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• Activity deltas table
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Motif ID: EOMES.p2

Z-value: 1.375

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr6_+_105511615	2.737	NM_001004317	LIN28B	lin-28 homolog B (C. elegans)
chr2_+_171280046	2.218	NM_001003845	SP5	Sp5 transcription factor
chr2_-_74606819	2.007	NM_133637	DQX1	DEAQ box RNA-dependent ATPase 1
chr2_+_171280944	1.984		SP5	Sp5 transcription factor
chr2_+_171280182	1.941
chr10_+_4995685	1.824		AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr4_-_186969041	1.703	NM_001145672	SORBS2	sorbin and SH3 domain containing 2
chr4_-_186969202	1.664	NM_001145671	SORBS2	sorbin and SH3 domain containing 2
chr14_+_94148466	1.508	NM_001085	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr17_-_40858775	1.474	NM_199282	ARHGAP27	Rho GTPase activating protein 27
chr10_+_4995597	1.443		AKR1C1 AKR1C3	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr3_+_10832867	1.280	NM_014229	SLC6A11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr2_+_228386800	1.265	NM_001130046 NM_004591	CCL20	chemokine (C-C motif) ligand 20
chr20_-_22513050	1.243	NM_021784	FOXA2	forkhead box A2
chr11_-_65070625	1.240		LTBP3	latent transforming growth factor beta binding protein 3
chr12_+_130004404	1.070	NM_198827	GPR133	G protein-coupled receptor 133
chr14_-_22516271	1.064	NM_198086	JUB	jub, ajuba homolog (Xenopus laevis)
chr14_-_23107106	1.060	NM_003917	AP1G2	adaptor-related protein complex 1, gamma 2 subunit
chr1_+_148496792	1.022	NM_012113	CA14	carbonic anhydrase XIV
chr10_+_114125955	0.971		ACSL5	acyl-CoA synthetase long-chain family member 5
chr3_-_49434874	0.958		AMT	aminomethyltransferase
chr11_+_73037382	0.893	NM_001130036	PLEKHB1	pleckstrin homology domain containing, family B (evectins) member 1
chr1_+_26609893	0.890		LIN28A	lin-28 homolog A (C. elegans)
chr17_+_53761293	0.889		LOC100506779	hypothetical LOC100506779
chr1_+_224477941	0.889	NM_031944	MIXL1	Mix1 homeobox-like 1 (Xenopus laevis)
chr14_-_23106779	0.884		AP1G2	adaptor-related protein complex 1, gamma 2 subunit
chr7_+_50318801	0.883		IKZF1	IKAROS family zinc finger 1 (Ikaros)
chr1_+_42920946	0.859		YBX1	Y box binding protein 1
chr10_+_24537725	0.858	NM_001098501 NM_019590	KIAA1217	KIAA1217
chr6_+_167456230	0.835	NM_031409	CCR6	chemokine (C-C motif) receptor 6
chr7_-_150283794	0.833	NM_172057	KCNH2	potassium voltage-gated channel, subfamily H (eag-related), member 2
chr1_+_144149794	0.831	NM_006472	TXNIP	thioredoxin interacting protein
chr16_+_11966464	0.829	NM_001192	TNFRSF17	tumor necrosis factor receptor superfamily, member 17
chr3_-_49701085	0.822	NM_020998	MST1	macrophage stimulating 1 (hepatocyte growth factor-like)
chr20_+_32926452	0.818		ACSS2	acyl-CoA synthetase short-chain family member 2
chr11_+_60858611	0.817		DAK	dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr14_-_23106372	0.810		AP1G2	adaptor-related protein complex 1, gamma 2 subunit
chr1_+_42920755	0.795		YBX1	Y box binding protein 1
chrX_-_135783496	0.794
chr1_+_42920635	0.790	NM_004559	YBX1	Y box binding protein 1
chr10_+_24538094	0.778		KIAA1217	KIAA1217
chr6_-_130578110	0.776	NM_152552	SAMD3	sterile alpha motif domain containing 3
chr15_-_50270856	0.775	NM_016194	GNB5	guanine nucleotide binding protein (G protein), beta 5
chr7_-_16471817	0.772	NM_015464	SOSTDC1	sclerostin domain containing 1
chr16_+_56259657	0.756	NM_170776	GPR97	G protein-coupled receptor 97
chr17_-_36346240	0.745		KRT23	keratin 23 (histone deacetylase inducible)
chrX_+_57329834	0.743	NM_174912	FAAH2	fatty acid amide hydrolase 2
chr2_+_176680251	0.737	NM_021192	HOXD11	homeobox D11
chr1_+_42920718	0.737		YBX1	Y box binding protein 1
chr12_-_23995109	0.728		SOX5	SRY (sex determining region Y)-box 5
chr1_+_42920685	0.719		YBX1	Y box binding protein 1
chr20_+_35406497	0.715	NM_005417	SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr1_+_26609819	0.713	NM_024674	LIN28A	lin-28 homolog A (C. elegans)
chr12_-_23995220	0.711		SOX5	SRY (sex determining region Y)-box 5
chr3_+_47004457	0.696		NBEAL2	neurobeachin-like 2
chr1_+_42920692	0.694		YBX1	Y box binding protein 1
chr16_-_51139214	0.691	NM_001146188	TOX3	TOX high mobility group box family member 3
chr1_+_42920683	0.688		YBX1	Y box binding protein 1
chr18_+_53863865	0.673		NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like
chrX_+_70360184	0.659		GJB1	gap junction protein, beta 1, 32kDa
chr1_+_151867483	0.659	NM_006271	S100A1	S100 calcium binding protein A1
chr3_-_140879463	0.646	NM_178177	NMNAT3	nicotinamide nucleotide adenylyltransferase 3
chr9_+_34642125	0.646	NM_001142784	IL11RA	interleukin 11 receptor, alpha
chr10_+_114125927	0.643	NM_016234	ACSL5	acyl-CoA synthetase long-chain family member 5
chr11_+_46358909	0.629	NM_001012334	MDK	midkine (neurite growth-promoting factor 2)
chr11_+_20000938	0.605		NAV2	neuron navigator 2
chr6_+_34867794	0.595		UHRF1BP1	UHRF1 binding protein 1
chr1_-_51198383	0.594		FAF1	Fas (TNFRSF6) associated factor 1
chr2_-_25328452	0.593	NM_153759	DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha
chr7_+_113853790	0.591	NM_001172767 NM_148899	FOXP2	forkhead box P2
chr5_+_147754467	0.581		FBXO38	F-box protein 38
chr1_-_151867338	0.576	NM_005979	S100A13	S100 calcium binding protein A13
chr4_+_109763119	0.576		RPL34	ribosomal protein L34
chr11_-_5227611	0.575	NM_000559	HBG1 HBG2	hemoglobin, gamma A hemoglobin, gamma G
chr12_+_56435042	0.564	NM_138396	MARCH9	membrane-associated ring finger (C3HC4) 9
chr12_+_97513644	0.559		SLC25A3	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
chr16_-_18845223	0.549	NM_015092	SMG1	SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chrX_+_152608159	0.549	NM_001142806	SLC6A8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr17_-_53761119	0.543	NM_004758 NM_024418	BZRAP1	benzodiazapine receptor (peripheral) associated protein 1
chr21_+_39745649	0.543	NM_007341	SH3BGR	SH3 domain binding glutamic acid-rich protein
chr2_-_61098867	0.536	NM_144709	PUS10	pseudouridylate synthase 10
chr10_+_114126004	0.534		ACSL5	acyl-CoA synthetase long-chain family member 5
chr3_-_42818221	0.534
chr1_-_51198052	0.528		FAF1	Fas (TNFRSF6) associated factor 1
chr2_-_61551350	0.524	NM_014709	USP34	ubiquitin specific peptidase 34
chr5_+_61750467	0.519	NM_001134779	IPO11	importin 11
chr19_-_45947667	0.518	NM_198476	C19orf54	chromosome 19 open reading frame 54
chr1_-_159459814	0.518		APOA2	apolipoprotein A-II
chrX_-_106033202	0.516	NM_001171706 NM_138382	RIPPLY1	ripply1 homolog (zebrafish)
chr1_-_167822248	0.515		F5	coagulation factor V (proaccelerin, labile factor)
chr17_+_38247493	0.514		PSME3	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr11_+_20001130	0.512	NM_001111019	NAV2	neuron navigator 2
chr20_+_42463350	0.508		HNF4A	hepatocyte nuclear factor 4, alpha
chr1_-_51198417	0.508		FAF1	Fas (TNFRSF6) associated factor 1
chr5_-_138746840	0.508		SLC23A1	solute carrier family 23 (nucleobase transporters), member 1
chr1_-_199259133	0.508		KIF21B	kinesin family member 21B
chr13_+_51496679	0.506	NM_021645	ALG11 UTP14C	asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast) UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr5_-_138746917	0.505	NM_005847 NM_152685	SLC23A1	solute carrier family 23 (nucleobase transporters), member 1
chr12_+_54760211	0.505		ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr12_+_73219826	0.504
chr18_+_30812205	0.502	NM_001143827	MAPRE2	microtubule-associated protein, RP/EB family, member 2
chr5_+_133478252	0.499	NM_003202	TCF7	transcription factor 7 (T-cell specific, HMG-box)
chr10_+_114125003	0.480	NM_203380	ACSL5	acyl-CoA synthetase long-chain family member 5
chr12_-_1791146	0.467		CACNA2D4	calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr2_+_218954995	0.466	NM_000578	SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr6_+_131936057	0.462	NM_000045	ARG1	arginase, liver
chr1_-_155053124	0.455	NM_001161441 NM_001161442 NM_001161444 NM_003975	SH2D2A	SH2 domain containing 2A
chr12_-_7172641	0.454	NM_031491	RBP5	retinol binding protein 5, cellular
chr17_+_22823151	0.453	NM_014238	KSR1	kinase suppressor of ras 1
chr20_+_42463279	0.453	NM_000457 NM_178849 NM_178850	HNF4A	hepatocyte nuclear factor 4, alpha
chr7_-_20793028	0.452	NM_182700 NM_198956	SP8	Sp8 transcription factor
chr3_+_152970904	0.449		LOC201651	arylacetamide deacetylase (esterase) pseudogene
chr2_+_218992053	0.449	NM_007127	VIL1	villin 1
chr2_-_61551403	0.443		USP34	ubiquitin specific peptidase 34
chr17_-_36232366	0.443	NM_000421	KRT10	keratin 10
chr19_+_10242763	0.441		ICAM1	intercellular adhesion molecule 1
chr3_-_197549588	0.436		TM4SF19	transmembrane 4 L six family member 19
chr1_-_44255583	0.434	NM_006934 NM_201649	SLC6A9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr12_+_119418294	0.429		DYNLL1	dynein, light chain, LC8-type 1
chr20_+_42463419	0.429		HNF4A	hepatocyte nuclear factor 4, alpha
chr7_-_96471544	0.425		DLX6-AS1	DLX6 antisense RNA 1 (non-protein coding)
chr1_-_16843764	0.423		CROCCP2	ciliary rootlet coiled-coil, rootletin pseudogene 2
chr2_+_27573206	0.420	NM_001486	GCKR	glucokinase (hexokinase 4) regulator
chr19_+_60283571	0.415	NM_017729	EPS8L1	EPS8-like 1
chr11_-_124311512	0.415	NM_152722	HEPACAM	hepatic and glial cell adhesion molecule
chr2_+_152900076	0.408		FMNL2	formin-like 2
chr20_+_42463387	0.407		HNF4A	hepatocyte nuclear factor 4, alpha
chrX_+_38545636	0.404		MID1IP1	MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr12_+_27740694	0.403	NM_001029874	REP15	RAB15 effector protein
chr1_-_23998515	0.403	NM_001127621	GALE	UDP-galactose-4-epimerase
chr17_+_43082302	0.402		KPNB1	karyopherin (importin) beta 1
chr10_-_123346148	0.400	NM_001144915	FGFR2	fibroblast growth factor receptor 2
chr6_+_124166767	0.399	NM_001040214 NM_153355	NKAIN2	Na+/K+ transporting ATPase interacting 2
chr11_-_118405288	0.397	NM_001164280	SLC37A4	solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr1_+_156991133	0.397	NM_001005184	OR6K6	olfactory receptor, family 6, subfamily K, member 6
chr16_-_87244896	0.390	NM_000101	CYBA	cytochrome b-245, alpha polypeptide
chr11_-_111255354	0.389	NM_138378	ALG9 FDXACB1	asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog (S. cerevisiae) ferredoxin-fold anticodon binding domain containing 1
chr1_-_16006779	0.388	NM_001089591	UQCRHL	ubiquinol-cytochrome c reductase hinge protein-like
chr10_+_7785235	0.387	NM_002216	ITIH2	inter-alpha (globulin) inhibitor H2
chrX_+_23595579	0.385		PRDX4	peroxiredoxin 4
chrX_-_15783015	0.384	NM_003916	AP1S2	adaptor-related protein complex 1, sigma 2 subunit
chr12_+_119418215	0.383	NM_001037495 NM_003746	DYNLL1	dynein, light chain, LC8-type 1
chr1_-_16843744	0.380		CROCCP2	ciliary rootlet coiled-coil, rootletin pseudogene 2
chr2_+_62787534	0.379	NM_001142614	EHBP1	EH domain binding protein 1
chr1_+_93072947	0.379		RPL5	ribosomal protein L5
chr12_-_51173238	0.374	NM_005554	KRT6A	keratin 6A
chr2_+_154436670	0.373	NM_052917	GALNT13	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
chr16_+_70646008	0.369	NM_001126102 NM_005143	HP	haptoglobin
chrX_+_38545597	0.369	NM_001098790 NM_001098791	MID1IP1	MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))
chr12_-_7935010	0.366		SLC2A14	solute carrier family 2 (facilitated glucose transporter), member 14
chr16_+_67697622	0.365	NM_138612	HAS3	hyaluronan synthase 3
chr1_+_42920729	0.360		YBX1	Y box binding protein 1
chr1_+_559129	0.359
chr2_+_169021039	0.359	NM_203463	LASS6	LAG1 homolog, ceramide synthase 6
chr4_-_68793928	0.358	NM_182502	TMPRSS11B	transmembrane protease, serine 11B
chr3_+_143797895	0.356	NM_001145319	PLS1	plastin 1
chr17_-_44226595	0.354	NM_173623	TTLL6	tubulin tyrosine ligase-like family, member 6
chr1_+_32489426	0.352	NM_005356	LCK	lymphocyte-specific protein tyrosine kinase
chr1_-_51198328	0.352		FAF1	Fas (TNFRSF6) associated factor 1
chr1_-_167822334	0.352	NM_000130	F5	coagulation factor V (proaccelerin, labile factor)
chr1_+_17719405	0.352		ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like
chr1_-_51198506	0.351	NM_007051	FAF1	Fas (TNFRSF6) associated factor 1
chr17_+_38014883	0.349	NM_001070	TUBG1	tubulin, gamma 1
chr8_+_86345274	0.346
chrX_+_70359780	0.344	NM_000166	GJB1	gap junction protein, beta 1, 32kDa
chr19_+_41419165	0.344		ZNF146	zinc finger protein 146
chr17_+_43082273	0.344	NM_002265	KPNB1	karyopherin (importin) beta 1
chrX_-_154216929	0.341	NM_001289	CLIC2	chloride intracellular channel 2
chr1_+_158317967	0.340	NM_004983	KCNJ9	potassium inwardly-rectifying channel, subfamily J, member 9
chr16_+_70654625	0.339	NM_020995	HPR	haptoglobin-related protein
chr3_-_197549640	0.338	NM_138461	TM4SF19	transmembrane 4 L six family member 19
chr20_+_43943254	0.335	NM_080603	ZSWIM1	zinc finger, SWIM-type containing 1
chr3_-_186752952	0.335	NM_139248	LIPH	lipase, member H
chr6_+_30402599	0.334	NM_021253	TRIM39	tripartite motif containing 39
chr20_-_54013418	0.333	NM_080617	CBLN4	cerebellin 4 precursor
chr8_-_42353719	0.333	NM_014420	DKK4	dickkopf homolog 4 (Xenopus laevis)
chr20_+_55338221	0.330	NM_012444 NM_198265	SPO11	SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)
chr21_+_42697058	0.330	NM_001001895 NM_018961	UBASH3A	ubiquitin associated and SH3 domain containing A
chr9_+_109131814	0.328		RAD23B	RAD23 homolog B (S. cerevisiae)
chr9_+_114289178	0.326		KIAA1958	KIAA1958
chr17_-_77462506	0.320	NM_001184917 NM_002861	PCYT2	phosphate cytidylyltransferase 2, ethanolamine
chr12_+_55148567	0.320	NM_207344	SPRYD4	SPRY domain containing 4
chr18_-_3209846	0.320		MYOM1	myomesin 1, 185kDa
chr5_+_176446425	0.320	NM_002011 NM_213647	FGFR4	fibroblast growth factor receptor 4
chr6_+_131190237	0.319	NM_001195597	LOC285733	hypothetical LOC285733
chr5_-_78318112	0.319	NM_000046	ARSB	arylsulfatase B
chr16_-_79811475	0.317	NM_001076780 NM_052892	PKD1L2	polycystic kidney disease 1-like 2
chr14_+_20537253	0.316	NM_014579	SLC39A2	solute carrier family 39 (zinc transporter), member 2
chr19_+_8180179	0.316	NM_024552	LASS4	LAG1 homolog, ceramide synthase 4
chr18_-_46977103	0.316		MEX3C	mex-3 homolog C (C. elegans)
chr1_-_12599934	0.316	NM_004753	DHRS3	dehydrogenase/reductase (SDR family) member 3
chr2_-_169455167	0.313	NM_020675	SPC25	SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr1_-_26505653	0.312	NM_001077262 NM_183008	UBXN11	UBX domain protein 11
chr1_+_42920889	0.311		YBX1	Y box binding protein 1
chr1_-_243092581	0.309		HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chr7_-_99365178	0.306	NM_181538	GJC3	gap junction protein, gamma 3, 30.2kDa
chr20_+_2465252	0.303	NM_080751	TMC2	transmembrane channel-like 2
chr20_-_2589476	0.302		IDH3B	isocitrate dehydrogenase 3 (NAD+) beta
chr12_+_54000611	0.300	NM_001005182	OR6C1	olfactory receptor, family 6, subfamily C, member 1
chr5_+_154072654	0.300	NM_015315	LARP1	La ribonucleoprotein domain family, member 1

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.22	1.85e-03	GO:0032501	multicellular organismal process
1.26	5.48e-03	GO:0023052	signaling
5.56	1.16e-02	GO:0045840	positive regulation of mitosis
5.56	1.16e-02	GO:0051785	positive regulation of nuclear division
1.55	1.38e-02	GO:0007154	cell communication

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.85	6.75e-03	GO:0015267	channel activity
1.84	7.26e-03	GO:0022803	passive transmembrane transporter activity
5.21	1.54e-02	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
1.79	2.49e-02	GO:0022838	substrate-specific channel activity
1.47	2.85e-02	GO:0022892	substrate-specific transporter activity
1.43	3.01e-02	GO:0005215	transporter activity
1.51	3.03e-02	GO:0022891	substrate-specific transmembrane transporter activity
1.89	3.70e-02	GO:0022836	gated channel activity
1.48	4.25e-02	GO:0022857	transmembrane transporter activity