Motif ID: AIRE.p2

Z-value: 1.378


Transcription factors associated with AIRE.p2:

Gene SymbolEntrez IDGene Name
AIRE 326 autoimmune regulator



Activity profile for motif AIRE.p2.

activity profile for motif AIRE.p2


Sorted Z-values histogram for motif AIRE.p2

Sorted Z-values for motif AIRE.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_75734759 2.188 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr13_-_40454188 1.759 ELF1
E74-like factor 1 (ets domain transcription factor)
chr19_+_55627971 1.494 NM_004533
MYBPC2
myosin binding protein C, fast type
chr11_-_73371531 1.479 NM_003355
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr17_-_59437782 1.451 NM_000873
ICAM2
intercellular adhesion molecule 2
chr4_-_139382672 1.243 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr13_-_40454360 1.224 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr4_+_69716298 1.221 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr16_+_20328355 1.195 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr17_+_38259620 1.111 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr8_-_41774296 1.039 NM_000037
NM_020475
NM_020476
NM_020477
ANK1



ankyrin 1, erythrocytic



chr7_+_116238309 1.023 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chrX_-_2892288 0.978 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr19_+_18069596 0.928 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr4_-_123761615 0.928 NM_021803
IL21
interleukin 21
chr8_-_30704984 0.872 NM_000637
NM_001195102
NM_001195103
NM_001195104
GSR



glutathione reductase



chr19_-_44518516 0.821 NM_004877
GMFG
glia maturation factor, gamma
chr6_+_31791063 0.793 NM_021246
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr11_-_62195587 0.785 C11orf48
chromosome 11 open reading frame 48
chr19_-_6621078 0.761 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr7_-_149960612 0.751 NM_024711
GIMAP6
GTPase, IMAP family member 6
chr6_+_10629550 0.742 NM_145649
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr16_-_3567354 0.726 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr11_+_64694200 0.709 NM_001008778
SPDYC
speedy homolog C (Xenopus laevis)
chr6_-_99957253 0.706 SFRS18
splicing factor, arginine/serine-rich 18
chr3_-_17757402 0.702 NM_014744
TBC1D5
TBC1 domain family, member 5
chr13_-_40491491 0.681 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_-_180624494 0.671 GLUL
glutamate-ammonia ligase
chrX_-_100193747 0.670 NM_001167970
NM_001167971
NM_001167972
NM_024917
TRMT2B



TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)



chr17_+_59875623 0.665 NM_001085423
C17orf60
chromosome 17 open reading frame 60
chr17_-_31231421 0.651 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr1_-_89437098 0.650 NM_052941
GBP4
guanylate binding protein 4
chrX_-_100193698 0.634 TRMT2B
TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)
chr1_-_143708467 0.624 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr22_+_34979118 0.622 APOL1
apolipoprotein L, 1
chr9_-_85761353 0.619 C9orf64
chromosome 9 open reading frame 64
chr2_-_176656935 0.605 NM_001080458
EVX2
even-skipped homeobox 2
chr22_+_34979062 0.594 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr22_-_34886727 0.586 NM_145640
APOL3
apolipoprotein L, 3
chr1_+_20353284 0.583


chr10_-_101831579 0.580 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chrX_+_153310313 0.576 ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
chr1_-_7895873 0.571 UTS2
urotensin 2
chr18_+_27425727 0.563 NM_000371
TTR
transthyretin
chr4_-_176970895 0.563 GPM6A
glycoprotein M6A
chr7_-_64104441 0.550 NM_001007253
ERV3
ZNF117
endogenous retroviral sequence 3
zinc finger protein 117
chr19_-_53444733 0.546 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr13_-_40491405 0.538 ELF1
E74-like factor 1 (ets domain transcription factor)
chr19_-_10474767 0.531 NM_203500
KEAP1
kelch-like ECH-associated protein 1
chr1_-_159543847 0.528 MPZ
myelin protein zero
chr2_-_190336168 0.516 NM_022353
OSGEPL1
O-sialoglycoprotein endopeptidase-like 1
chr1_+_153222464 0.514 FLAD1
FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
chr12_+_49605010 0.514 METTL7A
methyltransferase like 7A
chr19_-_12695628 0.512 NM_001136195
TNPO2
transportin 2
chr6_+_6533932 0.506 NM_004271
LY86
lymphocyte antigen 86
chr8_-_102034777 0.494 NM_003406
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr4_+_53986759 0.493 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr2_+_215885053 0.491 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr10_+_7785360 0.489 ITIH2
inter-alpha (globulin) inhibitor H2
chr16_-_28528780 0.484 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr6_-_37575599 0.472 C6orf129
chromosome 6 open reading frame 129
chr7_+_77307382 0.466 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr1_-_17638729 0.464 RCC2
regulator of chromosome condensation 2
chr12_+_108035424 0.449


chrX_+_47999740 0.443 NM_005635
SSX1
synovial sarcoma, X breakpoint 1
chr2_+_215884923 0.434 NM_004044
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr12_+_70119785 0.433 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr2_-_231498184 0.431 NM_005683
GPR55
G protein-coupled receptor 55
chr10_+_7785347 0.430 ITIH2
inter-alpha (globulin) inhibitor H2
chr16_-_73258218 0.428 RFWD3
ring finger and WD repeat domain 3
chr9_+_116413443 0.427 NM_153045
C9orf91
chromosome 9 open reading frame 91
chr10_-_32707549 0.424 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr4_-_38710376 0.420 NM_024943
TMEM156
transmembrane protein 156
chr21_-_42608774 0.404 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr1_+_51208499 0.403 CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr15_+_64372876 0.399 NM_001143688
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr16_+_88154582 0.397 NM_000977
NM_033251
RPL13

ribosomal protein L13

chr10_+_7785331 0.396 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785290 0.392 ITIH2
inter-alpha (globulin) inhibitor H2
chr16_+_88154562 0.385 RPL13
ribosomal protein L13
chr5_-_149772563 0.385 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr17_+_63766874 0.385 NM_014960
ARSG
arylsulfatase G
chr7_-_99518294 0.384 ZNF3
zinc finger protein 3
chr15_+_53398697 0.380 PIGB
phosphatidylinositol glycan anchor biosynthesis, class B
chr11_-_73371452 0.376 UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr2_+_215885063 0.375 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr19_+_56958452 0.370 NM_001462
FPR2
formyl peptide receptor 2
chr11_-_32772731 0.369 NM_001008391
CCDC73
coiled-coil domain containing 73
chr19_+_2818332 0.363 NM_024967
ZNF556
zinc finger protein 556
chr3_-_195601283 0.362 NM_004488
GP5
glycoprotein V (platelet)
chr12_+_45896318 0.359 NM_138371
FAM113B
family with sequence similarity 113, member B
chr6_-_31938572 0.350 NM_000434
NEU1
sialidase 1 (lysosomal sialidase)
chr16_-_56886380 0.350 NM_001080492
PRSS54
protease, serine, 54
chr4_+_159662349 0.347 NM_021634
RXFP1
relaxin/insulin-like family peptide receptor 1
chr4_-_68793928 0.342 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr8_-_42742729 0.340 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr19_-_8314120 0.338 NM_198471
KANK3
KN motif and ankyrin repeat domains 3
chr4_+_39084867 0.336 NM_175737
KLB
klotho beta
chr1_+_153222393 0.334 NM_001184891
NM_001184892
NM_025207
NM_201398
FLAD1



FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)



chr6_+_31910623 0.333 NM_001040437
NM_001040438
C6orf48

chromosome 6 open reading frame 48

chr16_-_11282595 0.332 NM_002761
PRM1
protamine 1
chr20_+_35755865 0.324 CTNNBL1
catenin, beta like 1
chr15_+_39363442 0.319 LOC729082
hypothetical LOC729082
chr17_-_64649608 0.318 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr1_-_21249974 0.316 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr1_+_40715465 0.316 ZNF642
zinc finger protein 642
chr20_-_33658823 0.312 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr4_+_39874921 0.310 NM_004310
RHOH
ras homolog gene family, member H
chr12_-_47031287 0.307 NM_001172682
ZNF641
zinc finger protein 641
chrX_+_153310171 0.306 NM_001183
ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
chr4_-_75066533 0.306 NM_002619
PF4
platelet factor 4
chr12_+_100512877 0.305 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr9_-_85761451 0.304 C9orf64
chromosome 9 open reading frame 64
chr19_-_44014228 0.302 NM_001398
ECH1
enoyl CoA hydratase 1, peroxisomal
chr6_-_33085329 0.301 NM_002119
HLA-DOA
major histocompatibility complex, class II, DO alpha
chr2_-_32344192 0.300 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr1_-_9052207 0.293 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr5_+_60969392 0.291 NM_173667
FLJ37543
hypothetical protein FLJ37543
chr3_+_63859114 0.289 NM_001177387
ATXN7
ataxin 7
chr1_+_157067729 0.288 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr19_-_53450953 0.288 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chr6_+_43005214 0.288 CNPY3
canopy 3 homolog (zebrafish)
chr20_-_31452964 0.286 CDK5RAP1
CDK5 regulatory subunit associated protein 1
chr1_+_158975662 0.285 NM_021181
SLAMF7
SLAM family member 7
chrX_+_153310219 0.285 ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
chr19_-_10475083 0.283 KEAP1
kelch-like ECH-associated protein 1
chr1_-_114855281 0.283 NM_015906
NM_033020
TRIM33

tripartite motif containing 33

chr2_-_85490997 0.283 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr4_+_187424336 0.282 F11
coagulation factor XI
chr12_+_53534565 0.282 NM_058173
MUCL1
mucin-like 1
chr1_-_32157845 0.279 NM_001195100
NM_001195101
PTP4A2

protein tyrosine phosphatase type IVA, member 2

chr2_+_201806410 0.278 NM_001080124
NM_001228
NM_033355
NM_033358
CASP8



caspase 8, apoptosis-related cysteine peptidase



chr9_-_129740583 0.277 NM_003863
DPM2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
chr6_+_163904564 0.277 QKI
quaking homolog, KH domain RNA binding (mouse)
chr3_+_173954940 0.276 NM_018098
ECT2
epithelial cell transforming sequence 2 oncogene
chr19_-_6542012 0.269 CD70
CD70 molecule
chr20_+_29598848 0.268 HM13
histocompatibility (minor) 13
chr16_+_10430225 0.267 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chr1_+_179269183 0.267 NM_001194999
NM_001195000
NM_001195035
NM_001531
MR1



major histocompatibility complex, class I-related



chr16_-_4464896 0.266 NM_020677
NMRAL1
NmrA-like family domain containing 1
chr22_+_21359175 0.266 IGLV3-25
immunoglobulin lambda variable 3-25
chr13_-_35327798 0.266 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr19_-_14646626 0.264 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr16_-_1434490 0.261 NM_001143980
CCDC154
coiled-coil domain containing 154
chr3_-_152403636 0.260 NM_013308
GPR171
G protein-coupled receptor 171
chr16_+_65144019 0.260 CKLF
chemokine-like factor
chr12_+_49604782 0.257 NM_014033
METTL7A
methyltransferase like 7A
chr17_-_23151522 0.256 NOS2
nitric oxide synthase 2, inducible
chr12_-_30740072 0.255 NM_006390
IPO8
importin 8
chr6_-_37575666 0.255 NM_138493
C6orf129
chromosome 6 open reading frame 129
chr10_-_7699192 0.255 ITIH5
inter-alpha (globulin) inhibitor H5
chr19_+_21056792 0.255 NM_182515
ZNF714
zinc finger protein 714
chr2_-_188021117 0.254 NM_005795
CALCRL
calcitonin receptor-like
chr20_+_35755832 0.252 NM_030877
CTNNBL1
catenin, beta like 1
chr6_+_43005126 0.249 CNPY3
canopy 3 homolog (zebrafish)
chr8_+_30072463 0.249 NM_001128208
NM_015344
LEPROTL1

leptin receptor overlapping transcript-like 1

chr6_-_149847809 0.247 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr20_+_35755857 0.244 CTNNBL1
catenin, beta like 1
chr1_-_167947301 0.240 NM_000655
SELL
selectin L
chr1_+_559129 0.240


chr15_-_38953628 0.240 NM_133639
RHOV
ras homolog gene family, member V
chr11_-_47467094 0.239 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr7_-_97439590 0.234


chr22_+_34126294 0.231 MCM5
minichromosome maintenance complex component 5
chr12_+_132124125 0.230 ZNF84
zinc finger protein 84
chr1_+_239762179 0.228 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr4_+_55907213 0.224 SRD5A3
steroid 5 alpha-reductase 3
chr20_-_10360569 0.222 NM_018848
MKKS
McKusick-Kaufman syndrome
chr13_+_48968097 0.222 PHF11
PHD finger protein 11
chr6_-_159386007 0.222 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr5_+_43645018 0.221 NNT
nicotinamide nucleotide transhydrogenase
chr5_+_118993152 0.218 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chr16_+_20682812 0.216 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr12_+_132124211 0.216 ZNF84
zinc finger protein 84
chr20_-_31452991 0.215 NM_016082
NM_016408
CDK5RAP1

CDK5 regulatory subunit associated protein 1

chr19_-_6375801 0.214 KHSRP
KH-type splicing regulatory protein
chr11_+_125000245 0.213 NM_001114121
NM_001114122
CHEK1

CHK1 checkpoint homolog (S. pombe)

chr2_+_65069081 0.212 NM_001193493
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chrX_-_19443299 0.212 NM_001001671
MAP3K15
mitogen-activated protein kinase kinase kinase 15
chr6_+_36318922 0.211 NM_173676
NM_001145716
PNPLA1

patatin-like phospholipase domain containing 1

chr19_+_59866237 0.210 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr4_+_170817787 0.210 CLCN3
chloride channel 3
chr6_-_31668476 0.209 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chrX_-_70045285 0.207 NM_001003811
NM_031276
TEX11

testis expressed 11

chr18_+_2896178 0.206 EMILIN2
elastin microfibril interfacer 2
chr2_+_113911737 0.206 NM_172003
CBWD2
CBWD1
COBW domain containing 2
COBW domain containing 1
chr12_+_28301399 0.204 NM_018318
CCDC91
coiled-coil domain containing 91
chr1_-_201162938 0.204 KLHL12
kelch-like 12 (Drosophila)
chr6_+_26473376 0.203 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr12_-_55405209 0.202 NM_001113201
NM_005594
NACA

nascent polypeptide-associated complex alpha subunit

chr2_+_73864823 0.202 NM_001080474
C2orf78
chromosome 2 open reading frame 78
chr19_+_13999959 0.200 NM_080864
RLN3
relaxin 3
chr19_+_17499064 0.199 FAM129C
family with sequence similarity 129, member C
chr14_-_105796268 0.199 ZCWPW2
IGHV3-23
IGKV3-20
zinc finger, CW type with PWWP domain 2
immunoglobulin heavy variable 3-23
immunoglobulin kappa variable 3-20
chr11_-_6418705 0.198 NM_000613
HPX
hemopexin
chr6_+_153060722 0.198 NM_025107
MYCT1
myc target 1
chr17_-_47591949 0.196 CA10
carbonic anhydrase X
chr19_-_6375820 0.195 NM_003685
KHSRP
KH-type splicing regulatory protein
chr11_-_59237893 0.194 NM_001005324
OR10V1
olfactory receptor, family 10, subfamily V, member 1
chr12_-_65359148 0.194 NM_001178074
NM_021150
GRIP1

glutamate receptor interacting protein 1


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.03 1.75e-02 GO:0002682 regulation of immune system process
1.72 2.98e-02 GO:0002376 immune system process

Nothing significant found in compartment category.

Nothing significant found in function category.