Motif ID: bHLH_family.p2

Z-value: 2.499


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
ARNTL 406 aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 56938 aryl hydrocarbon receptor nuclear translocator-like 2
CLOCK 9575 clock homolog (mouse)
HES6 55502 hairy and enhancer of split 6 (Drosophila)
HEY1 23462 hairy/enhancer-of-split related with YRPW motif 1
HEY2 23493 hairy/enhancer-of-split related with YRPW motif 2
HEYL 26508 hairy/enhancer-of-split related with YRPW motif-like
ID1 3397 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MITF 4286 microphthalmia-associated transcription factor
MLXIPL 51085 MLX interacting protein-like
MNT 4335 MAX binding protein
MXD3 83463 MAX dimerization protein 3
MXD4 10608 MAX dimerization protein 4
MXI1 4601 MAX interactor 1
NPAS2 4862 neuronal PAS domain protein 2
OLIG1 116448 oligodendrocyte transcription factor 1
OLIG2 10215 oligodendrocyte lineage transcription factor 2
TFE3 7030 transcription factor binding to IGHM enhancer 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MLXIPLchr7_-_726767500.647.6e-03Click!
MXD4chr4_-_2233606-0.476.6e-02Click!
HEYLchr1_-_39871226-0.457.9e-02Click!
MITFchr3_+_69895651-0.401.2e-01Click!
MXD3chr5_-_176671437-0.381.5e-01Click!
CLOCKchr4_-_56107725-0.371.5e-01Click!
NPAS2chr2_+_1008029230.361.7e-01Click!
MXI1chr10_+_1119599780.351.9e-01Click!
HEY1chr8_-_80842452-0.302.6e-01Click!
ARNTLchr11_+_13255952-0.282.9e-01Click!
TFE3chrX_-_48787696-0.282.9e-01Click!
OLIG1chr21_+_33364420,
chr21_+_33364316		-0.263.3e-01Click!
HEY2chr6_+_126112417-0.253.5e-01Click!
ID1chr20_+_296567440.224.1e-01Click!
ARNTL2chr12_+_27377034-0.214.3e-01Click!
MNTchr17_-_2250967-0.175.4e-01Click!
HES6chr2_-_238813365-0.058.6e-01Click!
OLIG2chr21_+_333200800.039.2e-01Click!


Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_120289735 4.180 NM_052886
 MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr16_-_66827449 4.148 NM_024939
 ESRP2
epithelial splicing regulatory protein 2
chr8_-_17702991 3.671


chr6_+_143423738 2.888 AIG1
androgen-induced 1
chr6_+_143423656 2.872 NM_016108
 AIG1
androgen-induced 1
chr16_-_5023934 2.659 NM_016256
 NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr6_+_143423723 2.616 AIG1
androgen-induced 1
chr16_-_23068010 2.598 NM_020718
 USP31
ubiquitin specific peptidase 31
chr16_-_5023914 2.572 NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr22_+_38720881 2.541 NM_138435
 FAM83F
family with sequence similarity 83, member F
chr1_-_12599934 2.538 NM_004753
 DHRS3
dehydrogenase/reductase (SDR family) member 3
chr12_-_56432292 2.516 CDK4
cyclin-dependent kinase 4
chr7_-_1562272 2.485 NM_001097620
 TMEM184A
transmembrane protein 184A
chr17_+_9489578 2.446 NM_153210
 USP43
ubiquitin specific peptidase 43
chr5_+_78567604 2.423 NM_152405
 JMY
junction mediating and regulatory protein, p53 cofactor
chr12_-_56432375 2.363 CDK4
cyclin-dependent kinase 4
chr12_-_56432385 2.357 NM_000075
 CDK4
cyclin-dependent kinase 4
chr12_-_56432377 2.348 CDK4
cyclin-dependent kinase 4
chr17_-_73636362 2.339 TMC6
transmembrane channel-like 6
chr2_-_172572993 2.283



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
1.27 1.16e-03 GO:0010467 gene expression
1.21 7.41e-03 GO:0044249 cellular biosynthetic process
1.20 1.31e-02 GO:0009058 biosynthetic process
1.18 1.49e-09 GO:0044237 cellular metabolic process
1.18 5.64e-05 GO:0044260 cellular macromolecule metabolic process
1.18 7.13e-03 GO:0006807 nitrogen compound metabolic process
1.18 8.80e-03 GO:0034641 cellular nitrogen compound metabolic process
1.17 5.93e-11 GO:0008152 metabolic process
1.17 3.33e-09 GO:0044238 primary metabolic process
1.17 1.35e-05 GO:0043170 macromolecule metabolic process
1.10 2.00e-09 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
3.03 4.24e-02 GO:0044452 nucleolar part
1.42 1.73e-02 GO:0005730 nucleolus
1.42 1.94e-02 GO:0030529 ribonucleoprotein complex
1.29 1.02e-03 GO:0005739 mitochondrion
1.26 8.42e-06 GO:0031974 membrane-enclosed lumen
1.25 1.83e-05 GO:0043233 organelle lumen
1.25 3.56e-05 GO:0070013 intracellular organelle lumen
1.25 8.62e-04 GO:0031981 nuclear lumen
1.23 3.89e-04 GO:0044428 nuclear part
1.21 2.11e-04 GO:0043228 non-membrane-bounded organelle
1.21 2.11e-04 GO:0043232 intracellular non-membrane-bounded organelle
1.21 6.22e-03 GO:0005829 cytosol
1.18 1.57e-09 GO:0044446 intracellular organelle part
1.18 1.82e-09 GO:0044422 organelle part
1.15 6.29e-13 GO:0005737 cytoplasm
1.15 1.35e-07 GO:0044444 cytoplasmic part
1.14 2.53e-02 GO:0032991 macromolecular complex
1.10 6.93e-14 GO:0005622 intracellular
1.10 1.30e-12 GO:0044424 intracellular part
1.10 4.40e-08 GO:0043226 organelle

Gene overrepresentation in function category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
1.13 1.94e-07 GO:0005515 protein binding
1.06 8.32e-04 GO:0005488 binding