Motif ID: TBX4,5.p2

Z-value: 1.977


Transcription factors associated with TBX4,5.p2:

Gene SymbolEntrez IDGene Name
TBX4 9496 T-box 4
TBX5 6910 T-box 5



Activity profile for motif TBX4,5.p2.

activity profile for motif TBX4,5.p2


Sorted Z-values histogram for motif TBX4,5.p2

Sorted Z-values for motif TBX4,5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX4,5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_205161821 2.156 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr17_+_53769562 1.829 LOC100506779
hypothetical LOC100506779
chr17_+_4621924 1.748 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr22_-_28992787 1.727 NM_020530
OSM
oncostatin M
chr10_+_114125003 1.667 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr19_-_43800374 1.612 NM_001042600
NM_007181
MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

chr17_-_6958282 1.577 NM_080914
ASGR2
asialoglycoprotein receptor 2
chr4_-_105631915 1.359 NM_025212
CXXC4
CXXC finger protein 4
chr19_+_17377502 1.351 LOC100507535
hypothetical LOC100507535
chr19_-_10074332 1.275 NM_031917
ANGPTL6
angiopoietin-like 6
chr12_-_116021473 1.137 NM_001168325
NM_017899
TESC

tescalcin

chr6_+_31651319 1.130 NM_000594
TNF
tumor necrosis factor
chr5_+_133889584 1.099 NM_015288
PHF15
PHD finger protein 15
chr16_-_49272741 1.083 NM_001144972
NM_153337
NM_182854
SNX20


sorting nexin 20


chr22_+_37823174 1.077 NM_001166002
NM_001166003
NM_001166004
NM_181773
APOBEC3H



apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H



chr19_+_18312365 1.057 NM_017712
FKBP8
PGPEP1
FK506 binding protein 8, 38kDa
pyroglutamyl-peptidase I
chr3_+_187813553 1.023 AHSG
alpha-2-HS-glycoprotein
chr16_-_49272617 1.010 SNX20
sorting nexin 20
chr3_-_49701085 0.975 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr6_-_25044156 0.973 FAM65B
family with sequence similarity 65, member B
chr22_-_49363711 0.971 NM_004377
NM_152246
NM_001145134
NM_001145135
NM_001145136
NM_152245
CPT1B





carnitine palmitoyltransferase 1B (muscle)





chr4_-_105635499 0.969 CXXC4
CXXC finger protein 4
chr14_+_92188546 0.964 RIN3
Ras and Rab interactor 3
chr17_-_33178987 0.956 HNF1B
HNF1 homeobox B
chr22_+_23153529 0.955 NM_000675
ADORA2A
adenosine A2a receptor
chr4_-_186970366 0.952 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr10_+_114125955 0.941 ACSL5
acyl-CoA synthetase long-chain family member 5
chr20_+_8060762 0.940 NM_015192
NM_182734
PLCB1

phospholipase C, beta 1 (phosphoinositide-specific)

chr16_+_48865521 0.937 ADCY7
adenylate cyclase 7
chr14_+_94148466 0.933 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr6_-_32268615 0.927 GPSM3
G-protein signaling modulator 3
chr9_-_131845077 0.906 FNBP1
formin binding protein 1
chr17_+_31455332 0.888 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr17_-_16816113 0.888 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr15_+_86983038 0.885 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr1_-_114215768 0.879 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr3_+_52254782 0.878 PPM1M
protein phosphatase, Mg2+/Mn2+ dependent, 1M
chr6_+_167456230 0.878 NM_031409
CCR6
chemokine (C-C motif) receptor 6
chr11_-_124137260 0.876 NM_138961
ESAM
endothelial cell adhesion molecule
chr16_+_88512769 0.859 MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
chr2_+_219453487 0.856 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr12_+_130004404 0.851 NM_198827
GPR133
G protein-coupled receptor 133
chr7_+_29200850 0.848 CHN2
chimerin (chimaerin) 2
chr10_+_114125927 0.846 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr20_-_24987615 0.831 NM_032501
ACSS1
acyl-CoA synthetase short-chain family member 1
chr6_+_97479216 0.827 NM_052904
KLHL32
kelch-like 32 (Drosophila)
chr11_-_60819110 0.827 VWCE
von Willebrand factor C and EGF domains
chr9_-_116190038 0.818 AKNA
AT-hook transcription factor
chr3_+_114733907 0.811 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr3_-_121883647 0.807 HGD
homogentisate 1,2-dioxygenase
chr18_+_30810889 0.805 NM_001143826
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr1_+_26609819 0.799 NM_024674
LIN28A
lin-28 homolog A (C. elegans)
chr1_+_26609893 0.795 LIN28A
lin-28 homolog A (C. elegans)
chr7_-_960897 0.779 ADAP1
ArfGAP with dual PH domains 1
chr1_-_200395741 0.774 NM_080588
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr11_-_60819273 0.766 NM_152718
VWCE
von Willebrand factor C and EGF domains
chr14_-_53491019 0.761 NM_130851
BMP4
bone morphogenetic protein 4
chr2_+_96355661 0.760 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr11_+_19095215 0.760 NM_001001483
NM_019028
ZDHHC13

zinc finger, DHHC-type containing 13

chr20_-_22513050 0.759 NM_021784
FOXA2
forkhead box A2
chr9_-_131845277 0.756 NM_015033
FNBP1
formin binding protein 1
chr1_-_27825633 0.756 NM_001042729
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr17_+_72958207 0.751 NM_001113496
SEPT9
septin 9
chr20_-_4752067 0.748 NM_014737
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr16_+_28785087 0.743 SH2B1
SH2B adaptor protein 1
chr11_-_118405288 0.741 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr1_-_28375722 0.741 NM_001164723
PTAFR
platelet-activating factor receptor
chr2_+_171280944 0.739 SP5
Sp5 transcription factor
chr10_-_101831579 0.730 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr2_+_171280046 0.728 NM_001003845
SP5
Sp5 transcription factor
chr6_+_31731647 0.728 NM_019101
APOM
apolipoprotein M
chr14_+_23675233 0.726 PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr1_-_159459814 0.722 APOA2
apolipoprotein A-II
chr17_+_4841923 0.711 NM_006612
KIF1C
kinesin family member 1C
chr2_+_65070030 0.709 SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr5_+_139008667 0.708 CXXC5
CXXC finger protein 5
chr7_+_150065376 0.700 NM_018384
GIMAP5
GTPase, IMAP family member 5
chr16_+_10878539 0.695 NM_000246
CIITA
class II, major histocompatibility complex, transactivator
chr12_+_56435042 0.695 NM_138396
MARCH9
membrane-associated ring finger (C3HC4) 9
chr3_+_187813538 0.694 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr6_-_149847718 0.694 ZC3H12D
zinc finger CCCH-type containing 12D
chr6_+_28200365 0.689 NM_025231
ZSCAN16
zinc finger and SCAN domain containing 16
chr11_+_59979857 0.681 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chrX_+_46825179 0.677 RGN
regucalcin (senescence marker protein-30)
chr3_+_135996990 0.674 EPHB1
EPH receptor B1
chr5_+_133889243 0.674 PHF15
PHD finger protein 15
chr14_+_23675206 0.670 NM_006263
NM_176783
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr9_-_103237851 0.667 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr22_-_49317873 0.664 NM_001014440
ODF3B
outer dense fiber of sperm tails 3B
chr22_-_49363209 0.662 NM_001145137
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr22_-_35835548 0.662 TMPRSS6
transmembrane protease, serine 6
chr17_-_36346240 0.662 KRT23
keratin 23 (histone deacetylase inducible)
chr22_-_49317408 0.659 ODF3B
outer dense fiber of sperm tails 3B
chr1_-_205012348 0.658 NM_000572
IL10
interleukin 10
chr14_+_23508922 0.657 NM_001193636
NM_001193637
NM_001193635
DHRS4L2


DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 2


dehydrogenase/reductase (SDR family) member 4 like 1
chr7_-_22363036 0.653 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr20_-_44713466 0.651 NM_001193339
NM_001193342
NM_022829
SLC13A3


solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3


chr14_+_30413393 0.651 NM_001135058
NM_004086
COCH

coagulation factor C homolog, cochlin (Limulus polyphemus)

chr5_+_140870881 0.648


chr16_+_73810383 0.646 NM_001906
CTRB1
CTRB2
chymotrypsinogen B1
chymotrypsinogen B2
chr17_-_35273947 0.645 NM_012481
NM_183228
NM_183229
NM_183230
NM_183231
NM_183232
IKZF3





IKAROS family zinc finger 3 (Aiolos)





chr3_+_187813405 0.644 AHSG
alpha-2-HS-glycoprotein
chr2_+_127892489 0.644 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr17_+_72958330 0.642 SEPT9
septin 9
chrX_+_78087484 0.638 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr8_+_76482661 0.638 HNF4G
hepatocyte nuclear factor 4, gamma
chr3_+_135996734 0.637 NM_004441
EPHB1
EPH receptor B1
chr6_+_31691745 0.636 NM_032955
AIF1
allograft inflammatory factor 1
chr5_-_142795269 0.634 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr7_-_960785 0.633 NM_006869
ADAP1
ArfGAP with dual PH domains 1
chr19_+_51059357 0.632 NM_004497
FOXA3
forkhead box A3
chr19_-_8279157 0.632 NM_001165895
NM_016579
CD320

CD320 molecule

chr16_+_56134037 0.629 GPR114
G protein-coupled receptor 114
chr1_-_200396328 0.623 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr17_+_43165608 0.622 NM_013351
TBX21
T-box 21
chr6_-_89884324 0.619 NM_080743
SRSF12
serine/arginine-rich splicing factor 12
chr2_+_171280182 0.615


chr10_+_97505398 0.610 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr17_+_35277942 0.609 NM_198844
NM_199321
ZPBP2

zona pellucida binding protein 2

chr21_-_45786709 0.608 NM_194255
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr6_-_32268267 0.608 GPSM3
G-protein signaling modulator 3
chr6_+_167445284 0.607 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr17_+_22823151 0.606 NM_014238
KSR1
kinase suppressor of ras 1
chr7_+_29200636 0.606 NM_004067
CHN2
chimerin (chimaerin) 2
chr7_+_150065594 0.598 GIMAP5
GTPase, IMAP family member 5
chr5_-_78318112 0.593 NM_000046
ARSB
arylsulfatase B
chr2_-_61551403 0.591 USP34
ubiquitin specific peptidase 34
chr2_-_61551350 0.591 NM_014709
USP34
ubiquitin specific peptidase 34
chr16_+_55963899 0.585 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr16_+_56134077 0.585 NM_153837
GPR114
G protein-coupled receptor 114
chr17_-_50854054 0.583 NM_012329
MMD
monocyte to macrophage differentiation-associated
chr13_+_34414390 0.582 NM_015678
NBEA
neurobeachin
chr14_-_23734433 0.580 TM9SF1
transmembrane 9 superfamily member 1
chr19_+_54530512 0.579 CD37
CD37 molecule
chr19_-_5789740 0.576 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr8_-_145132551 0.576 PARP10
poly (ADP-ribose) polymerase family, member 10
chr5_+_140871107 0.576


chr2_+_170298700 0.574 KLHL23
kelch-like 23 (Drosophila)
chr1_+_204797516 0.574 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr2_+_74583130 0.573 LOC151534
hypothetical LOC151534
chr17_+_64922420 0.573 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr11_-_114880275 0.571 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr2_+_218992053 0.570 NM_007127
VIL1
villin 1
chr3_+_10832867 0.566 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr2_+_170298487 0.563


chr16_+_11966464 0.559 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr11_+_61279436 0.558 NM_013279
C11orf9
chromosome 11 open reading frame 9
chr6_+_31731667 0.557 APOM
apolipoprotein M
chr10_-_6144119 0.554 NM_000417
IL2RA
interleukin 2 receptor, alpha
chr2_-_231498184 0.551 NM_005683
GPR55
G protein-coupled receptor 55
chr6_+_32090516 0.551 NM_007293
NM_001002029
C4A
C4B
complement component 4A (Rodgers blood group)
complement component 4B (Chido blood group)
chr20_+_30103642 0.548 NM_001172129
NM_001172130
NM_001172131
NM_001172132
NM_001172133
NM_002110
HCK





hemopoietic cell kinase





chr19_+_7647934 0.545 NM_174918
C19orf59
chromosome 19 open reading frame 59
chr19_-_41191423 0.544 NM_001039876
C19orf46
chromosome 19 open reading frame 46
chr2_-_152663454 0.540 NM_001005746
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr22_-_35875890 0.539 NM_000878
IL2RB
interleukin 2 receptor, beta
chr16_+_55963883 0.537 CX3CL1
chemokine (C-X3-C motif) ligand 1
chr1_-_36721010 0.534 CSF3R
colony stimulating factor 3 receptor (granulocyte)
chr11_+_70915960 0.532 NM_001012503
KRTAP5-7
keratin associated protein 5-7
chr8_-_145132582 0.531 NM_032789
PARP10
poly (ADP-ribose) polymerase family, member 10
chr19_+_54530458 0.523 CD37
CD37 molecule
chr12_-_26877189 0.522 NM_002223
ITPR2
inositol 1,4,5-triphosphate receptor, type 2
chr12_-_47545816 0.512 NM_014470
RND1
Rho family GTPase 1
chr14_-_23734446 0.511 TM9SF1
transmembrane 9 superfamily member 1
chr19_+_54530546 0.509 CD37
CD37 molecule
chr8_+_56177567 0.505 NM_052898
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr2_-_152663748 0.503 NM_000726
NM_001145798
CACNB4

calcium channel, voltage-dependent, beta 4 subunit

chr2_+_74594093 0.501 TLX2
T-cell leukemia homeobox 2
chr17_-_40858775 0.499 NM_199282
ARHGAP27
Rho GTPase activating protein 27
chr1_-_27113018 0.498 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr3_-_10307408 0.497 NM_001134941
NM_016362
GHRL

ghrelin/obestatin prepropeptide

chr19_+_10242763 0.497 ICAM1
intercellular adhesion molecule 1
chr13_+_23742846 0.495 SPATA13
spermatogenesis associated 13
chr6_-_41781655 0.495 TFEB
transcription factor EB
chr17_+_39654808 0.491


chr15_-_36644122 0.491 NM_001128602
NM_005739
RASGRP1

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

chr13_-_99983945 0.490 NM_033110
A2LD1
AIG2-like domain 1
chr10_+_104145421 0.490 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr9_-_115877104 0.487 AMBP
alpha-1-microglobulin/bikunin precursor
chr2_-_197883739 0.485 NM_001195144
NM_153697
ANKRD44

ankyrin repeat domain 44

chr19_+_54530485 0.483 NM_001040031
NM_001774
CD37

CD37 molecule

chr8_+_145700272 0.483 NM_005309
GPT
glutamic-pyruvate transaminase (alanine aminotransferase)
chr9_+_115151632 0.482 NM_017688
BSPRY
B-box and SPRY domain containing
chr6_-_149847809 0.480 NM_207360
ZC3H12D
zinc finger CCCH-type containing 12D
chr1_-_57057956 0.476 NM_001004303
C1orf168
chromosome 1 open reading frame 168
chr19_-_56567602 0.476 NM_005601
NKG7
natural killer cell group 7 sequence
chr20_-_3133286 0.475 NM_023935
DDRGK1
DDRGK domain containing 1
chr15_-_63457378 0.472 NM_004884
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chr3_-_126576693 0.469 NM_021964
ZNF148
zinc finger protein 148
chrX_-_70248022 0.469 NM_000206
IL2RG
interleukin 2 receptor, gamma
chrX_+_153766442 0.468 NM_001017990
NM_080720
H2AFB2
H2AFB1
H2AFB3
H2A histone family, member B2
H2A histone family, member B1
H2A histone family, member B3
chr11_-_65070625 0.468 LTBP3
latent transforming growth factor beta binding protein 3
chr19_-_6621078 0.467 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr19_-_56561444 0.463 NM_001985
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr2_-_88946767 0.462


chr1_+_9522107 0.462 NM_032315
SLC25A33
solute carrier family 25, member 33
chr22_-_31732648 0.461 NM_003490
NM_133633
SYN3

synapsin III

chr5_+_132237253 0.460 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chr17_+_7283412 0.459 NM_004112
FGF11
fibroblast growth factor 11
chr3_+_16901455 0.454 NM_001144382
PLCL2
phospholipase C-like 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.32 9.73e-03 GO:0016126 sterol biosynthetic process
1.10 1.82e-02 GO:0065007 biological regulation
3.46 1.99e-02 GO:0006695 cholesterol biosynthetic process
1.17 4.73e-02 GO:0023052 signaling

Nothing significant found in compartment category.

Nothing significant found in function category.