Motif ID: ALX1.p2

Z-value: 0.655


Transcription factors associated with ALX1.p2:

Gene SymbolEntrez IDGene Name
ALX1 8092 ALX homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ALX1chr12_+_841980150.504.9e-02Click!


Activity profile for motif ALX1.p2.

activity profile for motif ALX1.p2


Sorted Z-values histogram for motif ALX1.p2

Sorted Z-values for motif ALX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ALX1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_41362370 1.285 NM_018643
TREM1
triggering receptor expressed on myeloid cells 1
chr2_+_132196533 1.139 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chrX_-_131089552 0.980 NM_194277
FRMD7
FERM domain containing 7
chr10_-_23673777 0.972 NM_153714
C10orf67
chromosome 10 open reading frame 67
chr3_+_63238854 0.914 NM_001130003
SYNPR
synaptoporin
chr2_+_204279442 0.910 NM_006139
CD28
CD28 molecule
chr9_+_89687560 0.895 NM_178828
C9orf79
chromosome 9 open reading frame 79
chr11_-_5212168 0.880 NM_000519
HBD
hemoglobin, delta
chr7_-_115458010 0.854 NM_001018058
NM_012252
TFEC

transcription factor EC

chr10_-_42183441 0.849 LOC283027
hypothetical protein LOC283027
chr7_-_107667728 0.845 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr3_+_122769467 0.843 NM_001012659
ARGFX
arginine-fifty homeobox
chr1_+_559129 0.820


chr19_+_53450743 0.808


chr3_+_8750485 0.807 NM_033337
NM_001234
CAV3

caveolin 3

chr6_+_12825818 0.747 NM_030948
PHACTR1
phosphatase and actin regulator 1
chr11_+_55362802 0.739 NM_001005496
OR5D16
olfactory receptor, family 5, subfamily D, member 16
chr7_+_22733290 0.731 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr3_-_113495763 0.700 NM_183061
SLC9A10
solute carrier family 9, member 10
chr10_+_49279647 0.699 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr9_-_21207303 0.696 NM_002173
IFNA16
interferon, alpha 16
chr1_-_114215768 0.683 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr10_+_124310170 0.681 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr17_-_44006808 0.675 NM_002146
HOXB3
homeobox B3
chr4_+_156807311 0.672 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chr1_+_54132447 0.669 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr1_+_156991133 0.662 NM_001005184
OR6K6
olfactory receptor, family 6, subfamily K, member 6
chr10_-_21226536 0.653 NM_006393
NEBL
nebulette
chr19_+_41177882 0.651 NM_001042631
SDHAF1
succinate dehydrogenase complex assembly factor 1
chr22_-_15682555 0.648 NM_175878
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr19_-_21438525 0.642


chr3_+_28406990 0.641 NM_001040432
ZCWPW2
zinc finger, CW type with PWWP domain 2
chr1_+_180685878 0.634 NM_001137669
RGSL1
regulator of G-protein signaling like 1
chr1_-_155788775 0.634 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr4_-_38534802 0.634 NM_006068
TLR6
toll-like receptor 6
chr2_-_162717159 0.627 NM_002054
GCG
glucagon
chr5_+_121493113 0.623 NM_207317
ZNF474
zinc finger protein 474
chr1_+_559618 0.620


chr12_+_26239535 0.617 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr9_-_73865318 0.614 NM_001128618
C9orf57
chromosome 9 open reading frame 57
chr5_+_57823017 0.606 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr21_-_38792173 0.603 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr12_-_7547552 0.592 NM_004244
NM_203416
CD163

CD163 molecule

chr1_-_180908639 0.590 NM_001102450
NM_033345
RGS8

regulator of G-protein signaling 8

chr7_-_113346284 0.586 NM_002711
PPP1R3A
protein phosphatase 1, regulatory (inhibitor) subunit 3A
chr10_-_128199986 0.581 NM_001004298
C10orf90
chromosome 10 open reading frame 90
chr12_+_9871343 0.573 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr1_+_194887630 0.566 NM_000186
NM_001014975
CFH

complement factor H

chr14_+_93455010 0.556 NM_138344
FAM181A
family with sequence similarity 181, member A
chr2_-_224974954 0.555 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr6_-_31756119 0.550 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr16_+_21603250 0.544 NM_001161683
OTOA
otoancorin
chr4_-_185376012 0.542 NM_153343
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr4_-_69218909 0.539 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr7_-_16811131 0.536 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr11_-_7906784 0.532 NM_001004461
OR10A6
olfactory receptor, family 10, subfamily A, member 6
chr7_-_112545847 0.530 LOC401397
hypothetical LOC401397
chr17_+_18588050 0.526 NM_031456
FBXW10
CDRT1
F-box and WD repeat domain containing 10
CMT1A duplicated region transcript 1
chr1_-_76170563 0.512 NM_080868
ASB17
ankyrin repeat and SOCS box containing 17
chr19_+_60962318 0.505 NM_001145014
RFPL4A
ret finger protein-like 4A
chr9_-_28709302 0.505 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr2_-_87102453 0.503 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr9_+_5221401 0.498 NM_002195
INSL4
insulin-like 4 (placenta)
chr4_-_69570919 0.497 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr2_+_102456193 0.493 NM_001011552
SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chr15_+_67094087 0.493 NM_001184779
NM_024505
NOX5

NADPH oxidase, EF-hand calcium binding domain 5

chr6_+_26359805 0.487 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr12_-_9651748 0.484 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr4_-_160175782 0.475 NM_152543
C4orf45
chromosome 4 open reading frame 45
chr3_-_197726587 0.474 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr1_+_154120170 0.469 SYT11
synaptotagmin XI
chr3_+_35658852 0.461 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr12_-_54150188 0.457 NM_001005499
OR6C70
olfactory receptor, family 6, subfamily C, member 70
chr7_-_92615593 0.453 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr11_-_59707074 0.451 NM_022349
NM_152851
NM_152852
MS4A6A


membrane-spanning 4-domains, subfamily A, member 6A


chr19_-_18763077 0.450 NM_000095
COMP
cartilage oligomeric matrix protein
chr10_-_69095362 0.442 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr1_+_63022359 0.442 NM_032852
NM_178221
ATG4C

ATG4 autophagy related 4 homolog C (S. cerevisiae)

chr1_-_201465395 0.438 NM_003465
CHIT1
chitinase 1 (chitotriosidase)
chr11_-_123695302 0.437 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr9_+_106496480 0.434 NM_001004484
OR13D1
olfactory receptor, family 13, subfamily D, member 1
chr19_-_4486202 0.432 NM_001013706
PLIN5
perilipin 5
chr17_+_58440629 0.415 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr18_+_28023984 0.408 NM_005925
MEP1B
meprin A, beta
chr18_+_27152049 0.402 NM_001942
DSG1
desmoglein 1
chr5_+_76470829 0.402


chrX_+_90976314 0.398 NM_014522
NM_032968
NM_032969
PCDH11X


protocadherin 11 X-linked


chr7_-_81237162 0.395 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chrX_+_90977115 0.392 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr3_+_110338250 0.386 FLJ22763
hypothetical LOC401081
chr18_-_3835295 0.384 NM_001003809
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr5_-_176258920 0.381 NM_002115
HK3
hexokinase 3 (white cell)
chr3_+_63613383 0.381 NM_001080537
SNTN
sentan, cilia apical structure protein
chr12_-_61832856 0.374 NM_000706
AVPR1A
arginine vasopressin receptor 1A
chr7_+_143043871 0.373 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr19_-_6384772 0.370 NM_173637
SLC25A41
solute carrier family 25, member 41
chr4_+_120276386 0.368 NM_016599
MYOZ2
myozenin 2
chr22_-_41815277 0.365 NM_012263
TTLL1
tubulin tyrosine ligase-like family, member 1
chr2_+_204279624 0.364 CD28
CD28 molecule
chrX_+_66705407 0.362 NM_001011645
AR
androgen receptor
chr3_+_44667504 0.361 ZNF35
zinc finger protein 35
chr22_+_23532135 0.361 NM_001039948
NM_001098497
NM_001098498
NM_133454
SGSM1



small G protein signaling modulator 1



chrX_+_154764136 0.361 NM_001145149
NM_001185183
NM_005638
VAMP7


vesicle-associated membrane protein 7


chr22_-_22252376 0.356 NM_020070
NM_152855
IGLL1

immunoglobulin lambda-like polypeptide 1

chr6_+_31791063 0.355 NM_021246
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr15_-_88023576 0.353 NM_001145311
NM_002666
PLIN1

perilipin 1

chr1_-_67039518 0.349 NM_005478
INSL5
insulin-like 5
chr5_+_140594121 0.342 PCDHB18
protocadherin beta 18 pseudogene
chr11_-_51269023 0.339 NM_001005272
OR4A5
olfactory receptor, family 4, subfamily A, member 5
chr1_-_156954528 0.339 NM_001005327
OR6K3
olfactory receptor, family 6, subfamily K, member 3
chr7_+_150319076 0.338 NM_000603
NOS3
nitric oxide synthase 3 (endothelial cell)
chr3_-_168853982 0.336 NM_178824
WDR49
WD repeat domain 49
chr1_-_156923111 0.335 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr12_+_100512877 0.335 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr4_+_71713324 0.334 NM_031889
ENAM
enamelin
chr14_-_106084085 0.333 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr17_+_9670105 0.331 NM_004246
GLP2R
glucagon-like peptide 2 receptor
chr5_+_140200995 0.330 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr5_+_40877053 0.330 NM_032587
CARD6
caspase recruitment domain family, member 6
chr11_+_93940121 0.329 NM_152431
PIWIL4
piwi-like 4 (Drosophila)
chr5_+_140583098 0.329 NM_018934
PCDHB14
protocadherin beta 14
chr11_-_113971681 0.323 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr3_+_150065732 0.323 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr11_+_113351006 0.320 NM_000869
NM_213621
HTR3A

5-hydroxytryptamine (serotonin) receptor 3A

chr3_-_170347019 0.318 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr1_-_156635879 0.317 NM_001004475
OR10T2
olfactory receptor, family 10, subfamily T, member 2
chr7_-_102070473 0.316 NM_001114403
UPK3BL
POLR2J2
uroplakin 3B-like
polymerase (RNA) II (DNA directed) polypeptide J2
chr7_+_37689903 0.314


chr3_-_46224791 0.307 NM_001295
CCR1
chemokine (C-C motif) receptor 1
chr3_+_49210864 0.306 NM_178173
CCDC36
coiled-coil domain containing 36
chr3_-_170864111 0.303 NM_004991
MECOM
MDS1 and EVI1 complex locus
chr11_-_5321329 0.301 NM_001005567
OR51B5
olfactory receptor, family 51, subfamily B, member 5
chr5_+_140227951 0.300 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr7_-_86433139 0.299 NM_152748
KIAA1324L
KIAA1324-like
chr6_+_47857733 0.298 NM_181744
OPN5
opsin 5
chr5_-_39306465 0.294 FYB
FYN binding protein
chr11_-_76800525 0.294 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr10_+_118946989 0.292 NM_181840
KCNK18
potassium channel, subfamily K, member 18
chr17_+_25292748 0.289 NM_198529
EFCAB5
EF-hand calcium binding domain 5
chr8_-_111056099 0.285 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chr4_+_43185 0.285 NM_182524
ZNF595
ZNF718
zinc finger protein 595
zinc finger protein 718
chr2_-_190635566 0.285 NM_005259
MSTN
myostatin
chr6_+_118976134 0.283 NM_002667
PLN
phospholamban
chr9_+_124416768 0.283 NM_012364
OR1Q1
olfactory receptor, family 1, subfamily Q, member 1
chr11_+_88550687 0.282 NM_000372
TYR
tyrosinase (oculocutaneous albinism IA)
chr2_+_87828718 0.281 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr1_-_35143570 0.281 NM_001080418
DLGAP3
discs, large (Drosophila) homolog-associated protein 3
chr7_-_112545840 0.279 LOC401397
hypothetical LOC401397
chr20_+_34019942 0.278 NM_080834
C20orf152
chromosome 20 open reading frame 152
chr10_-_28611020 0.278 NM_173496
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr5_+_147562531 0.277 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr5_-_35083996 0.275 NM_031900
AGXT2
alanine--glyoxylate aminotransferase 2
chr11_+_120478584 0.274 NM_005422
TECTA
tectorin alpha
chr13_+_22653059 0.273 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr5_-_14706486 0.271


chr19_-_4510713 0.270 SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr10_+_69539255 0.264 NM_032578
MYPN
myopalladin
chr1_+_157676135 0.264 NM_012351
OR10J1
olfactory receptor, family 10, subfamily J, member 1
chr18_-_54447168 0.264 NM_052947
ALPK2
alpha-kinase 2
chr11_+_123600553 0.264 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr22_-_38619739 0.260 NM_152512
ENTHD1
ENTH domain containing 1
chr1_+_156590109 0.258 NM_001042583
NM_001042584
NM_001042585
NM_001042586
NM_001042587
NM_001185107
NM_001185108
NM_001185110
NM_001185112
NM_001185113
NM_001185114
NM_001185115
NM_030893
CD1E












CD1e molecule












chr6_-_50097606 0.257 NM_001037497
NM_001037728
DEFB110

defensin, beta 110 locus

chr4_-_26100986 0.257 NM_000730
CCKAR
cholecystokinin A receptor
chr5_+_140605100 0.257 PCDHB15
protocadherin beta 15
chr19_-_5821546 0.256 NM_002034
FUT5
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr22_-_14829803 0.254 NM_001005239
OR11H1
olfactory receptor, family 11, subfamily H, member 1
chr7_-_15568099 0.254 NM_001004320
AGMO
alkylglycerol monooxygenase
chr3_+_123817151 0.254 NM_152615
PARP15
poly (ADP-ribose) polymerase family, member 15
chr3_+_69895310 0.253 NM_001184967
MITF
microphthalmia-associated transcription factor
chr12_+_53177789 0.251 NCKAP1L
NCK-associated protein 1-like
chr2_+_102320148 0.251 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr5_-_158690047 0.250 NM_002187
IL12B
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
chr19_+_12064077 0.250 ZNF788
zinc finger family member 788
chr7_+_73826244 0.246 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr12_-_69434598 0.246 NM_130846
PTPRR
protein tyrosine phosphatase, receptor type, R
chr12_+_20739555 0.244 NM_001145945
NM_001145946
NM_001145944
NM_017435
SLCO1C1



solute carrier organic anion transporter family, member 1C1



chr9_+_101628829 0.244 NM_173200
NR4A3
nuclear receptor subfamily 4, group A, member 3
chr19_+_52908412 0.243 NM_014601
EHD2
EH-domain containing 2
chr12_+_53177758 0.242 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr4_-_123761615 0.241 NM_021803
IL21
interleukin 21
chr4_+_74566325 0.240 NM_001133
AFM
afamin
chr13_+_107719977 0.240 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr13_+_50813168 0.239 NM_001101320
SERPINE3
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
chr6_-_25982418 0.239 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr6_-_128281434 0.236 NM_001164687
THEMIS
thymocyte selection associated
chr3_-_9895633 0.235 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr5_-_22889487 0.235 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chrX_-_23835868 0.235 NM_024122
APOO
apolipoprotein O
chr2_-_130619038 0.235 NM_207310
CCDC74B
coiled-coil domain containing 74B
chr7_+_129693938 0.234 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chr3_-_36756355 0.233 NM_033403
DCLK3
doublecortin-like kinase 3
chr12_+_53177806 0.232 NCKAP1L
NCK-associated protein 1-like
chr3_+_108578877 0.229 NM_032600
CCDC54
coiled-coil domain containing 54
chr19_-_63556632 0.229 NM_130786
A1BG
alpha-1-B glycoprotein
chr4_-_75083160 0.228 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chr5_-_43432969 0.227 CCL28
chemokine (C-C motif) ligand 28
chr4_-_122304925 0.226 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr6_-_2696152 0.226 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr9_+_35032222 0.226 NM_001040410
NM_203299
C9orf131

chromosome 9 open reading frame 131


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.89 2.04e-16 GO:0007600 sensory perception
3.53 4.57e-15 GO:0007606 sensory perception of chemical stimulus
3.69 7.19e-15 GO:0007608 sensory perception of smell
2.09 2.66e-13 GO:0003008 system process
2.23 8.21e-13 GO:0050877 neurological system process
1.35 1.74e-05 GO:0032501 multicellular organismal process
2.13 5.43e-05 GO:0006955 immune response
1.27 1.12e-03 GO:0050896 response to stimulus
1.70 4.70e-03 GO:0002376 immune system process
2.23 7.61e-03 GO:0050776 regulation of immune response
3.42 8.29e-03 GO:0007156 homophilic cell adhesion
6.64 2.87e-02 GO:0060338 regulation of type I interferon-mediated signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.63 1.69e-15 GO:0005886 plasma membrane
1.61 5.54e-15 GO:0071944 cell periphery
1.50 9.63e-15 GO:0031224 intrinsic to membrane
1.49 5.69e-14 GO:0016021 integral to membrane
1.40 3.10e-12 GO:0044425 membrane part
1.83 6.15e-11 GO:0005576 extracellular region
1.89 1.03e-06 GO:0005887 integral to plasma membrane
1.88 1.19e-06 GO:0031226 intrinsic to plasma membrane
1.24 1.05e-05 GO:0016020 membrane
1.55 5.54e-05 GO:0044459 plasma membrane part
1.79 3.60e-04 GO:0044421 extracellular region part
1.85 1.47e-03 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.57 2.58e-20 GO:0004888 transmembrane receptor activity
2.31 3.10e-20 GO:0004872 receptor activity
2.88 1.32e-17 GO:0004930 G-protein coupled receptor activity
3.87 1.79e-16 GO:0004984 olfactory receptor activity
2.03 2.34e-16 GO:0004871 signal transducer activity
2.03 2.34e-16 GO:0060089 molecular transducer activity
3.13 1.77e-04 GO:0005125 cytokine activity
2.96 2.15e-03 GO:0005126 cytokine receptor binding
1.91 5.79e-03 GO:0005509 calcium ion binding