Motif ID: TGIF1.p2

Z-value: 1.844


Transcription factors associated with TGIF1.p2:

Gene SymbolEntrez IDGene Name
TGIF1 7050 TGFB-induced factor homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TGIF1chr18_+_3402071-0.322.2e-01Click!


Activity profile for motif TGIF1.p2.

activity profile for motif TGIF1.p2


Sorted Z-values histogram for motif TGIF1.p2

Sorted Z-values for motif TGIF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TGIF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_27320983 3.016 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr15_-_46725087 2.599 NM_000138
FBN1
fibrillin 1
chr6_-_33822659 2.478 NM_001142883
NM_054111
IP6K3

inositol hexakisphosphate kinase 3

chr2_+_33213111 2.444 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr15_-_68781662 2.393 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr2_+_223625105 2.344 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr8_+_67201684 2.295 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr2_-_225519974 2.227 DOCK10
dedicator of cytokinesis 10
chr1_-_38185312 2.182 NM_005540
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr17_+_65677255 2.115 NM_000891
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr9_-_16717887 2.052 BNC2
basonuclin 2
chr8_-_41641881 2.047 NM_001142445
NM_020478
NM_020480
ANK1


ankyrin 1, erythrocytic


chr1_-_38185307 1.966 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr1_-_85816520 1.923 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr4_+_3341521 1.878 NM_198227
RGS12
regulator of G-protein signaling 12
chr2_+_88148413 1.853 NM_198274
SMYD1
SET and MYND domain containing 1
chr2_-_202271598 1.844 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr2_-_179623030 1.841 NM_173648
CCDC141
coiled-coil domain containing 141
chr1_-_38185291 1.794 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr1_-_38185254 1.744 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr8_-_49996353 1.713 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr2_+_96566190 1.647 NM_212481
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr10_+_123862430 1.571 TACC2
transforming, acidic coiled-coil containing protein 2
chr11_-_26700121 1.568 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr9_+_133154896 1.474 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr12_+_51728999 1.457 NM_015319
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr1_+_101474892 1.402 NM_001400
S1PR1
sphingosine-1-phosphate receptor 1
chr14_+_99220349 1.393 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr11_-_85115105 1.376 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr5_+_125786975 1.372 GRAMD3
GRAM domain containing 3
chr11_-_77806413 1.371 GAB2
GRB2-associated binding protein 2
chr12_+_51729239 1.366 TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr10_+_69539255 1.361 NM_032578
MYPN
myopalladin
chr1_+_101475149 1.349 S1PR1
sphingosine-1-phosphate receptor 1
chr8_+_42671718 1.342 NM_000749
CHRNB3
cholinergic receptor, nicotinic, beta 3
chr10_+_90629880 1.328 NM_020799
STAMBPL1
STAM binding protein-like 1
chr1_-_143750988 1.316 NM_001198832
PDE4DIP
phosphodiesterase 4D interacting protein
chr20_+_8997791 1.293 PLCB4
phospholipase C, beta 4
chr5_+_125786717 1.247 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr10_-_73203202 1.244 NM_022153
C10orf54
chromosome 10 open reading frame 54
chr9_+_101623957 1.235 NM_006981
NM_173199
NR4A3

nuclear receptor subfamily 4, group A, member 3

chr16_+_30951915 1.233 STX4
syntaxin 4
chr3_+_120495906 1.224 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr9_+_34980715 1.224 DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr12_+_118100977 1.222 NM_014365
HSPB8
heat shock 22kDa protein 8
chr22_-_36212160 1.207 NM_001166343
NM_002405
MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr10_-_49483002 1.176 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr11_-_77806500 1.157 NM_080491
GAB2
GRB2-associated binding protein 2
chr1_-_197173159 1.128 LOC100131234
familial acute myelogenous leukemia related factor
chr1_-_206484258 1.106 NM_025179
PLXNA2
plexin A2
chr2_+_190916863 1.093 INPP1
inositol polyphosphate-1-phosphatase
chr10_+_104525877 1.072 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr7_+_101715137 1.069 SH2B2
SH2B adaptor protein 2
chr2_-_188021117 1.068 NM_005795
CALCRL
calcitonin receptor-like
chr15_+_41597097 1.052 NM_002373
MAP1A
microtubule-associated protein 1A
chr1_-_16217025 1.047 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr15_+_87540238 1.042 ABHD2
abhydrolase domain containing 2
chr11_-_76059435 1.041 NM_001128922
LRRC32
leucine rich repeat containing 32
chr9_+_127550298 1.035 NM_001134778
PBX3
pre-B-cell leukemia homeobox 3
chr8_-_93099040 1.031 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr14_-_72430545 1.027 NM_012074
DPF3
D4, zinc and double PHD fingers, family 3
chr3_-_39209075 1.022 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr2_+_66519949 1.020 MEIS1
Meis homeobox 1
chr5_+_180190585 1.011 LOC729678
hypothetical LOC729678
chr7_+_101715110 1.010 NM_020979
SH2B2
SH2B adaptor protein 2
chr6_-_119137923 1.008 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr7_-_27158726 1.005


chr4_+_78089968 0.983 SEPT11
septin 11
chr3_+_46423682 0.981 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr3_-_52694554 0.972 NM_018313
PBRM1
polybromo 1
chr2_+_238200922 0.965 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr6_-_109521969 0.952 NM_014454
SESN1
sestrin 1
chr8_+_38363150 0.949 NM_144652
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr3_-_130807865 0.940 NM_015103
PLXND1
plexin D1
chr2_-_207738858 0.919 NM_003709
KLF7
Kruppel-like factor 7 (ubiquitous)
chr9_+_18464090 0.917 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr5_+_180190542 0.909


chr18_+_64616296 0.905 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr9_+_18464138 0.898 ADAMTSL1
ADAMTS-like 1
chr5_+_140848905 0.895 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr9_-_35802142 0.893 NM_001039592
NM_172312
SPAG8

sperm associated antigen 8

chr6_+_136214495 0.889 NM_018945
PDE7B
phosphodiesterase 7B
chrX_-_48818585 0.887 NM_007213
PRAF2
PRA1 domain family, member 2
chr3_-_184756101 0.886 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr12_+_102982365 0.882 NM_013320
HCFC2
host cell factor C2
chr5_-_54317102 0.873 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr1_-_202595666 0.873 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr3_+_46894239 0.870 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr4_+_120168002 0.862 SYNPO2
synaptopodin 2
chr1_+_78858675 0.846 NM_006820
IFI44L
interferon-induced protein 44-like
chr16_-_52094613 0.832 NM_001012398
NM_022476
AKTIP

AKT interacting protein

chr9_-_129537372 0.826 NM_001085347
NM_001134430
NM_001134431
NM_130459
TOR2A



torsin family 2, member A



chr4_+_113958652 0.818 NM_001127493
ANK2
ankyrin 2, neuronal
chr17_-_33043514 0.804 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chr3_+_52694975 0.802 NM_014366
NM_206825
NM_206826
GNL3


guanine nucleotide binding protein-like 3 (nucleolar)


chr1_-_191341866 0.800 NM_016066
GLRX2
glutaredoxin 2
chr11_+_111288669 0.796 NM_001541
HSPB2-C11ORF52
HSPB2
HSPB2-C11orf52 read-through transcript
heat shock 27kDa protein 2
chr17_+_73886290 0.795 NM_024419
PGS1
phosphatidylglycerophosphate synthase 1
chr1_+_226462363 0.790 NM_001098623
NM_052843
OBSCN

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

chr4_+_120167950 0.789 SYNPO2
synaptopodin 2
chr9_-_8723893 0.789 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr9_-_33437527 0.788 NM_004925
AQP3
aquaporin 3 (Gill blood group)
chr8_-_72431274 0.786 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr11_-_76058542 0.778 NM_005512
LRRC32
leucine rich repeat containing 32
chr4_+_120167770 0.775 SYNPO2
synaptopodin 2
chr7_-_19123765 0.765 TWIST1
twist homolog 1 (Drosophila)
chr18_+_13601664 0.761 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr13_+_47775951 0.759 RB1
retinoblastoma 1
chr20_+_8997660 0.755 NM_001172646
PLCB4
phospholipase C, beta 4
chr11_+_111288686 0.748 HSPB2-C11ORF52
HSPB2
HSPB2-C11orf52 read-through transcript
heat shock 27kDa protein 2
chr9_-_71476917 0.746 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr7_+_33911636 0.737 NM_133468
BMPER
BMP binding endothelial regulator
chr10_+_94598204 0.736 NM_019053
EXOC6
exocyst complex component 6
chr1_+_36394338 0.736 NM_018067
MAP7D1
MAP7 domain containing 1
chr10_+_124210980 0.733 NM_002775
HTRA1
HtrA serine peptidase 1
chr5_-_36337756 0.732 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr12_+_8741746 0.731 NM_020734
RIMKLB
ribosomal modification protein rimK-like family member B
chr4_+_146622154 0.730 NM_005900
SMAD1
SMAD family member 1
chr9_-_133605037 0.729 RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr8_-_6407882 0.728 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr13_-_59223074 0.727


chr6_-_109522207 0.720 SESN1
sestrin 1
chr8_-_42184194 0.720 PLAT
plasminogen activator, tissue
chr6_+_32515596 0.707 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr7_-_137337354 0.706 NM_194071
CREB3L2
cAMP responsive element binding protein 3-like 2
chr14_+_92049396 0.702 NM_024832
RIN3
Ras and Rab interactor 3
chr11_+_63730720 0.701 NM_031471
NM_178443
FERMT3

fermitin family member 3

chr5_-_172976212 0.700 BOD1
biorientation of chromosomes in cell division 1
chr12_+_76749199 0.697 NM_014903
NAV3
neuron navigator 3
chr4_+_159909658 0.690 FNIP2
folliculin interacting protein 2
chr19_-_54557450 0.686 NM_003598
TEAD2
TEA domain family member 2
chr6_-_27948065 0.685 NM_003533
HIST1H3I
histone cluster 1, H3i
chr1_-_153098811 0.683 NM_170782
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr7_-_19123787 0.682 NM_000474
TWIST1
twist homolog 1 (Drosophila)
chr9_+_34980266 0.681 NM_001135005
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr20_-_49612574 0.680 NM_001136021
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr9_+_129900637 0.680 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr1_-_143643064 0.679 PDE4DIP
phosphodiesterase 4D interacting protein
chr19_-_14089362 0.679 NM_002730
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr16_-_65774904 0.678 KIAA0895L
KIAA0895-like
chr9_-_36266930 0.677 NM_001128227
NM_001190388
GNE

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

chr5_+_149867866 0.676 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr12_+_63958689 0.673 NM_001031679
NM_001193460
NM_198080
MSRB3


methionine sulfoxide reductase B3


chr9_-_131845077 0.670 FNBP1
formin binding protein 1
chr13_+_47776026 0.663 RB1
retinoblastoma 1
chr4_+_54790020 0.662 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr2_-_179380301 0.660 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr12_+_108921776 0.652 ANKRD13A
ankyrin repeat domain 13A
chr2_+_33514896 0.650 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr15_-_48192804 0.642 ATP8B4
ATPase, class I, type 8B, member 4
chr10_+_102662675 0.640 FAM178A
family with sequence similarity 178, member A
chr10_+_70331100 0.640 DDX50
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr10_+_115300579 0.640 NM_001177660
HABP2
hyaluronan binding protein 2
chr19_+_53664386 0.632 CYTH2
cytohesin 2
chr5_+_149845503 0.631 NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr9_+_129900590 0.626 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr5_-_159730196 0.626 NM_031908
C1QTNF2
C1q and tumor necrosis factor related protein 2
chr9_-_131845277 0.626 NM_015033
FNBP1
formin binding protein 1
chr19_-_14089560 0.621 PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr1_-_171442937 0.618 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr6_-_112301123 0.607 NM_002037
FYN
FYN oncogene related to SRC, FGR, YES
chr9_+_17124974 0.606 NM_001114395
NM_017738
CNTLN

centlein, centrosomal protein

chr16_-_65775326 0.600 NM_001040715
KIAA0895L
KIAA0895-like
chr3_-_129024665 0.593 NM_001003794
MGLL
monoglyceride lipase
chr4_+_120167721 0.591 SYNPO2
synaptopodin 2
chr13_-_49597776 0.583 DLEU2
deleted in lymphocytic leukemia 2 (non-protein coding)
chr1_+_26220852 0.581 NM_004455
EXTL1
exostoses (multiple)-like 1
chr9_-_35640852 0.580 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr19_+_16169664 0.578 NM_001130524
NM_032493
AP1M1

adaptor-related protein complex 1, mu 1 subunit

chr5_-_172976259 0.577 NM_001159651
NM_138369
BOD1

biorientation of chromosomes in cell division 1

chr1_+_149309703 0.576 NM_144618
GABPB2
GA binding protein transcription factor, beta subunit 2
chr9_+_131123115 0.574 NM_001012715
C9orf106
chromosome 9 open reading frame 106
chr2_+_71059082 0.569 NM_001115116
NM_024933
ANKRD53

ankyrin repeat domain 53

chr10_+_70330961 0.569 NM_024045
DDX50
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr19_-_44518516 0.565 NM_004877
GMFG
glia maturation factor, gamma
chr5_-_172976196 0.562 BOD1
biorientation of chromosomes in cell division 1
chr2_+_170074457 0.559 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr15_+_42815851 0.557 NM_080745
NM_182985
TRIM69

tripartite motif containing 69

chr12_-_69289889 0.554 NM_002837
PTPRB
protein tyrosine phosphatase, receptor type, B
chr6_-_56824672 0.545 DST
dystonin
chr15_+_90738108 0.545 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr12_+_108921686 0.544 ANKRD13A
ankyrin repeat domain 13A
chr11_-_127897271 0.539 NM_001162422
NM_005238
ETS1

v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

chr3_+_114733907 0.539 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr12_+_108921616 0.535 NM_033121
ANKRD13A
ankyrin repeat domain 13A
chr3_+_45042754 0.535 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr6_+_151229003 0.533 MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr7_+_120378052 0.532 NM_019071
NM_198267
ING3

inhibitor of growth family, member 3

chr6_-_46401363 0.518 NM_005822
RCAN2
regulator of calcineurin 2
chr13_-_32757835 0.518 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr9_-_14769530 0.515 NM_001177704
FREM1
FRAS1 related extracellular matrix 1
chr8_+_94999167 0.514 NM_001161778
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr4_-_158111916 0.512 PDGFC
platelet derived growth factor C
chr3_+_23219707 0.508 NM_152653
UBE2E2
ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)
chr10_+_102662315 0.506 NM_001136123
NM_018121
FAM178A

family with sequence similarity 178, member A

chr1_+_26220895 0.506 EXTL1
exostoses (multiple)-like 1
chr13_-_22905822 0.504 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr19_-_51856129 0.503 NM_145056
DACT3
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chr9_-_129580732 0.497 NM_170600
SH2D3C
SH2 domain containing 3C
chr11_+_111353218 0.496 NM_033425
DIXDC1
DIX domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.43 1.45e-03 GO:0007166 cell surface receptor linked signaling pathway
1.29 1.69e-03 GO:0007165 signal transduction
1.26 4.15e-03 GO:0023052 signaling
1.24 8.50e-03 GO:0051716 cellular response to stimulus
1.18 1.19e-02 GO:0050896 response to stimulus
1.29 3.75e-02 GO:0048518 positive regulation of biological process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.29 3.16e-06 GO:0071944 cell periphery
1.29 5.18e-06 GO:0005886 plasma membrane
1.36 4.18e-04 GO:0044459 plasma membrane part
2.80 5.15e-03 GO:0030017 sarcomere
2.59 7.83e-03 GO:0030016 myofibril
1.13 1.08e-02 GO:0016020 membrane
1.36 2.01e-02 GO:0005856 cytoskeleton
2.45 2.07e-02 GO:0043292 contractile fiber
1.39 3.19e-02 GO:0031226 intrinsic to plasma membrane
1.40 3.22e-02 GO:0005887 integral to plasma membrane
2.43 4.69e-02 GO:0044449 contractile fiber part

Nothing significant found in function category.