Motif ID: AHR_ARNT_ARNT2.p2

Z-value: 1.484


Transcription factors associated with AHR_ARNT_ARNT2.p2:

Gene SymbolEntrez IDGene Name
AHR 196 aryl hydrocarbon receptor
ARNT 405 aryl hydrocarbon receptor nuclear translocator
ARNT2 9915 aryl-hydrocarbon receptor nuclear translocator 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ARNT2chr15_+_78520634-0.712.0e-03Click!
ARNTchr1_-_149115686-0.467.4e-02Click!
AHRchr7_+_17304707-0.332.1e-01Click!


Activity profile for motif AHR_ARNT_ARNT2.p2.

activity profile for motif AHR_ARNT_ARNT2.p2


Sorted Z-values histogram for motif AHR_ARNT_ARNT2.p2

Sorted Z-values for motif AHR_ARNT_ARNT2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AHR_ARNT_ARNT2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_163754903 1.680 LOC100526820
hypothetical LOC100526820
chr2_+_203208064 1.359 NM_173511
FAM117B
family with sequence similarity 117, member B
chr12_+_53229625 1.246 PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr12_+_101875581 1.197 NM_004316
ASCL1
achaete-scute complex homolog 1 (Drosophila)
chr1_+_6767968 1.146 NM_001195563
NM_015215
CAMTA1

calmodulin binding transcription activator 1

chr9_-_133141726 1.066 NM_033387
FAM78A
family with sequence similarity 78, member A
chr20_+_20296744 1.050 NM_002196
INSM1
insulinoma-associated 1
chr14_-_22840249 1.040


chr15_+_81906983 1.028 NM_003027
SH3GL3
SH3-domain GRB2-like 3
chr8_+_85258056 1.007 NM_173848
RALYL
RALY RNA binding protein-like
chr18_+_53253775 0.994 NM_004852
ONECUT2
one cut homeobox 2
chr8_+_85258007 0.971 NM_001100392
NM_001100393
RALYL

RALY RNA binding protein-like

chrX_+_37429927 0.944 NM_021083
XK
X-linked Kx blood group (McLeod syndrome)
chr1_+_30964199 0.916 LOC100129196
hypothetical LOC100129196
chr20_-_30636535 0.867 LOC284804
hypothetical protein LOC284804
chrX_-_132947141 0.840 GPC3
glypican 3
chr17_-_24253821 0.840 NM_144683
DHRS13
dehydrogenase/reductase (SDR family) member 13
chr14_+_32478209 0.834 NM_001164749
NM_001165893
NM_022123
NM_173159
NPAS3



neuronal PAS domain protein 3



chr3_+_39826032 0.819 NM_015460
MYRIP
myosin VIIA and Rab interacting protein
chr3_+_6877797 0.819 NM_000844
NM_181874
GRM7

glutamate receptor, metabotropic 7

chr18_+_22060383 0.808 NM_005640
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr1_+_61320213 0.800 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr10_+_94439658 0.727 NM_002729
HHEX
hematopoietically expressed homeobox
chr6_-_10520592 0.722 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr20_-_44370537 0.718 CDH22
cadherin 22, type 2
chr5_-_81082699 0.693 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr6_+_126112506 0.689 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr18_+_53170718 0.683 NM_015879
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr9_-_100510657 0.681 NM_005458
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr17_-_71747867 0.678 NM_052916
RNF157
ring finger protein 157
chr1_-_203916160 0.674 SLC45A3
solute carrier family 45, member 3
chr15_+_74416129 0.662 ISL2
ISL LIM homeobox 2
chr17_-_70690525 0.649 SUMO2
SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)
chr15_+_39739933 0.642 MGA
MAX gene associated
chrX_+_38305634 0.635 NM_004615
TSPAN7
tetraspanin 7
chrX_-_132947290 0.632 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr15_+_74416156 0.629 NM_145805
ISL2
ISL LIM homeobox 2
chr3_-_13436802 0.628 NM_024923
NUP210
nucleoporin 210kDa
chr2_-_213111525 0.610 NM_001042599
NM_005235
ERBB4

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

chr17_-_70690625 0.610 SUMO2
SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)
chr22_+_40702709 0.607 NM_019106
NM_145733
SEPT3

septin 3

chr20_+_51022352 0.606 NM_173485
TSHZ2
teashirt zinc finger homeobox 2
chr6_+_43846735 0.606 VEGFA
vascular endothelial growth factor A
chr21_+_34367747 0.603 MRPS6
mitochondrial ribosomal protein S6
chr17_-_70690664 0.601 SUMO2
SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)
chr17_+_69939130 0.601 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr17_+_52026058 0.589 NM_005450
NOG
noggin
chr6_-_136652625 0.582 NM_001077440
NM_001077441
NM_014739
BCLAF1


BCL2-associated transcription factor 1


chr13_+_27392136 0.577 NM_000209
PDX1
pancreatic and duodenal homeobox 1
chr12_+_123023521 0.569 NM_152437
ZNF664
zinc finger protein 664
chr7_+_139523623 0.568 LOC100134229
hypothetical LOC100134229
chr4_-_113656762 0.563 NM_024019
NEUROG2
neurogenin 2
chr6_-_40663089 0.561 NM_020737
LRFN2
leucine rich repeat and fibronectin type III domain containing 2
chr7_-_105712646 0.556 NM_005746
NAMPT
nicotinamide phosphoribosyltransferase
chr8_+_85258257 0.553 RALYL
RALY RNA binding protein-like
chr15_+_81907176 0.552 SH3GL3
SH3-domain GRB2-like 3
chr15_+_24799174 0.552 NM_033223
GABRG3
gamma-aminobutyric acid (GABA) A receptor, gamma 3
chr16_-_76026431 0.551 NM_199355
ADAMTS18
ADAM metallopeptidase with thrombospondin type 1 motif, 18
chr2_+_169021039 0.541 NM_203463
LASS6
LAG1 homolog, ceramide synthase 6
chr3_+_135996734 0.535 NM_004441
EPHB1
EPH receptor B1
chr12_-_22378833 0.530 NM_003034
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr5_+_151131655 0.529 NM_005754
NM_198395
G3BP1

GTPase activating protein (SH3 domain) binding protein 1

chr3_-_172660545 0.525 NM_001161560
NM_001161561
NM_001161562
NM_001161563
NM_001161564
NM_001161565
NM_001161566
NM_015028
TNIK







TRAF2 and NCK interacting kinase







chr16_+_54782751 0.525 NM_020988
NM_138736
GNAO1

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

chr14_+_23850494 0.519 NM_001143919
LTB4R
leukotriene B4 receptor
chr13_-_20374895 0.516 NM_022459
XPO4
exportin 4
chr5_+_151131709 0.515 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr6_-_136652587 0.515 BCLAF1
BCL2-associated transcription factor 1
chr6_+_126112417 0.513 NM_012259
HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr15_+_39739864 0.510 NM_001080541
NM_001164273
MGA

MAX gene associated

chr1_+_60053050 0.510 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr8_-_105548323 0.508 NM_001385
DPYS
dihydropyrimidinase
chr1_-_50262203 0.508 NM_032785
AGBL4
ATP/GTP binding protein-like 4
chr7_+_138695537 0.502 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr9_+_86473273 0.502 NM_001018064
NM_006180
NTRK2

neurotrophic tyrosine kinase, receptor, type 2

chr6_+_137285071 0.499 NM_001008783
SLC35D3
solute carrier family 35, member D3
chr5_+_176170041 0.499 NM_133369
UNC5A
unc-5 homolog A (C. elegans)
chr1_-_38285033 0.498 NM_002699
POU3F1
POU class 3 homeobox 1
chr7_+_113513828 0.494 FOXP2
forkhead box P2
chr6_+_34312667 0.494 HMGA1
high mobility group AT-hook 1
chrX_-_18282698 0.493 NM_006089
SCML2
sex comb on midleg-like 2 (Drosophila)
chr6_+_108593907 0.492 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr1_+_226937732 0.491 RHOU
ras homolog gene family, member U
chr14_+_34413157 0.484


chr1_-_37991160 0.481 EPHA10
EPH receptor A10
chr6_-_10520264 0.481 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr2_+_185171682 0.479 ZNF804A
zinc finger protein 804A
chr16_+_22733307 0.478 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr17_+_59429442 0.476 NM_001164257
NM_001191029
NM_001191030
NM_001191031
C17orf72



chromosome 17 open reading frame 72



chr17_-_70690688 0.473 NM_001005849
NM_006937
SUMO2

SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)

chr9_-_101621964 0.471


chr5_+_138920893 0.469 NM_003339
NM_181838
UBE2D2

ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)

chr4_-_129428414 0.468 PGRMC2
progesterone receptor membrane component 2
chr7_+_24579239 0.466 NM_016447
MPP6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr6_-_119712596 0.466 NM_005907
MAN1A1
mannosidase, alpha, class 1A, member 1
chr4_-_129428378 0.465 PGRMC2
progesterone receptor membrane component 2
chr8_+_126079929 0.464 SQLE
squalene epoxidase
chr17_-_37586716 0.463 NM_012285
KCNH4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr22_-_17891777 0.456 CLDN5
claudin 5
chr1_-_203916239 0.449 NM_033102
SLC45A3
solute carrier family 45, member 3
chr15_-_66900309 0.444 NM_006305
ANP32A
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr3_+_135996990 0.441 EPHB1
EPH receptor B1
chr1_-_54076695 0.438 NM_001168551
NM_018087
TMEM48

transmembrane protein 48

chr20_+_13924014 0.438 NM_080676
MACROD2
MACRO domain containing 2
chr16_+_22732982 0.437 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr5_+_151131707 0.436 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr3_+_6877812 0.435 GRM7
glutamate receptor, metabotropic 7
chr11_+_799985 0.433 RPLP2
ribosomal protein, large, P2
chr21_+_34367678 0.430 NM_032476
NM_006933
MRPS6
SLC5A3
mitochondrial ribosomal protein S6
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
chr3_+_4510160 0.428 ITPR1
inositol 1,4,5-triphosphate receptor, type 1
chr2_-_182253457 0.427 NM_002500
NEUROD1
neurogenic differentiation 1
chr8_+_126079900 0.426 NM_003129
SQLE
squalene epoxidase
chr2_+_32435800 0.425 BIRC6
baculoviral IAP repeat containing 6
chr2_+_32435550 0.423 NM_016252
BIRC6
baculoviral IAP repeat containing 6
chr2_-_219141199 0.422 NM_020935
USP37
ubiquitin specific peptidase 37
chr5_-_130528871 0.420 HINT1
histidine triad nucleotide binding protein 1
chr10_-_35970363 0.420 NM_031866
FZD8
frizzled homolog 8 (Drosophila)
chr10_+_23521464 0.418 NM_178161
PTF1A
pancreas specific transcription factor, 1a
chr13_+_99432258 0.415 NM_007129
ZIC2
Zic family member 2 (odd-paired homolog, Drosophila)
chr2_+_181554048 0.415 UBE2E3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr17_+_6495694 0.414 NM_001105520
C17orf100
chromosome 17 open reading frame 100
chr4_-_152156314 0.414 NM_006726
LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr9_+_4975243 0.411 NM_004972
JAK2
Janus kinase 2
chr16_-_65422365 0.407 NM_001018159
NM_001018160
NM_003905
NAE1


NEDD8 activating enzyme E1 subunit 1


chr15_+_38923914 0.406 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr2_+_30523586 0.406 NM_182551
NM_001002257
LCLAT1

lysocardiolipin acyltransferase 1

chr2_-_68332985 0.405 NM_000945
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha
chr15_+_38923470 0.405 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr12_-_55368323 0.405 NM_006601
PTGES3
prostaglandin E synthase 3 (cytosolic)
chr4_+_94969064 0.403 NM_005172
ATOH1
atonal homolog 1 (Drosophila)
chr3_+_214668 0.402


chr11_+_14621844 0.402 NM_000922
PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr20_-_1321744 0.401 NM_000801
NM_054014
FKBP1A

FK506 binding protein 1A, 12kDa

chr22_-_17892001 0.400 CLDN5
claudin 5
chr4_-_83569572 0.399 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr5_-_81082614 0.397 SSBP2
single-stranded DNA binding protein 2
chr4_-_83569476 0.394 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr4_-_83569853 0.390 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr19_-_43089073 0.390 NM_031951
WDR87
WD repeat domain 87
chr2_+_185171480 0.389 ZNF804A
zinc finger protein 804A
chr1_-_12599934 0.388 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr20_+_13924263 0.387 MACROD2
MACRO domain containing 2
chr16_+_55684030 0.385 CPNE2
copine II
chr4_-_103968104 0.385 NM_003340
NM_181886
NM_181888
NM_181889
UBE2D3



ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)



chr21_-_39642808 0.384 HMGN1
high-mobility group nucleosome binding domain 1
chr1_-_24179326 0.383 SRSF10
serine/arginine-rich splicing factor 10
chr2_+_26110232 0.382 NM_016131
RAB10
RAB10, member RAS oncogene family
chr9_-_139316523 0.380 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chr8_+_69026895 0.378 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr9_+_99214190 0.377 TDRD7
tudor domain containing 7
chr2_+_198073257 0.375 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr6_+_99389300 0.373 NM_005604
POU3F2
POU class 3 homeobox 2
chr8_-_144887876 0.372 NM_198488
FAM83H
family with sequence similarity 83, member H
chr21_-_38954433 0.372 ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr17_+_50697319 0.372 NM_002126
HLF
hepatic leukemia factor
chr13_-_20374849 0.371 XPO4
exportin 4
chr9_+_99214000 0.370 NM_014290
TDRD7
tudor domain containing 7
chrX_+_70232362 0.370 NM_001170931
NM_005938
FOXO4

forkhead box O4

chr21_-_39642712 0.369 HMGN1
high-mobility group nucleosome binding domain 1
chr7_+_107171514 0.369 NM_024814
CBLL1
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
chr12_-_55368190 0.368 PTGES3
prostaglandin E synthase 3 (cytosolic)
chr21_-_39642935 0.365 HMGN1
high-mobility group nucleosome binding domain 1
chr1_-_54076521 0.364 TMEM48
transmembrane protein 48
chr2_-_99472843 0.362 REV1
REV1 homolog (S. cerevisiae)
chr17_+_25280999 0.362 NM_001145053
EFCAB5
EF-hand calcium binding domain 5
chr4_-_24641404 0.361 NM_018176
LGI2
leucine-rich repeat LGI family, member 2
chr8_+_110621485 0.360 NM_004215
EBAG9
estrogen receptor binding site associated, antigen, 9
chr7_+_138695144 0.356 NM_016019
LUC7L2
LUC7-like 2 (S. cerevisiae)
chr3_-_137953876 0.356 NM_005862
STAG1
stromal antigen 1
chr5_-_130998806 0.354 NM_001164386
NM_001164387
NM_001164388
NM_001164389
NM_001164390
NM_016340
RAPGEF6





Rap guanine nucleotide exchange factor (GEF) 6





chr5_+_169863601 0.352 NM_001034837
NM_014592
KCNIP1

Kv channel interacting protein 1

chr1_+_153366559 0.351 EFNA1
ephrin-A1
chr4_-_168392151 0.351 SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr7_-_91601613 0.350 CYP51A1
cytochrome P450, family 51, subfamily A, polypeptide 1
chr8_+_69027277 0.349 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr20_+_60130866 0.348 NM_144703
LSM14B
LSM14B, SCD6 homolog B (S. cerevisiae)
chr4_-_105635499 0.345 CXXC4
CXXC finger protein 4
chr18_-_5533967 0.343 NM_012307
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr6_+_34312641 0.341 HMGA1
high mobility group AT-hook 1
chr6_+_126112431 0.340 HEY2
hairy/enhancer-of-split related with YRPW motif 2
chr7_-_72735665 0.340 NM_032317
DNAJC30
DnaJ (Hsp40) homolog, subfamily C, member 30
chr1_-_6182203 0.338 NM_000983
RPL22
ribosomal protein L22
chr4_+_82171142 0.336 NM_001201
BMP3
bone morphogenetic protein 3
chr9_-_124030770 0.335 NM_014368
NM_199160
LHX6

LIM homeobox 6

chr1_-_114855281 0.334 NM_015906
NM_033020
TRIM33

tripartite motif containing 33

chrX_-_54401161 0.334 NM_001002838
NM_020922
WNK3

WNK lysine deficient protein kinase 3

chrX_+_109132994 0.334 NM_032227
TMEM164
transmembrane protein 164
chr16_-_65422304 0.333 NAE1
NEDD8 activating enzyme E1 subunit 1
chr6_+_99389318 0.333 POU3F2
POU class 3 homeobox 2
chr5_-_139761182 0.333


chr2_-_171725150 0.332 TLK1
tousled-like kinase 1
chr3_+_14419066 0.331 SLC6A6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr16_+_23754772 0.331 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr4_-_152155827 0.331 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr17_-_70430839 0.331 NM_173477
USH1G
Usher syndrome 1G (autosomal recessive)
chr3_+_31998269 0.328 NM_001137674
ZNF860
zinc finger protein 860
chr7_-_50485515 0.328 NM_001042762
NM_022116
FIGNL1

fidgetin-like 1

chr1_+_111963920 0.327 NM_001010935
NM_002884
RAP1A

RAP1A, member of RAS oncogene family

chr9_+_86474393 0.327 NM_001018065
NM_001018066
NTRK2

neurotrophic tyrosine kinase, receptor, type 2

chr8_+_110621092 0.326 NM_198120
EBAG9
estrogen receptor binding site associated, antigen, 9

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.29 2.46e-23 GO:0044237 cellular metabolic process
1.37 5.57e-22 GO:0044260 cellular macromolecule metabolic process
1.48 4.06e-20 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.25 1.17e-17 GO:0044238 primary metabolic process
1.40 2.63e-16 GO:0034641 cellular nitrogen compound metabolic process
1.38 1.99e-15 GO:0006807 nitrogen compound metabolic process
1.21 2.28e-15 GO:0008152 metabolic process
1.53 3.31e-15 GO:0010467 gene expression
1.13 1.15e-14 GO:0009987 cellular process
1.27 5.19e-14 GO:0043170 macromolecule metabolic process
1.45 3.60e-13 GO:0090304 nucleic acid metabolic process
1.48 5.09e-11 GO:0016070 RNA metabolic process
1.38 5.99e-11 GO:0044267 cellular protein metabolic process
1.36 2.29e-09 GO:0009058 biosynthetic process
1.36 2.49e-09 GO:0044249 cellular biosynthetic process
1.45 4.96e-09 GO:0034645 cellular macromolecule biosynthetic process
1.44 5.09e-09 GO:0009059 macromolecule biosynthetic process
1.27 2.56e-08 GO:0031323 regulation of cellular metabolic process
1.27 9.94e-08 GO:0060255 regulation of macromolecule metabolic process
1.95 2.15e-07 GO:0007420 brain development
1.32 2.24e-07 GO:0010468 regulation of gene expression
1.79 2.70e-07 GO:0007417 central nervous system development
1.24 6.60e-07 GO:0019222 regulation of metabolic process
1.66 1.73e-06 GO:0006396 RNA processing
1.42 1.83e-06 GO:0007399 nervous system development
1.25 1.84e-06 GO:0080090 regulation of primary metabolic process
1.32 1.95e-06 GO:0051252 regulation of RNA metabolic process
1.31 2.13e-06 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.51 4.54e-06 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.29 4.92e-06 GO:0031326 regulation of cellular biosynthetic process
1.30 5.07e-06 GO:0010556 regulation of macromolecule biosynthetic process
1.28 5.45e-06 GO:0009889 regulation of biosynthetic process
1.35 1.16e-05 GO:0006464 protein modification process
2.25 1.48e-05 GO:0030900 forebrain development
1.28 1.93e-05 GO:0071842 cellular component organization at cellular level
1.27 4.10e-05 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.32 6.89e-05 GO:0043412 macromolecule modification
1.14 8.98e-05 GO:0050794 regulation of cellular process
1.26 9.76e-05 GO:0071841 cellular component organization or biogenesis at cellular level
1.59 1.10e-04 GO:0051276 chromosome organization
1.46 1.13e-04 GO:0032774 RNA biosynthetic process
1.24 1.24e-04 GO:0019538 protein metabolic process
1.12 1.64e-04 GO:0065007 biological regulation
1.29 2.36e-04 GO:0006355 regulation of transcription, DNA-dependent
1.67 2.39e-04 GO:0006325 chromatin organization
2.57 3.80e-04 GO:0021537 telencephalon development
1.33 4.23e-04 GO:0006996 organelle organization
1.72 4.63e-04 GO:0006397 mRNA processing
1.24 4.81e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.38 6.45e-04 GO:0009893 positive regulation of metabolic process
1.20 7.98e-04 GO:0032502 developmental process
1.80 8.37e-04 GO:0006412 translation
1.21 1.11e-03 GO:0016043 cellular component organization
1.57 1.42e-03 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
1.12 1.43e-03 GO:0050789 regulation of biological process
1.45 1.51e-03 GO:0006351 transcription, DNA-dependent
1.59 1.96e-03 GO:0006753 nucleoside phosphate metabolic process
1.59 1.96e-03 GO:0009117 nucleotide metabolic process
1.64 2.54e-03 GO:0072521 purine-containing compound metabolic process
1.69 2.85e-03 GO:0016568 chromatin modification
1.21 3.44e-03 GO:0048856 anatomical structure development
1.19 4.82e-03 GO:0071840 cellular component organization or biogenesis
1.22 5.93e-03 GO:0048731 system development
1.36 6.22e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.70 6.44e-03 GO:0009259 ribonucleotide metabolic process
1.48 6.65e-03 GO:0010628 positive regulation of gene expression
1.64 8.79e-03 GO:0006163 purine nucleotide metabolic process
1.72 8.99e-03 GO:0009141 nucleoside triphosphate metabolic process
1.54 9.17e-03 GO:0016071 mRNA metabolic process
1.50 9.66e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.35 9.75e-03 GO:0031325 positive regulation of cellular metabolic process
1.27 1.17e-02 GO:0044281 small molecule metabolic process
1.55 1.37e-02 GO:0019226 transmission of nerve impulse
1.55 1.37e-02 GO:0035637 multicellular organismal signaling
1.92 1.43e-02 GO:0016569 covalent chromatin modification
1.71 1.45e-02 GO:0009144 purine nucleoside triphosphate metabolic process
1.48 1.71e-02 GO:0045893 positive regulation of transcription, DNA-dependent
1.46 1.79e-02 GO:0051254 positive regulation of RNA metabolic process
1.48 1.83e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.92 2.00e-02 GO:0016570 histone modification
1.24 2.36e-02 GO:0048523 negative regulation of cellular process
1.67 2.41e-02 GO:0009150 purine ribonucleotide metabolic process
1.53 2.50e-02 GO:0034621 cellular macromolecular complex subunit organization
1.51 2.57e-02 GO:0051253 negative regulation of RNA metabolic process
1.18 2.59e-02 GO:0007275 multicellular organismal development
1.43 2.66e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
1.77 2.71e-02 GO:0050767 regulation of neurogenesis
1.57 2.80e-02 GO:0007268 synaptic transmission
1.19 3.14e-02 GO:0051234 establishment of localization
1.39 3.17e-02 GO:0009891 positive regulation of biosynthetic process
1.62 3.41e-02 GO:0051301 cell division
1.19 3.77e-02 GO:0006810 transport
1.68 3.90e-02 GO:0009205 purine ribonucleoside triphosphate metabolic process
1.39 4.24e-02 GO:0048699 generation of neurons
1.38 4.27e-02 GO:0031324 negative regulation of cellular metabolic process
1.68 4.42e-02 GO:0009199 ribonucleoside triphosphate metabolic process
1.17 4.43e-02 GO:0051179 localization
1.70 4.45e-02 GO:0010608 posttranscriptional regulation of gene expression
1.39 4.52e-02 GO:0031328 positive regulation of cellular biosynthetic process
1.31 4.60e-02 GO:0051641 cellular localization
1.22 4.68e-02 GO:0048519 negative regulation of biological process
2.37 4.75e-02 GO:0021953 central nervous system neuron differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.15 4.42e-27 GO:0005622 intracellular
1.15 4.52e-26 GO:0044424 intracellular part
1.19 7.10e-21 GO:0043231 intracellular membrane-bounded organelle
1.19 8.03e-21 GO:0043227 membrane-bounded organelle
1.29 1.06e-20 GO:0005634 nucleus
1.16 2.61e-19 GO:0043226 organelle
1.16 3.66e-19 GO:0043229 intracellular organelle
1.15 2.18e-10 GO:0005737 cytoplasm
1.38 2.58e-10 GO:0044428 nuclear part
1.37 5.06e-10 GO:0070013 intracellular organelle lumen
1.36 6.58e-10 GO:0031974 membrane-enclosed lumen
1.40 3.78e-09 GO:0031981 nuclear lumen
1.35 4.21e-09 GO:0043233 organelle lumen
1.48 5.43e-09 GO:0005654 nucleoplasm
1.05 2.68e-08 GO:0044464 cell part
1.05 2.83e-08 GO:0005623 cell
1.63 5.07e-08 GO:0044451 nucleoplasm part
1.18 7.03e-08 GO:0044446 intracellular organelle part
1.17 3.26e-07 GO:0044422 organelle part
1.22 7.01e-06 GO:0032991 macromolecular complex
1.65 1.32e-05 GO:0030529 ribonucleoprotein complex
1.13 3.23e-04 GO:0044444 cytoplasmic part
4.43 7.03e-04 GO:0031519 PcG protein complex
1.72 1.22e-02 GO:0000785 chromatin
2.60 1.48e-02 GO:0034708 methyltransferase complex
2.60 1.48e-02 GO:0035097 histone methyltransferase complex
5.45 1.76e-02 GO:0035098 ESC/E(Z) complex
3.89 2.67e-02 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
1.18 2.73e-02 GO:0043228 non-membrane-bounded organelle
1.18 2.73e-02 GO:0043232 intracellular non-membrane-bounded organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.37 2.13e-16 GO:0003676 nucleic acid binding
1.41 8.45e-13 GO:0000166 nucleotide binding
1.72 3.96e-12 GO:0003723 RNA binding
1.10 8.96e-11 GO:0005488 binding
1.16 4.72e-09 GO:0005515 protein binding
1.53 5.75e-08 GO:0030528 transcription regulator activity
1.33 5.64e-06 GO:0035639 purine ribonucleoside triphosphate binding
1.33 6.41e-06 GO:0017076 purine nucleotide binding
1.32 1.10e-05 GO:0032553 ribonucleotide binding
1.32 1.10e-05 GO:0032555 purine ribonucleotide binding
1.27 6.80e-05 GO:0003677 DNA binding
1.33 2.04e-04 GO:0030554 adenyl nucleotide binding
1.30 2.16e-04 GO:0016740 transferase activity
1.32 3.13e-04 GO:0005524 ATP binding
1.32 3.89e-04 GO:0032559 adenyl ribonucleotide binding
1.39 3.20e-03 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.36 4.24e-03 GO:0001071 nucleic acid binding transcription factor activity
1.36 4.24e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.41 6.98e-03 GO:0019899 enzyme binding
1.40 8.36e-03 GO:0016301 kinase activity