Motif ID: NFE2L2.p2

Z-value: 2.339


Transcription factors associated with NFE2L2.p2:

Gene SymbolEntrez IDGene Name
NFE2L2 4780 nuclear factor (erythroid-derived 2)-like 2



Activity profile for motif NFE2L2.p2.

activity profile for motif NFE2L2.p2


Sorted Z-values histogram for motif NFE2L2.p2

Sorted Z-values for motif NFE2L2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_977163 4.959 NM_022042
NM_134425
NM_213613
SLC26A1


solute carrier family 26 (sulfate transporter), member 1


chr19_-_54350457 3.512 NM_002152
HRC
histidine rich calcium binding protein
chr7_+_37926943 3.498 EPDR1
ependymin related protein 1 (zebrafish)
chr22_+_43451600 3.434 PRR5
proline rich 5 (renal)
chr10_-_76538859 3.319 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr1_-_156923111 3.218 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr22_+_43451351 3.020 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr16_-_28528149 2.928 NM_177530
NM_177534
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr20_+_34206070 2.888 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr16_+_2023279 2.661 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chrX_-_154216929 2.659 NM_001289
CLIC2
chloride intracellular channel 2
chr22_+_19699441 2.642 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr19_-_53914768 2.618 NM_001130915
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr16_+_88515917 2.602 NM_001197181
TUBB3
tubulin, beta 3
chrX_-_100527799 2.559 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chrX_+_9391314 2.488 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr9_-_126309510 2.466 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr12_+_54361685 2.464 METTL7B
methyltransferase like 7B
chr11_+_118463906 2.335 NM_001024382
HMBS
hydroxymethylbilane synthase
chr17_-_25642962 2.289 NM_000386
BLMH
bleomycin hydrolase
chr6_-_30792830 2.273 MDC1
mediator of DNA-damage checkpoint 1
chr16_-_28528780 2.250 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr12_+_54361596 2.194 NM_152637
METTL7B
methyltransferase like 7B
chr4_+_22608252 2.169


chr22_+_21340757 2.159


chr20_-_581844 2.136 NM_080725
SRXN1
sulfiredoxin 1
chr17_+_72883759 2.073 NM_001113494
SEPT9
septin 9
chr6_-_32121784 2.064 NM_032470
TNXB
tenascin XB
chr6_-_31853027 2.060 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr6_-_30793436 2.042 NM_014641
MDC1
mediator of DNA-damage checkpoint 1
chr3_+_142569988 2.017 ZBTB38
zinc finger and BTB domain containing 38
chr20_+_41621079 1.979 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr8_-_30704762 1.955 GSR
glutathione reductase
chr20_+_41621119 1.944 SGK2
serum/glucocorticoid regulated kinase 2
chr9_-_139042416 1.933 ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr16_+_30903963 1.906 NM_001142777
NM_001142778
NM_025193
HSD3B7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr16_-_28515195 1.898 NM_177528
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr9_-_139042526 1.897 NM_001606
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr6_+_150112537 1.849 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr16_-_1369613 1.814 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chr22_+_21393107 1.808 IGLJ3
immunoglobulin lambda joining 3
chr3_-_115826481 1.778 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr1_-_45045543 1.710 NM_001013632
TCTEX1D4
Tctex1 domain containing 4
chr17_+_77910411 1.703 NM_207459
TEX19
testis expressed 19
chr8_-_11242408 1.690 LOC100129129
hypothetical LOC100129129
chr15_-_32875040 1.688 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr6_-_31812049 1.678 CLIC1
chloride intracellular channel 1
chr7_-_100667750 1.669 NM_014343
CLDN15
claudin 15
chr1_-_93030538 1.662 NM_005665
EVI5
ecotropic viral integration site 5
chr19_+_55398680 1.619 NM_001077186
NM_001145809
NM_024729
MYH14


myosin, heavy chain 14, non-muscle


chrX_+_153423652 1.579 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr1_+_153232685 1.572 NM_018655
LENEP
lens epithelial protein
chr6_+_150112511 1.566 NM_005389
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr12_-_51629874 1.551 KRT8
keratin 8
chr3_-_121883647 1.537 HGD
homogentisate 1,2-dioxygenase
chr5_+_179180447 1.533 NM_003900
SQSTM1
sequestosome 1
chr22_+_21079355 1.529


chr9_-_115880372 1.516 AMBP
alpha-1-microglobulin/bikunin precursor
chr6_+_32229599 1.513 NM_005155
PPT2-EGFL8
PPT2
PPT2-EGFL8 read-through transcript
palmitoyl-protein thioesterase 2
chr22_+_20316968 1.504 NM_152612
CCDC116
coiled-coil domain containing 116
chr16_-_30032330 1.492 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr22_+_21116283 1.477


chr6_-_31812266 1.465 CLIC1
chloride intracellular channel 1
chr5_+_179180509 1.463 SQSTM1
sequestosome 1
chr6_-_31812251 1.457 CLIC1
chloride intracellular channel 1
chr22_+_21094094 1.452


chr16_-_68317945 1.432 NM_000903
NM_001025433
NM_001025434
NQO1


NAD(P)H dehydrogenase, quinone 1


chr6_-_31812260 1.427 CLIC1
chloride intracellular channel 1
chr3_-_121884091 1.425 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr6_-_31812214 1.407 CLIC1
chloride intracellular channel 1
chr6_-_31812283 1.399 CLIC1
chloride intracellular channel 1
chr14_+_102672745 1.395 TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr2_+_87536174 1.386 NCRNA00152
non-protein coding RNA 152
chr19_-_10474266 1.385 NM_012289
KEAP1
kelch-like ECH-associated protein 1
chr6_+_32229278 1.385 NM_138717
PPT2
palmitoyl-protein thioesterase 2
chr6_+_150112549 1.364 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr6_-_31812072 1.360 CLIC1
chloride intracellular channel 1
chr16_+_82544327 1.344 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr6_+_32003380 1.343 C2
complement component 2
chr7_+_72883128 1.339 NM_001305
CLDN4
claudin 4
chr2_+_87536106 1.327 NCRNA00152
non-protein coding RNA 152
chr22_+_21484240 1.323


chr5_+_179180517 1.322 SQSTM1
sequestosome 1
chr9_+_129962292 1.308 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr19_-_56260135 1.300 NM_015596
KLK13
kallikrein-related peptidase 13
chr16_+_29984611 1.295 ALDOA
aldolase A, fructose-bisphosphate
chr17_+_44429748 1.293 NM_001160423
NM_006546
IGF2BP1

insulin-like growth factor 2 mRNA binding protein 1

chr17_-_53764867 1.293


chr19_-_50977592 1.283 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr6_-_31812297 1.279 NM_001288
CLIC1
chloride intracellular channel 1
chr22_+_21495273 1.258


chr17_+_14145051 1.246 NM_006041
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr16_+_29984544 1.242 NM_184041
ALDOA
aldolase A, fructose-bisphosphate
chr22_-_39189369 1.239 MKL1
megakaryoblastic leukemia (translocation) 1
chr22_+_21407066 1.236


chr22_+_21042091 1.219 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr6_-_36518643 1.216 NM_152990
PXT1
peroxisomal, testis specific 1
chr16_+_29984647 1.213 ALDOA
aldolase A, fructose-bisphosphate
chr6_+_36518521 1.213 NM_173562
KCTD20
potassium channel tetramerisation domain containing 20
chr5_-_90645974 1.203 LOC100505994
hypothetical LOC100505994
chr7_+_111850367 1.199 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr6_+_64289585 1.194 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr9_+_139041736 1.192 NM_207511
C9orf139
chromosome 9 open reading frame 139
chr17_+_77529070 1.185 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr7_-_150352484 1.178 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chr17_+_77261477 1.177 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr6_+_36518778 1.170 KCTD20
potassium channel tetramerisation domain containing 20
chr22_+_18388656 1.164 C22orf25
chromosome 22 open reading frame 25
chr22_+_20899155 1.160


chr22_-_25344037 1.146 CRYBB1
crystallin, beta B1
chr1_+_26220852 1.146 NM_004455
EXTL1
exostoses (multiple)-like 1
chr9_-_115880494 1.125 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr19_+_18560494 1.121 NM_001100418
NM_001100419
C19orf60

chromosome 19 open reading frame 60

chr9_-_115880425 1.118 AMBP
alpha-1-microglobulin/bikunin precursor
chr7_+_139175420 1.113 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr22_+_21053972 1.112


chr16_+_29984591 1.111 ALDOA
aldolase A, fructose-bisphosphate
chr11_+_46358909 1.107 NM_001012334
MDK
midkine (neurite growth-promoting factor 2)
chr19_-_43926953 1.104 NM_144691
CAPN12
calpain 12
chr17_+_77261401 1.103 NM_004712
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr2_-_219881937 1.102 PTPRN
protein tyrosine phosphatase, receptor type, N
chr19_-_50977485 1.095 DMPK
dystrophia myotonica-protein kinase
chr16_+_29984621 1.087 ALDOA
aldolase A, fructose-bisphosphate
chr9_-_115880366 1.077 AMBP
alpha-1-microglobulin/bikunin precursor
chr6_+_31782618 1.077 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr1_+_19511326 1.076 NM_001040125
NM_001040126
NM_017765
PQLC2


PQ loop repeat containing 2


chr16_+_28413421 1.071 NM_018690
APOBR
apolipoprotein B receptor
chr12_+_54910767 1.070 NM_001135195
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr2_+_119905812 1.066 NM_183240
TMEM37
transmembrane protein 37
chr22_+_21359175 1.066 IGLV3-25
immunoglobulin lambda variable 3-25
chr20_+_48240772 1.064 NM_005194
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr22_+_21370394 1.063 IGL@
immunoglobulin lambda locus
chr22_-_25343959 1.060 NM_001887
CRYBB1
crystallin, beta B1
chr11_+_123600553 1.057 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr2_+_74635019 1.057 NM_001381
DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr11_+_2881080 1.056 SLC22A18
solute carrier family 22, member 18
chr20_+_48240705 1.054 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr17_+_77261440 1.048 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr5_-_75954807 1.041 NM_004101
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr1_-_199390183 1.035 TMEM9
transmembrane protein 9
chr14_+_38772870 1.023 NM_054024
MIA2
melanoma inhibitory activity 2
chr10_-_71562520 1.016 AIFM2
apoptosis-inducing factor, mitochondrion-associated, 2
chr1_+_26220895 1.008 EXTL1
exostoses (multiple)-like 1
chr5_-_149515613 0.998 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr10_+_134751398 0.989 NM_001083909
GPR123
G protein-coupled receptor 123
chr1_+_17507276 0.975 NM_012387
PADI4
peptidyl arginine deiminase, type IV
chr19_-_50977586 0.973 DMPK
dystrophia myotonica-protein kinase
chr17_-_74433048 0.959 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr3_+_185377341 0.955 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr1_-_172258129 0.953


chr9_+_131291224 0.952 LOC100506190
hypothetical LOC100506190
chr15_+_57691382 0.935 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr5_-_149515502 0.934 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr9_-_115880281 0.933 AMBP
alpha-1-microglobulin/bikunin precursor
chr3_-_180460372 0.933 NM_171829
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr2_-_11523666 0.910 E2F6
E2F transcription factor 6
chr14_-_22658078 0.907 NM_001805
CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr17_-_77474597 0.907 NM_032711
MAFG
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr12_+_63084317 0.902 NM_007235
XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr16_-_4778317 0.896 NM_001154458
NM_144605
SEPT12

septin 12

chr1_-_52116994 0.895 NRD1
nardilysin (N-arginine dibasic convertase)
chr22_+_21006814 0.894


chr17_+_77261457 0.892


chr2_-_11523727 0.890 NM_198256
E2F6
E2F transcription factor 6
chr2_+_27358800 0.890 NM_032546
NM_187841
TRIM54

tripartite motif containing 54

chr6_-_28429950 0.889 NM_145909
ZNF323
zinc finger protein 323
chr20_+_8060762 0.888 NM_015192
NM_182734
PLCB1

phospholipase C, beta 1 (phosphoinositide-specific)

chr1_-_52117021 0.877 NM_001101662
NM_002525
NRD1

nardilysin (N-arginine dibasic convertase)

chr5_-_95184121 0.872 GLRX
glutaredoxin (thioltransferase)
chr1_-_52116965 0.869 NRD1
nardilysin (N-arginine dibasic convertase)
chr20_+_48240867 0.869 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr5_-_95184221 0.866 NM_001118890
NM_002064
GLRX

glutaredoxin (thioltransferase)

chr16_+_30876115 0.865 NM_014712
SETD1A
SET domain containing 1A
chr1_-_176205672 0.860 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr17_+_27795635 0.857 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr22_+_21065134 0.851 LOC100290481
immunoglobulin lambda light chain-like
chr22_-_17846621 0.841 UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr17_-_35140307 0.839 NM_032339
C17orf37
chromosome 17 open reading frame 37
chr17_-_71287417 0.839 NM_005324
H3F3B
H3 histone, family 3B (H3.3B)
chr1_-_45249603 0.833 NM_024602
HECTD3
HECT domain containing 3
chr22_-_17846725 0.831 NM_001035247
NM_005659
UFD1L

ubiquitin fusion degradation 1 like (yeast)

chr15_+_38520594 0.829 NM_014952
BAHD1
bromo adjacent homology domain containing 1
chr12_-_54387934 0.829 NM_001144996
NM_002206
ITGA7

integrin, alpha 7

chr3_+_185377430 0.829 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr17_+_71109734 0.823 MYO15B
myosin XVB pseudogene
chr7_+_150319076 0.815 NM_000603
NOS3
nitric oxide synthase 3 (endothelial cell)
chr1_-_223683141 0.813 NM_194442
LBR
lamin B receptor
chr14_+_22422270 0.811 NM_173527
REM2
RAS (RAD and GEM)-like GTP binding 2
chr14_-_23847024 0.810 CIDEB
cell death-inducing DFFA-like effector b
chr20_-_61728866 0.809 GMEB2
glucocorticoid modulatory element binding protein 2
chrX_-_152863251 0.800 NM_002910
RENBP
renin binding protein
chr16_+_30326077 0.799 NM_001142305
NM_016643
ZNF771

zinc finger protein 771

chr17_-_74432800 0.797 TIMP2
TIMP metallopeptidase inhibitor 2
chr8_-_59734975 0.795 NSMAF
neutral sphingomyelinase (N-SMase) activation associated factor
chr10_-_71562602 0.794 NM_001198696
NM_032797
AIFM2

apoptosis-inducing factor, mitochondrion-associated, 2

chr16_+_155972 0.794 NM_001003938
HBM
hemoglobin, mu
chr1_+_12046020 0.792 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr12_-_101835026 0.791 PAH
phenylalanine hydroxylase
chr22_+_21065202 0.789


chr1_-_159543847 0.788 MPZ
myelin protein zero

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.33 1.22e-03 GO:0051351 positive regulation of ligase activity
5.02 5.94e-03 GO:0006521 regulation of cellular amino acid metabolic process
3.77 8.07e-03 GO:0051340 regulation of ligase activity
3.98 1.69e-02 GO:0051443 positive regulation of ubiquitin-protein ligase activity
4.36 2.79e-02 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
4.36 2.79e-02 GO:0072395 signal transduction involved in cell cycle checkpoint
4.36 2.79e-02 GO:0072401 signal transduction involved in DNA integrity checkpoint
4.36 2.79e-02 GO:0072404 signal transduction involved in G1/S transition checkpoint
4.36 2.79e-02 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
4.36 2.79e-02 GO:0072422 signal transduction involved in DNA damage checkpoint
4.36 2.79e-02 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
4.36 2.79e-02 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
4.06 2.81e-02 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
4.16 4.64e-02 GO:0033238 regulation of cellular amine metabolic process
4.16 4.64e-02 GO:0071158 positive regulation of cell cycle arrest

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.58 1.14e-03 GO:0000502 proteasome complex
1.27 1.03e-02 GO:0005886 plasma membrane
1.26 1.88e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
4.99 2.50e-02 GO:0003823 antigen binding