Motif ID: NR5A1,2.p2

Z-value: 2.614


Transcription factors associated with NR5A1,2.p2:

Gene SymbolEntrez IDGene Name
NR5A1 2516 nuclear receptor subfamily 5, group A, member 1
NR5A2 2494 nuclear receptor subfamily 5, group A, member 2



Activity profile for motif NR5A1,2.p2.

activity profile for motif NR5A1,2.p2


Sorted Z-values histogram for motif NR5A1,2.p2

Sorted Z-values for motif NR5A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR5A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_27113018 3.954 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr8_-_37576515 3.209 LOC157860
hypothetical protein LOC157860
chr12_-_120781002 2.526 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr3_-_49435114 2.356 NM_000481
NM_001164710
NM_001164711
NM_001164712
AMT



aminomethyltransferase



chr3_+_50281582 2.335 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr6_-_2785682 2.234 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr16_-_28515868 2.168 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr2_+_219354948 2.104 CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr20_-_44713466 2.018 NM_001193339
NM_001193342
NM_022829
SLC13A3


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3


chr10_-_21826192 1.962 C10orf114
chromosome 10 open reading frame 114
chr17_-_6557375 1.947 NM_001143838
NM_177550
SLC13A5

solute carrier family 13 (sodium-dependent citrate transporter), member 5

chr10_+_60607232 1.913 NM_001143774
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr22_+_19458378 1.909 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr10_-_21826211 1.877 NM_001010911
C10orf114
chromosome 10 open reading frame 114
chr19_+_11211282 1.763 NM_018687
LOC55908
hepatocellular carcinoma-associated gene TD26
chr5_+_176449156 1.710 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr14_-_93829347 1.697 NM_001100607
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr1_-_159459814 1.674 APOA2
apolipoprotein A-II
chr8_-_17812151 1.656


chr14_-_60185659 1.647 NM_005982
SIX1
SIX homeobox 1
chr5_+_73145098 1.626 RGNEF
190 kDa guanine nucleotide exchange factor
chr5_-_42847716 1.607 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr2_-_88208650 1.583 NM_001443
FABP1
fatty acid binding protein 1, liver
chr11_-_16380967 1.582 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr12_-_51585004 1.569 NM_002273
KRT8
keratin 8
chr3_+_186529376 1.492 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr16_-_16224791 1.442 NM_001079528
NM_001171
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr17_+_1586034 1.440 WDR81
WD repeat domain 81
chr20_+_48241334 1.428 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chrX_+_152608159 1.425 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr17_-_7023378 1.423 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr8_-_17811750 1.417 FGL1
fibrinogen-like 1
chr18_-_28606839 1.406 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr6_+_131190237 1.382 NM_001195597
LOC285733
hypothetical LOC285733
chr3_-_188492163 1.371 NM_001031849
NM_001879
NM_139125
MASP1


mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)


chr2_+_119905812 1.368 NM_183240
TMEM37
transmembrane protein 37
chr20_+_54420574 1.367 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr3_-_49701085 1.332 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr22_+_36531246 1.317 H1F0
H1 histone family, member 0
chr19_-_17217022 1.302 NM_005234
NR2F6
nuclear receptor subfamily 2, group F, member 6
chr7_-_100077072 1.293 NM_003227
TFR2
transferrin receptor 2
chr12_-_23993830 1.273 NM_006940
SOX5
SRY (sex determining region Y)-box 5
chr22_+_43451600 1.271 PRR5
proline rich 5 (renal)
chrX_-_24600661 1.252 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr7_+_116238309 1.234 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr3_+_50281309 1.210 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr5_+_80564894 1.179 NM_001099735
NM_001099736
NM_001825
CKMT2


creatine kinase, mitochondrial 2 (sarcomeric)


chr12_+_54910767 1.156 NM_001135195
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr11_+_22652957 1.149 GAS2
growth arrest-specific 2
chr22_+_43451351 1.148 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr11_-_5227611 1.143 NM_000559
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr12_-_9159707 1.131 A2M
alpha-2-macroglobulin
chr12_-_9159742 1.131 A2M
alpha-2-macroglobulin
chr7_+_94374862 1.125 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr12_-_9159780 1.120 A2M
alpha-2-macroglobulin
chr17_-_7023283 1.094 ASGR1
asialoglycoprotein receptor 1
chr3_-_124822113 1.090 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr8_-_145725197 1.089 NM_001001795
C8orf82
chromosome 8 open reading frame 82
chr17_-_17426416 1.088 PEMT
phosphatidylethanolamine N-methyltransferase
chr11_+_22652894 1.081 NM_005256
GAS2
growth arrest-specific 2
chr12_-_52975777 1.080 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr20_-_3097070 1.077 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr10_+_685887 1.076 C10orf108
chromosome 10 open reading frame 108
chr5_-_148738980 1.069 NM_014443
IL17B
interleukin 17B
chr3_-_124821868 1.068 MYLK
myosin light chain kinase
chr2_-_238164042 1.062 RAB17
RAB17, member RAS oncogene family
chr3_-_24511180 1.055 NM_001128176
NM_000461
NM_001128177
THRB


thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)


chr12_-_113328271 1.036 NM_181486
TBX5
T-box 5
chr12_-_9159789 1.034 NM_000014
A2M
alpha-2-macroglobulin
chr9_-_129752687 1.031 NM_203305
FAM102A
family with sequence similarity 102, member A
chr2_+_138438277 1.023 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr17_+_38306339 1.020 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr1_-_2129031 1.016 NM_001146310
C1orf86
chromosome 1 open reading frame 86
chr8_-_145725289 1.009 C8orf82
chromosome 8 open reading frame 82
chr16_-_51138306 1.006 NM_001080430
TOX3
TOX high mobility group box family member 3
chr1_+_160306093 1.006 NM_001164757
NM_014697
NOS1AP

nitric oxide synthase 1 (neuronal) adaptor protein

chr11_+_60858611 0.990 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr20_+_34937928 0.988 NM_080628
C20orf118
chromosome 20 open reading frame 118
chr11_+_73037382 0.985 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr12_-_52975823 0.983 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr17_+_1595012 0.980 SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr16_+_55963899 0.973 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr17_-_53849929 0.966 NM_017763
RNF43
ring finger protein 43
chr17_-_53849888 0.957 RNF43
ring finger protein 43
chr16_+_30903963 0.954 NM_001142777
NM_001142778
NM_025193
HSD3B7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr8_-_145090045 0.937 NM_201382
PLEC
plectin
chr2_-_32344192 0.934 NM_021209
NLRC4
NLR family, CARD domain containing 4
chr17_-_53847937 0.933 RNF43
ring finger protein 43
chr17_+_24394281 0.930 PIPOX
pipecolic acid oxidase
chr3_-_185578621 0.930 NM_000460
NM_001177597
NM_001177598
THPO


thrombopoietin


chr1_-_158306570 0.930 NM_002241
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr19_-_5789740 0.920 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr19_-_4486202 0.915 NM_001013706
PLIN5
perilipin 5
chr17_-_35774467 0.908 NM_152219
GJD3
gap junction protein, delta 3, 31.9kDa
chr17_+_77289775 0.908 NM_012140
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr16_+_20328355 0.907 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr19_-_47723183 0.905 CEACAM1
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
chr17_-_34015631 0.896 NM_025248
SRCIN1
SRC kinase signaling inhibitor 1
chr19_-_4491078 0.895 LRG1
leucine-rich alpha-2-glycoprotein 1
chr2_+_63131466 0.891 NM_014562
OTX1
orthodenticle homeobox 1
chr6_-_3401512 0.889 SLC22A23
solute carrier family 22, member 23
chr20_+_29656744 0.886 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr2_+_172658453 0.883 NM_001038493
NM_178120
DLX1

distal-less homeobox 1

chr11_+_116205830 0.883 NM_000040
APOC3
apolipoprotein C-III
chr16_+_70646008 0.880 NM_001126102
NM_005143
HP

haptoglobin

chr3_+_134947940 0.879 TF
transferrin
chr6_+_27883877 0.873 NM_003509
HIST1H2AI
HIST1H3F
histone cluster 1, H2ai
histone cluster 1, H3f
chr6_+_43846735 0.867 VEGFA
vascular endothelial growth factor A
chr19_-_4491024 0.864 NM_052972
LRG1
leucine-rich alpha-2-glycoprotein 1
chr17_+_77289804 0.858 SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr2_+_70981223 0.851 NM_012476
VAX2
ventral anterior homeobox 2
chr20_-_22514092 0.849 NM_153675
FOXA2
forkhead box A2
chr1_-_42978320 0.843 NM_001123395
NM_001185117
NM_148960
CLDN19


claudin 19


chr6_+_31731647 0.842 NM_019101
APOM
apolipoprotein M
chr2_+_70981233 0.839 VAX2
ventral anterior homeobox 2
chr8_-_17702991 0.839


chr3_+_134947788 0.836 TF
transferrin
chr17_+_35472566 0.834 NM_001190918
NM_003250
NM_199334
THRA


thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)


chr16_+_55963883 0.831 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr16_-_86082818 0.829 NM_015144
ZCCHC14
zinc finger, CCHC domain containing 14
chr17_+_77289704 0.827 SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr17_-_17426469 0.827 NM_007169
PEMT
phosphatidylethanolamine N-methyltransferase
chr3_+_134947894 0.827 TF
transferrin
chr3_+_120983556 0.826 NR1I2
nuclear receptor subfamily 1, group I, member 2
chr22_+_29848923 0.825 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr1_+_154605626 0.823 NM_020407
RHBG
Rh family, B glycoprotein (gene/pseudogene)
chr13_-_51483473 0.821 NM_000053
NM_001005918
ATP7B

ATPase, Cu++ transporting, beta polypeptide

chr1_-_12599934 0.821 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr2_-_208702760 0.820 NM_020989
CRYGC
crystallin, gamma C
chr3_-_127719283 0.819 NM_001165974
NM_144639
UROC1

urocanase domain containing 1

chrX_+_49718954 0.817 NM_000084
CLCN5
chloride channel 5
chr20_+_54367389 0.812 NM_080821
C20orf108
chromosome 20 open reading frame 108
chr3_-_49434874 0.810 AMT
aminomethyltransferase
chr1_+_46413335 0.809 NM_005727
TSPAN1
tetraspanin 1
chr6_+_31731667 0.806 APOM
apolipoprotein M
chr20_-_22512893 0.806 FOXA2
forkhead box A2
chr20_-_22513050 0.804 NM_021784
FOXA2
forkhead box A2
chr17_-_64108529 0.803 NM_017565
FAM20A
family with sequence similarity 20, member A
chr12_-_7935010 0.803 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr7_-_86942910 0.802 NM_000443
NM_018849
NM_018850
ABCB4


ATP-binding cassette, sub-family B (MDR/TAP), member 4


chr20_+_43468617 0.798 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr5_+_176807931 0.797 NM_001174102
PRR7
proline rich 7 (synaptic)
chr2_-_200033445 0.796 SATB2
SATB homeobox 2
chr20_-_47963682 0.793 NM_001135773
SPATA2
spermatogenesis associated 2
chrX_-_43626444 0.793 MAOB
monoamine oxidase B
chr6_+_20510019 0.791 NM_001949
E2F3
E2F transcription factor 3
chr10_+_102722275 0.789 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr10_+_101532450 0.789 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr9_+_116131889 0.789 NM_000608
ORM2
orosomucoid 2
chr19_+_11510578 0.785 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr16_-_73708118 0.783 LDHD
lactate dehydrogenase D
chr10_-_91395194 0.783 NM_148977
PANK1
pantothenate kinase 1
chr10_+_101532544 0.781 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr2_-_65512619 0.780 SPRED2
sprouty-related, EVH1 domain containing 2
chr12_+_6768966 0.777 CD4
CD4 molecule
chr13_+_96726415 0.774 MBNL2
muscleblind-like 2 (Drosophila)
chr2_-_175754366 0.770 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr1_+_20751518 0.767 NM_207334
FAM43B
family with sequence similarity 43, member B
chr8_+_121892719 0.767


chr14_-_103058865 0.766 NM_001823
CKB
creatine kinase, brain
chr8_-_121893468 0.762 NM_021021
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr17_+_56832492 0.759 TBX2
T-box 2
chr16_-_65510230 0.753 NM_004062
CDH16
cadherin 16, KSP-cadherin
chr5_+_154072654 0.753 NM_015315
LARP1
La ribonucleoprotein domain family, member 1
chr1_+_16203317 0.752 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr19_-_411995 0.749 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr3_+_52803823 0.748 NM_002217
ITIH3
inter-alpha (globulin) inhibitor H3
chr5_-_41249270 0.747 NM_000065
C6
complement component 6
chr3_-_24511456 0.746 THRB
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
chr17_-_1499849 0.743 NM_031430
RILP
Rab interacting lysosomal protein
chr1_-_224143389 0.734 NM_020997
LEFTY1
left-right determination factor 1
chr13_+_92677012 0.731 NM_005708
GPC6
glypican 6
chr22_-_35835548 0.728 TMPRSS6
transmembrane protease, serine 6
chr2_-_238164452 0.727 NM_022449
RAB17
RAB17, member RAS oncogene family
chr14_-_103058568 0.716 CKB
creatine kinase, brain
chr17_+_78286687 0.709 NM_022158
FN3K
fructosamine 3 kinase
chr7_+_29486010 0.707 NM_001039936
CHN2
chimerin (chimaerin) 2
chr6_+_105511615 0.704 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr4_-_40212670 0.703 NM_019027
RBM47
RNA binding motif protein 47
chr13_+_112825113 0.703 NM_000504
F10
coagulation factor X
chrX_-_105169370 0.702 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr16_-_65781499 0.695 NM_178516
EXOC3L1
exocyst complex component 3-like 1
chr5_-_101659864 0.690 NM_180991
SLCO4C1
solute carrier organic anion transporter family, member 4C1
chr17_-_71385651 0.687 TRIM47
tripartite motif containing 47
chr1_+_54132447 0.686 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr1_+_18680010 0.685 NM_152375
KLHDC7A
kelch domain containing 7A
chr7_+_142692165 0.678 NM_153345
TMEM139
transmembrane protein 139
chr6_+_32021899 0.678 CFB
complement factor B
chr10_+_111755715 0.676 NM_019903
ADD3
adducin 3 (gamma)
chr3_-_10522221 0.676 ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr1_+_205329206 0.676 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr20_+_41621079 0.675 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr17_+_56832255 0.674 TBX2
T-box 2
chr20_-_34921689 0.674 NM_199181
KIAA0889
KIAA0889
chr6_+_24603145 0.672 NM_001080
NM_170740
ALDH5A1

aldehyde dehydrogenase 5 family, member A1

chr20_+_41621119 0.671 SGK2
serum/glucocorticoid regulated kinase 2
chr12_-_55042793 0.670 NM_001638
APOF
apolipoprotein F
chr19_-_4468715 0.669 NM_001080400
PLIN4
perilipin 4
chr16_+_620932 0.668 NM_053284
WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr7_+_96473225 0.665 NM_005222
DLX6
distal-less homeobox 6

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.65 1.67e-04 GO:0022904 respiratory electron transport chain
1.69 2.00e-03 GO:0006091 generation of precursor metabolites and energy
1.15 3.89e-03 GO:0032501 multicellular organismal process
2.19 4.55e-03 GO:0022900 electron transport chain
1.80 6.94e-03 GO:0015980 energy derivation by oxidation of organic compounds
1.60 7.04e-03 GO:0006066 alcohol metabolic process
2.18 1.00e-02 GO:0045333 cellular respiration
1.21 1.01e-02 GO:0006810 transport
1.20 2.27e-02 GO:0051234 establishment of localization
1.06 4.59e-02 GO:0009987 cellular process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.82 5.29e-05 GO:0005743 mitochondrial inner membrane
1.37 7.11e-05 GO:0005739 mitochondrion
1.64 1.01e-04 GO:0005740 mitochondrial envelope
1.65 1.57e-04 GO:0031966 mitochondrial membrane
1.51 2.09e-04 GO:0044429 mitochondrial part
1.14 3.72e-04 GO:0044422 organelle part
1.48 4.01e-04 GO:0031975 envelope
1.71 4.45e-04 GO:0019866 organelle inner membrane
1.47 6.78e-04 GO:0031967 organelle envelope
1.13 1.34e-03 GO:0044446 intracellular organelle part
1.12 3.02e-03 GO:0044444 cytoplasmic part
4.92 1.57e-02 GO:0005833 hemoglobin complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
7.39 3.98e-02 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity
1.09 4.05e-02 GO:0005515 protein binding