Motif ID: ATF4.p2

Z-value: 1.159


Transcription factors associated with ATF4.p2:

Gene SymbolEntrez IDGene Name
ATF4 468 activating transcription factor 4 (tax-responsive enhancer element B67)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF4chr22_+_382465090.019.7e-01Click!


Activity profile for motif ATF4.p2.

activity profile for motif ATF4.p2


Sorted Z-values histogram for motif ATF4.p2

Sorted Z-values for motif ATF4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_586997 2.529 NM_014410
 CLUL1
clusterin-like 1 (retinal)
chr4_+_75699652 1.375 NM_001657
 AREG
amphiregulin
chr7_-_140270749 1.225 NM_004333
 BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr7_-_44992729 1.201 C7orf40
chromosome 7 open reading frame 40
chr5_+_112877251 1.122 NM_022828
 YTHDC2
YTH domain containing 2
chr3_-_33734544 1.034 CLASP2
cytoplasmic linker associated protein 2
chr4_+_75529716 1.029 NM_001657
 AREG
amphiregulin
chr4_+_170778265 1.026 NM_001829
NM_173872
 CLCN3

chloride channel 3

chr3_+_10043139 0.958 FANCD2
Fanconi anemia, complementation group D2
chr7_+_140042932 0.939 NM_004546
 NDUFB2
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
chr7_+_151353707 0.884 NM_022087
 GALNT11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr18_+_18767275 0.879 NM_002894
 RBBP8
retinoblastoma binding protein 8
chr14_-_54563554 0.878 NM_001008396
NM_007086
 WDHD1

WD repeat and HMG-box DNA binding protein 1

chr4_-_186584031 0.876 NM_018359
 UFSP2
UFM1-specific peptidase 2
chr1_+_109090868 0.874 STXBP3
syntaxin binding protein 3
chr17_+_54124952 0.870 NM_002876
NM_058216
 RAD51C

RAD51 homolog C (S. cerevisiae)

chr3_+_171558188 0.856 SKIL
SKI-like oncogene
chr14_+_67156386 0.849 ARG2
arginase, type II
chr3_-_33734747 0.845 NM_015097
 CLASP2
cytoplasmic linker associated protein 2
chr12_+_95825131 0.827 NM_001135176
NM_001135177
NM_152905
 NEDD1


neural precursor cell expressed, developmentally down-regulated 1



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 61 entries
enrichment   p-value GO term description
15.08 4.29e-02 GO:0070584 mitochondrion morphogenesis
3.07 1.55e-03 GO:0050657 nucleic acid transport
3.07 1.55e-03 GO:0050658 RNA transport
3.07 1.55e-03 GO:0051236 establishment of RNA localization
2.97 2.92e-03 GO:0006403 RNA localization
2.93 1.60e-02 GO:0051028 mRNA transport
2.64 2.40e-02 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
2.25 1.04e-03 GO:0051325 interphase
2.24 3.79e-04 GO:0006281 DNA repair
2.19 4.21e-03 GO:0000087 M phase of mitotic cell cycle
2.19 4.21e-03 GO:0051329 interphase of mitotic cell cycle
2.15 4.77e-06 GO:0006974 response to DNA damage stimulus
2.14 1.26e-02 GO:0000280 nuclear division
2.14 1.26e-02 GO:0007067 mitosis
2.12 1.14e-02 GO:0048285 organelle fission
2.11 2.07e-04 GO:0000279 M phase
2.11 1.02e-02 GO:0006511 ubiquitin-dependent protein catabolic process
2.08 1.49e-07 GO:0022403 cell cycle phase
2.07 9.77e-03 GO:0044257 cellular protein catabolic process
2.07 1.70e-02 GO:0019941 modification-dependent protein catabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 30 entries
enrichment   p-value GO term description
12.06 3.50e-02 GO:0005663 DNA replication factor C complex
3.22 1.79e-03 GO:0000776 kinetochore
3.10 2.82e-02 GO:0000777 condensed chromosome kinetochore
2.64 2.84e-03 GO:0000775 chromosome, centromeric region
2.48 1.81e-02 GO:0000793 condensed chromosome
2.21 4.40e-07 GO:0044427 chromosomal part
2.20 1.66e-08 GO:0005694 chromosome
1.76 9.36e-03 GO:0030529 ribonucleoprotein complex
1.76 9.55e-03 GO:0005730 nucleolus
1.66 6.15e-07 GO:0005654 nucleoplasm
1.62 4.86e-09 GO:0031981 nuclear lumen
1.59 5.24e-10 GO:0044428 nuclear part
1.58 3.18e-10 GO:0070013 intracellular organelle lumen
1.56 1.31e-09 GO:0043233 organelle lumen
1.54 3.70e-09 GO:0031974 membrane-enclosed lumen
1.42 2.52e-18 GO:0005634 nucleus
1.37 2.78e-03 GO:0005829 cytosol
1.35 1.69e-12 GO:0044446 intracellular organelle part
1.34 4.27e-04 GO:0043228 non-membrane-bounded organelle
1.34 4.27e-04 GO:0043232 intracellular non-membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
1.72 1.88e-04 GO:0003723 RNA binding
1.61 9.17e-07 GO:0005524 ATP binding
1.60 1.48e-06 GO:0032559 adenyl ribonucleotide binding
1.60 2.12e-02 GO:0019899 enzyme binding
1.59 2.17e-06 GO:0030554 adenyl nucleotide binding
1.54 1.18e-06 GO:0035639 purine ribonucleoside triphosphate binding
1.51 4.09e-06 GO:0032553 ribonucleotide binding
1.51 4.09e-06 GO:0032555 purine ribonucleotide binding
1.50 6.20e-06 GO:0017076 purine nucleotide binding
1.46 2.76e-06 GO:0000166 nucleotide binding
1.38 8.23e-07 GO:0003676 nucleic acid binding
1.31 2.05e-02 GO:0003677 DNA binding
1.24 1.12e-08 GO:0005515 protein binding
1.21 1.25e-03 GO:0003824 catalytic activity
1.12 7.30e-08 GO:0005488 binding