Motif ID: TFAP2{A,C}.p2

Z-value: 6.569


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Achr6_-_10523203-0.263.2e-01Click!
TFAP2Cchr20_+_54637714-0.165.5e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_45090025 8.951 NM_016932
 SIX2
SIX homeobox 2
chr15_-_46724360 8.938 FBN1
fibrillin 1
chr17_+_52026058 8.562 NM_005450
 NOG
noggin
chr8_-_80842452 8.154 NM_001040708
NM_012258
 HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr3_+_51403760 7.984 NM_013286
 RBM15B
RNA binding motif protein 15B
chr9_+_136673464 7.426 NM_000093
 COL5A1
collagen, type V, alpha 1
chr9_+_136673534 6.876 COL5A1
collagen, type V, alpha 1
chr2_+_85834111 6.876 NM_032827
 ATOH8
atonal homolog 8 (Drosophila)
chr15_+_64782468 6.662 SMAD6
SMAD family member 6
chr16_+_85158357 6.482 NM_005251
 FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr3_-_126257425 6.298 NM_020733
 HEG1
HEG homolog 1 (zebrafish)
chr5_-_159672060 6.218 NM_024565
 CCNJL
cyclin J-like
chr10_+_23768203 6.138 NM_001145373
 OTUD1
OTU domain containing 1
chr3_-_130807865 5.874 NM_015103
 PLXND1
plexin D1
chr5_+_34692124 5.836 NM_001145522
NM_015577
 RAI14

retinoic acid induced 14

chr19_+_39664706 5.728 NM_001080436
 WTIP
Wilms tumor 1 interacting protein
chr14_-_24588916 5.722 NM_014178
 STXBP6
syntaxin binding protein 6 (amisyn)
chr9_+_127549437 5.705 NM_006195
 PBX3
pre-B-cell leukemia homeobox 3
chr11_-_124175467 5.680 C11orf61
chromosome 11 open reading frame 61
chr4_+_108965167 5.583 NM_001136258
 SGMS2
sphingomyelin synthase 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 142 entries
enrichment   p-value GO term description
1.79 1.52e-03 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
1.53 1.50e-02 GO:0031398 positive regulation of protein ubiquitination
1.49 3.82e-03 GO:0000082 G1/S transition of mitotic cell cycle
1.45 1.88e-07 GO:0051325 interphase
1.45 5.72e-07 GO:0051329 interphase of mitotic cell cycle
1.41 7.83e-04 GO:0051129 negative regulation of cellular component organization
1.41 3.02e-03 GO:0045786 negative regulation of cell cycle
1.40 3.14e-03 GO:0071156 regulation of cell cycle arrest
1.40 1.14e-02 GO:0000375 RNA splicing, via transesterification reactions
1.38 1.55e-05 GO:0044419 interspecies interaction between organisms
1.38 3.44e-03 GO:0030036 actin cytoskeleton organization
1.38 3.15e-02 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
1.38 3.15e-02 GO:0000398 nuclear mRNA splicing, via spliceosome
1.37 2.12e-10 GO:0051726 regulation of cell cycle
1.37 1.15e-05 GO:0006397 mRNA processing
1.37 5.64e-05 GO:0010564 regulation of cell cycle process
1.37 2.36e-02 GO:0000075 cell cycle checkpoint
1.36 2.82e-09 GO:0000278 mitotic cell cycle
1.36 7.23e-04 GO:0008380 RNA splicing
1.35 4.78e-03 GO:0030029 actin filament-based process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 57 entries
enrichment   p-value GO term description
1.99 1.07e-02 GO:0032154 cleavage furrow
1.56 4.52e-03 GO:0042470 melanosome
1.56 4.52e-03 GO:0048770 pigment granule
1.55 2.17e-02 GO:0014069 postsynaptic density
1.55 3.14e-02 GO:0031985 Golgi cisterna
1.54 3.39e-02 GO:0031984 organelle subcompartment
1.48 2.67e-02 GO:0005795 Golgi stack
1.46 1.02e-04 GO:0031252 cell leading edge
1.42 1.03e-02 GO:0031965 nuclear membrane
1.41 1.52e-02 GO:0005912 adherens junction
1.37 3.21e-02 GO:0070161 anchoring junction
1.35 2.48e-03 GO:0005635 nuclear envelope
1.28 4.10e-04 GO:0044427 chromosomal part
1.28 3.97e-02 GO:0015629 actin cytoskeleton
1.27 5.61e-05 GO:0005694 chromosome
1.26 2.69e-02 GO:0005815 microtubule organizing center
1.25 3.10e-21 GO:0044428 nuclear part
1.25 1.34e-11 GO:0005654 nucleoplasm
1.24 1.76e-18 GO:0005829 cytosol
1.24 4.78e-16 GO:0031981 nuclear lumen

Gene overrepresentation in function category:

Showing 1 to 20 of 32 entries
enrichment   p-value GO term description
2.35 2.48e-02 GO:0070412 R-SMAD binding
1.88 5.37e-04 GO:0046332 SMAD binding
1.55 4.31e-02 GO:0031625 ubiquitin protein ligase binding
1.45 4.45e-02 GO:0051020 GTPase binding
1.37 9.94e-08 GO:0019904 protein domain specific binding
1.33 2.41e-03 GO:0005083 small GTPase regulator activity
1.31 1.59e-05 GO:0030695 GTPase regulator activity
1.30 4.40e-05 GO:0060589 nucleoside-triphosphatase regulator activity
1.28 1.21e-07 GO:0019899 enzyme binding
1.28 2.37e-02 GO:0016563 transcription activator activity
1.27 3.71e-02 GO:0003779 actin binding
1.25 1.59e-03 GO:0008092 cytoskeletal protein binding
1.24 2.18e-02 GO:0004674 protein serine/threonine kinase activity
1.20 9.33e-05 GO:0030528 transcription regulator activity
1.20 3.98e-03 GO:0016301 kinase activity
1.19 9.05e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.18 4.30e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.17 1.56e-09 GO:0000166 nucleotide binding
1.17 2.23e-05 GO:0005524 ATP binding
1.17 2.81e-05 GO:0030554 adenyl nucleotide binding