Motif ID: AIRE.p2

Z-value: 0.928


Transcription factors associated with AIRE.p2:

Gene SymbolEntrez IDGene Name
AIRE 326 autoimmune regulator

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
AIREchr21_+_445345750.224.2e-01Click!


Activity profile for motif AIRE.p2.

activity profile for motif AIRE.p2


Sorted Z-values histogram for motif AIRE.p2

Sorted Z-values for motif AIRE.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_10430225 1.385 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chr18_+_27425727 1.125 NM_000371
TTR
transthyretin
chrX_-_2892288 0.836 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr4_+_69716298 0.745 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr19_-_12028126 0.666 NM_001080404
ZNF878
zinc finger protein 878
chr11_-_64484184 0.647 NM_001037225
C11orf85
chromosome 11 open reading frame 85
chr9_-_124329392 0.589 NM_012363
OR1N1
olfactory receptor, family 1, subfamily N, member 1
chr16_+_20328355 0.583 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr10_+_7785290 0.582 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785347 0.562 ITIH2
inter-alpha (globulin) inhibitor H2
chr17_+_38259620 0.561 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr10_+_7785360 0.561 ITIH2
inter-alpha (globulin) inhibitor H2
chr17_+_63367052 0.546 BPTF
bromodomain PHD finger transcription factor
chr10_+_7785331 0.521 ITIH2
inter-alpha (globulin) inhibitor H2
chr12_+_100512877 0.514 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr14_+_38804226 0.499 NM_203354
CTAGE5
CTAGE family, member 5
chr2_+_201689060 0.486 NM_001127184
NM_003879
CFLAR

CASP8 and FADD-like apoptosis regulator

chr9_+_6710862 0.485 NM_001146696
KDM4C
lysine (K)-specific demethylase 4C
chr7_-_64104441 0.480 NM_001007253
ERV3
ZNF117
endogenous retroviral sequence 3
zinc finger protein 117
chr17_+_55098280 0.462 CLTC
clathrin, heavy chain (Hc)
chr3_-_172227223 0.448 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr14_+_101345878 0.447 NM_002719
NM_178586
NM_178587
PPP2R5C


protein phosphatase 2, regulatory subunit B', gamma


chr19_-_14646626 0.446 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr20_+_35755865 0.442 CTNNBL1
catenin, beta like 1
chr7_+_116238309 0.435 CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr16_-_1434490 0.431 NM_001143980
CCDC154
coiled-coil domain containing 154
chr20_+_35755857 0.427 CTNNBL1
catenin, beta like 1
chr4_-_84254873 0.427 PLAC8
placenta-specific 8
chr17_+_38256710 0.424 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr19_-_42355407 0.417 NM_152655
ZNF585A
zinc finger protein 585A
chr19_+_2818332 0.410 NM_024967
ZNF556
zinc finger protein 556
chr20_+_35755832 0.395 NM_030877
CTNNBL1
catenin, beta like 1
chr2_+_65069081 0.394 NM_001193493
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr17_+_63766874 0.393 NM_014960
ARSG
arylsulfatase G
chr13_-_98708549 0.391 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr10_-_101831579 0.372 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr7_+_111908143 0.369 NM_001134468
NM_182597
C7orf53

chromosome 7 open reading frame 53

chr4_+_170817787 0.366 CLCN3
chloride channel 3
chr15_-_43458247 0.364 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr9_+_117955890 0.364 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr13_-_40454188 0.363 ELF1
E74-like factor 1 (ets domain transcription factor)
chr8_-_37847095 0.354 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr19_-_53912025 0.353 NM_182574
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr20_-_43440290 0.349 NM_014477
TP53TG5
TP53 target 5
chr15_-_74941339 0.347 NM_001145923
SCAPER
S-phase cyclin A-associated protein in the ER
chr12_-_55979413 0.345


chr8_+_7340777 0.340 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr19_+_22027118 0.335 ZNF257
zinc finger protein 257
chr6_+_26473376 0.330 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr5_+_118993152 0.325 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chr6_-_99957253 0.320 SFRS18
splicing factor, arginine/serine-rich 18
chr11_-_1586190 0.320 NM_001012708
KRTAP5-3
keratin associated protein 5-3
chr19_+_53189719 0.319 NM_022142
ELSPBP1
epididymal sperm binding protein 1
chr11_-_73371531 0.318 NM_003355
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr16_+_14201687 0.316 MKL2
MKL/myocardin-like 2
chr22_+_34979118 0.315 APOL1
apolipoprotein L, 1
chr2_-_199922047 0.314 SATB2
SATB homeobox 2
chrX_-_102418329 0.311 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr10_+_123738678 0.310 NM_206861
NM_206862
TACC2

transforming, acidic coiled-coil containing protein 2

chr16_-_70080678 0.310 NM_006961
ZNF19
zinc finger protein 19
chr2_+_215885053 0.307 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr20_-_42373151 0.305 NM_001080472
FITM2
fat storage-inducing transmembrane protein 2
chr16_-_4757125 0.301 NM_021646
ZNF500
zinc finger protein 500
chr6_+_41996971 0.300 BYSL
bystin-like
chrX_+_153310313 0.300 ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
chr12_-_44644216 0.299


chr16_-_11588257 0.298 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr21_+_39674112 0.292 WRB
tryptophan rich basic protein
chr6_+_4835224 0.285 NM_001143971
CDYL
chromodomain protein, Y-like
chr12_+_70119785 0.271 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr4_+_88187215 0.269 AFF1
AF4/FMR2 family, member 1
chr4_-_84254932 0.267 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr2_-_202192097 0.266 ALS2CR11
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11
chr19_-_23661779 0.266 NM_138330
ZNF675
zinc finger protein 675
chr17_-_18207416 0.264 NM_004169
NM_148918
SHMT1

serine hydroxymethyltransferase 1 (soluble)

chr20_-_31452991 0.264 NM_016082
NM_016408
CDK5RAP1

CDK5 regulatory subunit associated protein 1

chr20_-_31452964 0.264 CDK5RAP1
CDK5 regulatory subunit associated protein 1
chr3_-_172227152 0.256 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr1_-_7895873 0.256 UTS2
urotensin 2
chr9_+_70840298 0.254 NM_000144
NM_001161706
NM_181425
FXN


frataxin


chr19_+_13999959 0.251 NM_080864
RLN3
relaxin 3
chr16_-_3567354 0.250 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr16_+_2749934 0.249


chr15_+_57696200 0.245 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr3_-_127810087 0.245 NM_001039783
TXNRD3IT1
thioredoxin reductase 3 intronic transcript 1
chr1_-_158521491 0.244 PEX19
peroxisomal biogenesis factor 19
chr15_+_57696016 0.243 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr9_-_103187082 0.240 NM_001701
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr2_+_38009405 0.240 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr22_+_34979062 0.239 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr2_+_215884923 0.239 NM_004044
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr15_-_75135496 0.239 TSPAN3
tetraspanin 3
chr14_+_34585098 0.237 NM_173607
FAM177A1
family with sequence similarity 177, member A1
chr9_-_129740583 0.235 NM_003863
DPM2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
chr14_-_21074875 0.235 NM_005407
SALL2
sal-like 2 (Drosophila)
chr6_+_53043729 0.234 NM_012347
FBXO9
F-box protein 9
chr19_-_54557450 0.229 NM_003598
TEAD2
TEA domain family member 2
chr19_+_21056792 0.228 NM_182515
ZNF714
zinc finger protein 714
chr19_+_18069596 0.228 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr1_-_21249974 0.226 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr2_+_113911737 0.225 NM_172003
CBWD2
CBWD1
COBW domain containing 2
COBW domain containing 1
chr19_-_16111594 0.225


chr4_+_70950747 0.224 NM_002159
HTN1
histatin 1
chr11_+_129484540 0.221 APLP2
amyloid beta (A4) precursor-like protein 2
chr3_-_31998241 0.221 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr12_+_49605010 0.220 METTL7A
methyltransferase like 7A
chr1_-_180624494 0.219 GLUL
glutamate-ammonia ligase
chr19_-_16111695 0.217


chr1_+_208568218 0.216 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr1_-_155336223 0.215 NM_001004341
ETV3L
ets variant 3-like
chr1_-_159474503 0.213 NM_001077469
NM_001077470
NM_001077471
NM_001077472
NM_001077473
NM_001077474
NM_001077475
NM_001077476
NM_001077477
NM_001077478
NM_001077479
NM_001077480
NM_001077481
NM_001077482
NM_005122
NR1I3














nuclear receptor subfamily 1, group I, member 3














chr20_-_33658823 0.212 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr2_+_215885063 0.211 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr9_-_85761353 0.210 C9orf64
chromosome 9 open reading frame 64
chr17_-_37275142 0.209 NM_018143
KLHL11
kelch-like 11 (Drosophila)
chr15_-_23204887 0.205 NM_000462
UBE3A
ubiquitin protein ligase E3A
chr11_-_47467094 0.205 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr4_+_152417774 0.204 NM_183375
PRSS48
protease, serine, 48
chr15_+_20287609 0.203 NM_001001413
GOLGA6L1
golgin A6 family-like 1
chr3_+_51550635 0.203 NM_015106
RAD54L2
RAD54-like 2 (S. cerevisiae)
chr19_+_39402167 0.202 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr4_+_39084936 0.202 KLB
klotho beta
chr8_-_30704984 0.202 NM_000637
NM_001195102
NM_001195103
NM_001195104
GSR



glutathione reductase



chr12_+_99391870 0.200 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr6_+_32240357 0.198 NM_030652
EGFL8
EGF-like-domain, multiple 8
chr3_-_124822113 0.197 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr13_-_40454360 0.197 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chrX_-_19443299 0.196 NM_001001671
MAP3K15
mitogen-activated protein kinase kinase kinase 15
chr2_-_215998181 0.193 FN1
fibronectin 1
chr17_-_30414789 0.193 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr8_-_11966664 0.190 NM_001195257
NM_001037804
LOC100133267
DEFB130
defensin, beta 130-like
defensin, beta 130
chr1_-_158521547 0.190 NM_001193644
NM_002857
PEX19

peroxisomal biogenesis factor 19

chr11_+_69872033 0.189 PPFIA1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
chr1_+_559129 0.187


chr17_+_39778191 0.187 GRN
granulin
chr6_+_41996942 0.186 NM_004053
BYSL
bystin-like
chr1_+_28637247 0.184 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr4_+_53975597 0.180 FIP1L1
FIP1 like 1 (S. cerevisiae)
chr7_-_45117797 0.180 TBRG4
transforming growth factor beta regulator 4
chr2_+_233112680 0.179 NM_005199
CHRNG
cholinergic receptor, nicotinic, gamma
chr5_+_161427225 0.179 NM_000816
NM_198903
NM_198904
GABRG2


gamma-aminobutyric acid (GABA) A receptor, gamma 2


chr6_+_31698447 0.179


chr15_-_48198697 0.179 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chr2_-_198248828 0.177 NM_144629
RFTN2
raftlin family member 2
chr4_+_39084867 0.176 NM_175737
KLB
klotho beta
chr5_+_75734759 0.175 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr16_+_88154582 0.175 NM_000977
NM_033251
RPL13

ribosomal protein L13

chr9_+_130719034 0.175 LRRC8A
leucine rich repeat containing 8 family, member A
chr19_+_2340768 0.175 NM_182973
TMPRSS9
transmembrane protease, serine 9
chr2_+_151922350 0.175 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr1_+_51208499 0.174 CDKN2C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr13_-_40491491 0.173 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_+_144595224 0.173 NM_001097616
GPR89C
G protein-coupled receptor 89C
chr2_+_99344060 0.172 EIF5B
eukaryotic translation initiation factor 5B
chr6_+_142510108 0.171 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr10_+_7785235 0.171 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr1_+_15655809 0.170 NM_033440
CELA2A
chymotrypsin-like elastase family, member 2A
chr1_+_40715465 0.169 ZNF642
zinc finger protein 642
chr17_-_36113502 0.168 NM_019016
KRT24
keratin 24
chr19_-_60528480 0.166 NM_001085488
TMEM150B
transmembrane protein 150B
chr15_-_97607108 0.165 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr19_+_46489987 0.165 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr7_-_5534252 0.163 ACTB
actin, beta
chr4_-_75066533 0.161 NM_002619
PF4
platelet factor 4
chrX_-_77037563 0.160 NM_032121
MAGT1
magnesium transporter 1
chr6_+_36318922 0.160 NM_173676
NM_001145716
PNPLA1

patatin-like phospholipase domain containing 1

chr6_+_131508153 0.160 NM_016377
AKAP7
A kinase (PRKA) anchor protein 7
chr5_+_55276278 0.159 RPL41P5
ribosomal protein L41 pseudogene 5
chr4_-_84254912 0.159 PLAC8
placenta-specific 8
chr1_-_115070413 0.158 CSDE1
cold shock domain containing E1, RNA-binding
chr3_-_17757402 0.158 NM_014744
TBC1D5
TBC1 domain family, member 5
chr17_-_10500189 0.158 NM_002470
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chr3_+_63859114 0.157 NM_001177387
ATXN7
ataxin 7
chr6_-_43129368 0.157 CUL7
cullin 7
chr5_-_96544639 0.157 RIOK2
RIO kinase 2 (yeast)
chr2_+_232354675 0.157 COPS7B
COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis)
chr9_-_98580148 0.155 NM_014930
ZNF510
zinc finger protein 510
chr20_+_29598848 0.154 HM13
histocompatibility (minor) 13
chr4_+_187424336 0.154 F11
coagulation factor XI
chr16_+_20682812 0.153 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr15_-_70838703 0.152


chr3_-_139960874 0.151 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr12_-_7979896 0.150 NM_006931
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr19_+_52504914 0.150 NM_001736
C5AR1
complement component 5a receptor 1
chr15_+_39363442 0.149 LOC729082
hypothetical LOC729082
chr2_+_28892366 0.147 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr3_+_153074118 0.146 NM_033050
SUCNR1
succinate receptor 1
chr3_-_152403636 0.145 NM_013308
GPR171
G protein-coupled receptor 171
chr1_+_226741665 0.145 NM_001010858
RNF187
ring finger protein 187
chr4_+_128773529 0.144 NM_015693
INTU
inturned planar cell polarity effector homolog (Drosophila)
chr13_-_36471474 0.143 NM_001142364
NM_013338
ALG5

asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog (S. cerevisiae)

chr10_+_4995453 0.142 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr1_-_114855281 0.142 NM_015906
NM_033020
TRIM33

tripartite motif containing 33

chrX_+_153310171 0.142 NM_001183
ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
chr2_-_37397669 0.142 NM_005813
PRKD3
protein kinase D3
chr11_-_46569489 0.142 NM_017749
AMBRA1
autophagy/beclin-1 regulator 1
chr21_-_42219849 0.142 NM_199050
C2CD2
C2 calcium-dependent domain containing 2
chr3_+_9451506 0.141


chr20_-_18425811 0.141 NM_006606
RBBP9
retinoblastoma binding protein 9
chr5_+_138657317 0.140 NM_001194955
NM_001194956
MATR3

matrin 3


Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.