Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 1.108


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3



Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_55489973 2.282 WNT5A
wingless-type MMTV integration site family, member 5A
chr3_-_115960807 1.558 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr16_+_7322751 1.405 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr12_+_52697160 1.397 HOXC5
HOXC6
homeobox C5
homeobox C6
chr11_+_10433241 1.276 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr3_-_143230124 1.255 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr9_+_102380156 1.224 NM_001018116
MURC
muscle-related coiled-coil protein
chr5_+_125786975 1.169 GRAMD3
GRAM domain containing 3
chr8_+_77756061 1.153 NM_024721
ZFHX4
zinc finger homeobox 4
chr12_+_52696908 1.139 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr2_-_190635566 1.132 NM_005259
MSTN
myostatin
chr15_+_47502666 1.115 NM_002009
FGF7
fibroblast growth factor 7
chr13_+_100902942 1.092 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr15_-_53996597 1.086 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr8_+_77756077 1.081 ZFHX4
zinc finger homeobox 4
chr11_-_85107569 1.063 NM_206929
SYTL2
synaptotagmin-like 2
chr5_+_155686333 1.029 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr8_-_72431274 1.009 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr17_-_10265991 1.009 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr1_-_191422346 0.979 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr2_-_144994038 0.944 ZEB2
zinc finger E-box binding homeobox 2
chr1_+_556968 0.849


chr2_+_157822355 0.823 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr4_-_74307637 0.802 ANKRD17
ankyrin repeat domain 17
chr16_+_85169615 0.801 NM_005250
FOXL1
forkhead box L1
chr15_+_55298908 0.749 NM_207040
TCF12
transcription factor 12
chr12_+_52680143 0.726 NM_006897
HOXC9
homeobox C9
chr11_+_113672378 0.719 NNMT
nicotinamide N-methyltransferase
chr1_+_78243181 0.714 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr6_-_101018271 0.710 NM_005068
SIM1
single-minded homolog 1 (Drosophila)
chr8_-_49996353 0.704 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr11_+_113672407 0.701 NNMT
nicotinamide N-methyltransferase
chr2_+_200031333 0.699


chr2_-_200030412 0.696 SATB2
SATB homeobox 2
chr2_-_200033445 0.687 SATB2
SATB homeobox 2
chr3_-_33675484 0.655 CLASP2
cytoplasmic linker associated protein 2
chrX_-_153698930 0.648 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr9_-_99740243 0.647 NM_197978
HEMGN
hemogen
chr11_-_33870411 0.644 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr13_-_34948758 0.638 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr11_-_85108030 0.633 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr8_-_37847095 0.627 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr5_+_38481392 0.611 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr13_+_34948977 0.595 NBEA
neurobeachin
chr3_-_113841200 0.587 CCDC80
coiled-coil domain containing 80
chr7_-_76667045 0.583 NM_006682
FGL2
fibrinogen-like 2
chr3_+_35696119 0.579 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr15_-_23201740 0.579 NM_130838
UBE3A
ubiquitin protein ligase E3A
chr7_-_13992351 0.567 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr5_+_42792676 0.565 NM_001134848
CCDC152
coiled-coil domain containing 152
chr8_+_67201684 0.564 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr2_-_200030944 0.549 NM_001172509
SATB2
SATB homeobox 2
chr6_-_76259976 0.548 NM_015687
FILIP1
filamin A interacting protein 1
chr5_-_88235624 0.548 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr8_+_70541631 0.547 SULF1
sulfatase 1
chr7_-_112514990 0.527 GPR85
G protein-coupled receptor 85
chr5_+_152850276 0.526 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr12_+_79362256 0.523 NM_001145026
PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr11_+_113671744 0.522 NM_006169
NNMT
nicotinamide N-methyltransferase
chr14_-_34252695 0.516 NM_021914
CFL2
cofilin 2 (muscle)
chr9_-_74757735 0.515 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr21_-_35343456 0.514 NM_001754
RUNX1
runt-related transcription factor 1
chr9_-_94338072 0.513 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr7_-_104696678 0.512 NM_182691
SRPK2
SRSF protein kinase 2
chr2_-_87102453 0.509 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr12_+_79634820 0.509 NM_005593
MYF5
myogenic factor 5
chr5_+_81636921 0.509 NM_001017971
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr21_-_35343428 0.508 RUNX1
runt-related transcription factor 1
chr21_+_37713076 0.498 NM_130436
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr4_+_14985272 0.493 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr2_+_189547377 0.488 COL3A1
collagen, type III, alpha 1
chr21_-_35343500 0.487 RUNX1
runt-related transcription factor 1
chr11_+_120478584 0.482 NM_005422
TECTA
tectorin alpha
chr17_-_44037332 0.480 NM_018952
HOXB6
homeobox B6
chr21_-_35343448 0.477 RUNX1
runt-related transcription factor 1
chr12_-_21379098 0.476 NM_021094
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr7_-_112515068 0.471 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr1_+_557269 0.469


chr6_+_136214495 0.468 NM_018945
PDE7B
phosphodiesterase 7B
chr10_+_89257569 0.465 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chr8_-_122722674 0.464 NM_005328
HAS2
hyaluronan synthase 2
chr6_+_42896771 0.460 NM_015349
KIAA0240
KIAA0240
chrX_-_33139349 0.459 NM_004006
DMD
dystrophin
chr17_-_44006808 0.456 NM_002146
HOXB3
homeobox B3
chr21_-_35343331 0.456 RUNX1
runt-related transcription factor 1
chr17_-_15495534 0.453 TRIM16
tripartite motif containing 16
chr8_-_72436519 0.452 EYA1
eyes absent homolog 1 (Drosophila)
chr21_-_35174742 0.452 RUNX1
runt-related transcription factor 1
chr13_+_34948885 0.449 NBEA
neurobeachin
chr8_+_70541412 0.444 NM_001128204
NM_015170
SULF1

sulfatase 1

chr7_-_13996166 0.440 NM_001163147
NM_004956
ETV1

ets variant 1

chr3_-_113841448 0.440 CCDC80
coiled-coil domain containing 80
chr2_-_45090025 0.434 NM_016932
SIX2
SIX homeobox 2
chr22_-_34564611 0.433 RPL41P5
ribosomal protein L41 pseudogene 5
chr5_+_140772691 0.431 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr3_+_35697432 0.430 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr3_-_69254226 0.427 NM_198271
LMOD3
leiomodin 3 (fetal)
chr17_-_10362583 0.427 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr1_-_201321999 0.427 NM_002479
MYOG
myogenin (myogenic factor 4)
chr17_+_59875623 0.426 NM_001085423
C17orf60
chromosome 17 open reading frame 60
chr5_+_140698537 0.424 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr8_-_108579270 0.424 NM_001146
ANGPT1
angiopoietin 1
chr10_+_70172257 0.415 CCAR1
cell division cycle and apoptosis regulator 1
chr10_+_75343352 0.413 PLAU
plasminogen activator, urokinase
chr22_+_21006814 0.413


chr3_-_158704056 0.412 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr1_+_100957883 0.409 NM_001078
NM_080682
VCAM1

vascular cell adhesion molecule 1

chr5_-_134291882 0.407


chr6_-_49820030 0.405 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr3_+_46894239 0.403 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr7_-_112515035 0.398 GPR85
G protein-coupled receptor 85
chr1_-_156923111 0.397 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr2_+_202379442 0.395 NM_139158
CDK15
cyclin-dependent kinase 15
chr11_+_65027721 0.394


chr11_-_71424614 0.390


chr9_+_74956614 0.385 ANXA1
annexin A1
chr3_-_113841967 0.384 CCDC80
coiled-coil domain containing 80
chr6_-_28429950 0.383 NM_145909
ZNF323
zinc finger protein 323
chr11_+_124539768 0.381 NM_022062
PKNOX2
PBX/knotted 1 homeobox 2
chr1_+_202033273 0.378 NM_001174108
ZBED6
zinc finger, BED-type containing 6
chr1_-_53972464 0.375 NM_147193
GLIS1
GLIS family zinc finger 1
chr9_+_117955890 0.374 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr10_+_49279647 0.373 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr5_-_75044001 0.372 NM_152408
POC5
POC5 centriolar protein homolog (Chlamydomonas)
chr5_+_125786717 0.369 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr3_-_166278969 0.366 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr15_+_46285789 0.364 NM_000338
NM_001184832
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporters), member 1

chr3_-_71262426 0.363 FOXP1
forkhead box P1
chr5_+_71438796 0.356 NM_005909
MAP1B
microtubule-associated protein 1B
chr3_-_113841941 0.353 CCDC80
coiled-coil domain containing 80
chr4_-_153493133 0.347 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr11_+_123600553 0.344 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr12_-_52281050 0.344 NM_001130059
ATF7
activating transcription factor 7
chr11_+_117982422 0.341 NM_015157
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr17_-_44026321 0.341 HOXB5
homeobox B5
chr11_+_65023556 0.340


chr17_-_10393664 0.339 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr10_+_68355797 0.339 NM_178011
LRRTM3
leucine rich repeat transmembrane neuronal 3
chrX_-_77801480 0.339 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr2_-_99284070 0.335 NM_174898
LYG1
lysozyme G-like 1
chr6_-_89984214 0.334 NM_002042
GABRR1
gamma-aminobutyric acid (GABA) receptor, rho 1
chr8_+_32905027 0.334


chr1_+_160868822 0.333 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr4_-_152366970 0.328 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr1_+_160868932 0.325 DDR2
discoidin domain receptor tyrosine kinase 2
chr12_-_68379331 0.322 NM_032735
BEST3
bestrophin 3
chr2_+_220087135 0.318 NM_018674
NM_182847
ACCN4

amiloride-sensitive cation channel 4, pituitary

chr3_-_71262405 0.317 FOXP1
forkhead box P1
chr1_-_115039614 0.316 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr9_+_129900637 0.315 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr10_+_44726635 0.314 NM_001123376
TMEM72
transmembrane protein 72
chr1_-_177378801 0.313 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr5_-_111340421 0.310 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr1_+_15145001 0.309 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr1_-_153480980 0.309 NM_001005741
NM_001005742
NM_001171811
GBA


glucosidase, beta, acid


chr17_-_46479127 0.305 SPAG9
sperm associated antigen 9
chr9_+_129900590 0.301 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr6_-_46401174 0.300 RCAN2
regulator of calcineurin 2
chr1_+_154120170 0.299 SYT11
synaptotagmin XI
chr15_-_70350609 0.299 NM_020214
PARP6
poly (ADP-ribose) polymerase family, member 6
chr22_+_40286957 0.297 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chrX_-_19727775 0.296 SH3KBP1
SH3-domain kinase binding protein 1
chr12_-_69434330 0.294 PTPRR
protein tyrosine phosphatase, receptor type, R
chr7_-_135083906 0.293 NM_205855
FAM180A
family with sequence similarity 180, member A
chr2_-_144991556 0.292 ZEB2
zinc finger E-box binding homeobox 2
chr5_+_35892747 0.292 NM_002185
IL7R
interleukin 7 receptor
chrX_-_135690699 0.291 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr15_-_74091817 0.290 NM_138573
NRG4
neuregulin 4
chr10_+_70745615 0.289 NM_033496
HK1
hexokinase 1
chr5_-_178977441 0.289 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr4_+_169250281 0.289 NM_007193
ANXA10
annexin A10
chr1_-_16217871 0.288 NM_014424
HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr7_+_129057152 0.285 NM_001040110
NRF1
nuclear respiratory factor 1
chr1_-_103269356 0.284 COL11A1
collagen, type XI, alpha 1
chr11_-_57173823 0.284 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chr6_+_158990982 0.283 NM_001009991
SYTL3
synaptotagmin-like 3
chr7_-_13995811 0.282 ETV1
ets variant 1
chr12_+_9871343 0.282 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr21_+_29439768 0.280 C21orf7
chromosome 21 open reading frame 7
chr7_+_106897737 0.280 NM_005295
GPR22
G protein-coupled receptor 22
chr5_+_140742585 0.279 NM_018920
NM_032087
PCDHGA7

protocadherin gamma subfamily A, 7

chr3_+_110338250 0.278 FLJ22763
hypothetical LOC401081
chrX_+_77889861 0.278 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr7_+_129634935 0.277 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr1_+_84402962 0.275 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr17_-_64462976 0.274 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr11_-_56951628 0.274 NM_017611
SLC43A3
solute carrier family 43, member 3
chr10_+_91051685 0.274 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr3_-_197726587 0.274 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr4_+_146820805 0.272 NM_001080531
C4orf51
chromosome 4 open reading frame 51
chr12_+_43972732 0.271 NM_001142678
ANO6
anoctamin 6
chr2_+_151922350 0.271 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr17_-_51155073 0.269 NM_018286
TMEM100
transmembrane protein 100
chr6_+_158653679 0.269 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr2_+_189547358 0.268 COL3A1
collagen, type III, alpha 1
chr21_-_35343065 0.268 RUNX1
runt-related transcription factor 1
chr14_-_80934523 0.266 NM_033104
STON2
stonin 2
chr6_+_144227265 0.266 NM_001013623
C6orf94
chromosome 6 open reading frame 94
chr15_-_70838703 0.265


chr1_-_93030538 0.265 NM_005665
EVI5
ecotropic viral integration site 5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.71 1.39e-16 GO:0007606 sensory perception of chemical stimulus
2.71 1.07e-14 GO:0007608 sensory perception of smell
2.01 5.98e-11 GO:0007600 sensory perception
1.54 5.80e-07 GO:0003008 system process
1.61 8.70e-07 GO:0050877 neurological system process
1.24 2.60e-05 GO:0032501 multicellular organismal process
1.17 7.46e-03 GO:0050896 response to stimulus
1.61 1.26e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
2.19 4.37e-02 GO:0007517 muscle organ development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.26 3.10e-05 GO:0071944 cell periphery
1.25 8.66e-05 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.81 3.48e-16 GO:0004984 olfactory receptor activity
2.00 7.11e-12 GO:0004930 G-protein coupled receptor activity
1.70 2.35e-09 GO:0004888 transmembrane receptor activity
1.52 5.87e-07 GO:0004872 receptor activity
1.40 3.31e-05 GO:0004871 signal transducer activity
1.40 3.31e-05 GO:0060089 molecular transducer activity