Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 3.522


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)



Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_11597530 7.620 NM_148903
GREB1
growth regulation by estrogen in breast cancer 1
chr17_-_76985538 7.248


chr17_-_60986905 6.740 AXIN2
axin 2
chr6_-_128883125 6.415 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr12_-_120781002 6.146 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr13_+_75232797 5.193 NM_015842
LMO7
LIM domain 7
chr8_+_121892719 4.648


chr10_+_53744043 4.427 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr18_-_24011349 4.213 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr5_-_16791346 4.128 MYO10
myosin X
chr2_+_228386800 4.106 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr11_+_101488380 4.077 NM_001195045
YAP1
Yes-associated protein 1
chr18_-_24010944 4.077 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr5_-_58370693 3.813 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr7_-_27186400 3.778 NM_153715
HOXA10
homeobox A10
chr14_-_22521544 3.746 NM_032876
JUB
jub, ajuba homolog (Xenopus laevis)
chr2_-_75641587 3.735 NM_001135032
FAM176A
family with sequence similarity 176, member A
chr2_-_75641535 3.682 FAM176A
family with sequence similarity 176, member A
chr2_+_233443237 3.656 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr6_-_138935359 3.643 NM_020464
NHSL1
NHS-like 1
chr8_-_121892877 3.621 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr3_-_150422474 3.590 NM_000096
CP
ceruloplasmin (ferroxidase)
chr8_-_121893196 3.505


chr10_+_7785347 3.462 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785360 3.298 ITIH2
inter-alpha (globulin) inhibitor H2
chr6_+_167624792 3.151 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr10_+_7785331 3.118 ITIH2
inter-alpha (globulin) inhibitor H2
chr3_+_152970904 2.951 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr2_+_171280046 2.808 NM_001003845
SP5
Sp5 transcription factor
chr14_+_105012106 2.806 NM_001312
CRIP2
cysteine-rich protein 2
chr2_+_219354948 2.709 CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr15_-_63457378 2.707 NM_004884
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chr2_+_171280182 2.672


chr10_+_7785235 2.638 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr9_+_115265827 2.608 NM_017790
RGS3
regulator of G-protein signaling 3
chr9_+_96806235 2.593 C9orf3
chromosome 9 open reading frame 3
chr7_+_72883128 2.576 NM_001305
CLDN4
claudin 4
chr11_+_69165065 2.567 CCND1
cyclin D1
chr4_-_158111504 2.559 PDGFC
platelet derived growth factor C
chr6_-_2785682 2.548 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr17_+_72795567 2.506 NM_001113492
SEPT9
septin 9
chr19_+_59061422 2.483 NM_001020820
MYADM
myeloid-associated differentiation marker
chr6_+_144649142 2.482 UTRN
utrophin
chr6_+_131190237 2.464 NM_001195597
LOC285733
hypothetical LOC285733
chr4_-_7991992 2.463 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chr10_+_7785290 2.456 ITIH2
inter-alpha (globulin) inhibitor H2
chr7_+_29200636 2.431 NM_004067
CHN2
chimerin (chimaerin) 2
chr13_+_23042722 2.419 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr11_+_69165018 2.381 NM_053056
CCND1
cyclin D1
chr2_+_54537842 2.361 SPTBN1
spectrin, beta, non-erythrocytic 1
chr16_-_71639670 2.332 NM_006885
ZFHX3
zinc finger homeobox 3
chr11_+_69165119 2.331 CCND1
cyclin D1
chr10_+_114699953 2.327 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr3_-_150858274 2.314 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr1_-_229071957 2.249 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr17_+_7900926 2.222


chr11_+_69165159 2.199 CCND1
cyclin D1
chr2_+_69093641 2.171 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr14_-_64479198 2.160 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr4_-_158111916 2.146 PDGFC
platelet derived growth factor C
chr22_+_18330049 2.122 NM_007310
COMT
catechol-O-methyltransferase
chr4_-_158111995 2.113 NM_016205
PDGFC
platelet derived growth factor C
chr9_-_14858974 2.112 FREM1
FRAS1 related extracellular matrix 1
chr17_+_69939806 2.095 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr3_-_115960807 2.044 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr12_-_15833383 2.039 EPS8
epidermal growth factor receptor pathway substrate 8
chr8_-_145613034 2.024 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr18_-_63333487 2.002 DSEL
dermatan sulfate epimerase-like
chr1_-_95165089 1.999 NM_001839
CNN3
calponin 3, acidic
chr6_-_11340886 1.975 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr9_+_111927601 1.967 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr20_-_42457717 1.918


chr6_-_11340887 1.912 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr6_-_11340869 1.888 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr11_-_88864061 1.882 NM_001143836
NM_016931
NOX4

NADPH oxidase 4

chr9_-_126309510 1.868 NM_004959
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr3_-_115826481 1.865 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr7_-_107430566 1.851 NM_002291
LAMB1
laminin, beta 1
chr15_+_38082041 1.839 EIF2AK4
eukaryotic translation initiation factor 2 alpha kinase 4
chr1_+_9222489 1.835 H6PD
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr1_+_16203317 1.816 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr17_-_36347197 1.790 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr10_-_116434364 1.788 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr2_+_11600238 1.782 GREB1
growth regulation by estrogen in breast cancer 1
chr1_+_15957832 1.761 NM_017556
FBLIM1
filamin binding LIM protein 1
chr10_+_73393998 1.754 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr10_+_24795446 1.740 KIAA1217
KIAA1217
chr2_+_101680594 1.701 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr1_+_93686154 1.685 NM_001024948
NM_001164473
NM_017737
FNBP1L


formin binding protein 1-like


chr2_+_70981223 1.671 NM_012476
VAX2
ventral anterior homeobox 2
chr15_-_53667800 1.625 PYGO1
pygopus homolog 1 (Drosophila)
chr16_+_56259657 1.614 NM_170776
GPR97
G protein-coupled receptor 97
chr13_+_75108450 1.596 LMO7
LIM domain 7
chr2_+_11600287 1.596 NM_033090
GREB1
growth regulation by estrogen in breast cancer 1
chr11_+_46697345 1.593 F2
coagulation factor II (thrombin)
chr11_+_22646229 1.583 NM_177553
GAS2
growth arrest-specific 2
chr11_+_46697312 1.576 NM_000506
F2
coagulation factor II (thrombin)
chr4_-_40911212 1.572 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr3_-_127258299 1.555 NM_001008487
SLC41A3
solute carrier family 41, member 3
chr13_-_22905822 1.554 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr9_-_98185815 1.551 SLC35D2
solute carrier family 35, member D2
chr10_-_116382089 1.542 ABLIM1
actin binding LIM protein 1
chrX_-_2857351 1.524 NM_001669
NM_009589
ARSD

arylsulfatase D

chr2_-_74606819 1.521 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr9_-_98185613 1.512 NM_007001
SLC35D2
solute carrier family 35, member D2
chr10_+_24795465 1.511 KIAA1217
KIAA1217
chr7_-_158304062 1.507 ESYT2
extended synaptotagmin-like protein 2
chr1_+_48460943 1.502 NM_001011547
NM_001135181
SLC5A9

solute carrier family 5 (sodium/glucose cotransporter), member 9

chr17_-_60988077 1.500 NM_004655
AXIN2
axin 2
chr19_-_18578467 1.496 CRLF1
cytokine receptor-like factor 1
chr19_-_18578577 1.494 CRLF1
cytokine receptor-like factor 1
chrX_-_2857315 1.476 ARSD
arylsulfatase D
chr11_+_46697335 1.472 F2
coagulation factor II (thrombin)
chr1_-_176329357 1.412 LOC100302401
hypothetical LOC100302401
chr20_+_39199542 1.410 NM_002660
NM_182811
PLCG1

phospholipase C, gamma 1

chrX_+_54852217 1.384 NM_201222
MAGED2
melanoma antigen family D, 2
chr15_+_78483624 1.377 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr13_+_100902942 1.345 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr17_-_36346240 1.343 KRT23
keratin 23 (histone deacetylase inducible)
chr17_-_60988226 1.342 AXIN2
axin 2
chr2_-_98714020 1.342 NM_012214
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr4_-_159311959 1.339 FAM198B
family with sequence similarity 198, member B
chr9_-_73715666 1.330 FAM108B1
family with sequence similarity 108, member B1
chr2_+_233961538 1.323 NM_003648
DGKD
diacylglycerol kinase, delta 130kDa
chr5_-_16989290 1.320 MYO10
myosin X
chr18_-_44723116 1.319 NM_001190823
SMAD7
SMAD family member 7
chr19_-_18578631 1.318 NM_004750
CRLF1
cytokine receptor-like factor 1
chr10_-_52315390 1.318 A1CF
APOBEC1 complementation factor
chr1_-_16217871 1.317 NM_014424
HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr20_+_39199263 1.299 PLCG1
phospholipase C, gamma 1
chr16_-_12805194 1.294 NM_001099455
NM_018340
CPPED1

calcineurin-like phosphoesterase domain containing 1

chr12_-_16650697 1.294 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_-_11029737 1.290 NM_006610
NM_139208
MASP2

mannan-binding lectin serine peptidase 2

chr8_+_103889733 1.288 FLJ45248
FLJ45248 protein
chr1_+_99884018 1.283 NM_017734
PALMD
palmdelphin
chr10_+_114144512 1.280 ACSL5
acyl-CoA synthetase long-chain family member 5
chr12_-_16650687 1.264 LMO3
LIM domain only 3 (rhombotin-like 2)
chr9_+_18464090 1.243 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr7_-_27180398 1.221 NM_018951
HOXA10
homeobox A10
chr14_-_30746577 1.221


chrX_-_105169370 1.220 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr11_-_124311106 1.216 HEPACAM
hepatic and glial cell adhesion molecule
chr17_+_28279040 1.199 NM_001033504
NM_015544
TMEM98

transmembrane protein 98

chr4_+_78172966 1.197 SEPT11
septin 11
chr4_+_146622154 1.197 NM_005900
SMAD1
SMAD family member 1
chr20_-_42249146 1.187 JPH2
junctophilin 2
chr2_+_70981233 1.181 VAX2
ventral anterior homeobox 2
chr2_-_98713862 1.178 MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr14_-_30746431 1.175 NM_015382
HECTD1
HECT domain containing 1
chr17_+_19377732 1.169 NM_018242
SLC47A1
solute carrier family 47, member 1
chr20_-_17459973 1.154 NM_001195
BFSP1
beaded filament structural protein 1, filensin
chr5_-_16989371 1.152 NM_012334
MYO10
myosin X
chr7_+_128615948 1.148 NM_005631
SMO
smoothened homolog (Drosophila)
chr1_+_57093030 1.144 NM_000562
C8A
complement component 8, alpha polypeptide
chr13_-_98428244 1.142 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr17_+_28279283 1.141 TMEM98
transmembrane protein 98
chr12_+_19173669 1.137 NM_001143821
NM_001190860
NM_019012
PLEKHA5


pleckstrin homology domain containing, family A member 5


chr20_-_32363268 1.120 NM_001161766
AHCY
adenosylhomocysteinase
chr3_-_121883647 1.114 HGD
homogentisate 1,2-dioxygenase
chr17_-_44226595 1.112 NM_173623
TTLL6
tubulin tyrosine ligase-like family, member 6
chr14_+_38720085 1.111 PNN
pinin, desmosome associated protein
chr13_+_109936080 1.111 COL4A2
collagen, type IV, alpha 2
chr19_-_6671585 1.101 NM_000064
C3
complement component 3
chr16_+_49139694 1.101 NM_033119
NKD1
naked cuticle homolog 1 (Drosophila)
chr2_-_165768798 1.101 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr3_-_65999548 1.100 NM_001033057
NM_004742
NM_015520
MAGI1


membrane associated guanylate kinase, WW and PDZ domain containing 1


chrX_+_46822751 1.084 RGN
regucalcin (senescence marker protein-30)
chr16_-_18720192 1.082 NM_015161
ARL6IP1
ADP-ribosylation factor-like 6 interacting protein 1
chr16_-_12805133 1.073 CPPED1
calcineurin-like phosphoesterase domain containing 1
chr10_-_101831579 1.052 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr2_-_38683119 1.047 HNRPLL
heterogeneous nuclear ribonucleoprotein L-like
chr17_-_45427565 1.045 NM_005220
DLX3
distal-less homeobox 3
chr3_-_135575925 1.041 NM_016201
AMOTL2
angiomotin like 2
chr1_-_160260210 1.037 NM_015441
OLFML2B
olfactomedin-like 2B
chr9_-_16717887 1.032 BNC2
basonuclin 2
chr1_-_172153087 1.025 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chrX_+_49718954 1.021 NM_000084
CLCN5
chloride channel 5
chr10_+_135010833 1.019 NM_001145201
NM_145202
PRAP1

proline-rich acidic protein 1

chr12_-_15833617 1.003 NM_004447
EPS8
epidermal growth factor receptor pathway substrate 8
chr14_-_93924663 0.996 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_+_64339869 0.994 NM_003463
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_-_232810111 0.994 IRF2BP2
interferon regulatory factor 2 binding protein 2
chr3_+_9919511 0.992 NM_001193380
NM_153480
IL17RE

interleukin 17 receptor E

chr5_+_66160359 0.986 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr20_+_31334601 0.984 NM_033197
C20orf114
chromosome 20 open reading frame 114
chr10_-_30064600 0.981 NM_003174
SVIL
supervillin
chrX_+_46822688 0.978 NM_004683
NM_152869
RGN

regucalcin (senescence marker protein-30)

chr3_+_139550134 0.976 NM_001085049
MRAS
muscle RAS oncogene homolog
chr11_+_74548472 0.958 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr16_+_70646008 0.956 NM_001126102
NM_005143
HP

haptoglobin

chr17_+_35425139 0.947 NM_000759
NM_001178147
NM_172219
NM_172220
CSF3



colony stimulating factor 3 (granulocyte)



chr6_+_158877640 0.946 TMEM181
transmembrane protein 181
chr6_+_123152044 0.936 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr6_+_123151669 0.934 NM_006714
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr9_+_17568952 0.932 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr1_+_67923660 0.929 GADD45A
growth arrest and DNA-damage-inducible, alpha
chr10_-_52315436 0.922 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr7_-_133794404 0.919 NM_001628
AKR1B1
aldo-keto reductase family 1, member B1 (aldose reductase)
chr1_+_46151845 0.915 MAST2
microtubule associated serine/threonine kinase 2
chr17_-_40348378 0.914 NM_001131019
NM_002055
GFAP

glial fibrillary acidic protein


Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.43 3.71e-02 GO:0044421 extracellular region part

Nothing significant found in function category.