Motif ID: GTF2A1,2.p2

Z-value: 1.336


Transcription factors associated with GTF2A1,2.p2:

Gene SymbolEntrez IDGene Name
GTF2A1 2957 general transcription factor IIA, 1, 19/37kDa
GTF2A2 2958 general transcription factor IIA, 2, 12kDa



Activity profile for motif GTF2A1,2.p2.

activity profile for motif GTF2A1,2.p2


Sorted Z-values histogram for motif GTF2A1,2.p2

Sorted Z-values for motif GTF2A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_135233047 1.710 NM_153710
C9orf96
chromosome 9 open reading frame 96
chr2_+_27154938 1.551 NM_007046
EMILIN1
elastin microfibril interfacer 1
chr20_-_34635091 1.516


chr16_+_48857962 1.427 ADCY7
adenylate cyclase 7
chr2_+_27155197 1.395 EMILIN1
elastin microfibril interfacer 1
chr1_+_6537924 1.341 NM_138697
NM_177540
TAS1R1

taste receptor, type 1, member 1

chr17_+_4795128 1.323 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr9_+_135232937 1.292 C9orf96
chromosome 9 open reading frame 96
chr17_+_53769659 1.247 LOC100506779
hypothetical LOC100506779
chr1_+_95355415 1.173 NM_152487
TMEM56
transmembrane protein 56
chr17_-_60988077 1.156 NM_004655
AXIN2
axin 2
chr20_+_34635362 1.137 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr5_-_134397470 1.133 PITX1
paired-like homeodomain 1
chr9_-_135232790 1.122 NM_033161
SURF4
surfeit 4
chr17_+_42641712 1.115 NM_002476
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr5_-_114965959 1.094 NM_021649
TICAM2
toll-like receptor adaptor molecule 2
chr16_+_631902 1.078 FAM195A
family with sequence similarity 195, member A
chr2_-_65013070 1.065 LOC400958
hypothetical LOC400958
chr1_+_984935 1.055 LOC100288175
hypothetical LOC100288175
chr17_-_45633986 1.054 NM_000088
COL1A1
collagen, type I, alpha 1
chr2_-_144994038 0.989 ZEB2
zinc finger E-box binding homeobox 2
chr17_-_45633873 0.980 COL1A1
collagen, type I, alpha 1
chr16_+_631828 0.968 NM_138418
FAM195A
family with sequence similarity 195, member A
chr8_-_145119627 0.963 NM_201378
PLEC
plectin
chr16_+_56259657 0.950 NM_170776
GPR97
G protein-coupled receptor 97
chr20_-_35013459 0.949 SAMHD1
SAM domain and HD domain 1
chr17_-_71404611 0.948 NM_173547
TRIM65
tripartite motif containing 65
chr11_-_102001259 0.937 NM_004771
MMP20
matrix metallopeptidase 20
chr1_-_56817823 0.931 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr19_+_54160369 0.923 NM_000146
FTL
ferritin, light polypeptide
chr20_-_43889339 0.912 NM_003279
TNNC2
troponin C type 2 (fast)
chr19_+_5082230 0.910 KDM4B
lysine (K)-specific demethylase 4B
chr19_+_40895669 0.898 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr19_+_54160399 0.890 FTL
ferritin, light polypeptide
chr19_+_54160468 0.878 FTL
ferritin, light polypeptide
chr17_+_53769562 0.869 LOC100506779
hypothetical LOC100506779
chr6_-_46401174 0.856 RCAN2
regulator of calcineurin 2
chr3_+_123279439 0.852 NM_006889
CD86
CD86 molecule
chr1_+_35507197 0.842 ZMYM4
zinc finger, MYM-type 4
chr7_-_6490375 0.840 KDELR2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr17_-_77602493 0.833 RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr2_-_144994349 0.814 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr22_+_22445035 0.814 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr6_-_46401363 0.805 NM_005822
RCAN2
regulator of calcineurin 2
chr12_+_54910086 0.800 NM_173596
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr2_-_238813284 0.791 HES6
hairy and enhancer of split 6 (Drosophila)
chr11_-_85074848 0.782 NM_152723
CCDC89
coiled-coil domain containing 89
chr17_-_60988226 0.777 AXIN2
axin 2
chr1_-_56817717 0.771 PPAP2B
phosphatidic acid phosphatase type 2B
chr17_-_35774467 0.771 NM_152219
GJD3
gap junction protein, delta 3, 31.9kDa
chr11_+_63864263 0.769 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr9_-_135232767 0.767 SURF4
surfeit 4
chr2_-_238813365 0.766 NM_001142853
NM_018645
HES6

hairy and enhancer of split 6 (Drosophila)

chr17_-_44006808 0.763 NM_002146
HOXB3
homeobox B3
chr20_-_42457717 0.743


chr7_-_6490214 0.739 NM_001100603
NM_006854
KDELR2

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2

chr19_-_56549853 0.735 NM_001014763
ETFB
electron-transfer-flavoprotein, beta polypeptide
chrX_+_49718954 0.729 NM_000084
CLCN5
chloride channel 5
chr14_+_55654900 0.720 PELI2
pellino homolog 2 (Drosophila)
chr6_-_49712483 0.710 NM_000324
RHAG
Rh-associated glycoprotein
chr12_-_7136189 0.704 C1R
complement component 1, r subcomponent
chr1_-_154205675 0.702 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr22_-_37598176 0.698 NM_014292
CBX6
chromobox homolog 6
chr1_+_984972 0.696 LOC100288175
hypothetical LOC100288175
chr17_+_17147351 0.682 NM_020201
NT5M
5',3'-nucleotidase, mitochondrial
chr6_+_43247179 0.679 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr2_-_218516950 0.677 NM_022648
TNS1
tensin 1
chr2_+_171280182 0.677


chr7_+_68701704 0.672 NM_001127231
NM_001127232
NM_015570
AUTS2


autism susceptibility candidate 2


chr12_-_52179462 0.670 NM_001193511
NM_006301
MAP3K12

mitogen-activated protein kinase kinase kinase 12

chr10_+_70517863 0.670 SRGN
serglycin
chr15_-_73792234 0.664 NM_001897
CSPG4
chondroitin sulfate proteoglycan 4
chr2_+_113709553 0.663 LOC654433
hypothetical LOC654433
chr22_+_21116283 0.659


chr15_-_80125403 0.656 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr17_-_1335763 0.653 NM_001080950
MYO1C
myosin IC
chr3_+_99733432 0.653 NM_005290
GPR15
G protein-coupled receptor 15
chr1_-_56817568 0.651 PPAP2B
phosphatidic acid phosphatase type 2B
chr15_-_73792150 0.645 CSPG4
chondroitin sulfate proteoglycan 4
chr2_+_205118801 0.644 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr9_-_135232746 0.639 SURF4
surfeit 4
chr2_+_201833467 0.627 NM_033356
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr3_+_44601457 0.624 NM_173658
ZNF660
zinc finger protein 660
chr9_-_135232734 0.624 SURF4
surfeit 4
chr19_-_51081147 0.622 NM_015649
IRF2BP1
interferon regulatory factor 2 binding protein 1
chr17_-_77602938 0.621 NM_002917
RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr21_-_36836767 0.617 NM_001146078
CLDN14
claudin 14
chr12_-_7136147 0.614 NM_001733
C1R
complement component 1, r subcomponent
chr5_-_149772563 0.612 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr14_-_22358752 0.609 NM_001126106
SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr22_-_25205376 0.609 NM_152841
HPS4
Hermansky-Pudlak syndrome 4
chr8_-_145672525 0.607 NM_003923
FOXH1
forkhead box H1
chr5_-_134397740 0.604 NM_002653
PITX1
paired-like homeodomain 1
chr1_-_56817802 0.603 PPAP2B
phosphatidic acid phosphatase type 2B
chr9_-_139084833 0.601 NM_178448
C9orf140
chromosome 9 open reading frame 140
chr17_+_77603064 0.598 GPS1
G protein pathway suppressor 1
chr6_-_42821815 0.594 NM_003192
TBCC
tubulin folding cofactor C
chr17_+_37864441 0.588 ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr19_-_1827133 0.588


chr14_+_99859427 0.584 NM_207117
SLC25A47
solute carrier family 25, member 47
chr14_+_55654607 0.582 NM_021255
PELI2
pellino homolog 2 (Drosophila)
chr18_-_3001944 0.574 NM_014646
LPIN2
lipin 2
chr2_-_198248828 0.571 NM_144629
RFTN2
raftlin family member 2
chr16_+_56616970 0.569 MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr12_+_50342814 0.568 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr6_+_26212082 0.567 NM_003542
HIST1H4C
histone cluster 1, H4c
chr3_+_50279993 0.563 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr11_-_1549719 0.563 NM_004420
DUSP8
dual specificity phosphatase 8
chr6_-_33016561 0.563 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr17_+_37864423 0.563 ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr6_-_42821790 0.562 TBCC
tubulin folding cofactor C
chr1_-_205161821 0.562 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr1_-_26105954 0.556 NM_203399
STMN1
stathmin 1
chr21_+_44597911 0.553 NM_003307
TRPM2
transient receptor potential cation channel, subfamily M, member 2
chr16_+_56616782 0.553 NM_002428
MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr17_+_37864425 0.552 ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr15_-_41449399 0.549 NM_152455
ZSCAN29
zinc finger and SCAN domain containing 29
chr6_-_42821800 0.548 TBCC
tubulin folding cofactor C
chr22_-_37598115 0.545 CBX6
chromobox homolog 6
chr11_+_5610060 0.544 NM_130390
TRIM34
tripartite motif containing 34
chr11_-_63750138 0.544 NM_001033678
NM_001160389
NM_001160390
NM_001160392
NM_031472
TRPT1




tRNA phosphotransferase 1




chr6_-_42821761 0.543 TBCC
tubulin folding cofactor C
chr10_+_70517823 0.542 NM_002727
SRGN
serglycin
chr2_+_176737050 0.542 NM_006898
HOXD3
homeobox D3
chr5_-_149772528 0.540


chr9_+_130620540 0.540 NM_004435
ENDOG
endonuclease G
chr6_-_85529031 0.539 TBX18
T-box 18
chr10_-_49152918 0.538 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr13_+_31503436 0.537 NM_023037
FRY
furry homolog (Drosophila)
chr19_+_37874529 0.527 NM_001105570
NUDT19
nudix (nucleoside diphosphate linked moiety X)-type motif 19
chr16_-_4406632 0.526 NM_024535
CORO7
coronin 7
chr6_-_36272951 0.524


chr17_-_23721468 0.524 VTN
vitronectin
chr5_+_32621361 0.521 NM_006713
SUB1
SUB1 homolog (S. cerevisiae)
chr4_+_1330957 0.520 NM_020894
KIAA1530
KIAA1530
chr6_-_31977747 0.519 NM_181842
ZBTB12
zinc finger and BTB domain containing 12
chr22_-_37598160 0.519 CBX6
chromobox homolog 6
chr17_-_36456949 0.519 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr1_+_35507145 0.510 NM_005095
ZMYM4
zinc finger, MYM-type 4
chr19_+_6723705 0.510 NM_005428
VAV1
vav 1 guanine nucleotide exchange factor
chr6_+_43247168 0.509 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr12_+_56290229 0.509 NM_001111270
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr17_-_23721420 0.506 VTN
vitronectin
chr21_+_34112456 0.505 ITSN1
intersectin 1 (SH3 domain protein)
chr7_+_1094248 0.504 NM_001098201
GPER
G protein-coupled estrogen receptor 1
chr17_-_35975227 0.500 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr6_+_43246897 0.499 NM_003131
SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr5_-_175896829 0.495 NM_014901
RNF44
ring finger protein 44
chr16_-_4406608 0.492 CORO7
coronin 7
chr16_+_30569558 0.490 PRR14
proline rich 14
chr3_-_13032130 0.489


chr22_-_22389502 0.488 LOC91316
glucuronidase, beta/immunoglobulin lambda-like polypeptide 1 pseudogene
chr17_+_38259620 0.488 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr17_-_37599953 0.486 NM_001142622
NM_001142623
NM_032484
GHDC


GH3 domain containing


chr17_+_37864401 0.485 ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr16_-_727889 0.483 NARFL
nuclear prelamin A recognition factor-like
chr6_-_32259974 0.483 NM_001136
NM_172197
AGER

advanced glycosylation end product-specific receptor

chr1_+_201541241 0.483 BTG2
BTG family, member 2
chr14_+_23633101 0.483 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chr9_-_135232735 0.482 SURF4
surfeit 4
chr7_+_73826244 0.481 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr19_+_1018536 0.481 HMHA1
histocompatibility (minor) HA-1
chr8_+_40130143 0.480 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr9_+_132579088 0.479 NM_007313
ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
chr2_+_205118710 0.478 NM_057177
NM_152526
NM_205863
PARD3B


par-3 partitioning defective 3 homolog B (C. elegans)


chr17_-_44022595 0.478 HOXB3
homeobox B3
chr12_+_54700955 0.477 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr16_-_2970474 0.477 NM_004203
NM_182687
PKMYT1

protein kinase, membrane associated tyrosine/threonine 1

chr17_+_1612092 0.476 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr10_+_92970302 0.476 NM_032373
PCGF5
polycomb group ring finger 5
chr11_+_46255737 0.472 NM_052854
CREB3L1
cAMP responsive element binding protein 3-like 1
chr19_-_1430198 0.472 NM_152482
C19orf25
chromosome 19 open reading frame 25
chr17_-_39340638 0.470 NM_005374
MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr12_-_107551744 0.469 SELPLG
selectin P ligand
chr22_-_20419975 0.468 NM_013313
YPEL1
yippee-like 1 (Drosophila)
chr18_+_606671 0.467 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr16_-_2970390 0.466 PKMYT1
protein kinase, membrane associated tyrosine/threonine 1
chr12_-_101396459 0.465 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr19_+_60845229 0.464 NM_016202
NM_001163423
ZNF580

zinc finger protein 580

chr9_-_135232754 0.461 SURF4
surfeit 4
chr1_-_20179495 0.460 NM_000300
NM_001161727
NM_001161728
PLA2G2A


phospholipase A2, group IIA (platelets, synovial fluid)


chr19_-_1430116 0.459 C19orf25
chromosome 19 open reading frame 25
chr17_+_37864383 0.457 NM_001130020
NM_001130021
NM_005177
ATP6V0A1


ATPase, H+ transporting, lysosomal V0 subunit a1


chr20_-_44468641 0.457 ELMO2
engulfment and cell motility 2
chrX_-_70248022 0.453 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr17_+_1611983 0.453 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_37864466 0.453 ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr5_-_95184121 0.451 GLRX
glutaredoxin (thioltransferase)
chr19_+_40465249 0.450 NM_021175
HAMP
hepcidin antimicrobial peptide
chr16_-_73012740 0.449 NM_001011880
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr12_-_110291279 0.449 NM_001177996
NM_001177997
NM_144671
FAM109A


family with sequence similarity 109, member A


chr16_+_30843396 0.448 NM_001099784
FBXL19
F-box and leucine-rich repeat protein 19
chr5_-_149772469 0.447 NM_001025159
NM_004355
NM_001025158
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr4_+_24406283 0.446 SOD3
superoxide dismutase 3, extracellular
chr22_+_21852699 0.445 BCR
breakpoint cluster region
chr11_+_63750296 0.444 NM_001128612
NM_001128613
NM_032344
NUDT22


nudix (nucleoside diphosphate linked moiety X)-type motif 22


chr1_+_200246370 0.443 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr11_-_118799452 0.443 NM_006288
THY1
Thy-1 cell surface antigen
chr20_-_44468660 0.443 NM_133171
NM_182764
ELMO2

engulfment and cell motility 2

chr9_-_133602745 0.437 NM_005312
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.29 1.74e-03 GO:0006950 response to stress
1.52 8.45e-03 GO:0006955 immune response
1.49 9.03e-03 GO:0006952 defense response
1.39 9.96e-03 GO:0002376 immune system process
1.45 1.91e-02 GO:0009611 response to wounding
1.13 2.02e-02 GO:0050896 response to stimulus
1.11 3.04e-02 GO:0065007 biological regulation
1.81 3.47e-02 GO:0030029 actin filament-based process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.29 7.40e-04 GO:0005576 extracellular region

Nothing significant found in function category.