+_43447078 3.850 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr15_+_72005847 3.845 LOXL1
lysyl oxidase-like 1
chr1_-_95165089 3.845 NM_001839
CNN3
calponin 3, acidic
chr17_+_1905104 3.823 NM_006497
HIC1
hypermethylated in cancer 1
chr21_+_29439768 3.802 C21orf7
chromosome 21 open reading frame 7
chr5_+_148501178 3.772 NM_014945
ABLIM3
actin binding LIM protein family, member 3
chr2_-_37752731 3.742 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr17_+_36515166 3.716 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr19_-_12747263 3.689 HOOK2
hook homolog 2 (Drosophila)
chr10_+_11100111 3.624 CELF2
CUGBP, Elav-like family member 2
chr10_+_11099860 3.601 NM_006561
CELF2
CUGBP, Elav-like family member 2
chr19_+_58750305 3.598 NM_001079907
ZNF331
zinc finger protein 331
chr2_+_205118710 3.595 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr12_-_29827952 3.570 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr9_-_16717887 3.569 BNC2
basonuclin 2
chr4_+_114433551 3.510 ANK2
ankyrin 2, neuronal
chr1_-_32479785 3.509 MTMR9LP
myotubularin related protein 9-like, pseudogene
chr2_+_170074457 3.505 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr10_+_11100075 3.504 CELF2
CUGBP, Elav-like family member 2
chr15_-_23659329 3.495 NM_024490
ATP10A
ATPase, class V, type 10A
chr17_-_36456949 3.455 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr1_+_148521852 3.454 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr1_+_201364050 3.381 ADORA1
adenosine A1 receptor
chr11_+_12088639 3.377 NM_014632
MICAL2
microtubule associated monoxygenase, calponin and LIM domain containing 2
chr2_-_19421852 3.367 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr11_-_127897098 3.355 ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr17_+_45488356 3.339 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr12_-_50871953 3.329 NM_001081492
NM_182507
KRT80

keratin 80

chr1_-_84237316 3.315 NM_024686
TTLL7
tubulin tyrosine ligase-like family, member 7
chr14_+_99220349 3.282 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr6_-_33822659 3.275 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr21_+_36429079 3.262 NM_001236
CBR3
carbonyl reductase 3
chr22_+_29122932 3.258 NM_012429
NM_033382
SEC14L2

SEC14-like 2 (S. cerevisiae)

chr10_+_31648103 3.200 NM_001174093
NM_001174095
NM_001174096
NM_030751
ZEB1



zinc finger E-box binding homeobox 1



chr17_+_45488330 3.187 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr19_+_43447262 3.173 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr9_+_101623957 3.142 NM_006981
NM_173199
NR4A3

nuclear receptor subfamily 4, group A, member 3

chr16_+_87765661 3.140 NM_004933
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr9_-_96441409 3.128 FBP1
fructose-1,6-bisphosphatase 1
chr11_+_118374071 3.127 CCDC84
coiled-coil domain containing 84
chr1_-_143643324 3.115 NM_001002811
PDE4DIP
phosphodiesterase 4D interacting protein
chr12_+_27824429 3.067 NM_020782
KLHDC5
kelch domain containing 5
chr10_-_75080784 3.047 NM_024875
SYNPO2L
synaptopodin 2-like
chr1_-_16217871 3.030 NM_014424
HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr17_-_45629401 2.998


chr11_+_65536037 2.996 NM_001323
CST6
cystatin E/M
chr17_+_58058774 2.988 MRC2
mannose receptor, C type 2
chr10_-_92671005 2.987 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr10_-_31647925 2.973 LOC220930
hypothetical LOC220930
chr8_-_145088679 2.957 NM_201383
PLEC
plectin
chr1_+_15145001 2.930 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr21_-_38210531 2.919 NM_002240
KCNJ6
potassium inwardly-rectifying channel, subfamily J, member 6
chr17_+_65677255 2.890 NM_000891
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr3_+_49034050 2.884 NM_199069
NM_199070
NDUFAF3

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3

chr5_+_66160359 2.866 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr10_+_99248605 2.847 NM_024954
UBTD1
ubiquitin domain containing 1
chr2_+_85515428 2.829 NM_198482
SH2D6
SH2 domain containing 6
chr1_+_176330254 2.826 RASAL2
RAS protein activator like 2
chr18_+_32131628 2.825 NM_025135
FHOD3
formin homology 2 domain containing 3
chr1_-_231498081 2.784 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)
chr9_+_34980715 2.754 DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr8_-_72918697 2.745 MSC
musculin
chr2_-_216944911 2.730 NM_020814
MARCH4
membrane-associated ring finger (C3HC4) 4
chr2_-_217267742 2.722 IGFBP5
insulin-like growth factor binding protein 5
chr4_+_151218862 2.721 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr16_-_63713466 2.719 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr7_-_45927263 2.707 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr7_+_17304707 2.677 NM_001621
AHR
aryl hydrocarbon receptor
chr16_-_63713485 2.667 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr1_-_32940943 2.664 NM_001161708
NM_030786
SYNC

syncoilin, intermediate filament protein

chr6_-_139737042 2.657 NM_001168389
NM_001168388
CITED2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

chr12_+_79634820 2.656 NM_005593
MYF5
myogenic factor 5
chr15_-_68842799 2.655 NM_018003
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr11_+_118374051 2.651 NM_198489
CCDC84
coiled-coil domain containing 84
chr10_-_92670764 2.638 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr1_-_40140126 2.637 NM_001033081
NM_001033082
NM_005376
MYCL1


v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)


chr8_-_122722674 2.629 NM_005328
HAS2
hyaluronan synthase 2
chr3_-_11598829 2.629 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chrX_+_48221323 2.607 NM_177434
FTSJ1
FtsJ homolog 1 (E. coli)
chr9_-_109291575 2.604 KLF4
Kruppel-like factor 4 (gut)
chr9_-_116920232 2.595 NM_002160
TNC
tenascin C
chr1_-_39877883 2.594 HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr15_+_60838053 2.590 TLN2
talin 2
chr2_+_56265260 2.585


chr5_-_176832476 2.584 NM_080881
DBN1
drebrin 1
chr2_+_109112428 2.575 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chrX_-_13866366 2.575


chr1_+_31658549 2.572 NM_178865
SERINC2
serine incorporator 2
chr11_-_684842 2.520 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr1_-_39877928 2.512 NM_014571
HEYL
hairy/enhancer-of-split related with YRPW motif-like
chr4_-_158111916 2.512 PDGFC
platelet derived growth factor C
chr4_-_158111504 2.508 PDGFC
platelet derived growth factor C
chr10_+_99463446 2.500 NM_031484
MARVELD1
MARVEL domain containing 1
chr2_-_227371698 2.491 NM_005544
IRS1
insulin receptor substrate 1
chr2_-_189752575 2.489 NM_000393
COL5A2
collagen, type V, alpha 2
chr14_+_101500520 2.482 NM_001376
DYNC1H1
dynein, cytoplasmic 1, heavy chain 1
chr9_-_88751923 2.479 NM_002048
GAS1
growth arrest-specific 1
chr10_+_99248869 2.463


chr9_+_129893948 2.461 NM_001006642
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr15_-_42274529 2.459 NM_032892
FRMD5
FERM domain containing 5
chr4_+_184257337 2.454 NM_024949
WWC2
WW and C2 domain containing 2
chr4_-_158111995 2.449 NM_016205
PDGFC
platelet derived growth factor C
chr6_+_87921980 2.435 NM_015021
ZNF292
zinc finger protein 292
chr17_+_36647795 2.427 NM_031963
KRTAP9-8
keratin associated protein 9-8
chr5_-_172687798 2.415 STC2
stanniocalcin 2
chr2_+_233099113 2.415 NM_000751
CHRND
cholinergic receptor, nicotinic, delta
chr9_+_34980266 2.408 NM_001135005
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr2_-_73193581 2.399 NM_015470
RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr16_-_52876390 2.398 IRX3
iroquois homeobox 3
chr8_-_72436832 2.391 EYA1
eyes absent homolog 1 (Drosophila)
chr17_-_36475652 2.390 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr10_+_99463468 2.389 MARVELD1
MARVEL domain containing 1
chr1_-_32940850 2.384 SYNC
syncoilin, intermediate filament protein
chrX_+_100361588 2.384 NM_001171184
NM_001939
DRP2

dystrophin related protein 2

chr1_-_85703198 2.377 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr8_-_75396016 2.370 NM_020647
JPH1
junctophilin 1
chr11_-_85108030 2.360 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr7_+_116099648 2.356 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr15_-_49184764 2.356 NM_207381
TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr8_+_72918772 2.350 LOC100132891
hypothetical LOC100132891
chr9_-_21999270 2.350 NM_004936
NM_078487
CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

chr3_-_180272229 2.338 ZMAT3
zinc finger, matrin-type 3
chr13_-_25523164 2.336 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr11_+_131286513 2.326 NTM
neurotrimin
chr4_-_75938710 2.304 NM_001729
BTC
betacellulin
chr3_-_11585264 2.300 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr5_+_34692239 2.284 RAI14
retinoic acid induced 14
chr11_-_8695974 2.281 ST5
suppression of tumorigenicity 5
chr19_-_12747421 2.278 NM_001100176
NM_013312
HOOK2

hook homolog 2 (Drosophila)

chr19_-_50977485 2.257 DMPK
dystrophia myotonica-protein kinase
chr3_-_39209075 2.248 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr8_+_72918889 2.237


chr1_-_160260210 2.236 NM_015441
OLFML2B
olfactomedin-like 2B
chr21_+_36993860 2.231 NM_005069
NM_009586
SIM2

single-minded homolog 2 (Drosophila)

chr10_+_104525877 2.223 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr16_+_7322751 2.213 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr16_-_63713382 2.206 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr13_-_98428244 2.202 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr4_+_3341521 2.201 NM_198227
RGS12
regulator of G-protein signaling 12
chr5_+_102229425 2.197 NM_000919
NM_001177306
NM_138766
NM_138821
NM_138822
PAM




peptidylglycine alpha-amidating monooxygenase




chr12_-_6313219 2.192 TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A
chr6_+_129245978 2.182 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr5_-_58370693 2.180 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr20_-_39379533 2.178 ZHX3
zinc fingers and homeoboxes 3
chr8_-_72918938 2.175 MSC
musculin
chr12_+_120635021 2.168 NM_001080825
TMEM120B
transmembrane protein 120B
chr5_+_34692352 2.154 NM_001145520
RAI14
retinoic acid induced 14
chr9_-_130980302 2.151 IER5L
immediate early response 5-like
chr10_+_31647425 2.139 ZEB1
zinc finger E-box binding homeobox 1
chr7_-_130891861 2.136 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr2_-_73193419 2.126 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr17_-_7434113 2.121 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chrX_-_13866451 2.116 GPM6B
glycoprotein M6B
chr5_+_102229612 2.113 PAM
peptidylglycine alpha-amidating monooxygenase
chr2_+_238712101 2.100 NM_198582
KLHL30
kelch-like 30 (Drosophila)
chr12_-_52939584 2.100 NM_001127322
CBX5
chromobox homolog 5
chr10_-_62373828 2.089 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chr22_-_22511173 2.085 NM_001002862
NM_001135751
NM_198440
DERL3


Der1-like domain family, member 3


chr15_+_72005875 2.085 LOXL1
lysyl oxidase-like 1
chr12_-_6355165 2.085 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr19_-_15252261 2.080 NM_014299
NM_058243
BRD4

bromodomain containing 4


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.18 5.41e-08 GO:0007275 multicellular organismal development
1.37 7.78e-08 GO:0022008 neurogenesis
1.18 1.19e-07 GO:0048856 anatomical structure development
1.20 1.72e-07 GO:0048731 system development
1.36 2.10e-07 GO:0048468 cell development
1.28 3.78e-07 GO:0007399 nervous system development
1.16 7.30e-07 GO:0032502 developmental process
1.36 1.20e-06 GO:0048699 generation of neurons
1.37 2.05e-05 GO:0030182 neuron differentiation
1.21 2.17e-05 GO:0030154 cell differentiation
1.41 2.73e-05 GO:0048666 neuron development
1.56 2.80e-05 GO:0022603 regulation of anatomical structure morphogenesis
1.20 9.98e-05 GO:0048869 cellular developmental process
1.51 1.93e-04 GO:0007411 axon guidance
1.45 1.97e-04 GO:0007409 axonogenesis
1.14 2.24e-04 GO:0023052 signaling
1.44 3.12e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.65 3.56e-04 GO:0007517 muscle organ development
1.54 3.98e-04 GO:0061061 muscle structure development
1.09 4.08e-04 GO:0050794 regulation of cellular process
1.21 5.80e-04 GO:0023051 regulation of signaling
1.40 6.25e-04 GO:0000904 cell morphogenesis involved in differentiation
1.42 6.81e-04 GO:0048812 neuron projection morphogenesis
1.39 1.26e-03 GO:0031175 neuron projection development
1.22 1.28e-03 GO:0009653 anatomical structure morphogenesis
1.07 1.88e-03 GO:0065007 biological regulation
1.08 3.24e-03 GO:0050789 regulation of biological process
1.16 3.36e-03 GO:0048522 positive regulation of cellular process
1.13 3.45e-03 GO:0007165 signal transduction
1.25 3.53e-03 GO:0010646 regulation of cell communication
1.29 5.70e-03 GO:2000026 regulation of multicellular organismal development
1.21 7.93e-03 GO:0035556 intracellular signal transduction
1.44 1.11e-02 GO:0060284 regulation of cell development
1.14 1.12e-02 GO:0048518 positive regulation of biological process
1.21 1.55e-02 GO:0051239 regulation of multicellular organismal process
1.30 1.73e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.26 1.87e-02 GO:0016265 death
1.26 1.97e-02 GO:0040011 locomotion
1.30 2.14e-02 GO:0032989 cellular component morphogenesis
1.20 2.43e-02 GO:0009966 regulation of signal transduction
1.25 3.48e-02 GO:0008219 cell death
1.15 3.58e-02 GO:0048523 negative regulation of cellular process
1.09 3.63e-02 GO:0032501 multicellular organismal process
1.90 3.99e-02 GO:0050770 regulation of axonogenesis
1.29 4.10e-02 GO:0030030 cell projection organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.90 1.96e-06 GO:0043292 contractile fiber
1.92 2.37e-06 GO:0030016 myofibril
1.91 5.69e-06 GO:0044449 contractile fiber part
1.91 4.91e-05 GO:0030017 sarcomere
1.16 1.89e-03 GO:0044459 plasma membrane part
1.10 3.37e-03 GO:0071944 cell periphery
1.10 4.53e-03 GO:0005886 plasma membrane
1.36 1.08e-02 GO:0031012 extracellular matrix
1.99 3.13e-02 GO:0031674 I band
1.26 4.37e-02 GO:0030054 cell junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.07 4.42e-03 GO:0005515 protein binding