Motif ID: bHLH_family.p2

Z-value: 2.525


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
ARNTL 406 aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 56938 aryl hydrocarbon receptor nuclear translocator-like 2
CLOCK 9575 clock homolog (mouse)
HES6 55502 hairy and enhancer of split 6 (Drosophila)
HEY1 23462 hairy/enhancer-of-split related with YRPW motif 1
HEY2 23493 hairy/enhancer-of-split related with YRPW motif 2
HEYL 26508 hairy/enhancer-of-split related with YRPW motif-like
ID1 3397 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MITF 4286 microphthalmia-associated transcription factor
MLXIPL 51085 MLX interacting protein-like
MNT 4335 MAX binding protein
MXD3 83463 MAX dimerization protein 3
MXD4 10608 MAX dimerization protein 4
MXI1 4601 MAX interactor 1
NPAS2 4862 neuronal PAS domain protein 2
OLIG1 116448 oligodendrocyte transcription factor 1
OLIG2 10215 oligodendrocyte lineage transcription factor 2
TFE3 7030 transcription factor binding to IGHM enhancer 3



Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_120289735 5.532 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr16_-_66827449 4.608 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr22_+_38720881 4.540 NM_138435
FAM83F
family with sequence similarity 83, member F
chr8_+_95722448 3.392 ESRP1
epithelial splicing regulatory protein 1
chr8_-_17702991 3.117


chr16_+_67236699 3.115 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr17_-_73636362 3.106 TMC6
transmembrane channel-like 6
chr12_-_56432292 2.989 CDK4
cyclin-dependent kinase 4
chr17_+_9489578 2.942 NM_153210
USP43
ubiquitin specific peptidase 43
chr16_-_23068010 2.815 NM_020718
USP31
ubiquitin specific peptidase 31
chr8_+_95722575 2.734 ESRP1
epithelial splicing regulatory protein 1
chr2_-_172675873 2.694 DLX2
distal-less homeobox 2
chr8_+_95722516 2.690 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr12_-_56432377 2.643 CDK4
cyclin-dependent kinase 4
chr12_-_56432375 2.604 CDK4
cyclin-dependent kinase 4
chr12_-_56432385 2.600 NM_000075
CDK4
cyclin-dependent kinase 4
chr11_+_384199 2.564 NM_007183
PKP3
plakophilin 3
chr5_+_78567604 2.551 NM_152405
JMY
junction mediating and regulatory protein, p53 cofactor
chr11_+_384238 2.360 PKP3
plakophilin 3
chr11_+_45900731 2.301 GYLTL1B
glycosyltransferase-like 1B
chr17_+_35148084 2.295 NM_001030002
GRB7
growth factor receptor-bound protein 7
chr5_+_78568094 2.275


chr2_-_172675480 2.257 NM_004405
DLX2
distal-less homeobox 2
chr19_+_40431122 2.216 LSR
lipolysis stimulated lipoprotein receptor
chr19_-_5291700 2.177 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chrX_+_152562013 2.175 DUSP9
dual specificity phosphatase 9
chr11_-_118757477 2.123 USP2
ubiquitin specific peptidase 2
chr17_+_35147697 2.117 NM_005310
GRB7
growth factor receptor-bound protein 7
chr6_+_138230045 2.098 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr17_+_35147738 2.094 GRB7
growth factor receptor-bound protein 7
chr17_-_35510074 2.056 NR1D1
nuclear receptor subfamily 1, group D, member 1
chr2_+_27518736 1.962 NM_001168364
NM_173853
KRTCAP3

keratinocyte associated protein 3

chr17_-_35510431 1.898 NM_021724
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr1_-_159257486 1.896 F11R
F11 receptor
chr1_-_159257567 1.892 F11R
F11 receptor
chr16_+_70217564 1.864 NM_001017967
NM_052858
MARVELD3

MARVEL domain containing 3

chr8_-_75396016 1.826 NM_020647
JPH1
junctophilin 1
chr7_-_1562272 1.814 NM_001097620
TMEM184A
transmembrane protein 184A
chr16_-_5023914 1.801 NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr16_-_5023934 1.791 NM_016256
NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr19_+_40431359 1.756 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr2_-_172572993 1.739


chr7_-_22363036 1.711 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr16_+_67236730 1.680 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr3_-_57088332 1.671 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr14_+_102458745 1.667 NM_030943
AMN
amnionless homolog (mouse)
chr9_-_126309510 1.654 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr17_-_38979178 1.651 NM_001079675
ETV4
ets variant 4
chr17_-_73636386 1.645 NM_001127198
TMC6
transmembrane channel-like 6
chr2_+_172573049 1.633 NM_199227
METAP1D
methionyl aminopeptidase type 1D (mitochondrial)
chr6_-_47385205 1.616 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr1_-_159459999 1.576 NM_001643
APOA2
apolipoprotein A-II
chr7_+_16759845 1.561 NM_014399
TSPAN13
tetraspanin 13
chr19_+_40431618 1.554 LSR
lipolysis stimulated lipoprotein receptor
chr1_-_159257595 1.552 NM_016946
F11R
F11 receptor
chr6_-_33493792 1.548 CUTA
cutA divalent cation tolerance homolog (E. coli)
chr6_-_43305156 1.544 NM_006443
NM_199184
C6orf108

chromosome 6 open reading frame 108

chr14_+_23855291 1.542 LTB4R
leukotriene B4 receptor
chr11_+_119586879 1.496 NM_178507
OAF
OAF homolog (Drosophila)
chr1_-_199635057 1.494 LAD1
ladinin 1
chr1_-_1840564 1.489 NM_178545
TMEM52
transmembrane protein 52
chrX_+_130985316 1.476 NM_001042452
MST4
serine/threonine protein kinase MST4
chr16_+_5023672 1.452 LOC100507589
hypothetical LOC100507589
chr1_-_199635240 1.450 NM_005558
LAD1
ladinin 1
chr17_-_17050326 1.438 PLD6
phospholipase D family, member 6
chr17_+_77478858 1.438 LOC92659
hypothetical LOC92659
chr1_+_42920946 1.436 YBX1
Y box binding protein 1
chr16_+_84204424 1.436 NM_014615
KIAA0182
KIAA0182
chr1_+_181422016 1.432 LAMC2
laminin, gamma 2
chr16_-_5023562 1.417 NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr2_+_241903395 1.415 NM_001008491
NM_006155
SEPT2

septin 2

chr7_-_110989582 1.413 NM_032549
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr6_-_47385313 1.400 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr6_+_41622267 1.399 FOXP4
forkhead box P4
chr17_-_35911340 1.399 NM_032865
TNS4
tensin 4
chr2_+_46779553 1.382 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr6_-_53517397 1.380 GCLC
glutamate-cysteine ligase, catalytic subunit
chr1_-_199635339 1.380 LAD1
ladinin 1
chr9_-_99994704 1.379 NM_052820
CORO2A
coronin, actin binding protein, 2A
chr17_-_7078446 1.373 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr19_+_12966970 1.358 NM_002501
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr12_+_52713098 1.351 NM_018953
HOXC5
homeobox C5
chr17_-_7078304 1.347 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr11_-_118757574 1.338 NM_004205
USP2
ubiquitin specific peptidase 2
chr17_-_7078399 1.333 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr1_+_29113589 1.319 NM_001166006
EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr11_-_125586733 1.316 NM_001144827
NM_032795
RPUSD4

RNA pseudouridylate synthase domain containing 4

chr1_+_1971762 1.312 NM_002744
PRKCZ
protein kinase C, zeta
chr17_-_17050355 1.296 NM_178836
PLD6
phospholipase D family, member 6
chr13_-_19665036 1.295 GJB2
gap junction protein, beta 2, 26kDa
chr12_-_61614930 1.287 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr8_-_110726063 1.281 SYBU
syntabulin (syntaxin-interacting)
chr6_+_32090516 1.275 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr14_-_23106372 1.268 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr20_+_48781457 1.257 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr12_+_52653176 1.256 NM_014212
HOXC11
homeobox C11
chr13_+_112999538 1.250 LAMP1
lysosomal-associated membrane protein 1
chr12_-_61615124 1.244 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr3_+_46996150 1.243 NM_015175
NBEAL2
neurobeachin-like 2
chr7_+_150390566 1.236 SLC4A2
solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
chr11_+_125586828 1.229 NM_024556
FAM118B
family with sequence similarity 118, member B
chr7_-_23476497 1.224 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr6_-_33493898 1.213 CUTA
cutA divalent cation tolerance homolog (E. coli)
chr1_-_12599934 1.211 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr6_-_10527772 1.210 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr19_+_7608010 1.196 STXBP2
syntaxin binding protein 2
chr13_+_112999590 1.186 LAMP1
lysosomal-associated membrane protein 1
chr2_+_17585287 1.169 NM_003385
VSNL1
visinin-like 1
chr2_-_220116508 1.168 NM_024536
CHPF
chondroitin polymerizing factor
chr6_-_138862271 1.161 NM_001144060
NHSL1
NHS-like 1
chr2_-_171999473 1.159 NM_024770
METTL8
methyltransferase like 8
chr14_-_54438913 1.158 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr8_-_144887876 1.156 NM_198488
FAM83H
family with sequence similarity 83, member H
chr2_+_218992053 1.155 NM_007127
VIL1
villin 1
chr2_+_17585462 1.154 VSNL1
visinin-like 1
chr1_-_21868380 1.153 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chr1_-_158182006 1.151 NM_001135050
NM_020789
IGSF9

immunoglobulin superfamily, member 9

chr6_-_53517466 1.146 GCLC
glutamate-cysteine ligase, catalytic subunit
chr12_-_83830700 1.143 SLC6A15
solute carrier family 6 (neutral amino acid transporter), member 15
chr1_+_65385799 1.142 NM_203464
NM_001005353
AK4

adenylate kinase 4

chr5_+_3649167 1.141 NM_024337
IRX1
iroquois homeobox 1
chr19_+_7608015 1.138 STXBP2
syntaxin binding protein 2
chr17_-_34084682 1.137 NM_001130677
C17orf96
chromosome 17 open reading frame 96
chr6_+_41622111 1.136 NM_001012426
NM_001012427
NM_138457
FOXP4


forkhead box P4


chr12_+_52618815 1.136 NM_017410
HOXC13
homeobox C13
chr20_+_43953606 1.135 CTSA
cathepsin A
chr6_+_160310118 1.122 NM_000876
IGF2R
insulin-like growth factor 2 receptor
chr16_+_29726195 1.112 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr6_+_105511615 1.109 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr12_-_83830710 1.109 NM_001146335
NM_018057
NM_182767
SLC6A15


solute carrier family 6 (neutral amino acid transporter), member 15


chr19_-_38485161 1.107


chr17_-_68769613 1.104 NM_001129885
CPSF4L
cleavage and polyadenylation specific factor 4-like
chr1_-_11042555 1.097 SRM
spermidine synthase
chr3_-_49916304 1.095 NM_002447
MST1R
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
chr19_+_7607976 1.094 NM_001127396
NM_006949
STXBP2

syntaxin binding protein 2

chr12_-_83830670 1.092 SLC6A15
solute carrier family 6 (neutral amino acid transporter), member 15
chr17_+_36599664 1.090 NM_001190460
KRTAP9-1
keratin associated protein 9-1
chr5_+_70918856 1.090 NM_022132
MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr1_+_181421984 1.088 LAMC2
laminin, gamma 2
chr17_-_41625921 1.087 NM_001193466
KIAA1267
KIAA1267
chr1_+_61320213 1.087 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr16_-_21221872 1.075 NM_001014444
NM_001888
CRYM

crystallin, mu

chr17_-_18848713 1.074 NM_001039999
FAM83G
family with sequence similarity 83, member G
chr2_+_219751230 1.073 FAM134A
family with sequence similarity 134, member A
chr8_-_110726201 1.066 NM_001099753
NM_001099754
NM_001099755
SYBU


syntabulin (syntaxin-interacting)


chr2_-_178645718 1.066 NM_016953
PDE11A
phosphodiesterase 11A
chr1_+_3360880 1.064 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr6_-_47385470 1.059 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr6_-_138231006 1.055


chr11_-_116168316 1.051 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr3_+_160002571 1.044 MFSD1
major facilitator superfamily domain containing 1
chr6_+_7486862 1.040 NM_001008844
NM_004415
DSP

desmoplakin

chr19_-_12747421 1.039 NM_001100176
NM_013312
HOOK2

hook homolog 2 (Drosophila)

chr6_-_47385605 1.038 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr17_+_45911179 1.037 NM_018346
RSAD1
radical S-adenosyl methionine domain containing 1
chr6_+_7486836 1.033 DSP
desmoplakin
chr6_-_47385599 1.030 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr12_-_63439449 1.030 GNS
glucosamine (N-acetyl)-6-sulfatase
chr16_+_56616782 1.029 NM_002428
MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr17_+_45911216 1.029 RSAD1
radical S-adenosyl methionine domain containing 1
chr1_-_27113018 1.028 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr6_-_35996915 1.027 NM_003137
SRPK1
SRSF protein kinase 1
chr6_-_47385604 1.027 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr6_+_87921980 1.023 NM_015021
ZNF292
zinc finger protein 292
chr17_-_42250961 1.023 NM_030753
WNT3
wingless-type MMTV integration site family, member 3
chr17_+_69939806 1.022 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr16_+_65471881 1.021 NM_020786
PDP2
pyruvate dehyrogenase phosphatase catalytic subunit 2
chr20_+_46971618 1.019 NM_006420
ARFGEF2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr16_+_68353738 1.015 NM_007014
NM_199423
WWP2

WW domain containing E3 ubiquitin protein ligase 2

chr19_+_7608020 1.014 STXBP2
syntaxin binding protein 2
chr2_-_220116062 1.006 NM_001195731
CHPF
chondroitin polymerizing factor
chr20_+_43953331 1.002 CTSA
cathepsin A
chr5_+_70918888 0.998 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr3_+_10832867 0.998 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr11_+_76171780 0.992 NM_015516
TSKU
tsukushi small leucine rich proteoglycan homolog (Xenopus laevis)
chr6_-_28999388 0.990 TRIM27
tripartite motif containing 27
chr22_-_36907638 0.989 NM_001004426
NM_003560
PLA2G6

phospholipase A2, group VI (cytosolic, calcium-independent)

chr20_+_43028533 0.987 NM_006282
STK4
serine/threonine kinase 4
chr20_+_43953428 0.985 CTSA
cathepsin A
chr6_-_138862273 0.984


chr6_-_53517793 0.981 GCLC
glutamate-cysteine ligase, catalytic subunit
chr19_-_7607852 0.976


chr3_-_15875932 0.972 NM_015199
ANKRD28
ankyrin repeat domain 28
chr6_-_30151526 0.966 NM_170769
NM_025236
RNF39

ring finger protein 39

chr2_-_208342296 0.964 NM_003468
FZD5
frizzled homolog 5 (Drosophila)
chr1_-_24307514 0.961 MYOM3
myomesin family, member 3
chr6_-_35996867 0.959 SRPK1
SRSF protein kinase 1
chr6_+_32229771 0.959 PPT2-EGFL8
PPT2
PPT2-EGFL8 read-through transcript
palmitoyl-protein thioesterase 2
chr12_-_63439456 0.955 NM_002076
GNS
glucosamine (N-acetyl)-6-sulfatase
chr3_-_69674412 0.952 FRMD4B
FERM domain containing 4B
chr1_+_27541049 0.951 NM_001193308
NM_032872
SYTL1

synaptotagmin-like 1

chr2_+_219751207 0.950 FAM134A
family with sequence similarity 134, member A
chr10_+_5478521 0.949 NM_005863
NET1
neuroepithelial cell transforming 1
chr12_-_63439415 0.948 GNS
glucosamine (N-acetyl)-6-sulfatase
chr2_+_74610039 0.948 NM_013247
NM_145074
HTRA2

HtrA serine peptidase 2

chr1_+_27541086 0.947 SYTL1
synaptotagmin-like 1
chr16_+_29726962 0.946 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr2_-_74522513 0.945 RTKN
rhotekin
chr16_+_57106883 0.944 NM_001160305
NM_024860
SETD6

SET domain containing 6

chrX_+_130984912 0.943 NM_001042453
NM_016542
MST4

serine/threonine protein kinase MST4


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.16 1.64e-10 GO:0008152 metabolic process
1.18 8.77e-10 GO:0044237 cellular metabolic process
1.17 5.25e-09 GO:0044238 primary metabolic process
1.09 3.16e-08 GO:0009987 cellular process
1.18 1.57e-05 GO:0044260 cellular macromolecule metabolic process
1.29 1.00e-04 GO:0010467 gene expression
1.16 1.20e-04 GO:0043170 macromolecule metabolic process
1.24 2.93e-04 GO:0044249 cellular biosynthetic process
1.23 4.63e-04 GO:0009058 biosynthetic process
1.19 9.94e-04 GO:0034641 cellular nitrogen compound metabolic process
1.19 1.48e-03 GO:0006807 nitrogen compound metabolic process
1.26 4.15e-03 GO:0016070 RNA metabolic process
1.68 9.50e-03 GO:0034660 ncRNA metabolic process
1.80 1.19e-02 GO:0034470 ncRNA processing
1.24 1.31e-02 GO:0044281 small molecule metabolic process
1.22 1.38e-02 GO:0090304 nucleic acid metabolic process
1.18 2.73e-02 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.19 3.54e-02 GO:0044267 cellular protein metabolic process
1.93 4.26e-02 GO:0042254 ribosome biogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.09 2.26e-11 GO:0005622 intracellular
1.13 1.02e-10 GO:0005737 cytoplasm
1.09 4.61e-10 GO:0044424 intracellular part
1.09 1.02e-06 GO:0043226 organelle
1.15 1.60e-06 GO:0044422 organelle part
1.09 2.26e-06 GO:0043229 intracellular organelle
1.15 2.31e-06 GO:0044446 intracellular organelle part
1.14 2.40e-06 GO:0044444 cytoplasmic part
1.26 3.27e-06 GO:0031974 membrane-enclosed lumen
1.10 4.43e-06 GO:0043227 membrane-bounded organelle
1.26 5.02e-06 GO:0043233 organelle lumen
1.10 6.21e-06 GO:0043231 intracellular membrane-bounded organelle
1.26 9.56e-06 GO:0070013 intracellular organelle lumen
1.24 1.45e-04 GO:0044428 nuclear part
1.26 1.76e-04 GO:0031981 nuclear lumen
1.48 1.55e-03 GO:0005730 nucleolus
1.26 6.81e-03 GO:0005654 nucleoplasm
1.25 1.48e-02 GO:0005739 mitochondrion
1.20 1.60e-02 GO:0005829 cytosol
1.41 2.16e-02 GO:0030529 ribonucleoprotein complex
2.99 4.85e-02 GO:0044452 nucleolar part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.11 3.97e-05 GO:0005515 protein binding
1.24 2.90e-03 GO:0016740 transferase activity
1.39 7.76e-03 GO:0043565 sequence-specific DNA binding
1.11 4.04e-02 GO:0003824 catalytic activity