Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 0.661


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZHX1chr8_-_1243556700.552.6e-02Click!
IRX5chr16_+_535226110.514.6e-02Click!
SIX2chr2_-_450900250.381.5e-01Click!
ZHX3chr20_-_39379533-0.224.1e-01Click!
ZHX2chr8_+_124032830-0.204.5e-01Click!
IRX4chr5_-_19357640.194.8e-01Click!
ADNPchr20_-_489808580.116.9e-01Click!
SIX5chr19_-_50964336-0.058.6e-01Click!


Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_556968 2.545


chr9_-_205892 1.271 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr18_+_27210737 1.213 NM_001134453
NM_177986
DSG4

desmoglein 4

chr2_+_166137091 1.196 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr21_-_14840506 1.196 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr6_-_155818728 1.139 NM_015718
NOX3
NADPH oxidase 3
chr6_+_49575629 1.133 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr9_-_99740243 1.100 NM_197978
HEMGN
hemogen
chr17_-_64752550 1.044 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr17_-_36376663 1.035 NM_213656
KRT39
keratin 39
chr3_-_166278969 1.029 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr3_+_174598937 1.014 NM_014932
NLGN1
neuroligin 1
chr1_-_156923111 0.993 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr7_+_113842284 0.986 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr6_-_49820030 0.982 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr4_+_74520796 0.976 NM_001134
AFP
alpha-fetoprotein
chr17_-_10265991 0.961 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr14_+_67238355 0.960 NM_152443
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr7_-_91632525 0.959 NM_001161528
LOC401387
leucine-rich repeat and death domain-containing protein
chr2_+_200031333 0.953



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
3.46 1.96e-29 GO:0007608 sensory perception of smell
3.29 3.34e-29 GO:0007606 sensory perception of chemical stimulus
2.73 4.27e-32 GO:0007600 sensory perception
2.17 5.44e-27 GO:0050877 neurological system process
1.96 7.30e-24 GO:0003008 system process
1.56 4.16e-02 GO:0006955 immune response
1.39 1.51e-17 GO:0032501 multicellular organismal process
1.25 7.31e-09 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
1.97 3.68e-02 GO:0045177 apical part of cell
1.57 1.56e-03 GO:0005615 extracellular space
1.53 4.24e-04 GO:0044421 extracellular region part
1.50 5.55e-09 GO:0005576 extracellular region
1.42 2.29e-15 GO:0005886 plasma membrane
1.41 4.28e-15 GO:0071944 cell periphery
1.31 9.99e-13 GO:0031224 intrinsic to membrane
1.31 4.73e-12 GO:0016021 integral to membrane
1.29 9.85e-03 GO:0044459 plasma membrane part
1.24 8.86e-10 GO:0044425 membrane part
1.14 5.57e-04 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
5.78 3.96e-03 GO:0004890 GABA-A receptor activity
4.99 1.70e-02 GO:0016917 GABA receptor activity
4.36 2.47e-02 GO:0015020 glucuronosyltransferase activity
3.60 2.00e-31 GO:0004984 olfactory receptor activity
2.92 2.50e-02 GO:0005254 chloride channel activity
2.74 3.65e-02 GO:0005253 anion channel activity
2.48 1.61e-25 GO:0004930 G-protein coupled receptor activity
2.17 3.24e-26 GO:0004888 transmembrane receptor activity
1.94 5.07e-24 GO:0004872 receptor activity
1.72 1.80e-18 GO:0004871 signal transducer activity
1.72 1.80e-18 GO:0060089 molecular transducer activity