Motif ID: IKZF1.p2

Z-value: 1.772


Transcription factors associated with IKZF1.p2:

Gene SymbolEntrez IDGene Name
IKZF1 10320 IKAROS family zinc finger 1 (Ikaros)



Activity profile for motif IKZF1.p2.

activity profile for motif IKZF1.p2


Sorted Z-values histogram for motif IKZF1.p2

Sorted Z-values for motif IKZF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_95720870 2.199 LOC100288748
hypothetical LOC100288748
chr2_-_113310796 1.773 NM_000576
IL1B
interleukin 1, beta
chr11_+_20001130 1.647 NM_001111019
NAV2
neuron navigator 2
chr11_+_20000938 1.592 NAV2
neuron navigator 2
chr1_+_31814709 1.558 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_+_31814672 1.514 NM_022164
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_+_26728846 1.379 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr5_+_66160359 1.316 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr3_+_42176662 1.313 NM_014965
TRAK1
trafficking protein, kinesin binding 1
chr1_+_26728839 1.306 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr14_+_64240902 1.272 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr1_+_26728827 1.272 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr15_+_38923470 1.267 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr12_-_57599571 1.254 NM_001136051
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr1_-_151855413 1.241 NM_020672
S100A14
S100 calcium binding protein A14
chr1_+_31814712 1.237 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr2_+_17585287 1.174 NM_003385
VSNL1
visinin-like 1
chr2_+_17585462 1.142 VSNL1
visinin-like 1
chr1_-_207892420 1.114 NM_000228
LAMB3
laminin, beta 3
chr12_+_50913274 1.109 KRT7
keratin 7
chr8_-_81246215 1.102 NM_001025253
NM_005079
TPD52

tumor protein D52

chr14_+_64240996 1.062 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr1_+_117253882 1.028 NM_020440
PTGFRN
prostaglandin F2 receptor negative regulator
chr1_-_207892296 1.007 NM_001127641
LAMB3
laminin, beta 3
chr19_-_10558906 1.000 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr1_-_23393808 0.982 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chr19_-_56147971 0.966 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr15_+_61123327 0.941 TPM1
tropomyosin 1 (alpha)
chr4_+_108965167 0.935 NM_001136258
SGMS2
sphingomyelin synthase 2
chr12_+_64504408 0.933 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr6_+_31190505 0.930 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr12_-_56447090 0.929 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr12_+_50913220 0.900 NM_005556
KRT7
keratin 7
chr19_+_43447262 0.873 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr4_-_159311959 0.869 FAM198B
family with sequence similarity 198, member B
chr1_+_153366559 0.859 EFNA1
ephrin-A1
chr19_+_43447078 0.838 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr2_-_238164042 0.808 RAB17
RAB17, member RAS oncogene family
chr19_-_40693176 0.803 NM_001126059
DMKN
dermokine
chr3_-_189354510 0.802 LOC339929
hypothetical LOC339929
chr2_-_108972048 0.802 EDAR
ectodysplasin A receptor
chr12_-_32940931 0.799 NM_001005242
NM_004572
PKP2

plakophilin 2

chr19_+_50004134 0.795 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr8_-_125809831 0.785 NM_014751
MTSS1
metastasis suppressor 1
chr3_+_191714533 0.784 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr1_-_208046011 0.781 NM_006147
IRF6
interferon regulatory factor 6
chr18_-_26935883 0.756 NM_004949
NM_024422
DSC2

desmocollin 2

chr3_+_143925904 0.755 NM_003304
TRPC1
transient receptor potential cation channel, subfamily C, member 1
chr22_+_27609889 0.754 NM_032173
ZNRF3
zinc and ring finger 3
chr1_+_35020425 0.744 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr4_+_124537334 0.723 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr3_-_139315011 0.716 NM_001170538
DZIP1L
DAZ interacting protein 1-like
chr5_-_150441150 0.710 NM_006058
TNIP1
TNFAIP3 interacting protein 1
chr4_+_128773529 0.698 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr18_+_53865455 0.681 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_-_199635057 0.679 LAD1
ladinin 1
chr19_+_43446937 0.677 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr8_-_145881968 0.675 ARHGAP39
Rho GTPase activating protein 39
chr13_-_51878235 0.675 THSD1
thrombospondin, type I, domain containing 1
chr1_+_203740391 0.674 CDK18
cyclin-dependent kinase 18
chr2_+_95303947 0.673 PROM2
prominin 2
chr17_-_37181636 0.672 JUP
junction plakoglobin
chr12_-_56445653 0.672 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr19_+_447453 0.668 NM_130760
NM_130762
MADCAM1

mucosal vascular addressin cell adhesion molecule 1

chr1_+_1971762 0.667 NM_002744
PRKCZ
protein kinase C, zeta
chr4_-_35922288 0.658 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr10_+_124124196 0.656 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr7_-_22363036 0.654 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr3_-_69517913 0.651 FRMD4B
FERM domain containing 4B
chr3_-_69518119 0.650 NM_015123
FRMD4B
FERM domain containing 4B
chr22_+_38720881 0.639 NM_138435
FAM83F
family with sequence similarity 83, member F
chr1_-_228916486 0.637 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_+_181421796 0.633 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr11_-_16992524 0.627 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr1_-_228916470 0.624 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr5_+_76150588 0.621 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr17_+_46067114 0.620 NM_001144070
NM_003786
ABCC3

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

chr17_-_7434113 0.614 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr2_-_21120398 0.611 APOB
apolipoprotein B (including Ag(x) antigen)
chr14_+_23575460 0.610 NM_001082488
DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 1
chr17_+_50333021 0.609 NM_005486
TOM1L1
target of myb1 (chicken)-like 1
chr12_-_51585004 0.603 NM_002273
KRT8
keratin 8
chr2_-_238164452 0.600 NM_022449
RAB17
RAB17, member RAS oncogene family
chr10_-_62163083 0.597 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr14_+_38772870 0.594 NM_054024
MIA2
melanoma inhibitory activity 2
chr3_+_195336631 0.593 HES1
hairy and enhancer of split 1, (Drosophila)
chr3_-_52906608 0.591 TMEM110-MUSTN1
TMEM110-MUSTN1 readthrough
chr2_+_95303922 0.589 NM_001165977
NM_001165978
NM_144707
PROM2


prominin 2


chr15_-_38417564 0.585 C15orf52
chromosome 15 open reading frame 52
chr2_-_142605739 0.585 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr6_+_150505849 0.584 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr2_-_108972100 0.569 NM_022336
EDAR
ectodysplasin A receptor
chr1_-_26553168 0.565 NM_001039775
AIM1L
absent in melanoma 1-like
chr2_-_189752575 0.565 NM_000393
COL5A2
collagen, type V, alpha 2
chr1_+_27062215 0.564 NM_006142
SFN
stratifin
chr12_-_51153788 0.564 NM_173086
KRT6C
keratin 6C
chr19_+_43830189 0.559 ACTN4
actinin, alpha 4
chr2_+_27705366 0.558 NM_007266
GPN1
GPN-loop GTPase 1
chr5_-_125958503 0.555 NM_001182
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr8_+_95722516 0.553 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr3_-_52906381 0.552 TMEM110
transmembrane protein 110
chr16_-_11587647 0.547 NM_004862
LITAF
lipopolysaccharide-induced TNF factor
chr1_-_120413542 0.541 NOTCH2
notch 2
chr2_+_203587807 0.540 NM_001114132
NBEAL1
neurobeachin-like 1
chr14_-_23106779 0.535 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr2_-_27705248 0.532 NM_001142683
NM_024584
CCDC121

coiled-coil domain containing 121

chr4_+_169789327 0.532 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr14_+_23527866 0.531 NM_198083
DHRS4
DHRS4L2
dehydrogenase/reductase (SDR family) member 4
dehydrogenase/reductase (SDR family) member 4 like 2
chr12_+_39372456 0.529 NM_001843
NM_175038
CNTN1

contactin 1

chr2_-_165406173 0.529 NM_014900
COBLL1
COBL-like 1
chr1_-_6473216 0.523 NM_001042664
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr18_+_59295123 0.522 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr1_-_28392966 0.520 NM_001164722
NM_001164721
PTAFR

platelet-activating factor receptor

chr3_-_52906635 0.519 NM_001198974
NM_198563
TMEM110-MUSTN1
TMEM110
TMEM110-MUSTN1 readthrough
transmembrane protein 110
chr3_-_113495763 0.519 NM_183061
SLC9A10
solute carrier family 9, member 10
chr2_+_27705404 0.516 GPN1
GPN-loop GTPase 1
chr1_-_159257486 0.513 F11R
F11 receptor
chr2_-_165406098 0.501 COBLL1
COBL-like 1
chr1_-_228916559 0.501 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr20_+_43896178 0.500 SNX21
sorting nexin family member 21
chr2_-_21120314 0.497 APOB
apolipoprotein B (including Ag(x) antigen)
chr10_-_92670764 0.497 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr5_+_76150637 0.491 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr17_+_71154240 0.483 NM_001162997
LOC100130933
hypothetical protein LOC100130933
chr10_+_53744043 0.480 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr8_+_95722575 0.479 ESRP1
epithelial splicing regulatory protein 1
chr18_+_54489798 0.478 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr18_+_44319365 0.474 NM_001142397
NM_014772
CTIF

CBP80/20-dependent translation initiation factor

chr3_+_32255215 0.474 CMTM8
CKLF-like MARVEL transmembrane domain containing 8
chr11_+_66580861 0.469 NM_014578
RHOD
ras homolog gene family, member D
chr22_+_36531246 0.466 H1F0
H1 histone family, member 0
chr1_-_120413698 0.462 NOTCH2
notch 2
chr20_+_43874654 0.461 NM_007019
NM_181799
NM_181800
NM_181802
NM_181803
UBE2C




ubiquitin-conjugating enzyme E2C




chr20_-_23566325 0.459 NM_000099
CST3
cystatin C
chr5_-_16989290 0.458 MYO10
myosin X
chr2_+_27705018 0.457 NM_001145047
NM_001145048
NM_001145049
GPN1


GPN-loop GTPase 1


chr2_-_165406780 0.456 COBLL1
COBL-like 1
chr10_-_63698463 0.450 NM_145307
RTKN2
rhotekin 2
chr5_-_16989371 0.450 NM_012334
MYO10
myosin X
chr1_-_94779727 0.448 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr2_-_165406564 0.442 COBLL1
COBL-like 1
chr6_-_47117951 0.439 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr2_+_218790364 0.439 NM_005731
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr18_+_3443771 0.435 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr14_+_20580224 0.434 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr1_+_153366928 0.430 NM_004428
NM_182685
EFNA1

ephrin-A1

chr12_-_105056577 0.430 NUAK1
NUAK family, SNF1-like kinase, 1
chr3_-_12561962 0.426 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr4_+_109033868 0.424 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr3_+_189354167 0.421 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr2_-_39201066 0.421 NM_005633
SOS1
son of sevenless homolog 1 (Drosophila)
chr18_+_54489763 0.421 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr3_+_103029523 0.417 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr8_+_95722448 0.417 ESRP1
epithelial splicing regulatory protein 1
chr18_+_54489597 0.417 NM_006785
NM_173844
MALT1

mucosa associated lymphoid tissue lymphoma translocation gene 1

chr10_-_46593923 0.413 NM_001040084
NM_001098845
ANXA8L2
LOC653110
ANXA8
ANXA8L1
annexin A8-like 2
hypothetical LOC653110
annexin A8
annexin A8-like 1
chr2_-_152538694 0.412 NM_001005747
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr19_-_49552638 0.411 NM_001083335
NM_013380
ZFP112

zinc finger protein 112 homolog (mouse)

chr13_+_24152548 0.411 NM_001185085
NM_001676
ATP12A

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

chr14_+_22845851 0.410 NM_004050
BCL2L2-PABPN1
BCL2L2
BCL2L2-PABPN1 read-through transcript
BCL2-like 2
chr14_-_23107106 0.408 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr18_+_54489658 0.407 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr1_-_199635339 0.405 LAD1
ladinin 1
chr21_-_36774257 0.402 NM_001146079
NM_144492
CLDN14

claudin 14

chr16_+_55217180 0.402 MT1E
metallothionein 1E
chr13_-_51878629 0.401 NM_018676
NM_199263
THSD1

thrombospondin, type I, domain containing 1

chr1_-_120413783 0.401 NOTCH2
notch 2
chr9_-_15297148 0.401 TTC39B
tetratricopeptide repeat domain 39B
chr5_+_176807931 0.400 NM_001174102
PRR7
proline rich 7 (synaptic)
chr19_-_53814173 0.399 NM_000979
RPL18
ribosomal protein L18
chr15_-_88256922 0.397 NM_001199058
NM_182616
C15orf38-AP3S2
C15orf38
C15orf38-AP3S2 readthrough
chromosome 15 open reading frame 38
chr11_+_111294868 0.397 C11orf52
chromosome 11 open reading frame 52
chr14_-_23493169 0.397 C14orf167
chromosome 14 open reading frame 167
chr1_-_120413798 0.396 NM_024408
NOTCH2
notch 2
chr3_+_195336625 0.395 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr20_+_43896195 0.394 SNX21
sorting nexin family member 21
chr19_+_40431122 0.393 LSR
lipolysis stimulated lipoprotein receptor
chr16_+_23560187 0.391 NM_001199011
NM_032486
DCTN5

dynactin 5 (p25)

chr1_+_92268072 0.391 NM_173567
EPHX4
epoxide hydrolase 4
chr3_-_121295663 0.391 NM_001146156
NM_002093
GSK3B

glycogen synthase kinase 3 beta

chr1_-_158306570 0.385 NM_002241
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr17_-_37181626 0.384


chr6_+_139055244 0.384 FLJ46906
hypothetical LOC441172
chr2_-_74522534 0.381 RTKN
rhotekin
chr12_+_52618815 0.379 NM_017410
HOXC13
homeobox C13
chr9_+_86473273 0.379 NM_001018064
NM_006180
NTRK2

neurotrophic tyrosine kinase, receptor, type 2

chr14_+_22633728 0.374 C14orf119
chromosome 14 open reading frame 119
chr14_+_23492780 0.374 NM_021004
DHRS4
dehydrogenase/reductase (SDR family) member 4
chr2_+_242146791 0.372 NM_032515
BOK
BCL2-related ovarian killer
chr4_+_166468266 0.372 NM_001017369
NM_006745
SC4MOL

sterol-C4-methyl oxidase-like

chr16_+_4654710 0.371 MGRN1
mahogunin, ring finger 1
chr2_-_98646367 0.370 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr1_+_218930542 0.368 C1orf115
chromosome 1 open reading frame 115
chr16_+_55217085 0.366 NM_175617
MT1E
metallothionein 1E
chr9_+_130684601 0.365 NM_001127244
LRRC8A
leucine rich repeat containing 8 family, member A
chr2_-_74522563 0.365 NM_001015055
RTKN
rhotekin
chr15_+_39907447 0.360 NM_001114632
NM_001198588
NM_005090
JMJD7
JMJD7-PLA2G4B

jumonji domain containing 7
JMJD7-PLA2G4B readthrough

chr10_-_61335967 0.359


chr22_-_30388165 0.359 PISD
phosphatidylserine decarboxylase
chr7_+_147667461 0.357 CNTNAP2
contactin associated protein-like 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.11 4.64e-07 GO:0009987 cellular process
1.22 5.14e-03 GO:0016043 cellular component organization
1.25 8.88e-03 GO:0071842 cellular component organization at cellular level
1.48 1.27e-02 GO:0044093 positive regulation of molecular function
1.21 1.45e-02 GO:0071840 cellular component organization or biogenesis
1.24 1.74e-02 GO:0071841 cellular component organization or biogenesis at cellular level

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 4.28e-05 GO:0044444 cytoplasmic part
1.12 5.91e-05 GO:0005737 cytoplasm
1.31 1.96e-04 GO:0005829 cytosol
1.06 3.30e-02 GO:0005622 intracellular
1.04 4.78e-02 GO:0044464 cell part
1.04 4.93e-02 GO:0005623 cell

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 8.86e-03 GO:0005515 protein binding