Motif ID: FOXA2.p3

Z-value: 3.342


Transcription factors associated with FOXA2.p3:

Gene SymbolEntrez IDGene Name
FOXA2 3170 forkhead box A2



Activity profile for motif FOXA2.p3.

activity profile for motif FOXA2.p3


Sorted Z-values histogram for motif FOXA2.p3

Sorted Z-values for motif FOXA2.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXA2.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_69939130 6.971 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr3_-_150422474 6.512 NM_000096
CP
ceruloplasmin (ferroxidase)
chr6_+_131190237 6.354 NM_001195597
LOC285733
hypothetical LOC285733
chr4_+_69716298 6.077 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr3_-_71376919 5.200 FOXP1
forkhead box P1
chr12_+_119900931 5.193 NM_000545
HNF1A
HNF1 homeobox A
chr17_+_50699965 5.063 HLF
hepatic leukemia factor
chr3_+_152970904 5.029 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr12_-_51629874 4.885 KRT8
keratin 8
chr2_+_113601616 4.605 IL1RN
interleukin 1 receptor antagonist
chr12_+_119900677 4.595 HNF1A
HNF1 homeobox A
chr6_-_41823056 4.534 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr2_+_113601608 4.382 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr1_-_167822248 4.241 F5
coagulation factor V (proaccelerin, labile factor)
chr22_+_19458378 4.223 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr4_+_6746466 4.206 NM_005980
S100P
S100 calcium binding protein P
chr1_-_167822334 4.182 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr16_-_86527608 4.063 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr14_-_37134050 3.996 FOXA1
forkhead box A1
chr1_-_176205672 3.801 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr5_+_132237253 3.615 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chr10_+_101532544 3.572 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr2_-_233586164 3.562 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr12_-_9159707 3.411 A2M
alpha-2-macroglobulin
chr12_-_9159742 3.377 A2M
alpha-2-macroglobulin
chr2_-_233586145 3.362 NGEF
neuronal guanine nucleotide exchange factor
chr12_-_9159780 3.250 A2M
alpha-2-macroglobulin
chr10_+_7785360 3.153 ITIH2
inter-alpha (globulin) inhibitor H2
chr17_-_61655915 3.133 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr5_+_27508139 3.093 LOC643401
hypothetical protein LOC643401
chr10_+_7785347 3.078 ITIH2
inter-alpha (globulin) inhibitor H2
chr17_+_64922420 3.060 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr15_+_64661560 2.999


chr3_-_121883647 2.990 HGD
homogentisate 1,2-dioxygenase
chr10_+_7785235 2.946 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr3_-_121884091 2.946 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr10_+_7785290 2.931 ITIH2
inter-alpha (globulin) inhibitor H2
chr6_+_32003180 2.915 NM_000063
NM_001145903
C2

complement component 2

chr10_+_7785331 2.911 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_-_54201400 2.868 NM_000242
MBL2
mannose-binding lectin (protein C) 2, soluble
chr1_-_57204208 2.801 NM_000066
C8B
complement component 8, beta polypeptide
chr2_-_165133239 2.715 GRB14
growth factor receptor-bound protein 14
chr1_-_1346465 2.714 NM_001145210
LOC441869
hypothetical protein LOC441869
chr1_-_229627412 2.700 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr3_+_187813553 2.699 AHSG
alpha-2-HS-glycoprotein
chr17_-_23721351 2.673 VTN
vitronectin
chr5_+_147754467 2.651 FBXO38
F-box protein 38
chr10_+_101532450 2.616 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr4_-_186969202 2.603 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr11_+_22652894 2.585 NM_005256
GAS2
growth arrest-specific 2
chr17_-_23721430 2.573 VTN
vitronectin
chr5_-_42847716 2.562 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr4_+_39084936 2.485 KLB
klotho beta
chr6_-_26038817 2.423 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr14_-_20563698 2.367 NDRG2
NDRG family member 2
chr7_+_116238309 2.354 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr3_-_150569574 2.345 TM4SF1
transmembrane 4 L six family member 1
chr3_+_173043832 2.345 NM_001164436
TMEM212
transmembrane protein 212
chr11_-_117640078 2.335


chr1_+_16203317 2.321 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr1_-_20682541 2.286


chr18_-_50777634 2.274 NM_025214
CCDC68
coiled-coil domain containing 68
chr12_+_99391870 2.267 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr14_-_20563722 2.267 NM_016250
NM_201535
NM_201536
NM_201537
NDRG2



NDRG family member 2



chr11_-_116168316 2.264 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr17_-_6958695 2.263 ASGR2
asialoglycoprotein receptor 2
chr9_-_14900992 2.258 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chr18_+_27425727 2.239 NM_000371
TTR
transthyretin
chr11_+_22652957 2.228 GAS2
growth arrest-specific 2
chr12_-_101835026 2.222 PAH
phenylalanine hydroxylase
chr7_+_94953148 2.220 NM_016116
NM_145872
ASB4

ankyrin repeat and SOCS box containing 4

chr14_+_87560646 2.187 LOC283587
hypothetical protein LOC283587
chr14_-_22358752 2.179 NM_001126106
SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr4_+_39084867 2.156 NM_175737
KLB
klotho beta
chr12_+_99391681 2.139 NM_005123
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr2_-_21084077 2.124 APOB
apolipoprotein B (including Ag(x) antigen)
chr3_+_187813538 2.120 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr17_-_23721468 2.114 VTN
vitronectin
chr1_-_176205970 2.087 SEC16B
SEC16 homolog B (S. cerevisiae)
chr6_-_31953425 2.064 NM_001178045
SLC44A4
solute carrier family 44, member 4
chr17_-_23721420 2.014 VTN
vitronectin
chr12_-_9159789 2.002 NM_000014
A2M
alpha-2-macroglobulin
chr4_+_187424336 1.977 F11
coagulation factor XI
chr12_-_69837831 1.944 TSPAN8
tetraspanin 8
chr20_+_31334601 1.911 NM_033197
C20orf114
chromosome 20 open reading frame 114
chr14_-_93859394 1.885 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chrX_-_55037235 1.855 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr22_+_33792125 1.852 NM_001008494
ISX
intestine-specific homeobox
chr2_+_132196533 1.829 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr10_+_102722275 1.827 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr21_+_39117064 1.826 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr17_-_23721485 1.821 NM_000638
VTN
vitronectin
chr17_-_36418869 1.740 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr3_-_71715431 1.740 NM_001012505
NM_032682
FOXP1

forkhead box P1

chr20_+_41621079 1.729 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr2_-_135498716 1.718 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr1_-_159459999 1.677 NM_001643
APOA2
apolipoprotein A-II
chr8_-_30121741 1.635 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chr18_+_53863865 1.610 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr3_+_187813405 1.595 AHSG
alpha-2-HS-glycoprotein
chr12_-_69838045 1.592 NM_004616
TSPAN8
tetraspanin 8
chr10_-_44794146 1.590 NM_007021
C10orf10
chromosome 10 open reading frame 10
chrX_-_15198093 1.579 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr14_+_104337923 1.548 NM_001137601
ZBTB42
zinc finger and BTB domain containing 42
chr6_+_112481970 1.545 NM_003880
NM_198239
WISP3

WNT1 inducible signaling pathway protein 3

chr4_+_187424111 1.544 NM_000128
F11
coagulation factor XI
chr14_+_20226762 1.541 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr9_-_115880494 1.513 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr5_+_59819761 1.512 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chrX_-_106033202 1.491 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr6_+_64414389 1.490 NM_015153
PHF3
PHD finger protein 3
chr1_-_205272619 1.475 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr10_-_69267774 1.475 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr1_-_20179495 1.461 NM_000300
NM_001161727
NM_001161728
PLA2G2A


phospholipase A2, group IIA (platelets, synovial fluid)


chr17_+_7423685 1.456 CD68
CD68 molecule
chr2_-_21120314 1.442 APOB
apolipoprotein B (including Ag(x) antigen)
chr17_+_7423704 1.440 CD68
CD68 molecule
chr17_+_7423662 1.436 CD68
CD68 molecule
chr22_-_25205376 1.435 NM_152841
HPS4
Hermansky-Pudlak syndrome 4
chr13_+_49658016 1.430


chr5_+_175908948 1.427 NM_017675
CDHR2
cadherin-related family member 2
chr2_+_11591692 1.406 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr3_-_49434874 1.386 AMT
aminomethyltransferase
chr21_-_42608531 1.378 TFF3
trefoil factor 3 (intestinal)
chr17_-_6958773 1.367 NM_001181
NM_080912
NM_080913
ASGR2


asialoglycoprotein receptor 2


chr2_-_192420168 1.361 NM_004657
SDPR
serum deprivation response
chr5_-_59819642 1.346 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_+_27740694 1.329 NM_001029874
REP15
RAB15 effector protein
chr19_-_63715135 1.284 NM_012254
SLC27A5
solute carrier family 27 (fatty acid transporter), member 5
chr1_-_150070849 1.281 NM_005060
RORC
RAR-related orphan receptor C
chr13_-_47885018 1.273 LPAR6
lysophosphatidic acid receptor 6
chr4_+_187385618 1.261 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr1_+_212228482 1.260 NM_002763
PROX1
prospero homeobox 1
chr2_-_32344192 1.259 NM_021209
NLRC4
NLR family, CARD domain containing 4
chrX_-_10761729 1.243 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr1_+_148496792 1.222 NM_012113
CA14
carbonic anhydrase XIV
chr20_+_31613800 1.222 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr6_+_26359805 1.219 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr9_+_34643911 1.215 NM_004512
NM_147162
IL11RA

interleukin 11 receptor, alpha

chr17_+_38259620 1.213 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr13_-_47885248 1.209 LPAR6
lysophosphatidic acid receptor 6
chrX_+_49718954 1.207 NM_000084
CLCN5
chloride channel 5
chr14_+_104338423 1.188 ZBTB42
zinc finger and BTB domain containing 42
chr17_+_7423528 1.184 NM_001251
NM_001040059
CD68

CD68 molecule

chr1_+_40486159 1.174 NM_001008740
TMCO2
transmembrane and coiled-coil domains 2
chr20_-_52120421 1.169 BCAS1
breast carcinoma amplified sequence 1
chr19_+_18357966 1.154 NM_004864
GDF15
growth differentiation factor 15
chr22_-_35835548 1.153 TMPRSS6
transmembrane protease, serine 6
chr7_-_50596238 1.123 NM_000790
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr1_+_15351885 1.118 TMEM51
transmembrane protein 51
chr6_-_32227695 1.112 NM_030651
PRRT1
proline-rich transmembrane protein 1
chr17_-_43390108 1.103 NM_024320
PRR15L
proline rich 15-like
chr8_+_18072250 1.092 NM_001160179
NAT1
N-acetyltransferase 1 (arylamine N-acetyltransferase)
chr11_+_5431213 1.086 NM_001004754
OR51I2
olfactory receptor, family 51, subfamily I, member 2
chr1_+_15351585 1.086 NM_001136216
NM_001136217
TMEM51

transmembrane protein 51

chr7_+_113842470 1.085 FOXP2
forkhead box P2
chr2_+_173394560 1.083 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr1_-_177106702 1.070 NM_004673
ANGPTL1
angiopoietin-like 1
chr9_-_116305273 1.067 NM_001083885
DFNB31
deafness, autosomal recessive 31
chr2_-_20390601 1.064 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr10_-_21847126 1.063


chr6_+_31731647 1.054 NM_019101
APOM
apolipoprotein M
chr2_-_39201631 1.054 SOS1
son of sevenless homolog 1 (Drosophila)
chr1_-_159604287 1.049 NM_001013625
C1orf192
chromosome 1 open reading frame 192
chrX_-_131375217 1.049 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr11_-_63690069 1.048 NM_014067
MACROD1
MACRO domain containing 1
chr14_+_38772870 1.040 NM_054024
MIA2
melanoma inhibitory activity 2
chr1_+_54132447 1.036 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr7_+_99263571 1.030 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr17_-_23757312 1.028 NM_080669
SLC46A1
solute carrier family 46 (folate transporter), member 1
chr4_-_40211324 1.020 RBM47
RNA binding motif protein 47
chr2_-_21120398 1.015 APOB
apolipoprotein B (including Ag(x) antigen)
chr5_+_76150637 1.014 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr2_-_21084911 1.013 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_109651140 1.012 NM_001010985
MYBPHL
myosin binding protein H-like
chr4_+_74496575 1.008 ALB
albumin
chr1_-_57057956 1.007 NM_001004303
C1orf168
chromosome 1 open reading frame 168
chr11_+_22646229 1.000 NM_177553
GAS2
growth arrest-specific 2
chr20_+_41621119 0.996 SGK2
serum/glucocorticoid regulated kinase 2
chr11_-_6418705 0.994 NM_000613
HPX
hemopexin
chr2_-_21120420 0.992 NM_000384
APOB
apolipoprotein B (including Ag(x) antigen)
chr2_+_11597530 0.990 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr10_+_114144512 0.986 ACSL5
acyl-CoA synthetase long-chain family member 5
chr4_-_69852090 0.976 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr10_+_685887 0.974 C10orf108
chromosome 10 open reading frame 108
chr1_-_150079656 0.965 NM_001136003
C2CD4D
C2 calcium-dependent domain containing 4D
chrX_+_99726445 0.954 NM_022144
TNMD
tenomodulin
chr3_-_124822113 0.949 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr11_-_117628211 0.946 NM_198275
MPZL3
myelin protein zero-like 3
chr6_+_50789215 0.943 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr5_+_92944680 0.938 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr11_+_62893836 0.928 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr15_+_94670160 0.921 NM_001145155
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr1_+_74473672 0.918 NM_015978
TNNI3K
TNNI3 interacting kinase
chr11_-_63689780 0.911 MACROD1
MACRO domain containing 1
chr17_+_9686572 0.909 GLP2R
glucagon-like peptide 2 receptor
chr11_-_16953135 0.901 RPL36A
ribosomal protein L36a
chr2_+_241776596 0.895 NM_001001666
NM_001001891
ANO7

anoctamin 7

chr11_+_22644732 0.890 NM_001143830
GAS2
growth arrest-specific 2
chr17_-_74990157 0.880 NM_001082575
RBFOX3
RNA binding protein, fox-1 homolog (C. elegans) 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.22 1.42e-05 GO:0007606 sensory perception of chemical stimulus
2.23 7.37e-05 GO:0007608 sensory perception of smell
1.22 4.55e-04 GO:0050896 response to stimulus
1.24 1.86e-03 GO:0032501 multicellular organismal process
1.71 3.96e-03 GO:0007600 sensory perception
4.82 8.20e-03 GO:0031214 biomineral tissue development
1.44 2.02e-02 GO:0003008 system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.49 7.58e-06 GO:0005576 extracellular region
1.57 3.07e-03 GO:0044421 extracellular region part
1.23 1.14e-02 GO:0071944 cell periphery
1.22 1.72e-02 GO:0005886 plasma membrane
1.58 2.90e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.30 9.62e-06 GO:0004984 olfactory receptor activity
2.87 3.66e-04 GO:0030414 peptidase inhibitor activity
2.91 4.34e-04 GO:0004866 endopeptidase inhibitor activity
1.72 5.96e-04 GO:0004930 G-protein coupled receptor activity
3.56 6.01e-04 GO:0004867 serine-type endopeptidase inhibitor activity
2.80 9.54e-04 GO:0061135 endopeptidase regulator activity
2.58 1.35e-03 GO:0061134 peptidase regulator activity
1.51 5.36e-03 GO:0004888 transmembrane receptor activity
1.39 2.53e-02 GO:0004872 receptor activity