Motif ID: ATF4.p2

Z-value: 1.991


Transcription factors associated with ATF4.p2:

Gene SymbolEntrez IDGene Name
ATF4 468 activating transcription factor 4 (tax-responsive enhancer element B67)



Activity profile for motif ATF4.p2.

activity profile for motif ATF4.p2


Sorted Z-values histogram for motif ATF4.p2

Sorted Z-values for motif ATF4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_32610161 6.079 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr7_-_44992729 4.511 C7orf40
chromosome 7 open reading frame 40
chr6_+_139497933 3.591 NM_016217
HECA
headcase homolog (Drosophila)
chr12_-_121946635 2.846 NM_024667
VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr9_-_109291575 2.621 KLF4
Kruppel-like factor 4 (gut)
chr9_-_109291866 2.571 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr20_+_19863716 2.430 RIN2
Ras and Rab interactor 2
chr12_-_121946581 2.400 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr8_-_95343696 2.287 GEM
GTP binding protein overexpressed in skeletal muscle
chr8_-_95343716 2.267 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chrX_-_83644054 2.235 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr7_+_28415495 2.115 LOC401317
hypothetical LOC401317
chr2_-_156897286 2.057 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr18_+_55718171 2.018 NM_021127
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr14_+_75521806 2.008 NM_001102564
NM_052873
C14orf179

chromosome 14 open reading frame 179

chr4_+_75529716 1.941 NM_001657
AREG
amphiregulin
chr5_+_60663842 1.924 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr4_+_75699652 1.855 NM_001657
AREG
amphiregulin
chr4_-_48603501 1.828 NM_001014446
NM_152398
OCIAD2

OCIA domain containing 2

chr7_+_20336849 1.767 ITGB8
integrin, beta 8
chr1_-_86634511 1.675 NM_001007022
NM_001184765
NM_001184766
NM_020729
ODF2L



outer dense fiber of sperm tails 2-like



chr11_+_67107852 1.653 GSTP1
glutathione S-transferase pi 1
chr20_-_33329319 1.642 EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chrX_+_12903145 1.618 NM_021109
NM_183049
TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chr8_+_128875902 1.604 PVT1
Pvt1 oncogene (non-protein coding)
chr12_-_121946561 1.603


chr1_+_13899272 1.568 NM_001135610
PRDM2
PR domain containing 2, with ZNF domain
chr10_-_90957028 1.542 NM_003956
CH25H
cholesterol 25-hydroxylase
chr20_-_55718351 1.537 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr10_-_49483002 1.501 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr8_+_38763878 1.469 NM_001122824
NM_006283
TACC1

transforming, acidic coiled-coil containing protein 1

chr12_+_12935619 1.422 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr10_+_106018620 1.354 NM_001191013
NM_183239
GSTO2

glutathione S-transferase omega 2

chr19_-_7459867 1.341 NM_080662
PEX11G
peroxisomal biogenesis factor 11 gamma
chr5_-_1935764 1.327 NM_016358
IRX4
iroquois homeobox 4
chr8_+_38763911 1.326 TACC1
transforming, acidic coiled-coil containing protein 1
chrX_+_102749489 1.306 NM_001006933
NM_032926
TCEAL3

transcription elongation factor A (SII)-like 3

chr4_+_145786622 1.299 NM_022475
HHIP
hedgehog interacting protein
chr10_-_113933457 1.295 NM_020918
GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr12_+_12935759 1.294 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr8_-_11361594 1.289 NM_053279
FAM167A
family with sequence similarity 167, member A
chr16_+_22732982 1.287 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr7_-_129379947 1.276 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)

chr7_+_100302885 1.271 NM_003302
TRIP6
thyroid hormone receptor interactor 6
chr8_+_79591074 1.261 PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chrX_-_106846684 1.260 TSC22D3
TSC22 domain family, member 3
chrX_+_110226030 1.229 NM_002578
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr4_+_123967389 1.223 FGF2
fibroblast growth factor 2 (basic)
chr3_-_109423858 1.202 NM_018010
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr14_+_95740916 1.145 BDKRB2
bradykinin receptor B2
chr15_-_27349300 1.138 NM_138704
NDNL2
necdin-like 2
chrX_+_103103848 1.123 NM_194324
TMSB15B
thymosin beta 15B
chr4_+_123967265 1.118 NM_002006
FGF2
fibroblast growth factor 2 (basic)
chr1_-_93919789 1.108 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr19_-_55706156 1.090 NM_138334
JOSD2
Josephin domain containing 2
chr9_-_89779180 1.087 CDK20
cyclin-dependent kinase 20
chr7_+_39739690 1.087 NCRNA00265
non-protein coding RNA 265
chr8_+_42248008 1.082 NM_001190721
IKBKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr20_+_55718619 1.081


chr6_-_91063181 1.078 NM_021813
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr20_+_55718718 1.074


chr5_-_146869811 1.072 NM_001197294
DPYSL3
dihydropyrimidinase-like 3
chr17_+_30938391 1.057 NM_001030006
NM_001282
AP2B1

adaptor-related protein complex 2, beta 1 subunit

chr8_+_94998258 1.037 NM_018444
NM_001161780
NM_001161779
NM_001161781
PDP1



pyruvate dehyrogenase phosphatase catalytic subunit 1



chr7_+_20337249 1.030 NM_002214
ITGB8
integrin, beta 8
chrX_-_106846924 1.029 NM_004089
TSC22D3
TSC22 domain family, member 3
chr3_-_59010797 1.027 C3orf67
chromosome 3 open reading frame 67
chr4_+_47181987 1.019 NM_020453
ATP10D
ATPase, class V, type 10D
chr8_+_42247978 1.018 IKBKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr16_-_78192111 1.014 NM_001031804
NM_005360
MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr10_-_31360778 1.005 NM_001143766
NM_001143767
NM_001143768
NM_001143770
NM_001143771
NM_182755
ZNF438





zinc finger protein 438





chr14_+_104785898 1.003 NM_033271
BTBD6
BTB (POZ) domain containing 6
chr2_-_166358951 0.999 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr17_+_4743645 0.996 NM_001145536
C17orf107
chromosome 17 open reading frame 107
chr1_+_89871281 0.994 LRRC8C
leucine rich repeat containing 8 family, member C
chr1_+_226712430 0.990 NM_175055
HIST3H2BB
histone cluster 3, H2bb
chr3_-_59010777 0.979 C3orf67
chromosome 3 open reading frame 67
chr13_-_35818491 0.967 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr17_+_30938433 0.967 AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr7_-_105712565 0.966 NAMPT
nicotinamide phosphoribosyltransferase
chr3_+_33293915 0.965 NM_012157
NM_001171713
FBXL2

F-box and leucine-rich repeat protein 2

chr13_-_35818396 0.963 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr5_+_148186348 0.962 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr1_-_226712140 0.961 NM_033445
HIST3H2A
histone cluster 3, H2a
chr8_+_42247954 0.961 NM_001190722
NM_001556
IKBKB

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

chr8_+_42247991 0.959 NM_001190720
IKBKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr19_+_47593137 0.950


chr14_+_104785936 0.948 BTBD6
BTB (POZ) domain containing 6
chr6_+_116798791 0.947 NM_013352
DSE
dermatan sulfate epimerase
chr3_-_59010740 0.945 NM_198463
C3orf67
chromosome 3 open reading frame 67
chr18_+_9698299 0.943 RAB31
RAB31, member RAS oncogene family
chr3_+_62279707 0.937 C3orf14
chromosome 3 open reading frame 14
chr17_-_8000362 0.931 PER1
period homolog 1 (Drosophila)
chr6_-_91063301 0.930 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr4_-_170770111 0.920 NM_012224
NEK1
NIMA (never in mitosis gene a)-related kinase 1
chr14_-_22458134 0.915 RBM23
RNA binding motif protein 23
chr19_-_19793512 0.911 NM_001099269
NM_001145404
ZNF506

zinc finger protein 506

chr14_+_95740768 0.910 NM_000623
BDKRB2
bradykinin receptor B2
chr6_-_121697305 0.903 NM_152730
C6orf170
chromosome 6 open reading frame 170
chr2_+_33025872 0.892 NM_206943
LTBP1
latent transforming growth factor beta binding protein 1
chr16_+_22733307 0.868 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr8_-_116750277 0.853 NM_014112
TRPS1
trichorhinophalangeal syndrome I
chr1_+_208178198 0.852 SYT14
synaptotagmin XIV
chr19_+_50196526 0.839 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr7_+_116447499 0.833 ST7
suppression of tumorigenicity 7
chr17_+_1906262 0.814 NM_001098202
HIC1
hypermethylated in cancer 1
chr5_-_16561936 0.812 NM_019000
FAM134B
family with sequence similarity 134, member B
chr1_+_91739241 0.809 NM_001134420
CDC7
cell division cycle 7 homolog (S. cerevisiae)
chr11_-_76862197 0.804 NM_001128620
NM_002576
PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

chr5_+_174084137 0.803 NM_002449
MSX2
msh homeobox 2
chr10_+_17312654 0.799 VIM
vimentin
chr12_+_12935222 0.786 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr6_+_56927882 0.784 BEND6
BEN domain containing 6
chr6_-_38715901 0.783 NM_001099272
NM_052893
BTBD9

BTB (POZ) domain containing 9

chr17_+_58058479 0.780 NM_006039
MRC2
mannose receptor, C type 2
chr1_+_110328922 0.779 AHCYL1
adenosylhomocysteinase-like 1
chr18_+_22060383 0.777 NM_005640
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr20_+_19903778 0.777 RIN2
Ras and Rab interactor 2
chr5_-_133589670 0.773 PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme
chr5_-_147266257 0.770 NM_206966
C5orf46
chromosome 5 open reading frame 46
chr8_-_145097031 0.769 NM_201380
PLEC
plectin
chr3_+_129927716 0.756 RAB7A
RAB7A, member RAS oncogene family
chr7_+_5598979 0.750 NM_003088
FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr5_-_146869613 0.743 DPYSL3
dihydropyrimidinase-like 3
chr1_+_40193368 0.742 NM_001136493
NM_032793
MFSD2A

major facilitator superfamily domain containing 2A

chr1_+_109090868 0.741 STXBP3
syntaxin binding protein 3
chr4_+_170778265 0.740 NM_001829
NM_173872
CLCN3

chloride channel 3

chr1_+_19843261 0.734 NM_005380
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr7_+_5598964 0.734 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr1_+_154297588 0.726 NM_020387
RAB25
RAB25, member RAS oncogene family
chr22_-_37062114 0.724 CSNK1E
casein kinase 1, epsilon
chr5_+_108112537 0.724 FER
fer (fps/fes related) tyrosine kinase
chr14_-_60817621 0.722


chr12_+_70519753 0.718 NM_001146213
NM_001146214
NM_022771
TBC1D15


TBC1 domain family, member 15


chr19_+_55671600 0.716 C19orf63
chromosome 19 open reading frame 63
chr15_-_27349233 0.711 NDNL2
necdin-like 2
chr6_+_1556543 0.702 FOXC1
forkhead box C1
chr1_+_40193389 0.696 MFSD2A
major facilitator superfamily domain containing 2A
chr1_-_208024491 0.695 NM_152485
C1orf74
chromosome 1 open reading frame 74
chr7_-_105712646 0.686 NM_005746
NAMPT
nicotinamide phosphoribosyltransferase
chr1_+_40193424 0.684 MFSD2A
major facilitator superfamily domain containing 2A
chr1_+_44171578 0.684 NM_001136215
NM_057090
NM_057091
ARTN


artemin


chr7_+_100111712 0.680 GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr14_-_87529222 0.679 GALC
galactosylceramidase
chr19_+_18529652 0.677 C19orf50
chromosome 19 open reading frame 50
chr14_-_22458220 0.675 NM_001077351
NM_001077352
NM_018107
RBM23


RNA binding motif protein 23


chr2_+_192251105 0.672 NM_001031716
OBFC2A
oligonucleotide/oligosaccharide-binding fold containing 2A
chr7_+_151353707 0.667 NM_022087
GALNT11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr1_-_65204414 0.667 NM_002227
JAK1
Janus kinase 1
chr1_+_109090817 0.666 STXBP3
syntaxin binding protein 3
chr19_-_60610792 0.665 UBE2S
ubiquitin-conjugating enzyme E2S
chr7_+_151353759 0.659 GALNT11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr6_+_86216457 0.656 NT5E
5'-nucleotidase, ecto (CD73)
chr1_+_110328850 0.654 AHCYL1
adenosylhomocysteinase-like 1
chrX_-_50573759 0.651 NM_020717
SHROOM4
shroom family member 4
chr8_+_26296439 0.648 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr6_-_38715613 0.647 BTBD9
BTB (POZ) domain containing 9
chr18_+_11841388 0.641 NM_020412
CHMP1B
chromatin modifying protein 1B
chr1_+_152644471 0.640 IL6R
interleukin 6 receptor
chr14_+_100362204 0.640 MEG3
maternally expressed 3 (non-protein coding)
chr3_+_157877146 0.639 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr14_+_100362236 0.638 MEG3
maternally expressed 3 (non-protein coding)
chr19_-_57082907 0.637 NM_001135590
NM_032679
ZNF577

zinc finger protein 577

chr4_+_159812683 0.637 NM_004453
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr3_+_158026769 0.634 NM_001004316
NM_001193283
LEKR1

leucine, glutamate and lysine rich 1

chr1_-_23367934 0.632 NM_001142546
NM_033631
LUZP1

leucine zipper protein 1

chr9_+_101623957 0.631 NM_006981
NM_173199
NR4A3

nuclear receptor subfamily 4, group A, member 3

chr7_-_150847698 0.629 RHEB
Ras homolog enriched in brain
chr3_+_129927668 0.628 NM_004637
RAB7A
RAB7A, member RAS oncogene family
chr14_-_54563554 0.627 NM_001008396
NM_007086
WDHD1

WD repeat and HMG-box DNA binding protein 1

chr7_-_150847884 0.624 NM_005614
RHEB
Ras homolog enriched in brain
chr1_-_65204791 0.622 JAK1
Janus kinase 1
chr19_+_55671584 0.622 C19orf63
chromosome 19 open reading frame 63
chr17_+_30938470 0.622 AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr12_-_91063441 0.621 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr4_+_170778303 0.621 CLCN3
chloride channel 3
chr19_-_60610971 0.621 UBE2S
ubiquitin-conjugating enzyme E2S
chr14_-_87529212 0.618 GALC
galactosylceramidase
chr6_+_86216020 0.615 NM_002526
NT5E
5'-nucleotidase, ecto (CD73)
chr9_+_70978970 0.615 TJP2
tight junction protein 2 (zona occludens 2)
chr19_+_55671594 0.614 C19orf63
chromosome 19 open reading frame 63
chr3_+_185538998 0.613 FAM131A
family with sequence similarity 131, member A
chr7_+_151353775 0.612 GALNT11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr13_-_27967215 0.611 NM_001159920
NM_001160030
NM_001160031
NM_002019
FLT1



fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)



chr11_+_101723125 0.607 BIRC2
baculoviral IAP repeat containing 2
chr15_-_50259367 0.605 NM_006578
GNB5
guanine nucleotide binding protein (G protein), beta 5
chr1_-_143643324 0.604 NM_001002811
PDE4DIP
phosphodiesterase 4D interacting protein
chr8_-_98359347 0.603 NM_033512
TSPYL5
TSPY-like 5
chr6_-_38715567 0.599 BTBD9
BTB (POZ) domain containing 9
chr8_-_98359248 0.598 TSPYL5
TSPY-like 5
chr1_+_110328955 0.597 AHCYL1
adenosylhomocysteinase-like 1
chr19_+_55671468 0.597 NM_175063
NM_206538
C19orf63

chromosome 19 open reading frame 63

chr1_+_110328941 0.596 AHCYL1
adenosylhomocysteinase-like 1
chr14_-_54563520 0.594 WDHD1
WD repeat and HMG-box DNA binding protein 1
chr17_+_2443652 0.592 NM_000430
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr19_-_55671273 0.590 FAM71E1
family with sequence similarity 71, member E1
chr1_-_23367918 0.585 LUZP1
leucine zipper protein 1
chr11_+_101291134 0.583 KIAA1377
KIAA1377
chr13_-_73605914 0.582 NM_007249
KLF12
Kruppel-like factor 12
chr11_+_101723157 0.582 NM_001166
BIRC2
baculoviral IAP repeat containing 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.41 4.39e-12 GO:0043170 macromolecule metabolic process
1.45 6.59e-12 GO:0044260 cellular macromolecule metabolic process
1.28 1.22e-07 GO:0044237 cellular metabolic process
1.28 1.26e-07 GO:0044238 primary metabolic process
1.99 4.30e-07 GO:0033554 cellular response to stress
1.48 1.91e-06 GO:0071842 cellular component organization at cellular level
1.41 2.42e-06 GO:0016043 cellular component organization
1.46 5.93e-06 GO:0071841 cellular component organization or biogenesis at cellular level
1.39 5.98e-06 GO:0071840 cellular component organization or biogenesis
1.48 8.71e-06 GO:0044267 cellular protein metabolic process
1.22 1.08e-05 GO:0008152 metabolic process
1.42 1.59e-05 GO:0019538 protein metabolic process
2.17 1.61e-05 GO:0006974 response to DNA damage stimulus
1.90 1.68e-05 GO:0022402 cell cycle process
1.97 2.83e-05 GO:0022403 cell cycle phase
1.58 4.42e-05 GO:0006996 organelle organization
2.39 8.48e-05 GO:0006281 DNA repair
1.47 1.28e-04 GO:0090304 nucleic acid metabolic process
1.73 1.30e-04 GO:0043067 regulation of programmed cell death
1.72 1.47e-04 GO:0010941 regulation of cell death
1.73 1.64e-04 GO:0042981 regulation of apoptosis
1.40 2.02e-04 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.72 2.31e-04 GO:0007049 cell cycle
1.50 4.09e-04 GO:0006464 protein modification process
1.96 4.41e-04 GO:0006259 DNA metabolic process
1.12 5.13e-04 GO:0009987 cellular process
1.95 6.05e-04 GO:0000278 mitotic cell cycle
1.41 9.84e-04 GO:0048522 positive regulation of cellular process
1.45 2.25e-03 GO:0043412 macromolecule modification
1.34 1.09e-02 GO:0048518 positive regulation of biological process
1.30 1.24e-02 GO:0006807 nitrogen compound metabolic process
1.97 1.34e-02 GO:0000279 M phase
1.31 1.39e-02 GO:0034641 cellular nitrogen compound metabolic process
2.15 2.20e-02 GO:0051329 interphase of mitotic cell cycle
2.06 2.25e-02 GO:0051301 cell division
1.44 2.72e-02 GO:0034645 cellular macromolecule biosynthetic process
1.92 2.78e-02 GO:0060548 negative regulation of cell death
1.43 3.11e-02 GO:0009059 macromolecule biosynthetic process
5.69 3.19e-02 GO:0010332 response to gamma radiation
2.11 3.28e-02 GO:0051325 interphase
1.63 3.30e-02 GO:0016265 death
3.52 3.82e-02 GO:0006302 double-strand break repair
1.61 4.92e-02 GO:0008219 cell death

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.18 7.98e-16 GO:0005622 intracellular
1.19 2.42e-15 GO:0044424 intracellular part
1.20 1.09e-10 GO:0043229 intracellular organelle
1.22 1.14e-10 GO:0043231 intracellular membrane-bounded organelle
1.22 1.48e-10 GO:0043227 membrane-bounded organelle
1.20 1.72e-10 GO:0043226 organelle
1.33 6.55e-10 GO:0005634 nucleus
1.22 5.50e-09 GO:0005737 cytoplasm
2.04 1.42e-04 GO:0044427 chromosomal part
1.23 1.64e-04 GO:0044446 intracellular organelle part
1.23 2.17e-04 GO:0044422 organelle part
1.41 6.27e-04 GO:0044428 nuclear part
1.87 8.45e-04 GO:0005694 chromosome
1.42 2.43e-03 GO:0031981 nuclear lumen
1.18 6.75e-03 GO:0044444 cytoplasmic part
1.90 4.02e-02 GO:0005815 microtubule organizing center

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.24 3.09e-08 GO:0005515 protein binding
1.11 3.77e-05 GO:0005488 binding
1.25 4.61e-02 GO:0003676 nucleic acid binding