Motif ID: PBX1.p2

Z-value: 2.050


Transcription factors associated with PBX1.p2:

Gene SymbolEntrez IDGene Name
PBX1 5087 pre-B-cell leukemia homeobox 1



Activity profile for motif PBX1.p2.

activity profile for motif PBX1.p2


Sorted Z-values histogram for motif PBX1.p2

Sorted Z-values for motif PBX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PBX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_27108826 3.777 NM_006735
HOXA2
homeobox A2
chr13_-_32757835 3.274 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr2_-_189752575 3.045 NM_000393
COL5A2
collagen, type V, alpha 2
chr5_+_3649167 3.041 NM_024337
IRX1
iroquois homeobox 1
chr18_+_42780784 2.983 NM_031303
KATNAL2
katanin p60 subunit A-like 2
chr1_+_24518501 2.921 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr1_+_24518398 2.609 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr3_-_113495763 2.487 NM_183061
SLC9A10
solute carrier family 9, member 10
chr12_+_77782719 2.455 SYT1
synaptotagmin I
chr6_-_166960690 2.360 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr11_+_113671744 2.351 NM_006169
NNMT
nicotinamide N-methyltransferase
chr6_-_166960649 2.257 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr14_+_51025604 2.088 NM_001042481
FRMD6
FERM domain containing 6
chr5_-_58607673 2.086 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_-_28016182 2.063 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr21_+_29439768 1.891 C21orf7
chromosome 21 open reading frame 7
chr3_+_157877146 1.853 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr6_-_166960496 1.834 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr4_-_177950658 1.798 NM_005429
VEGFC
vascular endothelial growth factor C
chr1_+_162795328 1.774 NM_002585
PBX1
pre-B-cell leukemia homeobox 1
chr3_+_195336625 1.762 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr19_+_13767207 1.739 NM_023072
ZSWIM4
zinc finger, SWIM-type containing 4
chr13_-_109236897 1.714 NM_003749
IRS2
insulin receptor substrate 2
chr18_+_45342398 1.699 NM_006033
LIPG
lipase, endothelial
chr3_+_195336631 1.646 HES1
hairy and enhancer of split 1, (Drosophila)
chr22_-_28972683 1.627 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr6_-_26125939 1.542 NM_005325
HIST1H1A
histone cluster 1, H1a
chrX_-_10548458 1.539 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr3_-_21767819 1.537 NM_024697
ZNF385D
zinc finger protein 385D
chr5_-_171814026 1.529 NM_001017995
SH3PXD2B
SH3 and PX domains 2B
chr14_-_75196911 1.491 C14orf1
chromosome 14 open reading frame 1
chr9_-_83494198 1.440 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr13_+_94052022 1.426 NM_180989
GPR180
G protein-coupled receptor 180
chr21_-_35174742 1.420 RUNX1
runt-related transcription factor 1
chr2_+_12774264 1.342 NM_021643
TRIB2
tribbles homolog 2 (Drosophila)
chr6_-_26379567 1.339 NM_003534
HIST1H3G
histone cluster 1, H3g
chr14_+_75197303 1.251 NM_015072
TTLL5
tubulin tyrosine ligase-like family, member 5
chr16_+_81218074 1.234 NM_001257
CDH13
cadherin 13, H-cadherin (heart)
chr4_+_87734489 1.143 NM_006264
NM_080683
NM_080684
NM_080685
PTPN13



protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)



chr5_-_171813960 1.126 SH3PXD2B
SH3 and PX domains 2B
chr20_-_45848043 1.111 NM_018837
SULF2
sulfatase 2
chr14_+_75197345 1.103 TTLL5
tubulin tyrosine ligase-like family, member 5
chr14_+_75197409 1.094 TTLL5
tubulin tyrosine ligase-like family, member 5
chr14_+_54104383 1.094 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr1_-_147665783 1.065 HIST2H2BF
histone cluster 2, H2bf
chr15_+_39032927 1.058 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr8_-_49996353 1.041 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr4_+_86968069 1.040 ARHGAP24
Rho GTPase activating protein 24
chr3_+_173951163 1.034 ECT2
epithelial cell transforming sequence 2 oncogene
chr4_-_186537145 1.025 NM_018409
LRP2BP
LRP2 binding protein
chr16_+_81218142 1.010 CDH13
cadherin 13, H-cadherin (heart)
chr2_+_218843358 0.960 NM_001077399
NM_015488
PNKD

paroxysmal nonkinesigenic dyskinesia

chrX_-_15263596 0.950 NM_002641
NM_020473
PIGA

phosphatidylinositol glycan anchor biosynthesis, class A

chrX_+_46581418 0.931 RP2
retinitis pigmentosa 2 (X-linked recessive)
chr1_-_219982081 0.930 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr11_+_13646727 0.925 NM_032228
FAR1
fatty acyl CoA reductase 1
chr10_+_99390459 0.924 PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
chr3_+_185762233 0.918 NM_004443
EPHB3
EPH receptor B3
chrX_-_15263586 0.910 PIGA
phosphatidylinositol glycan anchor biosynthesis, class A
chr1_-_219982049 0.903 DUSP10
dual specificity phosphatase 10
chrX_-_15263555 0.887 PIGA
phosphatidylinositol glycan anchor biosynthesis, class A
chr17_+_8132539 0.849 NM_001177801
NM_001177802
NM_016492
RANGRF


RAN guanine nucleotide release factor


chr3_+_138132006 0.847 NM_001190796
NCK1
NCK adaptor protein 1
chr6_-_32892705 0.845 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr3_-_71196696 0.844 FOXP1
forkhead box P1
chrX_+_46581368 0.831 RP2
retinitis pigmentosa 2 (X-linked recessive)
chr11_+_13646839 0.830 FAR1
fatty acyl CoA reductase 1
chr11_+_13646822 0.822 FAR1
fatty acyl CoA reductase 1
chr1_-_219982016 0.822 DUSP10
dual specificity phosphatase 10
chr12_+_21059896 0.820 NM_001009562
LST-3TM12
organic anion transporter LST-3b
chr12_+_77782648 0.801 SYT1
synaptotagmin I
chr22_-_37520049 0.797 DNAL4
dynein, axonemal, light chain 4
chr6_-_46728188 0.792 NM_016593
CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr4_-_140696740 0.792 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr7_-_7646573 0.788 RPA3
replication protein A3, 14kDa
chr12_-_54409710 0.788 CD63
CD63 molecule
chr13_+_96726197 0.780 MBNL2
muscleblind-like 2 (Drosophila)
chr3_+_161040439 0.766 SCHIP1
schwannomin interacting protein 1
chr20_+_43874735 0.763 UBE2C
ubiquitin-conjugating enzyme E2C
chr5_-_94442941 0.763 MCTP1
multiple C2 domains, transmembrane 1
chrX_+_46581290 0.762 NM_006915
RP2
retinitis pigmentosa 2 (X-linked recessive)
chr7_+_7646840 0.761 LOC729852
hypothetical LOC729852
chr14_+_73621408 0.758 NM_001024674
LIN52
lin-52 homolog (C. elegans)
chr16_-_3433490 0.755 NM_152457
ZNF597
zinc finger protein 597
chr9_-_14303509 0.745 NFIB
nuclear factor I/B
chr10_+_13182061 0.729 NM_001008211
NM_001008212
NM_001008213
NM_021980
OPTN



optineurin



chr14_+_99220349 0.726 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr4_+_81325447 0.722 NM_020226
PRDM8
PR domain containing 8
chr3_+_161040343 0.718 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr14_-_91642703 0.712 NM_001127696
NM_001127697
NM_001164774
NM_001164776
NM_001164777
NM_001164778
NM_001164779
NM_001164780
NM_001164781
NM_001164782
NM_004993
NM_030660
ATXN3











ataxin 3











chr2_+_28469850 0.707 FOSL2
FOS-like antigen 2
chr7_-_121571472 0.689 NM_005763
AASS
aminoadipate-semialdehyde synthase
chr13_+_78953258 0.681 NM_001161407
NM_019080
NDFIP2

Nedd4 family interacting protein 2

chr11_-_56951628 0.678 NM_017611
SLC43A3
solute carrier family 43, member 3
chr19_-_63092099 0.647 NM_001144989
ZNF814
zinc finger protein 814
chr11_+_122258600 0.646 NM_024806
NM_199124
C11orf63

chromosome 11 open reading frame 63

chr21_-_31012965 0.641 NM_001164435
KRTAP21-3
keratin associated protein 21-3
chr10_+_17310263 0.639 NM_003380
VIM
vimentin
chr7_+_106596641 0.637 NM_012257
HBP1
HMG-box transcription factor 1
chr20_+_56369012 0.636


chr1_-_149586341 0.634 NM_000449
NM_001025603
RFX5

regulatory factor X, 5 (influences HLA class II expression)

chr12_-_14982708 0.633 NM_152321
ERP27
endoplasmic reticulum protein 27
chr16_+_3433606 0.633 NM_001083601
NAT15
N-acetyltransferase 15 (GCN5-related, putative)
chr6_+_26153590 0.621 NM_003531
HIST1H3C
histone cluster 1, H3c
chr2_+_191454157 0.617 GLS
glutaminase
chr1_-_205272619 0.614 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr11_+_13646806 0.606 FAR1
fatty acyl CoA reductase 1
chr4_-_118226119 0.604 NM_152402
TRAM1L1
translocation associated membrane protein 1-like 1
chr3_-_191322919 0.602 NM_001134418
LEPREL1
leprecan-like 1
chr17_+_70495318 0.596 NM_014603
CDR2L
cerebellar degeneration-related protein 2-like
chr2_-_162808123 0.594 NM_004460
FAP
fibroblast activation protein, alpha
chr6_+_26381122 0.589 NM_003525
HIST1H2BI
histone cluster 1, H2bi
chr6_+_26333361 0.587 NM_003532
HIST1H3E
histone cluster 1, H3e
chr17_+_72380323 0.577 NM_198955
MGAT5B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr5_-_171643247 0.563 UBTD2
ubiquitin domain containing 2
chr14_-_90596665 0.555 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr14_-_91642641 0.553 ATXN3
ATXN8
ataxin 3
ataxin 8
chr8_-_108579270 0.550 NM_001146
ANGPT1
angiopoietin 1
chr22_-_37520092 0.549 NM_005740
DNAL4
dynein, axonemal, light chain 4
chr19_-_63301386 0.547 ZSCAN18
zinc finger and SCAN domain containing 18
chr22_-_41741073 0.533 PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chrX_-_107568211 0.531 NM_033641
COL4A6
collagen, type IV, alpha 6
chr22_-_41741100 0.521 NM_001184970
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr22_+_28164571 0.515 NM_021026
RFPL1
ret finger protein-like 1
chr4_-_48477038 0.514 NM_015030
FRYL
FRY-like
chr1_+_85300580 0.509 NM_145172
WDR63
WD repeat domain 63
chr8_+_107807415 0.508 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chr20_+_43874654 0.505 NM_007019
NM_181799
NM_181800
NM_181802
NM_181803
UBE2C




ubiquitin-conjugating enzyme E2C




chr1_-_149586298 0.503 RFX5
regulatory factor X, 5 (influences HLA class II expression)
chr4_-_48477021 0.499 FRYL
FRY-like
chr3_+_130641840 0.498 IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr7_+_29569913 0.489 NM_175887
PRR15
proline rich 15
chr12_+_52689062 0.487 NM_022658
HOXC8
homeobox C8
chr12_+_27568311 0.486 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr19_-_44573468 0.485 NM_019088
PAF1
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
chr9_+_112470871 0.483 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr1_-_159257486 0.479 F11R
F11 receptor
chr19_+_16157198 0.472 NM_014077
FAM32A
family with sequence similarity 32, member A
chr14_-_73620912 0.470 NM_005589
ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr9_+_129604962 0.463 NM_004957
FPGS
folylpolyglutamate synthase
chr2_+_191454036 0.460 GLS
glutaminase
chr8_-_25371708 0.454 KCTD9
potassium channel tetramerisation domain containing 9
chr14_-_22722680 0.452 NM_012244
SLC7A8
solute carrier family 7 (amino acid transporter, L-type), member 8
chr12_-_51173238 0.451 NM_005554
KRT6A
keratin 6A
chr4_+_77575276 0.451 NM_020859
SHROOM3
shroom family member 3
chr12_+_28234657 0.449


chr3_-_150578023 0.449 TM4SF1
transmembrane 4 L six family member 1
chr19_+_55221023 0.448 NM_001006656
NM_015428
ZNF473

zinc finger protein 473

chr17_+_17816851 0.442 NM_001130090
NM_001130091
NM_001130092
NM_031294
LRRC48



leucine rich repeat containing 48



chr8_-_25371663 0.439 KCTD9
potassium channel tetramerisation domain containing 9
chr20_+_11846536 0.438 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr12_-_51132129 0.437 NM_005555
KRT6B
keratin 6B
chr10_+_99390431 0.436 NM_018425
PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
chr6_-_27222556 0.435 NM_080593
HIST1H2BK
histone cluster 1, H2bk
chr2_-_108972100 0.435 NM_022336
EDAR
ectodysplasin A receptor
chr3_+_130641639 0.433 NM_018262
NM_052985
NM_052989
NM_052990
IFT122



intraflagellar transport 122 homolog (Chlamydomonas)



chr5_-_145503190 0.432 LARS
leucyl-tRNA synthetase
chr10_+_63092724 0.432 NM_173554
C10orf107
chromosome 10 open reading frame 107
chr19_+_14501413 0.432 TECR
trans-2,3-enoyl-CoA reductase
chr14_+_23008723 0.430 NM_001042635
NM_015514
NGDN

neuroguidin, EIF4E binding protein

chr10_-_105835525 0.426 COL17A1
collagen, type XVII, alpha 1
chr15_-_84139021 0.425 KLHL25
kelch-like 25 (Drosophila)
chr11_+_6904167 0.422 NM_013250
ZNF215
zinc finger protein 215
chr5_+_86712376 0.421


chr2_+_28469864 0.420 FOSL2
FOS-like antigen 2
chr5_-_112658200 0.414 MCC
mutated in colorectal cancers
chr12_+_64982542 0.411 NM_033647
HELB
helicase (DNA) B
chr8_+_69027277 0.410 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr13_+_78953367 0.410 NDFIP2
Nedd4 family interacting protein 2
chr17_+_71174993 0.410 NM_013260
SAP30BP
SAP30 binding protein
chr19_-_55220495 0.407 NM_001025778
NM_016440
VRK3

vaccinia related kinase 3

chr6_+_46728590 0.405 NM_004277
SLC25A27
solute carrier family 25, member 27
chr4_+_8935987 0.403 NM_001105662
USP17L2
USP17L6P
USP17
ubiquitin specific peptidase 17-like 2
ubiquitin specific peptidase 17-like 6 (pseudogene)
ubiquitin specific peptidase 17
chr19_+_54067450 0.401 NM_014330
PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr19_+_54067491 0.400 PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr19_+_54067489 0.399 PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr20_-_56859352 0.398 GNAS-AS1
GNAS antisense RNA 1 (non-protein coding)
chr8_-_23768242 0.397 NM_003155
STC1
stanniocalcin 1
chr3_-_32519362 0.396 NM_017801
CMTM6
CKLF-like MARVEL transmembrane domain containing 6
chr1_+_216585298 0.390 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr10_+_63331401 0.390 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr19_-_55220439 0.388 VRK3
vaccinia related kinase 3
chrX_-_23671317 0.388 NM_001033583
NM_001037171
ACOT9

acyl-CoA thioesterase 9

chr18_+_37789187 0.387 NM_002647
PIK3C3
phosphoinositide-3-kinase, class 3
chrX_-_119550402 0.386 CUL4B
cullin 4B
chr6_+_151603201 0.384 AKAP12
A kinase (PRKA) anchor protein 12
chr3_-_52906608 0.384 TMEM110-MUSTN1
TMEM110-MUSTN1 readthrough
chr3_-_15814678 0.383 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr13_+_38159172 0.382 NM_207361
FREM2
FRAS1 related extracellular matrix protein 2
chr14_+_23008742 0.381 NGDN
neuroguidin, EIF4E binding protein
chr4_+_8940733 0.379 NM_001105662
USP17L2
USP17L6P
USP17
ubiquitin specific peptidase 17-like 2
ubiquitin specific peptidase 17-like 6 (pseudogene)
ubiquitin specific peptidase 17
chr19_-_63301418 0.377 NM_001145543
NM_001145544
NM_023926
ZSCAN18


zinc finger and SCAN domain containing 18


chr3_-_130641539 0.376 NM_003925
MBD4
methyl-CpG binding domain protein 4
chrX_-_92815222 0.376 NM_004538
NAP1L3
nucleosome assembly protein 1-like 3
chr3_-_52906381 0.374 TMEM110
transmembrane protein 110
chr6_+_151603346 0.374 AKAP12
A kinase (PRKA) anchor protein 12
chr19_+_44573858 0.374 MED29
mediator complex subunit 29
chr12_+_77782579 0.372 NM_005639
SYT1
synaptotagmin I
chr20_-_13567529 0.369 NM_017714
TASP1
taspase, threonine aspartase, 1
chr18_+_30427279 0.368 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha




Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.40 2.54e-06 GO:0065004 protein-DNA complex assembly
5.11 6.57e-06 GO:0071824 protein-DNA complex subunit organization
5.56 1.17e-05 GO:0006334 nucleosome assembly
5.28 2.67e-05 GO:0031497 chromatin assembly
5.02 5.76e-05 GO:0034728 nucleosome organization
4.22 1.66e-04 GO:0006333 chromatin assembly or disassembly
4.04 1.45e-03 GO:0006323 DNA packaging
2.59 4.23e-03 GO:0034622 cellular macromolecular complex assembly
3.47 1.20e-02 GO:0071103 DNA conformation change
2.22 2.42e-02 GO:0034621 cellular macromolecular complex subunit organization
1.92 4.45e-02 GO:0071844 cellular component assembly at cellular level

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.38 2.02e-05 GO:0000786 nucleosome
5.02 2.33e-05 GO:0032993 protein-DNA complex
1.11 1.37e-02 GO:0005622 intracellular
1.14 1.39e-02 GO:0043229 intracellular organelle
1.11 1.61e-02 GO:0044424 intracellular part
1.14 1.67e-02 GO:0043226 organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
9.50 4.05e-02 GO:0008395 steroid hydroxylase activity