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• Activity deltas table
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Motif ID: bHLH_family.p2

Z-value: 2.499

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr8_+_120289735	4.180	NM_052886	MAL2	mal, T-cell differentiation protein 2 (gene/pseudogene)
chr16_-_66827449	4.148	NM_024939	ESRP2	epithelial splicing regulatory protein 2
chr8_-_17702991	3.671
chr6_+_143423738	2.888		AIG1	androgen-induced 1
chr6_+_143423656	2.872	NM_016108	AIG1	androgen-induced 1
chr16_-_5023934	2.659	NM_016256	NAGPA	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr6_+_143423723	2.616		AIG1	androgen-induced 1
chr16_-_23068010	2.598	NM_020718	USP31	ubiquitin specific peptidase 31
chr16_-_5023914	2.572		NAGPA	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr22_+_38720881	2.541	NM_138435	FAM83F	family with sequence similarity 83, member F
chr1_-_12599934	2.538	NM_004753	DHRS3	dehydrogenase/reductase (SDR family) member 3
chr12_-_56432292	2.516		CDK4	cyclin-dependent kinase 4
chr7_-_1562272	2.485	NM_001097620	TMEM184A	transmembrane protein 184A
chr17_+_9489578	2.446	NM_153210	USP43	ubiquitin specific peptidase 43
chr5_+_78567604	2.423	NM_152405	JMY	junction mediating and regulatory protein, p53 cofactor
chr12_-_56432375	2.363		CDK4	cyclin-dependent kinase 4
chr12_-_56432385	2.357	NM_000075	CDK4	cyclin-dependent kinase 4
chr12_-_56432377	2.348		CDK4	cyclin-dependent kinase 4
chr17_-_73636362	2.339		TMC6	transmembrane channel-like 6
chr2_-_172572993	2.283
chr2_+_172573049	2.259	NM_199227	METAP1D	methionyl aminopeptidase type 1D (mitochondrial)
chr17_-_35510431	2.228	NM_021724	NR1D1	nuclear receptor subfamily 1, group D, member 1
chr17_+_35148084	2.192	NM_001030002	GRB7	growth factor receptor-bound protein 7
chr9_+_696744	2.190	NM_153186	KANK1	KN motif and ankyrin repeat domains 1
chr17_-_68769613	2.171	NM_001129885	CPSF4L	cleavage and polyadenylation specific factor 4-like
chr6_+_138230045	2.107	NM_006290	TNFAIP3	tumor necrosis factor, alpha-induced protein 3
chr16_+_5023672	2.084		LOC100507589	hypothetical LOC100507589
chr20_+_46971618	2.076	NM_006420	ARFGEF2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr11_-_116168316	2.076	NM_001166598 NM_052968	APOA5	apolipoprotein A-V
chr7_-_22363036	2.065	NM_012294	RAPGEF5	Rap guanine nucleotide exchange factor (GEF) 5
chr11_-_118757477	2.057		USP2	ubiquitin specific peptidase 2
chr1_-_27113018	2.057	NM_021969	NR0B2	nuclear receptor subfamily 0, group B, member 2
chr1_-_159459999	2.053	NM_001643	APOA2	apolipoprotein A-II
chr19_-_5291700	2.047	NM_002850 NM_130853 NM_130854 NM_130855	PTPRS	protein tyrosine phosphatase, receptor type, S
chr16_-_5023562	2.011		NAGPA	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr17_+_44429748	1.966	NM_001160423 NM_006546	IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1
chr17_-_18848713	1.964	NM_001039999	FAM83G	family with sequence similarity 83, member G
chr17_-_38979178	1.930	NM_001079675	ETV4	ets variant 4
chr2_-_208342296	1.929	NM_003468	FZD5	frizzled homolog 5 (Drosophila)
chr7_+_16759845	1.923	NM_014399	TSPAN13	tetraspanin 13
chr17_-_35510074	1.921		NR1D1	nuclear receptor subfamily 1, group D, member 1
chr11_-_125586733	1.893	NM_001144827 NM_032795	RPUSD4	RNA pseudouridylate synthase domain containing 4
chr12_-_61614930	1.873	NM_020700	PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr2_+_218992053	1.868	NM_007127	VIL1	villin 1
chr5_+_78568094	1.841
chr17_+_35147738	1.836		GRB7	growth factor receptor-bound protein 7
chr17_+_35147697	1.812	NM_005310	GRB7	growth factor receptor-bound protein 7
chr11_+_125586828	1.811	NM_024556	FAM118B	family with sequence similarity 118, member B
chr2_+_46779553	1.801	NM_014011	SOCS5	suppressor of cytokine signaling 5
chr12_-_61615124	1.780		PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr16_+_65471881	1.765	NM_020786	PDP2	pyruvate dehyrogenase phosphatase catalytic subunit 2
chr9_-_126309510	1.750	NM_004959	NR5A1	nuclear receptor subfamily 5, group A, member 1
chr6_+_41622267	1.723		FOXP4	forkhead box P4
chr7_-_110989582	1.690	NM_032549	IMMP2L	IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr2_+_176761552	1.689	NM_024501	HOXD1	homeobox D1
chr14_+_23855291	1.669		LTB4R	leukotriene B4 receptor
chr6_+_160310118	1.651	NM_000876	IGF2R	insulin-like growth factor 2 receptor
chr7_+_150390566	1.648		SLC4A2	solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
chr11_+_76171780	1.594	NM_015516	TSKU	tsukushi small leucine rich proteoglycan homolog (Xenopus laevis)
chr11_+_384199	1.591	NM_007183	PKP3	plakophilin 3
chr19_+_40431122	1.577		LSR	lipolysis stimulated lipoprotein receptor
chr6_+_32229771	1.569		PPT2-EGFL8 PPT2	PPT2-EGFL8 read-through transcript palmitoyl-protein thioesterase 2
chr6_+_32090516	1.559	NM_007293 NM_001002029	C4A C4B	complement component 4A (Rodgers blood group) complement component 4B (Chido blood group)
chr9_-_99994704	1.559	NM_052820	CORO2A	coronin, actin binding protein, 2A
chr20_+_48781457	1.554	NM_032521	PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)
chr2_-_101134146	1.537	NM_001102426	TBC1D8	TBC1 domain family, member 8 (with GRAM domain)
chr11_+_119586879	1.531	NM_178507	OAF	OAF homolog (Drosophila)
chr1_-_1840564	1.530	NM_178545	TMEM52	transmembrane protein 52
chr6_+_105511615	1.521	NM_001004317	LIN28B	lin-28 homolog B (C. elegans)
chr10_-_32257693	1.506		ARHGAP12	Rho GTPase activating protein 12
chr3_-_188945921	1.492		BCL6	B-cell CLL/lymphoma 6
chr6_+_32230172	1.487		PPT2	palmitoyl-protein thioesterase 2
chr8_+_95722448	1.479		ESRP1	epithelial splicing regulatory protein 1
chr11_+_384238	1.471		PKP3	plakophilin 3
chr11_-_16992524	1.459	NM_175058	PLEKHA7	pleckstrin homology domain containing, family A member 7
chr1_-_159257486	1.456		F11R	F11 receptor
chrX_+_152562013	1.450		DUSP9	dual specificity phosphatase 9
chr1_-_159257567	1.442		F11R	F11 receptor
chr14_-_54438913	1.427	NM_000161 NM_001024024 NM_001024070 NM_001024071	GCH1	GTP cyclohydrolase 1
chr17_+_52518098	1.426		AKAP1	A kinase (PRKA) anchor protein 1
chr12_+_52960798	1.420		HNRNPA1L2 HNRNPA1 HNRNPA1P10	heterogeneous nuclear ribonucleoprotein A1-like 2 heterogeneous nuclear ribonucleoprotein A1 heterogeneous nuclear ribonucleoprotein A1 pseudogene 10
chr8_-_121893468	1.416	NM_021021	SNTB1	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr4_-_186970366	1.400	NM_003603 NM_001145670	SORBS2	sorbin and SH3 domain containing 2
chr12_+_94861201	1.381	NM_152435	AMDHD1	amidohydrolase domain containing 1
chr3_-_12983959	1.363	NM_014869	IQSEC1	IQ motif and Sec7 domain 1
chr9_+_70926009	1.362	NM_001170414	TJP2	tight junction protein 2 (zona occludens 2)
chr1_+_32992131	1.348
chr16_+_68353738	1.330	NM_007014 NM_199423	WWP2	WW domain containing E3 ubiquitin protein ligase 2
chr2_-_25328452	1.327	NM_153759	DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha
chr18_+_30810889	1.320	NM_001143826	MAPRE2	microtubule-associated protein, RP/EB family, member 2
chr11_+_45900731	1.312		GYLTL1B	glycosyltransferase-like 1B
chr1_+_3360880	1.311	NM_014448	ARHGEF16	Rho guanine nucleotide exchange factor (GEF) 16
chr12_+_54910767	1.309	NM_001135195	SLC39A5	solute carrier family 39 (metal ion transporter), member 5
chr2_-_85683268	1.300	NM_001031738	TMEM150A	transmembrane protein 150A
chr16_+_67236699	1.290		CDH3	cadherin 3, type 1, P-cadherin (placental)
chr6_+_37245860	1.286	NM_002648	PIM1	pim-1 oncogene
chr2_+_206732859	1.273		EEF1B2	eukaryotic translation elongation factor 1 beta 2
chr3_-_188946168	1.271	NM_001706	BCL6	B-cell CLL/lymphoma 6
chr6_-_53517397	1.262		GCLC	glutamate-cysteine ligase, catalytic subunit
chr11_-_118757574	1.257	NM_004205	USP2	ubiquitin specific peptidase 2
chr10_-_82039158	1.253	NM_000429	MAT1A	methionine adenosyltransferase I, alpha
chrX_-_132947290	1.251	NM_001164617 NM_001164618 NM_001164619 NM_004484	GPC3	glypican 3
chr17_-_34084682	1.239	NM_001130677	C17orf96	chromosome 17 open reading frame 96
chr1_-_21868380	1.232	NM_001145657 NM_002885	RAP1GAP	RAP1 GTPase activating protein
chr19_+_40431359	1.231	NM_015925 NM_205834 NM_205835	LSR	lipolysis stimulated lipoprotein receptor
chr16_+_56616782	1.231	NM_002428	MMP15	matrix metallopeptidase 15 (membrane-inserted)
chr16_+_68353662	1.228		WWP2	WW domain containing E3 ubiquitin protein ligase 2
chrX_-_132947141	1.222		GPC3	glypican 3
chr1_+_205293217	1.221	NM_001018053 NM_006212	PFKFB2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
chr1_-_11909042	1.212	NM_138346	KIAA2013	KIAA2013
chr2_-_61618165	1.212		XPO1	exportin 1 (CRM1 homolog, yeast)
chr2_+_219751230	1.211		FAM134A	family with sequence similarity 134, member A
chr2_+_219751207	1.206		FAM134A	family with sequence similarity 134, member A
chr11_+_118463906	1.199	NM_001024382	HMBS	hydroxymethylbilane synthase
chr7_-_27149750	1.197	NM_019102	HOXA5	homeobox A5
chr2_+_17585287	1.197	NM_003385	VSNL1	visinin-like 1
chr5_+_70918856	1.194	NM_022132	MCCC2	methylcrotonoyl-CoA carboxylase 2 (beta)
chr9_+_70926205	1.189		TJP2	tight junction protein 2 (zona occludens 2)
chr7_-_23476497	1.181	NM_006547	IGF2BP3	insulin-like growth factor 2 mRNA binding protein 3
chr2_+_17585462	1.180		VSNL1	visinin-like 1
chr6_-_138862271	1.172	NM_001144060	NHSL1	NHS-like 1
chr6_+_80397690	1.168	NM_031469	SH3BGRL2	SH3 domain binding glutamic acid-rich protein like 2
chr1_-_159257595	1.166	NM_016946	F11R	F11 receptor
chr2_+_27518736	1.161	NM_001168364 NM_173853	KRTCAP3	keratinocyte associated protein 3
chr7_+_16652282	1.147	NM_001159767 NM_014038	BZW2	basic leucine zipper and W2 domains 2
chr17_-_21097170	1.144	NM_152914	C17orf103	chromosome 17 open reading frame 103
chr8_+_55210333	1.140	NM_014175	MRPL15	mitochondrial ribosomal protein L15
chr1_+_61320213	1.138	NM_001134673 NM_005595	NFIA	nuclear factor I/A
chr12_-_63439449	1.137		GNS	glucosamine (N-acetyl)-6-sulfatase
chr17_-_7078304	1.136		DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr16_-_15644465	1.128	NM_001184998 NM_001184999 NM_014647	KIAA0430	KIAA0430
chr3_-_50304706	1.127	NM_006764	IFRD2	interferon-related developmental regulator 2
chr19_-_53914768	1.125	NM_001130915	MAMSTR	MEF2 activating motif and SAP domain containing transcriptional regulator
chr19_+_40431618	1.123		LSR	lipolysis stimulated lipoprotein receptor
chr20_+_43028533	1.122	NM_006282	STK4	serine/threonine kinase 4
chr6_+_41622111	1.119	NM_001012426 NM_001012427 NM_138457	FOXP4	forkhead box P4
chrX_+_49531209	1.115	NM_001145073	USP27X	ubiquitin specific peptidase 27, X-linked
chr6_-_35996915	1.095	NM_003137	SRPK1	SRSF protein kinase 1
chr14_+_102458745	1.089	NM_030943	AMN	amnionless homolog (mouse)
chr8_+_95722516	1.084	NM_001034915 NM_001122825 NM_001122826 NM_001122827 NM_017697	ESRP1	epithelial splicing regulatory protein 1
chr8_-_143482433	1.081	NM_145003	TSNARE1	t-SNARE domain containing 1
chr6_-_53517466	1.079		GCLC	glutamate-cysteine ligase, catalytic subunit
chr17_-_7078446	1.074	NM_004422	DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr9_-_106730256	1.073	NM_005502	ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1
chr6_+_32057779	1.071	NM_007293 NM_001002029	C4A C4B	complement component 4A (Rodgers blood group) complement component 4B (Chido blood group)
chr19_-_44158130	1.069	NM_024907	FBXO17	F-box protein 17
chr10_+_101532450	1.068	NM_000392	ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr19_+_40224457	1.067		HPN	hepsin
chr1_-_28432060	1.067		DNAJC8	DnaJ (Hsp40) homolog, subfamily C, member 8
chr5_+_70918888	1.065		MCCC2	methylcrotonoyl-CoA carboxylase 2 (beta)
chr5_+_132237253	1.064	NM_052971	LEAP2	liver expressed antimicrobial peptide 2
chr10_+_101532544	1.062		ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr1_-_39097904	1.062	NM_022157	RRAGC	Ras-related GTP binding C
chr1_-_28432095	1.060	NM_014280	DNAJC8	DnaJ (Hsp40) homolog, subfamily C, member 8
chr17_-_7078399	1.058		DVL2	dishevelled, dsh homolog 2 (Drosophila)
chr2_+_46779827	1.057	NM_144949	SOCS5	suppressor of cytokine signaling 5
chr6_-_8047731	1.056	NM_001135650 NM_004280	EEF1E1	eukaryotic translation elongation factor 1 epsilon 1
chr12_+_51686512	1.055		EIF4B	eukaryotic translation initiation factor 4B
chr1_-_159459814	1.052		APOA2	apolipoprotein A-II
chr11_-_72141064	1.050	NM_001040118	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr2_+_219751192	1.050		FAM134A	family with sequence similarity 134, member A
chr2_+_241903395	1.045	NM_001008491 NM_006155	SEPT2	septin 2
chr14_+_19993204	1.038		APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1
chr12_-_94860504	1.036	NM_182496	CCDC38	coiled-coil domain containing 38
chr12_+_53005192	1.035		COPZ1	coatomer protein complex, subunit zeta 1
chr1_-_77921681	1.035		ZZZ3	zinc finger, ZZ-type containing 3
chr10_+_5478521	1.033	NM_005863	NET1	neuroepithelial cell transforming 1
chr12_-_63439456	1.033	NM_002076	GNS	glucosamine (N-acetyl)-6-sulfatase
chr12_+_53005183	1.033		COPZ1	coatomer protein complex, subunit zeta 1
chr17_-_73636386	1.032	NM_001127198	TMC6	transmembrane channel-like 6
chr5_-_141372721	1.031	NM_005471	GNPDA1	glucosamine-6-phosphate deaminase 1
chr9_-_106730157	1.031		ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1
chr12_+_51686504	1.031		EIF4B	eukaryotic translation initiation factor 4B
chr6_-_138862273	1.028
chr1_+_181422016	1.027		LAMC2	laminin, gamma 2
chr1_-_199635057	1.025		LAD1	ladinin 1
chr11_+_18300689	1.015		GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa
chr19_+_38979502	1.014	NM_001129994 NM_001129995 NM_024076	KCTD15	potassium channel tetramerisation domain containing 15
chr10_-_32257768	1.014	NM_018287	ARHGAP12	Rho GTPase activating protein 12
chrX_+_30581523	1.012		GK	glycerol kinase
chr8_+_95722575	1.010		ESRP1	epithelial splicing regulatory protein 1
chr2_+_206732575	1.006		EEF1B2	eukaryotic translation elongation factor 1 beta 2
chr17_-_6495566	0.998	NM_016060	MED31	mediator complex subunit 31
chr8_+_11599119	0.998	NM_002052	GATA4	GATA binding protein 4
chr1_-_152459697	0.997	NM_001098616 NM_015449 NM_138740	C1orf43	chromosome 1 open reading frame 43
chr5_+_70918893	0.994		MCCC2	methylcrotonoyl-CoA carboxylase 2 (beta)
chr6_-_35996794	0.993		SRPK1	SRSF protein kinase 1
chr2_+_113119985	0.990	NM_005415	SLC20A1	solute carrier family 20 (phosphate transporter), member 1
chr1_+_9522107	0.981	NM_032315	SLC25A33	solute carrier family 25, member 33
chr12_-_63439415	0.981		GNS	glucosamine (N-acetyl)-6-sulfatase
chr1_-_199635240	0.980	NM_005558	LAD1	ladinin 1
chr6_+_7486862	0.980	NM_001008844 NM_004415	DSP	desmoplakin
chr12_+_53005177	0.978	NM_016057	COPZ1	coatomer protein complex, subunit zeta 1
chr6_+_7486836	0.975		DSP	desmoplakin
chr2_+_74610039	0.973	NM_013247 NM_145074	HTRA2	HtrA serine peptidase 2
chr17_+_36636404	0.972	NM_031961	KRTAP9-2	keratin associated protein 9-2
chr3_-_57088332	0.970	NM_001128615	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3
chr17_-_32730804	0.967	NM_198837 NM_198838	ACACA	acetyl-CoA carboxylase alpha
chr1_-_152797707	0.966	NM_017582	UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1
chr1_-_152797760	0.966		UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.17	5.93e-11	GO:0008152	metabolic process
1.18	1.49e-09	GO:0044237	cellular metabolic process
1.10	2.00e-09	GO:0009987	cellular process
1.17	3.33e-09	GO:0044238	primary metabolic process
1.17	1.35e-05	GO:0043170	macromolecule metabolic process
1.18	5.64e-05	GO:0044260	cellular macromolecule metabolic process
1.27	1.16e-03	GO:0010467	gene expression
1.18	7.13e-03	GO:0006807	nitrogen compound metabolic process
1.21	7.41e-03	GO:0044249	cellular biosynthetic process
1.18	8.80e-03	GO:0034641	cellular nitrogen compound metabolic process
1.20	1.31e-02	GO:0009058	biosynthetic process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.10	6.93e-14	GO:0005622	intracellular
1.15	6.29e-13	GO:0005737	cytoplasm
1.10	1.30e-12	GO:0044424	intracellular part
1.18	1.57e-09	GO:0044446	intracellular organelle part
1.18	1.82e-09	GO:0044422	organelle part
1.10	4.40e-08	GO:0043226	organelle
1.10	6.22e-08	GO:0043229	intracellular organelle
1.15	1.35e-07	GO:0044444	cytoplasmic part
1.26	8.42e-06	GO:0031974	membrane-enclosed lumen
1.25	1.83e-05	GO:0043233	organelle lumen
1.25	3.56e-05	GO:0070013	intracellular organelle lumen
1.09	6.89e-05	GO:0043227	membrane-bounded organelle
1.09	9.44e-05	GO:0043231	intracellular membrane-bounded organelle
1.21	2.11e-04	GO:0043228	non-membrane-bounded organelle
1.21	2.11e-04	GO:0043232	intracellular non-membrane-bounded organelle
1.23	3.89e-04	GO:0044428	nuclear part
1.25	8.62e-04	GO:0031981	nuclear lumen
1.29	1.02e-03	GO:0005739	mitochondrion
1.21	6.22e-03	GO:0005829	cytosol
1.42	1.73e-02	GO:0005730	nucleolus
1.42	1.94e-02	GO:0030529	ribonucleoprotein complex
1.14	2.53e-02	GO:0032991	macromolecular complex
3.03	4.24e-02	GO:0044452	nucleolar part

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.13	1.94e-07	GO:0005515	protein binding
1.06	8.32e-04	GO:0005488	binding