Motif ID: ZIC1..3.p2

Z-value: 2.176


Transcription factors associated with ZIC1..3.p2:

Gene SymbolEntrez IDGene Name
ZIC1 7545 Zic family member 1 (odd-paired homolog, Drosophila)
ZIC2 7546 Zic family member 2 (odd-paired homolog, Drosophila)
ZIC3 7547 Zic family member 3 (odd-paired homolog, Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZIC1chr3_+_1486105160.495.6e-02Click!
ZIC3chrX_+_1364763530.292.8e-01Click!
ZIC2chr13_+_99432258-0.019.6e-01Click!


Activity profile for motif ZIC1..3.p2.

activity profile for motif ZIC1..3.p2


Sorted Z-values histogram for motif ZIC1..3.p2

Sorted Z-values for motif ZIC1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_85169615 6.537 NM_005250
 FOXL1
forkhead box L1
chr3_+_160964574 5.312 SCHIP1
schwannomin interacting protein 1
chr15_+_37660568 3.928 NM_003246
 THBS1
thrombospondin 1
chr3_-_73756668 3.359 NM_015009
 PDZRN3
PDZ domain containing ring finger 3
chr11_+_19691397 3.258 NM_145117
NM_182964
 NAV2

neuron navigator 2

chr4_+_72271218 2.941 NM_001098484
NM_001134742
 SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr3_+_64645819 2.874 LOC100507098
hypothetical LOC100507098
chr1_-_21478571 2.834 NM_001113347
 ECE1
endothelin converting enzyme 1
chr2_-_144991556 2.583 ZEB2
zinc finger E-box binding homeobox 2
chr16_+_85158357 2.505 NM_005251
 FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr10_-_62373828 2.503 NM_014836
 RHOBTB1
Rho-related BTB domain containing 1
chr2_-_144991386 2.470 ZEB2
zinc finger E-box binding homeobox 2
chr7_-_27191287 2.287 NM_005523
 HOXA11
homeobox A11
chr9_-_122516399 2.228 NM_001080497
 MEGF9
multiple EGF-like-domains 9
chr4_-_140696740 2.216 NM_030648
 SETD7
SET domain containing (lysine methyltransferase) 7
chr20_+_19903778 2.173 RIN2
Ras and Rab interactor 2
chr9_+_108665168 2.075 NM_021224
 ZNF462
zinc finger protein 462
chr11_+_117983515 2.064 NM_001144758
NM_001144759
 PHLDB1

pleckstrin homology-like domain, family B, member 1

chr7_-_112513379 2.055 NM_001146266
NM_001146267
 GPR85

G protein-coupled receptor 85

chr21_-_27139143 1.998 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 67 entries
enrichment   p-value GO term description
2.44 3.22e-02 GO:0040013 negative regulation of locomotion
2.22 2.32e-02 GO:0042692 muscle cell differentiation
2.16 1.29e-02 GO:0043062 extracellular structure organization
1.99 2.75e-04 GO:0061061 muscle structure development
1.98 5.37e-05 GO:0001501 skeletal system development
1.98 2.61e-02 GO:0007517 muscle organ development
1.86 3.88e-02 GO:0006897 endocytosis
1.86 3.88e-02 GO:0010324 membrane invagination
1.83 1.07e-02 GO:0001944 vasculature development
1.81 8.79e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.80 4.55e-02 GO:0001568 blood vessel development
1.78 1.22e-02 GO:0060284 regulation of cell development
1.69 2.16e-03 GO:0072358 cardiovascular system development
1.69 2.16e-03 GO:0072359 circulatory system development
1.61 2.05e-02 GO:0031175 neuron projection development
1.58 3.97e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.58 3.35e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.57 2.36e-03 GO:0051254 positive regulation of RNA metabolic process
1.56 4.63e-05 GO:0022008 neurogenesis
1.56 8.49e-05 GO:0048699 generation of neurons

Gene overrepresentation in compartment category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
3.70 2.92e-03 GO:0005913 cell-cell adherens junction
2.33 6.85e-05 GO:0005912 adherens junction
2.22 3.02e-02 GO:0005925 focal adhesion
2.21 1.81e-04 GO:0070161 anchoring junction
1.65 2.79e-05 GO:0030054 cell junction
1.57 2.99e-02 GO:0045202 synapse
1.44 8.20e-03 GO:0031410 cytoplasmic vesicle
1.41 2.38e-02 GO:0031982 vesicle
1.41 4.85e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.23 2.50e-02 GO:0044459 plasma membrane part
1.07 2.54e-03 GO:0005622 intracellular
1.07 1.20e-02 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
1.49 6.11e-03 GO:0043565 sequence-specific DNA binding
1.45 5.25e-04 GO:0001071 nucleic acid binding transcription factor activity
1.45 5.25e-04 GO:0003700 sequence-specific DNA binding transcription factor activity
1.42 1.70e-03 GO:0030528 transcription regulator activity
1.15 1.69e-06 GO:0005515 protein binding
1.07 2.48e-03 GO:0005488 binding