ISMARA results for ENCODE cell lines, H3K9ac, averaged replicates (Ernst 2011)

ISMARA - Integrated System for Motif Actitivity Response Analysis is a free online tool that recognizes most important transcription factors that are changing their activity in a set of samples.

Averaging sample configuration

Sample Condition
Rep1_GM12878 GM12878
Rep1_HepG2 HepG2
Rep1_HMEC HMEC
Rep1_HSMM HSMM
Rep1_Huvec Huvec
Rep1_K562 K562
Rep1_NHEK NHEK
Rep1_NHLF NHLF
Rep2_GM12878 GM12878
Rep2_HepG2 HepG2
Rep2_HMEC HMEC
Rep2_HSMM HSMM
Rep2_Huvec Huvec
Rep2_K562 K562
Rep2_NHEK NHEK
Rep2_NHLF NHLF

All motifs sorted by activity significance

Motif name Z-value Associated genes Profile Logo
HNF4A_NR2F1,2.p2 9.800 NR2F1 (EAR-3, COUP-TFI, TCFCOUP1, SVP44)
NR2F2 (COUP-TFII, COUPTFB, SVP40)
HNF4A (NR2A1, HNF4)
HNF1A.p2 9.466 HNF1A (HNF1, LFB1)
RFX1..5_RFXANK_RFXAP.p2 8.576 RFX1 (EF-C)
RFXAP
RFX5
RFXANK (BLS, RFX-B, ANKRA1, F14150_1, MGC138628)
RFX4
RFX3
RFX2 (FLJ14226)
FOS_FOS{B,L1}_JUN{B,D}.p2 8.225 FOS (c-fos, AP-1)
JUNB
FOSL1 (fra-1)
JUND (AP-1)
FOSB (G0S3, GOSB, GOS3, AP-1, MGC42291, DKFZp686C0818)
PITX1..3.p2 7.529 PITX2 (IGDS, RS, Brx1, Otlx2, ARP1)
PITX3
PITX1 (PTX1, POTX)
TEAD1.p2 7.458 TEAD1 (TEF-1)
TEAD2 (ETF, TEF4, TEF-4, TEAD-2)
TEAD3 (TEF5, TEAD5, TEF-5, DTEF-1, ETFR-1, TEAD-3)
TEAD4 (TEF3, RTEF1, TEF-3, EFTR-2, TEFR-1, TCF13L1, hRTEF-1B)
SNAI1..3.p2 7.067 SNAI2 (SLUGH1)
SNAI1 (SNA, SLUGH2, SNAH)
SNAI3 (SMUC, Zfp293)
IRF1,2,7.p3 6.502 IRF1 (MAR, IRF-1)
IRF2 (IRF-2, DKFZp686F0244)
IRF7 (IRF7A, IRF-7H)
RUNX1..3.p2 6.187 RUNX1 (PEBP2A2, AMLCR1)
RUNX3 (AML2, PEBP2A3)
RUNX2 (AML3, PEBP2A1, PEBP2aA1)
HBP1_HMGB_SSRP1_UBTF.p2 5.993 HMGB2
HMGB3 (HMG2A, MGC90319)
SSRP1 (FACT80)
UBTF (UBF, NOR-90)
HBP1
TCF4_dimer.p2 5.769 TCF4 (E2-2, ITF2, PTHS, SEF2, SEF2-1, SEF2-1A, SEF2-1B, bHLHb19, MGC149723, MGC149724)
MZF1.p2 5.734 MZF1 (MZF1B, ZSCAN6, MZF-1, Zfp98)
NFY{A,B,C}.p2 5.523 NFYC (CBF-C)
NFYB (CBF-A, HAP3)
NFYA (HAP2, CBF-B)
GATA6.p2 5.409 GATA6
ATF5_CREB3.p2 5.404 ATF5
CREB3 (LZIP, Luman)
SPIB.p2 5.313 SPIB (SPI-B)
SPI1.p2 5.221 SPI1 (PU.1, SPI-A, OF, SFPI1, SPI-1)
MYOD1.p2 4.836 MYOD1 (PUM, MYOD, bHLHc1)
HOX{A6,A7,B6,B7}.p2 4.701 HOXB6
HOXA7
HOXB7
HOXA6
NRF1.p2 4.697 NRF1 (EWG, ALPHA-PAL)
ZEB1.p2 4.567 ZEB1 (BZP, ZEB, AREB6, NIL-2-A, Zfhep, Zfhx1a)
NFKB1_REL_RELA.p2 4.511 RELA (p65)
REL (I-Rel)
NFKB1 (KBF1, p105)
TLX1..3_NFIC{dimer}.p2 4.381 TLX1
TLX3 (RNX)
ELK1,4_GABP{A,B1}.p3 4.251 GABPA (E4TF1A, NFT2, NRF2, E4TF1-60, NRF2A)
GABPB1 (E4TF1-47, GABPB)
ELK4 (SAP1)
ELK1
E2F1..5.p2 4.021 E2F4 (E2F-4)
E2F5
E2F2 (E2F-2)
E2F1 (RBP3)
E2F3
KLF4.p3 4.004 KLF4 (EZF, GKLF)
EP300.p2 3.897 EP300 (p300, KAT3B)
EN1,2.p2 3.823 EN1
EN2
SRF.p3 3.817 SRF (MCM1)
MTF1.p2 3.789 MTF1
EHF.p2 3.719 EHF
NHLH1,2.p2 3.689 NHLH1 (NSCL, NSCL1, bHLHa35)
NHLH2 (NSCL2, bHLHa34)
HAND1,2.p2 3.646 HAND1 (eHand, Thing1, Hxt, bHLHa27)
HAND2 (dHand, Thing2, Hed, bHLHa26)
POU2F1..3.p2 3.595 POU2F2 (OCT2)
POU2F1 (OCT1)
POU2F3 (OCT11, PLA-1, Skn-1a, Epoc-1)
ZNF143.p2 3.583 ZNF143 (SBF, pHZ-1, STAF)
ESRRA.p2 3.579 ESRRA (ERR1, ERRalpha, NR3B1, ERRa)
LMO2.p2 3.572 LMO2 (TTG2, RHOM2, RBTN2)
LEF1_TCF7_TCF7L1,2.p2 3.522 TCF7 (TCF-1)
TCF7L2 (TCF-4)
LEF1 (TCF1ALPHA)
TCF7L1
NKX3-2.p2 3.481 NKX3-2 (NKX3B, NKX3.2)
GFI1B.p2 3.412 GFI1B
FOXA2.p3 3.342 FOXA2
ZNF423.p2 3.309 ZNF423 (KIAA0760, OAZ, Roaz, Ebfaz, Zfp104)
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2 3.291 ARNT (HIF-1beta, bHLHe2)
MAX (bHLHd4)
MYC (c-Myc, bHLHe39)
USF1 (UEF, MLTFI, bHLHb11)
BHLHB2 (DEC1, bHLHe40)
ARNT2 (KIAA0307, bHLHe1)
NFATC1..3.p2 3.285 NFATC3 (NFAT4, NFATX)
NFATC2 (NF-ATP, NFATp, NFAT1)
NFATC1 (NF-ATC, NFATc, NFAT2)
FEV.p2 3.265 FEV (PET-1, HSRNAFEV)
MAFB.p2 3.251 MAFB
PRDM1.p3 3.159 PRDM1 (PRDI-BF1)
ETS1,2.p2 3.156 ETS2
ETS1 (FLJ10768, ETS-1)
DMAP1_NCOR{1,2}_SMARC.p2 3.155 SMARCA1 (SNF2LB, NURF140, ISWI, SWI)
SMARCC2 (BAF170, Rsc8, CRACC2)
SMARCA5 (hSNF2H, hISWI, ISWI)
NCOR1 (N-CoR, hCIT529I10, TRAC1, hN-CoR, KIAA1047, MGC104216)
NCOR2 (SMRT, SMRTE, TRAC-1, CTG26, TNRC14)
DMAP1 (DNMAP1, FLJ11543, KIAA1425, DNMTAP1, EAF2, SWC4)
HLF.p2 3.099 HLF (MGC33822)
PATZ1.p2 3.098 PATZ1 (MAZR, dJ400N23, ZBTB19, ZSG, RIAZ, PATZ)
FOX{D1,D2}.p2 3.036 FOXD2 (FREAC9)
FOXD1 (FREAC4)
ZNF238.p2 3.020 ZNF238 (C2H2-171, TAZ-1, RP58, ZBTB18)
DBP.p2 3.000 DBP (DABP)
SP1.p2 2.981 SP1
MAZ.p2 2.954 MAZ (ZF87, Pur-1, Zif87, ZNF801)
PAX5.p2 2.918 PAX5 (BSAP)
ELF1,2,4.p2 2.910 ELF2 (EU32, NERF, NERF-2, NERF-1A, NERF-1B)
ELF1
ELF4 (MEF, ELFR)
GFI1.p2 2.909 GFI1
ONECUT1,2.p2 2.890 ONECUT2 (OC-2)
ONECUT1 (HNF-6)
TFEB.p2 2.875 TFEB
ATF6.p2 2.870 ATF6 (ATF6A)
SOX{8,9,10}.p2 2.844 SOX9 (SRA1)
SOX8
SOX10 (DOM, WS4, WS2E)
MYB.p2 2.827 MYB (c-myb)
TFDP1.p2 2.808 TFDP1 (Dp-1, DRTF1, DP1)
TFAP2{A,C}.p2 2.800 TFAP2C (AP2-GAMMA, ERF1, TFAP2G, hAP-2g)
TFAP2A (AP-2)
NR1H4.p2 2.692 NR1H4 (FXR, RIP14, HRR1, HRR-1)
GTF2I.p2 2.658 GTF2I (TFII-I, BAP-135, SPIN, BTKAP1, DIWS, IB291)
MSX1,2.p2 2.652 MSX1 (HYD1, OFC5)
MSX2 (CRS2, FPP, HOX8, MSH, PFM)
GATA1..3.p2 2.648 GATA1 (ERYF1, NFE1)
GATA2 (NFE1B)
GATA3 (HDR)
XBP1.p3 2.642 XBP1
NR5A1,2.p2 2.614 NR5A1 (FTZ1, SF-1, ELP, AD4BP)
NR5A2 (FTZ-F1beta, hB1F, LRH-1, FTZ-F1, hB1F-2, B1F2)
CRX.p2 2.576 CRX (CRD, LCA7, OTX3)
TBP.p2 2.546 TBP (TFIID)
SOX2.p2 2.537 SOX2
NFIX.p2 2.532 NFIX (NF1A)
bHLH_family.p2 2.525 ARNTL (MOP3, JAP3, BMAL1, PASD3, bHLHe5)
MITF (WS2A, MI, bHLHe32)
MXI1 (MXD2, MAD2, MXI, bHLHc11)
TFE3 (TFEA, bHLHe33)
CLOCK (KIAA0334, KAT13D, bHLHe8)
OLIG2 (RACK17, OLIGO2, bHLHe19)
MXD4 (MAD4, MSTP149, MST149, bHLHc12)
HEY2 (bHLHb32)
HEY1 (HESR-1, CHF2, HESR1, HRT-1, CHF-2, HERP2, BHLHb31)
HEYL (bHLHb33)
MLXIPL (WS-bHLH, MIO, CHREBP, MONDOB)
HES6 (bHLHc23)
MXD3 (MAD3, bHLHc13)
ARNTL2 (BMAL2, MOP9, CLIF, PASD9, bHLHe6)
ID1 (dJ857M17.1.2, bHLHb24)
MNT (ROX, MXD6, MAD6, bHLHd3)
OLIG1 (BHLHB6, bHLHe21)
NPAS2 (MOP4, PASD4, bHLHe9)
NFE2L1.p2 2.508 NFE2L1 (NRF1, LCR-F1, FLJ00380, TCF11)
FOX{I1,J2}.p2 2.436 FOXI1 (FREAC6)
FOXJ2 (FHX)
EBF1.p2 2.419 EBF1 (OLF1)
TFCP2.p2 2.404 TFCP2 (CP2, LSF, LBP-1C, TFCP2C)
ESR1.p2 2.365 ESR1 (NR3A1, Era)
CEBPA,B_DDIT3.p2 2.365 DDIT3 (CHOP10, GADD153, CHOP)
CEBPA (C/EBP-alpha)
CEBPB (LAP, CRP2, NFIL6, IL6DBP)
RREB1.p2 2.342 RREB1 (HNT)
NFE2L2.p2 2.339 NFE2L2 (NRF2)
RXR{A,B,G}.p2 2.339 RXRA (NR2B1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
ZNF384.p2 2.305 ZNF384 (CAGH1A, CIZ, NMP4, NP)
ZIC1..3.p2 2.275 ZIC1 (ZIC, ZNF201)
ZIC2 (HPE5)
ZIC3 (HTX, ZNF203)
FOXQ1.p2 2.215 FOXQ1 (HFH1)
ZFP161.p2 2.214 ZFP161 (ZNF478, ZBTB14)
FOXO1,3,4.p2 2.208 FOXO1 (FKH1)
FOXO4 (AFX1)
FOXO3 (AF6q21, FOXO2)
NANOG{mouse}.p2 2.180 NANOG (FLJ12581, FLJ40451)
POU5F1.p2 2.167 POU5F1 (OCT3, Oct4, MGC22487)
MYBL2.p2 2.162 MYBL2 (BMYB, B-MYB)
BPTF.p2 2.160 BPTF (FAC1, NURF301)
TGIF1.p2 2.135 TGIF1
JUN.p2 2.101 JUN (c-Jun, AP-1)
JUND (AP-1)
JUNB
PAX4.p2 2.096 PAX4
ZBTB6.p2 2.055 ZBTB6 (ZID)
PBX1.p2 2.050 PBX1
MEF2{A,B,C,D}.p2 2.005 MEF2A (RSRFC4, RSRFC9)
MEF2C
MEF2D
MEF2BNB-MEF2B (MEF2B, LOC729991-MEF2B)
MEF2B (RSRFR2, FLJ32648)
FOXN1.p2 2.001 FOXN1 (FKHL20)
ATF4.p2 1.991 ATF4 (TAXREB67, CREB-2)
POU3F1..4.p2 1.986 POU3F1 (OCT6, SCIP)
POU3F3 (BRN1, OTF8)
POU3F2 (POUF3, BRN2, OCT7)
POU3F4 (BRN4, OTF9)
TBX4,5.p2 1.977 TBX5
TBX4
MYFfamily.p2 1.938 MYOD1 (PUM, MYOD, bHLHc1)
MYF6 (MRF4, bHLHc4)
MYF5 (bHLHc2)
MYOG (bHLHc3)
FOX{F1,F2,J1}.p2 1.931 FOXF2 (FREAC2)
FOXJ1 (HFH-4, HFH4)
FOXF1 (FREAC1)
EVI1.p2 1.884 EVI1 (MDS1-EVI1, PRDM3)
ATF2.p2 1.847 ATF2 (TREB7, CRE-BP1, HB16)
STAT2,4,6.p2 1.846 STAT2 (STAT113)
STAT4
STAT6 (D12S1644, IL-4-STAT)
HIF1A.p2 1.816 HIF1A (MOP1, HIF-1alpha, PASD8, HIF1)
HIC1.p2 1.785 HIC1 (ZBTB29)
IKZF1.p2 1.772 IKZF1 (hIk-1, LyF-1, Hs.54452, IKAROS)
HES1.p2 1.760 HES1 (FLJ20408, HES-1, Hes1, bHLHb39)
HOX{A5,B5}.p2 1.758 HOXB5
HOXA5
FOXL1.p2 1.748 FOXL1 (FREAC7, FKH6)
FOX{C1,C2}.p2 1.722 FOXC1 (FREAC3, ARA, IGDA, IHG1)
FOXC2 (MFH-1)
YY1.p2 1.719 YY1 (NF-E1, DELTA, UCRBP, YIN-YANG-1, INO80S)
TFAP4.p2 1.694 TFAP4 (AP-4)
HMGA1,2.p2 1.682 HMGA1
HMGA2 (BABL, LIPO)
EWSR1-FLI1.p2 1.670 FLI1 (EWSR2, SIC-1)
EWSR1 (EWS, K984G1.4)
POU6F1.p2 1.669 POU6F1 (BRN5, MPOU, TCFB1)
POU5F1_SOX2{dimer}.p2 1.664 POU5F1 (OCT3, Oct4, MGC22487)
SOX2
HOX{A4,D4}.p2 1.660 HOXA4
HOXD4
RXRA_VDR{dimer}.p2 1.644 VDR (NR1I1)
SRY.p2 1.643 SRY (TDF)
NFE2.p2 1.634 NFE2 (NF-E2)
EGR1..3.p2 1.598 EGR3 (PILOT)
EGR1 (TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225, ZNF225)
EGR2
ZBTB16.p2 1.597 ZBTB16 (PLZF)
PRRX1,2.p2 1.564 PRRX2 (PRX2, PMX2)
PRRX1 (PHOX1)
AHR_ARNT_ARNT2.p2 1.563 ARNT (HIF-1beta, bHLHe2)
AHR
ARNT2 (KIAA0307, bHLHe1)
RBPJ.p2 1.521 RBPJ (SUH, IGKJRB, RBPJK, KBF2, RBP-J, CBF1)
HOXA9_MEIS1.p2 1.511 MEIS1
HOXA9
CREB1.p2 1.505 CREB1
TLX2.p2 1.492 TLX2 (Enx, Tlx2, NCX)
NKX2-2,8.p2 1.491 NKX2-2 (NKX2.2)
NKX2-8 (NKX2.8, Nkx2-9)
FOXP3.p2 1.488 FOXP3 (JM2, XPID, AIID, PIDX, DIETER, SCURFIN)
FOXD3.p2 1.478 FOXD3 (Genesis, HFH2)
ZNF148.p2 1.463 ZNF148 (BERF-1, ZBP-89, BFCOL1, HT-BETA, ZFP148, pHZ-52)
STAT5{A,B}.p2 1.456 STAT5B
STAT5A (MGF)
TP53.p2 1.421 TP53 (p53, LFS1)
IKZF2.p2 1.410 IKZF2 (Helios)
HSF1,2.p2 1.398 HSF1 (HSTF1)
HSF2
SOX5.p2 1.396 SOX5 (L-SOX5, MGC35153)
KLF12.p2 1.381 KLF12 (AP-2rep, HSPC122, AP2REP)
AIRE.p2 1.378 AIRE (PGA1, APS1)
EOMES.p2 1.375 EOMES (TBR2)
TFAP2B.p2 1.373 TFAP2B (AP2-B)
T.p2 1.363 T
SOX17.p2 1.355 SOX17
CDC5L.p2 1.354 CDC5L (PCDC5RP, hCDC5, CEF1)
PAX2.p2 1.341 PAX2
GTF2A1,2.p2 1.336 GTF2A1 (TFIIA)
GTF2A2 (TFIIA, HsT18745)
CTCF.p2 1.333 CTCF
NANOG.p2 1.331 NANOG (FLJ12581, FLJ40451)
RXRG_dimer.p3 1.288 NR1H2 (NER, NER-I, RIP15, LXR-b)
RXRA (NR2B1)
PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
PPARA (hPPAR, NR1C1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
NKX3-1.p2 1.275 NKX3-1 (NKX3.1, BAPX2)
SPZ1.p2 1.272 SPZ1 (NYD-TSP1, FLJ25709)
POU1F1.p2 1.270 POU1F1 (GHF-1)
NKX2-1,4.p2 1.268 NKX2-1 (TTF-1)
NKX2-4 (NKX2.4)
SREBF1,2.p2 1.238 SREBF1 (SREBP1, bHLHd1)
SREBF2 (SREBP2, bHLHd2)
HMX1.p2 1.231 HMX1 (H6, NKX5-3)
NKX2-3_NKX2-5.p2 1.221 NKX2-5 (CSX1, NKX2.5, NKX4-1)
NKX2-3 (NKX2.3, CSX3, NKX4-3)
CUX2.p2 1.206 CUX2 (KIAA0293, CDP2)
GLI1..3.p2 1.204 GLI1
GLI2 (THP2, HPE9, THP1)
GLI3 (PAP-A, PAPA, PAPA1, PAPB, ACLS, PPDIV)
BACH2.p2 1.160 BACH2
TAL1_TCF{3,4,12}.p2 1.135 TCF3 (E2A, ITF1, MGC129647, MGC129648, bHLHb21)
TCF4 (SEF2-1B, ITF2, bHLHb19)
TAL1 (SCL, bHLHa17)
TCF12 (HEB, HTF4, HsT17266, bHLHb20)
FOSL2.p2 1.113 FOSL2 (FRA2, FLJ23306)
PPARG.p2 1.109 PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
ADNP_IRX_SIX_ZHX.p2 1.108 SIX5
ZHX1
IRX4
ADNP (KIAA0784, ADNP1)
ZHX3 (KIAA0395)
ZHX2 (KIAA0854)
IRX5 (IRX-2a)
SIX2
STAT1,3.p3 1.073 STAT1 (STAT91, ISGF-3)
STAT3 (APRF)
LHX3,4.p2 1.034 LHX3
LHX4 (Gsh4)
NKX6-1,2.p2 1.027 NKX6-1 (Nkx6.1)
NKX6-2 (NKX6B, GTX, NKX6.1)
SMAD1..7,9.p2 1.013 SMAD5 (Dwfc, JV5-1)
SMAD1 (MADR1, JV4-1)
SMAD3 (JV15-2, HsT17436)
SMAD4 (DPC4)
SMAD2 (MADR2, JV18-1)
SMAD6 (HsT17432)
SMAD7
SMAD9
NR3C1.p2 1.009 NR3C1 (GR)
REST.p3 1.003 REST (NRSF, XBR)
ALX1.p2 0.972 ALX1
CDX1,2,4.p2 0.936 CDX1
CDX2
CDX4
ARID5B.p2 0.935 ARID5B (FLJ21150, MRF2)
VSX1,2.p2 0.916 VSX2 (RET1)
VSX1 (PPD)
GZF1.p2 0.912 GZF1 (dJ322G13.2, ZBTB23)
PDX1.p2 0.856 PDX1 (IDX-1, STF-1, PDX-1, MODY4)
AR.p2 0.843 AR (AIS, NR3C4, SMAX1, HUMARA)
RORA.p2 0.685 RORA (RZRA, ROR1, ROR2, ROR3, NR1F1)
PAX6.p2 0.570 PAX6 (D11S812E, AN, WAGR)
NFIL3.p2 0.505 NFIL3 (E4BP4, NFIL3A, NF-IL3A)
NR6A1.p2 0.395 NR6A1 (GCNF1, RTR)
PAX8.p2 0.289 PAX8
PAX3,7.p2 0.282 PAX7 (Hup1)
PAX3 (HUP2)

All samples sorted alphabetically


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Sample name Condition Replicate/Batch
GM12878
HepG2
HMEC
HSMM
Huvec
K562
NHEK
NHLF