Motif ID: SOX17.p2

Z-value: 1.355


Transcription factors associated with SOX17.p2:

Gene SymbolEntrez IDGene Name
SOX17 64321 SRY (sex determining region Y)-box 17



Activity profile for motif SOX17.p2.

activity profile for motif SOX17.p2


Sorted Z-values histogram for motif SOX17.p2

Sorted Z-values for motif SOX17.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX17.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_26105477 1.551 NM_001145454
NM_005563
STMN1

stathmin 1

chr2_-_37752272 1.503 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr6_-_72187168 1.429 C6orf155
chromosome 6 open reading frame 155
chr14_-_22458220 1.421 NM_001077351
NM_001077352
NM_018107
RBM23


RNA binding motif protein 23


chr18_-_21186107 1.417 NM_015461
ZNF521
zinc finger protein 521
chr14_-_22458199 1.382 RBM23
RNA binding motif protein 23
chr14_-_22458134 1.345 RBM23
RNA binding motif protein 23
chr19_-_45888259 1.235 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr17_-_7996409 1.233 NM_002616
PER1
period homolog 1 (Drosophila)
chr8_-_9046460 1.226 PPP1R3B
protein phosphatase 1, regulatory (inhibitor) subunit 3B
chrX_-_83644054 1.177 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr12_-_6103945 1.148 NM_000552
VWF
von Willebrand factor
chr8_-_120033240 1.144 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr19_+_47593137 1.109


chr2_-_144991386 1.058 ZEB2
zinc finger E-box binding homeobox 2
chr13_-_98428244 1.001 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr11_+_113672378 0.997 NNMT
nicotinamide N-methyltransferase
chr14_-_37795001 0.997 CLEC14A
C-type lectin domain family 14, member A
chr8_-_93184629 0.976 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr8_+_55533047 0.951 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr13_+_110653407 0.948 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr20_+_42644633 0.926 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr11_+_113672407 0.924 NNMT
nicotinamide N-methyltransferase
chr13_-_107317460 0.918 NM_001080396
FAM155A
family with sequence similarity 155, member A
chr14_-_37795290 0.914 NM_175060
CLEC14A
C-type lectin domain family 14, member A
chr8_-_60194099 0.901 NM_014729
TOX
thymocyte selection-associated high mobility group box
chrX_+_15428820 0.899 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr14_-_87529600 0.899 NM_000153
NM_001037525
GALC

galactosylceramidase

chr9_+_81377419 0.897 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr13_-_32658215 0.890 NM_178007
STARD13
StAR-related lipid transfer (START) domain containing 13
chr2_-_37752731 0.886 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr11_-_4585947 0.883 NM_018073
TRIM68
tripartite motif containing 68
chr2_-_175578156 0.876 NM_001025201
NM_001822
CHN1

chimerin (chimaerin) 1

chr7_-_27171648 0.854 HOXA9
homeobox A9
chr7_-_99612757 0.845 NM_152742
GPC2
glypican 2
chr5_+_76047536 0.841 NM_001992
F2R
coagulation factor II (thrombin) receptor
chr7_-_13995811 0.841 ETV1
ets variant 1
chr11_+_128068982 0.833 NM_002017
FLI1
Friend leukemia virus integration 1
chr7_-_27171673 0.811 NM_152739
HOXA9
homeobox A9
chr14_-_87529212 0.811 GALC
galactosylceramidase
chr12_+_84198015 0.809 NM_006982
ALX1
ALX homeobox 1
chr19_+_13767207 0.805 NM_023072
ZSWIM4
zinc finger, SWIM-type containing 4
chr2_-_128138435 0.800 NM_017980
LIMS2
LIM and senescent cell antigen-like domains 2
chr10_+_70748581 0.789 NM_000188
HK1
hexokinase 1
chr10_+_17311242 0.788 VIM
vimentin
chr18_-_21185968 0.780 ZNF521
zinc finger protein 521
chr3_+_48482625 0.779 TREX1
three prime repair exonuclease 1
chr1_-_197173159 0.776 LOC100131234
familial acute myelogenous leukemia related factor
chr10_+_17311282 0.773 VIM
vimentin
chr7_+_148613304 0.772 LOC155060
AI894139 pseudogene
chr14_-_87529222 0.771 GALC
galactosylceramidase
chr17_-_59817456 0.765 PECAM1
platelet/endothelial cell adhesion molecule
chr1_-_26105230 0.763 NM_203401
STMN1
stathmin 1
chr1_+_149299530 0.756 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr10_+_17312654 0.751 VIM
vimentin
chr1_+_149299504 0.749 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr14_+_23711044 0.746 NM_001048205
NM_005132
REC8

REC8 homolog (yeast)

chr11_+_13646727 0.743 NM_032228
FAR1
fatty acyl CoA reductase 1
chr22_-_22511173 0.734 NM_001002862
NM_001135751
NM_198440
DERL3


Der1-like domain family, member 3


chr17_-_59817575 0.724 PECAM1
platelet/endothelial cell adhesion molecule
chr10_+_3099708 0.721 NM_002627
PFKP
phosphofructokinase, platelet
chr1_+_84539876 0.721 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr13_+_94052022 0.718 NM_180989
GPR180
G protein-coupled receptor 180
chr11_+_13646806 0.717 FAR1
fatty acyl CoA reductase 1
chr10_+_22765996 0.717 LOC100289455
hypothetical LOC100289455
chr3_+_44665220 0.703 NM_003420
ZNF35
zinc finger protein 35
chr17_-_59817654 0.702 PECAM1
platelet/endothelial cell adhesion molecule
chr10_+_31650069 0.699 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr5_-_88214720 0.695 MEF2C
myocyte enhancer factor 2C
chr10_+_17311283 0.691 VIM
vimentin
chr1_+_149299490 0.691 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr9_+_81377289 0.689 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr14_+_102659464 0.685 TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr5_+_177564102 0.685 NM_004499
NM_031266
HNRNPAB

heterogeneous nuclear ribonucleoprotein A/B

chr7_-_27171600 0.682 HOXA9
homeobox A9
chr11_+_128069165 0.682 FLI1
Friend leukemia virus integration 1
chr2_-_188021117 0.678 NM_005795
CALCRL
calcitonin receptor-like
chr10_+_17311307 0.677 VIM
vimentin
chr17_-_59817722 0.672 NM_000442
PECAM1
platelet/endothelial cell adhesion molecule
chr14_+_85066265 0.669 FLRT2
fibronectin leucine rich transmembrane protein 2
chr14_+_62740878 0.664 NM_020663
RHOJ
ras homolog gene family, member J
chr3_+_100840129 0.663 NM_001850
NM_020351
COL8A1

collagen, type VIII, alpha 1

chr7_-_130891861 0.662 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr5_+_177564139 0.659 HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr8_+_60194328 0.656


chr4_+_151218862 0.654 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr11_-_6633427 0.651 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr14_+_85066207 0.642 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr7_+_27102197 0.638


chr5_+_95093267 0.628


chr8_+_26491507 0.618 DPYSL2
dihydropyrimidinase-like 2
chrX_-_50403412 0.617 SHROOM4
shroom family member 4
chr17_-_59131210 0.608 NM_030576
LIMD2
LIM domain containing 2
chr5_+_14493905 0.607 TRIO
triple functional domain (PTPRF interacting)
chr7_-_27102049 0.601 NM_005522
NM_153620
HOXA1

homeobox A1

chr6_-_56824371 0.601 DST
dystonin
chr14_+_23710924 0.600 REC8
REC8 homolog (yeast)
chr6_+_116939500 0.598 NM_153711
FAM26E
family with sequence similarity 26, member E
chr5_-_111782637 0.597 NM_022140
EPB41L4A
erythrocyte membrane protein band 4.1 like 4A
chr9_-_35101592 0.596 KIAA1539
KIAA1539
chr19_+_54723044 0.595 RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr19_+_17281216 0.586 NM_024050
DDA1
DET1 and DDB1 associated 1
chr6_-_85529884 0.586 TBX18
T-box 18
chr3_+_158637273 0.586 NM_002852
PTX3
pentraxin 3, long
chr5_+_40715799 0.585 PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr11_+_128069183 0.584 FLI1
Friend leukemia virus integration 1
chr5_-_146813343 0.584 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr12_-_24946495 0.582 NM_001178094
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr8_-_70907957 0.579 NM_001146009
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr19_+_17281352 0.579 DDA1
DET1 and DDB1 associated 1
chr14_-_99842519 0.579 NM_001039355
SLC25A29
solute carrier family 25, member 29
chr3_+_48482213 0.576 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr4_-_2233606 0.576 MXD4
MAX dimerization protein 4
chr6_+_27222839 0.573 NM_080596
HIST1H2AH
histone cluster 1, H2ah
chr5_+_40715778 0.570 NM_000958
PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr19_+_17281374 0.565 DDA1
DET1 and DDB1 associated 1
chr12_+_74160779 0.562 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr3_-_161650294 0.560 NM_173084
TRIM59
tripartite motif containing 59
chr8_-_70908130 0.558 NM_001146008
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr6_-_139654807 0.558 NM_153235
TXLNB
taxilin beta
chr14_+_102870301 0.557 EIF5
eukaryotic translation initiation factor 5
chr3_+_25444753 0.555 NM_016152
RARB
retinoic acid receptor, beta
chr1_+_45565126 0.554 NM_032756
HPDL
4-hydroxyphenylpyruvate dioxygenase-like
chr7_+_150321771 0.554 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr19_-_51856129 0.550 NM_145056
DACT3
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
chr9_-_35101534 0.548 KIAA1539
KIAA1539
chr11_+_128069203 0.545 FLI1
Friend leukemia virus integration 1
chr3_-_161650219 0.539 TRIM59
tripartite motif containing 59
chr8_-_101187346 0.537 RGS22
regulator of G-protein signaling 22
chr19_-_6230797 0.535


chr1_-_68470585 0.534 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr7_+_27102508 0.532


chr7_-_5535726 0.532 ACTB
actin, beta
chr2_-_144991556 0.528 ZEB2
zinc finger E-box binding homeobox 2
chr14_+_102870431 0.527 EIF5
eukaryotic translation initiation factor 5
chr9_+_89302574 0.526 NM_004938
DAPK1
death-associated protein kinase 1
chr2_-_56266408 0.525 LOC100129434
hypothetical LOC100129434
chr21_-_14840506 0.525 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr12_+_14409875 0.524 NM_018179
ATF7IP
activating transcription factor 7 interacting protein
chr17_-_1478293 0.522 SLC43A2
solute carrier family 43, member 2
chr13_-_29937966 0.521 HMGB1
HMGB1P6
high-mobility group box 1
high-mobility group box 1 pseudogene 6
chr5_-_124108672 0.520 NM_020747
ZNF608
zinc finger protein 608
chr19_+_50086362 0.518 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr7_-_5535432 0.517 ACTB
actin, beta
chr5_+_95092384 0.516 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr11_+_13646839 0.514 FAR1
fatty acyl CoA reductase 1
chr4_-_2233504 0.513 NM_006454
MXD4
MAX dimerization protein 4
chr6_-_56824672 0.512 DST
dystonin
chr12_-_21701985 0.511 NM_001174097
LDHB
lactate dehydrogenase B
chr15_-_46257611 0.509 MYEF2
myelin expression factor 2
chr5_-_136862317 0.509 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr11_+_13646822 0.506 FAR1
fatty acyl CoA reductase 1
chrX_+_12903145 0.505 NM_021109
NM_183049
TMSB4X
TMSL3
thymosin beta 4, X-linked
thymosin-like 3
chr1_+_149299307 0.496 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr7_-_8268666 0.495 NM_004968
ICA1
islet cell autoantigen 1, 69kDa
chr12_-_21702000 0.493 LDHB
lactate dehydrogenase B
chr4_-_81212737 0.491 ANTXR2
anthrax toxin receptor 2
chr1_-_43692134 0.490 NM_001190880
NM_031207
HYI

hydroxypyruvate isomerase (putative)

chr7_+_26158257 0.490 NM_004289
NFE2L3
nuclear factor (erythroid-derived 2)-like 3
chr13_-_100125028 0.488 TMTC4
transmembrane and tetratricopeptide repeat containing 4
chr12_-_21702021 0.486 LDHB
lactate dehydrogenase B
chr17_-_44010543 0.485 NM_024015
HOXB4
homeobox B4
chr10_+_17311347 0.484 VIM
vimentin
chr12_-_21702036 0.484 LDHB
lactate dehydrogenase B
chr14_+_102870245 0.481 NM_001969
EIF5
eukaryotic translation initiation factor 5
chr13_-_29938029 0.480 NM_002128
HMGB1
high-mobility group box 1
chr3_-_170347019 0.478 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr5_+_66160359 0.474 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr20_-_55718982 0.473 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr8_+_1759502 0.473 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr9_+_123501186 0.471 DAB2IP
DAB2 interacting protein
chr22_-_37481925 0.468 SUN2
Sad1 and UNC84 domain containing 2
chr17_-_59818033 0.466 PECAM1
platelet/endothelial cell adhesion molecule
chr12_-_21702046 0.466 NM_002300
LDHB
lactate dehydrogenase B
chr5_+_177564140 0.466 HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
chr10_+_70748633 0.464 HK1
hexokinase 1
chr11_-_64247230 0.462 NM_015080
NM_138732
NRXN2

neurexin 2

chr11_-_27679022 0.461 NM_001143812
BDNF
brain-derived neurotrophic factor
chr14_+_102870287 0.457 EIF5
eukaryotic translation initiation factor 5
chr15_-_43457916 0.455 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr9_+_4480193 0.454 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr10_+_17311962 0.454 VIM
vimentin
chr7_+_134114957 0.450 CALD1
caldesmon 1
chr12_-_46499834 0.447 NM_001098416
NM_015401
HDAC7

histone deacetylase 7

chr1_-_26105954 0.447 NM_203399
STMN1
stathmin 1
chr19_+_50086357 0.444 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr19_+_50086299 0.443 NM_001128916
NM_001128917
NM_006114
TOMM40


translocase of outer mitochondrial membrane 40 homolog (yeast)


chr6_-_27222556 0.440 NM_080593
HIST1H2BK
histone cluster 1, H2bk
chr6_-_53321658 0.440 ELOVL5
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
chr5_-_141318810 0.434 NM_016580
PCDH12
protocadherin 12
chr10_-_14686243 0.434 FAM107B
family with sequence similarity 107, member B
chr1_+_43539239 0.433 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr5_-_136862130 0.432 SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr2_+_12775814 0.431


chr1_+_145479805 0.431 NM_004326
BCL9
B-cell CLL/lymphoma 9
chr15_-_42274760 0.427 FRMD5
FERM domain containing 5
chr7_+_134114912 0.426 CALD1
caldesmon 1
chr5_-_137099602 0.426 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr7_+_115637795 0.426 NM_015641
TES
testis derived transcript (3 LIM domains)
chr3_+_174598937 0.423 NM_014932
NLGN1
neuroligin 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.15 1.10e-04 GO:0050794 regulation of cellular process
1.13 8.02e-04 GO:0050789 regulation of biological process
1.54 1.07e-02 GO:0010628 positive regulation of gene expression
1.50 1.67e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
1.11 2.09e-02 GO:0065007 biological regulation
1.38 2.72e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.41 3.43e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.52 3.80e-02 GO:0045893 positive regulation of transcription, DNA-dependent
1.24 4.00e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 2.08e-04 GO:0005634 nucleus
1.30 1.08e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.49 8.54e-05 GO:0001071 nucleic acid binding transcription factor activity
1.49 8.54e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.72 9.82e-03 GO:0003779 actin binding
1.23 1.81e-02 GO:0003677 DNA binding
1.10 3.10e-02 GO:0005515 protein binding
1.45 3.71e-02 GO:0043565 sequence-specific DNA binding