Motif ID: TFAP2B.p2

Z-value: 4.823


Transcription factors associated with TFAP2B.p2:

Gene SymbolEntrez IDGene Name
TFAP2B 7021 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Bchr6_+_50894397-0.204.5e-01Click!


Activity profile for motif TFAP2B.p2.

activity profile for motif TFAP2B.p2


Sorted Z-values histogram for motif TFAP2B.p2

Sorted Z-values for motif TFAP2B.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2B.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_39664706 8.060 NM_001080436
 WTIP
Wilms tumor 1 interacting protein
chr9_+_127549437 7.181 NM_006195
 PBX3
pre-B-cell leukemia homeobox 3
chr2_-_160972606 6.312 RBMS1
RNA binding motif, single stranded interacting protein 1
chr21_-_43671355 5.966 NM_173354
 SIK1
salt-inducible kinase 1
chr4_+_89147821 5.545 NM_000297
 PKD2
polycystic kidney disease 2 (autosomal dominant)
chr5_+_14196287 5.450 NM_007118
 TRIO
triple functional domain (PTPRF interacting)
chr14_+_105012106 5.031 NM_001312
 CRIP2
cysteine-rich protein 2
chr20_+_56701224 4.962 NM_024663
 NPEPL1
aminopeptidase-like 1
chr10_+_11100111 4.805 CELF2
CUGBP, Elav-like family member 2
chr19_-_1518875 4.759 NM_001174118
NM_203304
 MEX3D

mex-3 homolog D (C. elegans)

chr10_+_11100075 4.607 CELF2
CUGBP, Elav-like family member 2
chrX_+_9943793 4.605 NM_015691
 WWC3
WWC family member 3
chr5_+_10617431 4.365 NM_001164440
 ANKRD33B
ankyrin repeat domain 33B
chr2_-_45090025 4.196 NM_016932
 SIX2
SIX homeobox 2
chr2_-_127580975 4.018 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
 BIN1









bridging integrator 1









chr1_-_95165089 3.968 NM_001839
 CNN3
calponin 3, acidic
chr10_-_131652007 3.810 NM_001005463
 EBF3
early B-cell factor 3
chr4_-_174327377 3.789


chr10_+_11099860 3.628 NM_006561
 CELF2
CUGBP, Elav-like family member 2
chr2_-_110769670 3.561 NM_001164463
NM_005054
 RGPD8
RGPD5
RANBP2-like and GRIP domain containing 8
RANBP2-like and GRIP domain containing 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 146 entries
enrichment   p-value GO term description
2.60 2.09e-03 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
1.77 3.15e-02 GO:0007173 epidermal growth factor receptor signaling pathway
1.62 1.82e-02 GO:0007050 cell cycle arrest
1.61 7.79e-03 GO:0008286 insulin receptor signaling pathway
1.53 5.82e-04 GO:0048011 nerve growth factor receptor signaling pathway
1.52 1.16e-03 GO:0045786 negative regulation of cell cycle
1.46 2.64e-03 GO:0016567 protein ubiquitination
1.45 1.65e-03 GO:0032446 protein modification by small protein conjugation
1.43 7.06e-07 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.41 1.58e-08 GO:0007167 enzyme linked receptor protein signaling pathway
1.40 5.36e-07 GO:0010629 negative regulation of gene expression
1.40 1.81e-05 GO:0000904 cell morphogenesis involved in differentiation
1.40 1.51e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.40 1.98e-04 GO:0007409 axonogenesis
1.40 1.60e-03 GO:0043009 chordate embryonic development
1.40 6.47e-03 GO:0060284 regulation of cell development
1.40 2.85e-02 GO:0010608 posttranscriptional regulation of gene expression
1.40 4.15e-02 GO:0001568 blood vessel development
1.39 2.33e-04 GO:0048812 neuron projection morphogenesis
1.39 2.22e-03 GO:0009792 embryo development ending in birth or egg hatching

Gene overrepresentation in compartment category:

Showing 1 to 20 of 44 entries
enrichment   p-value GO term description
1.99 7.21e-03 GO:0017053 transcriptional repressor complex
1.93 3.38e-04 GO:0031256 leading edge membrane
1.92 2.72e-02 GO:0030173 integral to Golgi membrane
1.86 4.55e-02 GO:0031228 intrinsic to Golgi membrane
1.73 1.63e-04 GO:0030055 cell-substrate junction
1.72 1.51e-06 GO:0005912 adherens junction
1.71 5.52e-04 GO:0005924 cell-substrate adherens junction
1.70 1.19e-03 GO:0005925 focal adhesion
1.63 2.58e-05 GO:0070161 anchoring junction
1.55 2.97e-04 GO:0031252 cell leading edge
1.40 2.65e-02 GO:0016604 nuclear body
1.39 1.76e-02 GO:0005635 nuclear envelope
1.34 9.80e-03 GO:0005815 microtubule organizing center
1.32 1.79e-06 GO:0044451 nucleoplasm part
1.30 1.55e-20 GO:0044428 nuclear part
1.30 1.37e-11 GO:0005654 nucleoplasm
1.29 3.57e-17 GO:0005829 cytosol
1.29 9.76e-16 GO:0031981 nuclear lumen
1.29 1.07e-02 GO:0000139 Golgi membrane
1.27 3.94e-03 GO:0044431 Golgi apparatus part

Gene overrepresentation in function category:

Showing 1 to 20 of 31 entries
enrichment   p-value GO term description
2.01 6.71e-03 GO:0046332 SMAD binding
1.59 1.31e-03 GO:0003714 transcription corepressor activity
1.54 2.63e-07 GO:0008134 transcription factor binding
1.44 2.00e-04 GO:0016564 transcription repressor activity
1.41 1.50e-02 GO:0019787 small conjugating protein ligase activity
1.40 1.63e-04 GO:0000988 protein binding transcription factor activity
1.40 1.63e-04 GO:0000989 transcription factor binding transcription factor activity
1.40 2.87e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.40 6.97e-03 GO:0016881 acid-amino acid ligase activity
1.39 2.31e-04 GO:0003712 transcription cofactor activity
1.35 1.88e-02 GO:0016563 transcription activator activity
1.33 2.10e-03 GO:0019904 protein domain specific binding
1.31 1.74e-08 GO:0030528 transcription regulator activity
1.28 3.06e-02 GO:0016874 ligase activity
1.27 2.76e-04 GO:0019899 enzyme binding
1.27 1.51e-03 GO:0043565 sequence-specific DNA binding
1.26 1.29e-05 GO:0001071 nucleic acid binding transcription factor activity
1.26 1.29e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.17 9.58e-33 GO:0005515 protein binding
1.17 5.01e-03 GO:0030554 adenyl nucleotide binding