Motif ID: SPI1.p2

Z-value: 5.221


Transcription factors associated with SPI1.p2:

Gene SymbolEntrez IDGene Name
SPI1 6688 spleen focus forming virus (SFFV) proviral integration oncogene spi1



Activity profile for motif SPI1.p2.

activity profile for motif SPI1.p2


Sorted Z-values histogram for motif SPI1.p2

Sorted Z-values for motif SPI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_35586950 7.768 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr16_-_87570716 5.892 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr5_-_88215034 5.289 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr11_+_63864263 5.116 NM_032251
CCDC88B
coiled-coil domain containing 88B
chr6_-_32268267 5.096 GPSM3
G-protein signaling modulator 3
chr3_-_113334657 4.885 NM_001190259
NM_001190260
NM_152785
GCET2


germinal center expressed transcript 2


chr10_+_49562866 4.823 WDFY4
WDFY family member 4
chr16_-_29664765 4.649 NM_175900
C16orf54
chromosome 16 open reading frame 54
chr1_+_111544469 4.508


chr10_+_26767698 4.392 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr11_+_107304344 4.375 NM_017516
RAB39
RAB39, member RAS oncogene family
chr11_+_65164767 4.344 SIPA1
signal-induced proliferation-associated 1
chr21_+_25856311 4.276 MIR155HG
MIR155 host gene (non-protein coding)
chr1_+_159899528 4.264 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr1_-_111544603 4.014


chr5_-_88214720 4.005 MEF2C
myocyte enhancer factor 2C
chr17_+_44643067 3.935 ABI3
ABI family, member 3
chr17_+_44642587 3.836 NM_001135186
NM_016428
ABI3

ABI family, member 3

chr6_-_32268615 3.819 GPSM3
G-protein signaling modulator 3
chr1_-_31003260 3.818 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr1_-_111544784 3.690 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr12_+_25096755 3.607 LRMP
lymphoid-restricted membrane protein
chr12_-_51887266 3.591 NM_000889
ITGB7
integrin, beta 7
chr11_+_66927976 3.574 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr1_-_111544820 3.551 DENND2D
DENN/MADD domain containing 2D
chr1_+_149309703 3.462 NM_144618
GABPB2
GA binding protein transcription factor, beta subunit 2
chr19_-_10311262 3.419 NM_002162
ICAM3
intercellular adhesion molecule 3
chr11_+_66927955 3.401 TBC1D10C
TBC1 domain family, member 10C
chr22_+_42908612 3.400 PARVG
parvin, gamma
chr7_+_114350144 3.384 MDFIC
MyoD family inhibitor domain containing
chr17_+_1906262 3.337 NM_001098202
HIC1
hypermethylated in cancer 1
chr5_+_118719591 3.320 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr3_+_195889845 3.294 FAM43A
family with sequence similarity 43, member A
chr17_-_40843530 3.247 ARHGAP27
Rho GTPase activating protein 27
chrX_+_72699834 3.243 CHIC1
cysteine-rich hydrophobic domain 1
chr6_-_33016561 3.191 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr1_-_26517342 3.158 NM_145345
UBXN11
UBX domain protein 11
chr1_+_159817752 3.074 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr17_-_31441390 3.048 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chrX_-_74062005 3.023 NM_001008537
KIAA2022
KIAA2022
chr19_-_6432765 3.005 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr4_-_105631915 3.000 NM_025212
CXXC4
CXXC finger protein 4
chr2_-_231498184 2.995 NM_005683
GPR55
G protein-coupled receptor 55
chr12_+_25096472 2.986 NM_006152
LRMP
lymphoid-restricted membrane protein
chr1_-_159306037 2.982 ARHGAP30
Rho GTPase activating protein 30
chr6_-_32265489 2.975 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr19_-_7672978 2.950 NM_002002
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr19_-_55091942 2.937 NM_152899
IL4I1
interleukin 4 induced 1
chr6_+_31648071 2.891 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr10_+_26767657 2.876 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chrX_+_48427103 2.862 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr19_-_43800374 2.833 NM_001042600
NM_007181
MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

chr22_-_35970230 2.792 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chrX_+_48427137 2.759 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr22_-_35970133 2.743 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr16_+_56134077 2.667 NM_153837
GPR114
G protein-coupled receptor 114
chr11_+_61352348 2.615 FADS2
fatty acid desaturase 2
chr1_+_111217314 2.606 CD53
CD53 molecule
chr17_-_40655347 2.598 LOC339192
hypothetical LOC339192
chr22_-_36212160 2.589 NM_001166343
NM_002405
MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr3_+_120495906 2.577 NM_020754
ARHGAP31
Rho GTPase activating protein 31
chr6_-_30760413 2.570 KIAA1949
KIAA1949
chr12_-_50004172 2.566 NM_016293
BIN2
bridging integrator 2
chr2_+_143603439 2.564 ARHGAP15
Rho GTPase activating protein 15
chr8_-_11096257 2.563 NM_173683
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr12_-_51887318 2.556 ITGB7
integrin, beta 7
chr6_+_31651319 2.552 NM_000594
TNF
tumor necrosis factor
chr14_+_20319049 2.536 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr1_+_111217244 2.533 NM_000560
CD53
CD53 molecule
chr12_-_50004102 2.532 BIN2
bridging integrator 2
chr16_+_56134037 2.526 GPR114
G protein-coupled receptor 114
chr12_-_50004208 2.522 BIN2
bridging integrator 2
chr2_+_143603368 2.519 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chrX_+_134482212 2.501 NM_182540
DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chrX_+_134482387 2.499 DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr1_-_159306327 2.446 ARHGAP30
Rho GTPase activating protein 30
chr2_+_227737524 2.444 NM_000091
COL4A3
collagen, type IV, alpha 3 (Goodpasture antigen)
chr17_-_44642934 2.440 NM_001198754
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr19_+_41085221 2.427 NM_001007469
NM_014266
HCST

hematopoietic cell signal transducer

chr1_-_31003181 2.427 LAPTM5
lysosomal protein transmembrane 5
chr6_+_31647854 2.415 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr1_-_25128951 2.414 RUNX3
runt-related transcription factor 3
chr6_+_73388713 2.408 KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
chr17_+_40655060 2.406 NM_005892
FMNL1
formin-like 1
chr17_-_59363352 2.397 NM_000626
NM_001039933
NM_021602
CD79B


CD79b molecule, immunoglobulin-associated beta


chr3_-_16530132 2.396 NM_015150
RFTN1
raftlin, lipid raft linker 1
chrX_-_47374187 2.370 NM_001145252
CFP
complement factor properdin
chr10_-_98021144 2.369 NM_001114094
NM_013314
BLNK

B-cell linker

chr14_-_22354457 2.366 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr10_-_121292139 2.355 NM_001005339
RGS10
regulator of G-protein signaling 10
chr1_+_26517032 2.351 CD52
CD52 molecule
chr7_-_3049872 2.320 NM_032415
CARD11
caspase recruitment domain family, member 11
chr7_+_128367961 2.284 NM_001098627
IRF5
interferon regulatory factor 5
chr11_+_61352209 2.270 NM_004265
FADS2
fatty acid desaturase 2
chr2_+_68445936 2.268 PLEK
pleckstrin
chr1_+_26517045 2.264 CD52
CD52 molecule
chr1_-_158883666 2.249 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr14_-_22354389 2.229 SLC7A7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr10_-_7493418 2.220 NM_001029880
SFMBT2
Scm-like with four mbt domains 2
chr15_+_72861470 2.217 NM_001127190
NM_004383
CSK

c-src tyrosine kinase

chr12_+_81605289 2.208 TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr17_-_8809656 2.193 NM_001142633
PIK3R5
phosphoinositide-3-kinase, regulatory subunit 5
chr11_+_128069340 2.187 FLI1
Friend leukemia virus integration 1
chr2_+_68445821 2.181 NM_002664
PLEK
pleckstrin
chr11_-_60475558 2.169 NM_016582
SLC15A3
solute carrier family 15, member 3
chr11_+_128068982 2.167 NM_002017
FLI1
Friend leukemia virus integration 1
chr6_-_31658044 2.150 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr2_-_96174865 2.144 NM_004418
DUSP2
dual specificity phosphatase 2
chr19_-_15436333 2.141 NM_022904
RASAL3
RAS protein activator like 3
chr12_-_53664722 2.127 NM_001136030
KIAA0748
KIAA0748
chr15_+_72861767 2.124 CSK
c-src tyrosine kinase
chr12_-_116890410 2.104 NM_173598
KSR2
kinase suppressor of ras 2
chr2_-_96174502 2.104 DUSP2
dual specificity phosphatase 2
chr11_-_66961709 2.070 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr17_+_53769562 2.057 LOC100506779
hypothetical LOC100506779
chr2_-_197883569 2.053 ANKRD44
ankyrin repeat domain 44
chr12_+_6930815 2.051 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chrX_-_83644054 2.047 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr17_+_53769659 2.047 LOC100506779
hypothetical LOC100506779
chr5_+_88220846 2.045


chr8_-_29262240 2.042 NM_057158
DUSP4
dual specificity phosphatase 4
chr12_-_53071285 2.042 NM_001130967
NM_001130968
ZNF385A

zinc finger protein 385A

chr1_-_205161821 2.041 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr5_+_49998528 2.034 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chr9_+_263025 2.034 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr5_+_49998677 2.033 PARP8
poly (ADP-ribose) polymerase family, member 8
chr17_-_73640082 2.020 NM_007267
TMC6
transmembrane channel-like 6
chr9_-_129580732 2.007 NM_170600
SH2D3C
SH2 domain containing 3C
chr3_-_15348811 1.997 SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr1_+_9634368 1.988 NM_005026
PIK3CD
phosphoinositide-3-kinase, catalytic, delta polypeptide
chr16_+_29582069 1.986 NM_003123
SPN
sialophorin
chr2_-_60634271 1.982 BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr7_-_44985084 1.980 MYO1G
myosin IG
chr12_+_55018925 1.977 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr19_+_40895669 1.961 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr4_+_8251818 1.950 NM_018986
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr2_+_130846263 1.938 PTPN18
protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
chr12_-_47605478 1.936 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chr16_+_29582065 1.932 SPN
sialophorin
chr5_-_33927724 1.918 NM_030955
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr4_-_25473528 1.916 NM_015187
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr16_+_28413421 1.895 NM_018690
APOBR
apolipoprotein B receptor
chr6_-_144427340 1.890 NM_001080951
NM_001080955
PLAGL1

pleiomorphic adenoma gene-like 1

chr7_-_44985175 1.889 MYO1G
myosin IG
chr16_+_27320983 1.883 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr10_+_26767288 1.876 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr7_-_44985202 1.861 NM_033054
MYO1G
myosin IG
chr7_+_73826244 1.860 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr11_+_65164167 1.848 NM_153253
SIPA1
signal-induced proliferation-associated 1
chr10_+_71908535 1.826 NM_014431
KIAA1274
KIAA1274
chr19_-_47328399 1.822 NM_002698
POU2F2
POU class 2 homeobox 2
chr19_+_14412080 1.819 NM_213560
PKN1
protein kinase N1
chr6_-_30762385 1.816 KIAA1949
KIAA1949
chr1_+_185064654 1.812 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr7_-_86686754 1.809 NM_024315
C7orf23
chromosome 7 open reading frame 23
chr10_+_26767268 1.794 NM_019043
APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr19_+_14412087 1.769 PKN1
protein kinase N1
chr5_+_176493752 1.768 NSD1
nuclear receptor binding SET domain protein 1
chr8_-_9045548 1.767 NM_024607
PPP1R3B
protein phosphatase 1, regulatory (inhibitor) subunit 3B
chr17_-_24491521 1.762 MYO18A
myosin XVIIIA
chr22_+_42908589 1.760 NM_001137606
PARVG
parvin, gamma
chr2_-_175207521 1.751 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr22_+_42908548 1.749 PARVG
parvin, gamma
chr9_-_129707392 1.734 LOC100131355
ST6GALNAC6
hypothetical protein LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr18_-_59137488 1.718 NM_000633
NM_000657
BCL2

B-cell CLL/lymphoma 2

chr19_+_14412052 1.706 PKN1
protein kinase N1
chr12_-_109611277 1.705 NM_032369
HVCN1
hydrogen voltage-gated channel 1
chr22_-_30071761 1.705 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr17_-_35975227 1.696 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr18_-_50004770 1.693 MBD2
methyl-CpG binding domain protein 2
chr5_-_142795269 1.693 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr1_-_159306210 1.691 ARHGAP30
Rho GTPase activating protein 30
chr22_+_35639564 1.687 NM_000395
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr22_-_28992787 1.685 NM_020530
OSM
oncostatin M
chr3_+_197851052 1.680 NM_198565
LRRC33
leucine rich repeat containing 33
chr6_+_43004837 1.679 NM_006586
CNPY3
canopy 3 homolog (zebrafish)
chr10_+_70748633 1.674 HK1
hexokinase 1
chr6_-_32920689 1.671 NM_004159
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr4_+_91267706 1.671 NM_001145065
FAM190A
family with sequence similarity 190, member A
chr9_-_35640852 1.651 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr1_-_142535878 1.647 LOC100286793
FLJ39739
hypothetical LOC100286793
hypothetical FLJ39739
chr1_-_181826292 1.641 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr13_-_45654292 1.635 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_-_159306273 1.634 ARHGAP30
Rho GTPase activating protein 30
chr6_+_21701942 1.626 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chrX_-_70248022 1.609 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr11_+_120828058 1.594 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr1_-_27825178 1.556 NM_001042747
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr19_+_54530497 1.551 CD37
CD37 molecule
chr16_+_48865521 1.549 ADCY7
adenylate cyclase 7
chr1_+_116718011 1.548 NM_001160233
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr6_-_32605898 1.536 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr11_-_76800525 1.532 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr2_-_152663748 1.531 NM_000726
NM_001145798
CACNB4

calcium channel, voltage-dependent, beta 4 subunit

chr10_-_13789628 1.516 FRMD4A
FERM domain containing 4A
chr11_+_122936246 1.505 GRAMD1B
GRAM domain containing 1B
chr11_-_46099531 1.503 NM_001101802
NM_016621
PHF21A

PHD finger protein 21A

chr10_+_129735796 1.502 NM_130435
PTPRE
protein tyrosine phosphatase, receptor type, E
chr22_+_23153529 1.495 NM_000675
ADORA2A
adenosine A2a receptor
chr14_-_22354851 1.495 NM_001126105
NM_003982
SLC7A7

solute carrier family 7 (cationic amino acid transporter, y+ system), member 7


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.15 4.41e-17 GO:0050794 regulation of cellular process
1.14 1.53e-16 GO:0050789 regulation of biological process
1.13 2.18e-16 GO:0065007 biological regulation
1.19 6.18e-13 GO:0051716 cellular response to stimulus
1.19 1.63e-11 GO:0023052 signaling
1.20 1.73e-11 GO:0007165 signal transduction
1.07 1.57e-09 GO:0009987 cellular process
1.32 6.84e-09 GO:0002376 immune system process
1.26 6.94e-09 GO:0048583 regulation of response to stimulus
1.52 9.20e-09 GO:0001775 cell activation
1.22 4.14e-08 GO:0048519 negative regulation of biological process
1.20 5.16e-08 GO:0048518 positive regulation of biological process
1.29 3.12e-07 GO:0035556 intracellular signal transduction
1.15 3.84e-07 GO:0019222 regulation of metabolic process
1.22 3.84e-07 GO:0048523 negative regulation of cellular process
1.20 5.71e-07 GO:0048522 positive regulation of cellular process
1.16 1.62e-06 GO:0031323 regulation of cellular metabolic process
1.14 1.67e-06 GO:0044260 cellular macromolecule metabolic process
1.23 3.33e-06 GO:0006464 protein modification process
1.24 3.37e-06 GO:0023051 regulation of signaling
1.64 5.83e-06 GO:0045321 leukocyte activation
1.15 8.43e-06 GO:0080090 regulation of primary metabolic process
1.21 1.56e-05 GO:0043412 macromolecule modification
1.25 2.06e-05 GO:0009966 regulation of signal transduction
1.10 2.46e-05 GO:0050896 response to stimulus
1.18 3.72e-05 GO:0006950 response to stress
1.15 4.85e-05 GO:0016043 cellular component organization
1.11 5.86e-05 GO:0043170 macromolecule metabolic process
1.36 1.68e-04 GO:0051726 regulation of cell cycle
1.40 1.80e-04 GO:0007599 hemostasis
1.64 2.98e-04 GO:0046649 lymphocyte activation
1.33 2.99e-04 GO:0002682 regulation of immune system process
1.16 3.00e-04 GO:0071842 cellular component organization at cellular level
1.40 3.02e-04 GO:0007596 blood coagulation
1.40 3.02e-04 GO:0050817 coagulation
1.21 3.08e-04 GO:0006996 organelle organization
1.14 5.04e-04 GO:0060255 regulation of macromolecule metabolic process
1.13 8.33e-04 GO:0071840 cellular component organization or biogenesis
1.36 9.34e-04 GO:0050878 regulation of body fluid levels
1.86 1.08e-03 GO:0030098 lymphocyte differentiation
1.41 1.48e-03 GO:0007243 intracellular protein kinase cascade
1.41 1.48e-03 GO:0023014 signal transduction via phosphorylation event
1.26 1.52e-03 GO:0009892 negative regulation of metabolic process
1.30 1.67e-03 GO:0006955 immune response
1.26 1.88e-03 GO:0006793 phosphorus metabolic process
1.26 1.88e-03 GO:0006796 phosphate metabolic process
1.25 2.63e-03 GO:0007049 cell cycle
1.25 3.16e-03 GO:0009605 response to external stimulus
1.54 3.32e-03 GO:0071156 regulation of cell cycle arrest
1.41 3.45e-03 GO:0007264 small GTPase mediated signal transduction
1.15 4.62e-03 GO:0044267 cellular protein metabolic process
1.23 5.05e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.59 5.65e-03 GO:0002757 immune response-activating signal transduction
1.22 5.87e-03 GO:0009893 positive regulation of metabolic process
1.25 6.66e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.22 7.16e-03 GO:0031325 positive regulation of cellular metabolic process
1.51 8.18e-03 GO:0030168 platelet activation
1.29 8.52e-03 GO:0009890 negative regulation of biosynthetic process
1.20 8.61e-03 GO:0065009 regulation of molecular function
1.37 8.70e-03 GO:0002684 positive regulation of immune system process
1.14 8.89e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.14 9.37e-03 GO:0071841 cellular component organization or biogenesis at cellular level
2.59 9.65e-03 GO:0001776 leukocyte homeostasis
1.23 1.06e-02 GO:0051246 regulation of protein metabolic process
1.24 1.06e-02 GO:0042981 regulation of apoptosis
1.16 1.09e-02 GO:0090304 nucleic acid metabolic process
1.40 1.09e-02 GO:0051056 regulation of small GTPase mediated signal transduction
1.29 1.12e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.31 1.18e-02 GO:0042060 wound healing
1.14 1.19e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.14 1.19e-02 GO:0031326 regulation of cellular biosynthetic process
1.25 1.23e-02 GO:0031324 negative regulation of cellular metabolic process
1.22 1.25e-02 GO:0050790 regulation of catalytic activity
1.23 1.30e-02 GO:0043067 regulation of programmed cell death
1.14 1.31e-02 GO:0009889 regulation of biosynthetic process
1.52 1.40e-02 GO:0000075 cell cycle checkpoint
1.35 1.40e-02 GO:0009628 response to abiotic stimulus
1.31 1.41e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.23 1.54e-02 GO:0032268 regulation of cellular protein metabolic process
1.33 1.58e-02 GO:0006974 response to DNA damage stimulus
1.56 1.74e-02 GO:0002764 immune response-regulating signaling pathway
1.13 1.91e-02 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.25 1.95e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.29 2.19e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.22 2.42e-02 GO:0010941 regulation of cell death
1.30 2.45e-02 GO:0010629 negative regulation of gene expression
2.55 2.51e-02 GO:0002260 lymphocyte homeostasis
1.47 2.82e-02 GO:0030097 hemopoiesis
1.40 2.92e-02 GO:0070647 protein modification by small protein conjugation or removal
1.24 3.52e-02 GO:0009611 response to wounding
1.07 3.57e-02 GO:0044238 primary metabolic process
1.67 3.58e-02 GO:0042110 T cell activation
1.16 3.58e-02 GO:0007166 cell surface receptor linked signaling pathway
1.29 3.75e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.92 3.99e-02 GO:0030217 T cell differentiation
1.26 4.08e-02 GO:0006468 protein phosphorylation
1.29 4.29e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.42 4.34e-02 GO:0002520 immune system development
1.25 4.54e-02 GO:0033554 cellular response to stress
1.58 4.60e-02 GO:0050900 leukocyte migration
1.13 4.64e-02 GO:0048731 system development
1.24 4.72e-02 GO:0016265 death

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.32 1.62e-10 GO:0005654 nucleoplasm
1.13 2.03e-10 GO:0005634 nucleus
1.06 4.80e-10 GO:0005622 intracellular
1.07 5.99e-10 GO:0044424 intracellular part
1.23 8.12e-09 GO:0005829 cytosol
1.03 1.36e-07 GO:0005623 cell
1.03 1.72e-07 GO:0044464 cell part
1.21 1.89e-07 GO:0044428 nuclear part
1.22 1.75e-06 GO:0031981 nuclear lumen
1.35 4.23e-06 GO:0044451 nucleoplasm part
1.08 4.90e-06 GO:0005737 cytoplasm
1.06 4.07e-05 GO:0043229 intracellular organelle
1.06 4.63e-05 GO:0043226 organelle
1.07 6.56e-05 GO:0043227 membrane-bounded organelle
1.07 6.99e-05 GO:0043231 intracellular membrane-bounded organelle
1.08 3.51e-03 GO:0044446 intracellular organelle part
1.49 3.55e-03 GO:0016604 nuclear body
1.08 5.37e-03 GO:0044422 organelle part
1.14 6.38e-03 GO:0043233 organelle lumen
1.14 9.70e-03 GO:0031974 membrane-enclosed lumen
1.12 9.99e-03 GO:0043234 protein complex
1.10 1.57e-02 GO:0032991 macromolecular complex
1.13 2.33e-02 GO:0070013 intracellular organelle lumen
1.28 2.40e-02 GO:0005694 chromosome
1.88 3.21e-02 GO:0016605 PML body
1.07 4.32e-02 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 6.22e-21 GO:0005515 protein binding
1.05 6.17e-07 GO:0005488 binding
1.53 8.91e-06 GO:0016564 transcription repressor activity
1.43 1.47e-05 GO:0030695 GTPase regulator activity
1.42 1.67e-05 GO:0060589 nucleoside-triphosphatase regulator activity
1.33 1.88e-05 GO:0019899 enzyme binding
1.27 8.39e-05 GO:0030528 transcription regulator activity
1.40 8.07e-04 GO:0008047 enzyme activator activity
1.40 1.25e-03 GO:0000988 protein binding transcription factor activity
1.40 1.25e-03 GO:0000989 transcription factor binding transcription factor activity
1.49 1.31e-03 GO:0005096 GTPase activator activity
1.39 1.78e-03 GO:0003712 transcription cofactor activity
1.23 1.11e-02 GO:0030234 enzyme regulator activity
1.72 1.12e-02 GO:0051427 hormone receptor binding
1.27 1.29e-02 GO:0043565 sequence-specific DNA binding
1.38 1.94e-02 GO:0016563 transcription activator activity
1.82 2.02e-02 GO:0047485 protein N-terminus binding