Motif ID: CEBPA,B_DDIT3.p2

Z-value: 0.970


Transcription factors associated with CEBPA,B_DDIT3.p2:

Gene SymbolEntrez IDGene Name
CEBPA 1050 CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB 1051 CCAAT/enhancer binding protein (C/EBP), beta
DDIT3 1649 DNA-damage-inducible transcript 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CEBPBchr20_+_482407720.514.5e-02Click!
CEBPAchr19_-_384852810.504.8e-02Click!
DDIT3chr12_-_56200547-0.273.2e-01Click!


Activity profile for motif CEBPA,B_DDIT3.p2.

activity profile for motif CEBPA,B_DDIT3.p2


Sorted Z-values histogram for motif CEBPA,B_DDIT3.p2

Sorted Z-values for motif CEBPA,B_DDIT3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CEBPA,B_DDIT3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_36346240 1.418 KRT23
keratin 23 (histone deacetylase inducible)
chr3_+_187813538 1.203 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr9_+_116125123 1.167 NM_000607
ORM1
orosomucoid 1
chr3_+_187813553 1.130 AHSG
alpha-2-HS-glycoprotein
chr3_+_187813405 0.986 AHSG
alpha-2-HS-glycoprotein
chr17_-_61655915 0.892 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr6_+_32003180 0.880 NM_000063
NM_001145903
C2

complement component 2

chr4_-_9632192 0.875 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr6_+_32003380 0.825 C2
complement component 2
chr12_+_99391870 0.764 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr6_+_158654890 0.754


chr1_+_149221122 0.733 NM_003568
ANXA9
annexin A9
chr14_+_61532293 0.704 NM_031914
SYT16
synaptotagmin XVI
chr4_+_187424336 0.690 F11
coagulation factor XI
chr10_-_116434364 0.687 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr6_+_167624792 0.674 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr10_-_116434102 0.662 ABLIM1
actin binding LIM protein 1
chr14_-_22515725 0.596 JUB
jub, ajuba homolog (Xenopus laevis)
chr15_-_64108718 0.529


chr17_-_31548167 0.523 NM_001001437
NM_021006
CCL3L3
CCL3
CCL3L1
chemokine (C-C motif) ligand 3-like 3
chemokine (C-C motif) ligand 3
chemokine (C-C motif) ligand 3-like 1
chr9_-_14769530 0.516 NM_001177704
FREM1
FRAS1 related extracellular matrix 1
chr20_+_309938 0.513 TRIB3
tribbles homolog 3 (Drosophila)
chr9_-_122852356 0.494 NM_001735
C5
complement component 5
chr7_-_111216180 0.487 DOCK4
dedicator of cytokinesis 4
chr9_+_674193 0.483


chr6_+_158654464 0.475 TULP4
tubby like protein 4
chr3_-_79899748 0.463 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr3_+_12367993 0.459 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr8_-_17787342 0.456 FGL1
fibrinogen-like 1
chr12_-_61615124 0.419 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr19_+_50144267 0.415 APOC2
apolipoprotein C-II
chr14_-_22516271 0.409 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr17_-_53335748 0.382 NM_017949
CUEDC1
CUE domain containing 1
chr9_+_80101810 0.375 NM_021154
NM_058179
PSAT1

phosphoserine aminotransferase 1

chr17_-_53847937 0.372 RNF43
ring finger protein 43
chr16_-_21571463 0.372 NM_005849
IGSF6
immunoglobulin superfamily, member 6
chr20_+_309272 0.369 NM_021158
TRIB3
tribbles homolog 3 (Drosophila)
chr11_+_75106512 0.359 NM_025098
MOGAT2
monoacylglycerol O-acyltransferase 2
chr6_-_11219932 0.346 NM_207582
ERVFRDE1
HERV-FRD provirus ancestral Env polyprotein
chr14_-_23752875 0.344 NM_014169
CHMP4A
chromatin modifying protein 4A
chr12_-_120781002 0.341 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr20_-_31055892 0.337 NM_080675
SUN5
Sad1 and UNC84 domain containing 5
chr11_-_8695974 0.337 ST5
suppression of tumorigenicity 5
chr5_-_139993469 0.337 NM_001040021
NM_001174104
NM_001174105
CD14


CD14 molecule


chr2_-_21081694 0.330 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_+_151081953 0.325 NM_001128600
LCE6A
late cornified envelope 6A
chr9_-_70780574 0.324


chr6_-_24597717 0.320 NM_177483
NM_001503
GPLD1

glycosylphosphatidylinositol specific phospholipase D1

chr15_-_70838703 0.311


chr20_+_31613800 0.304 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr16_+_65552600 0.302 NM_001185177
NM_024922
CES3

carboxylesterase 3

chr15_+_80741876 0.300 LOC80154
hypothetical LOC80154
chr17_-_77488258 0.297 NM_006907
NM_153824
PYCR1

pyrroline-5-carboxylate reductase 1

chr6_+_132000134 0.291 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr3_+_191588354 0.282 NM_006580
CLDN16
claudin 16
chr10_-_15237351 0.275 LOC100192204
peptidylprolyl isomerase A pseudogene
chr1_-_228916486 0.274 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr8_+_124263932 0.269 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr11_+_20000938 0.268 NAV2
neuron navigator 2
chr5_-_16791346 0.266 MYO10
myosin X
chr3_+_192413015 0.264 NM_198184
OSTN
osteocrin
chr6_+_7524691 0.264 DSP
desmoplakin
chr4_+_100704262 0.262 NM_000253
MTTP
microsomal triglyceride transfer protein
chr22_+_21393107 0.262 IGLJ3
immunoglobulin lambda joining 3
chr2_-_216009015 0.254 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr6_+_80397690 0.248 NM_031469
SH3BGRL2
SH3 domain binding glutamic acid-rich protein like 2
chr19_-_40684638 0.247 NM_001035516
DMKN
dermokine
chr1_-_16006779 0.245 NM_001089591
UQCRHL
ubiquinol-cytochrome c reductase hinge protein-like
chrX_+_96025562 0.241 NM_013347
RPA4
replication protein A4, 30kDa
chr8_+_22075112 0.238 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr17_-_37022465 0.237 NM_005557
KRT16
keratin 16
chr2_+_108360798 0.236 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr3_+_186563529 0.236 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr8_-_110730183 0.232 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr2_-_21084911 0.231 APOB
apolipoprotein B (including Ag(x) antigen)
chr17_-_45280377 0.231 NM_001077503
NM_001077504
NM_001077505
NM_001077506
NM_170685
TAC4




tachykinin 4 (hemokinin)




chr20_+_19903778 0.227 RIN2
Ras and Rab interactor 2
chr6_+_12824873 0.225 PHACTR1
phosphatase and actin regulator 1
chr20_+_5935897 0.222 NM_001127458
CRLS1
cardiolipin synthase 1
chr3_-_188903038 0.221 NM_001004312
RTP2
receptor (chemosensory) transporter protein 2
chr8_-_110726921 0.221 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr12_+_108452117 0.218 UBE3B
ubiquitin protein ligase E3B
chr20_+_309675 0.217 TRIB3
tribbles homolog 3 (Drosophila)
chr20_+_34428857 0.214 NM_014902
DLGAP4
discs, large (Drosophila) homolog-associated protein 4
chr1_-_55103938 0.212 DHCR24
24-dehydrocholesterol reductase
chr1_-_228916470 0.207 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr6_+_37511383 0.205


chr20_+_62266270 0.204 NM_004535
MYT1
myelin transcription factor 1
chr19_+_1401117 0.203 NM_005883
APC2
adenomatosis polyposis coli 2
chr20_+_32926452 0.202 ACSS2
acyl-CoA synthetase short-chain family member 2
chr1_+_151596953 0.200 NM_002965
S100A9
S100 calcium binding protein A9
chr8_-_13018123 0.197 NM_001164271
DLC1
deleted in liver cancer 1
chr13_-_27460773 0.197 NM_001105577
PRHOXNB
parahox cluster neighbor
chr19_+_48912053 0.196 NM_019612
IRGC
immunity-related GTPase family, cinema
chr1_+_17779528 0.195 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr11_-_116168316 0.193 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr10_+_70650064 0.193 NM_025130
HKDC1
hexokinase domain containing 1
chr11_+_59580630 0.193 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr22_+_24174039 0.191 CRYBB2P1
crystallin, beta B2 pseudogene 1
chrX_+_9391314 0.189 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr21_+_42492867 0.188 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr6_+_32021831 0.188 CFB
complement factor B
chr10_-_60792225 0.186 NM_001001971
NM_001166698
NM_198215
FAM13C


family with sequence similarity 13, member C


chr16_-_28457825 0.186 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr6_+_32021899 0.183 CFB
complement factor B
chr2_-_37150876 0.181 HEATR5B
HEAT repeat containing 5B
chr2_+_61225710 0.181 NM_001143960
C2orf74
chromosome 2 open reading frame 74
chr11_-_59237893 0.180 NM_001005324
OR10V1
olfactory receptor, family 10, subfamily V, member 1
chr16_-_28457728 0.179 NUPR1
nuclear protein, transcriptional regulator, 1
chr15_+_80741827 0.178 LOC80154
hypothetical LOC80154
chr19_+_9064854 0.178 NM_001004456
OR1M1
olfactory receptor, family 1, subfamily M, member 1
chr19_-_46504831 0.177


chr18_-_72221228 0.176 ZNF516
zinc finger protein 516
chr13_+_112746908 0.176 MCF2L
MCF.2 cell line derived transforming sequence-like
chr4_+_187424111 0.174 NM_000128
F11
coagulation factor XI
chr10_+_63331401 0.173 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr3_+_187917791 0.171 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr10_-_79459296 0.171 NM_007055
POLR3A
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
chr12_-_47545816 0.171 NM_014470
RND1
Rho family GTPase 1
chr17_-_75427644 0.170 NM_003655
CBX4
chromobox homolog 4
chr16_+_55523526 0.169 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr17_-_36232366 0.169 NM_000421
KRT10
keratin 10
chr8_-_27171852 0.167 STMN4
stathmin-like 4
chr2_-_158439868 0.167 NM_001105
ACVR1
activin A receptor, type I
chrX_-_13745108 0.167 GPM6B
glycoprotein M6B
chr14_+_34583863 0.166 NM_001079519
FAM177A1
family with sequence similarity 177, member A1
chr14_+_101345878 0.166 NM_002719
NM_178586
NM_178587
PPP2R5C


protein phosphatase 2, regulatory subunit B', gamma


chr17_+_71508581 0.164 NM_001258
CDK3
cyclin-dependent kinase 3
chr14_-_20642629 0.164 NM_001102454
ZNF219
zinc finger protein 219
chr3_-_150422474 0.163 NM_000096
CP
ceruloplasmin (ferroxidase)
chr4_+_184257337 0.161 NM_024949
WWC2
WW and C2 domain containing 2
chr3_-_39296933 0.161 NM_001171172
CX3CR1
chemokine (C-X3-C motif) receptor 1
chr20_-_5982617 0.161 NM_152611
LRRN4
leucine rich repeat neuronal 4
chr17_+_4621924 0.161 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr11_+_55554470 0.160 NM_001001921
OR5AS1
olfactory receptor, family 5, subfamily AS, member 1
chr20_+_56912146 0.160 GNAS
GNAS complex locus
chr3_-_49701085 0.158 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr11_+_59580705 0.157 MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr17_-_36074812 0.155 NM_152349
KRT222
keratin 222
chr1_-_150599105 0.154 NM_001014342
FLG2
filaggrin family member 2
chr5_-_16795336 0.154 MYO10
myosin X
chr14_+_31868229 0.153 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr11_+_71524403 0.150 NM_000804
FOLR3
folate receptor 3 (gamma)
chr19_+_11211282 0.150 NM_018687
LOC55908
hepatocellular carcinoma-associated gene TD26
chr16_-_88604029 0.149 NM_024043
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1
chr8_+_124264054 0.148 FAM83A
family with sequence similarity 83, member A
chr11_-_8636958 0.148 NM_014818
TRIM66
tripartite motif containing 66
chr3_-_131081910 0.144 NM_001017395
TMCC1
transmembrane and coiled-coil domain family 1
chr2_-_121964373 0.144 CLASP1
cytoplasmic linker associated protein 1
chr8_+_26569709 0.144 DPYSL2
dihydropyrimidinase-like 2
chr1_+_99884018 0.143 NM_017734
PALMD
palmdelphin
chr10_-_29963847 0.143


chr11_+_62893836 0.141 NM_080866
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr4_-_123596921 0.139 NM_000586
IL2
interleukin 2
chr19_-_48661563 0.139 NM_014400
LYPD3
LY6/PLAUR domain containing 3
chr1_-_176205672 0.139 NM_033127
SEC16B
SEC16 homolog B (S. cerevisiae)
chr8_-_27997306 0.135 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chrX_-_131401319 0.135 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr17_+_4283967 0.134 NM_182538
SPNS3
spinster homolog 3 (Drosophila)
chr8_-_86477585 0.133 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr2_+_101974737 0.132 NM_004633
IL1R2
interleukin 1 receptor, type II
chr20_+_24877904 0.132 CST7
cystatin F (leukocystatin)
chr20_+_24877862 0.130 NM_003650
CST7
cystatin F (leukocystatin)
chr11_-_49960646 0.129 NM_001005270
OR4C12
olfactory receptor, family 4, subfamily C, member 12
chr11_+_22646229 0.128 NM_177553
GAS2
growth arrest-specific 2
chr16_-_68880908 0.128 NM_001605
AARS
alanyl-tRNA synthetase
chrX_-_105169370 0.128 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr14_-_88086559 0.127 PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr20_+_30501108 0.126


chr16_+_55373241 0.126 NUP93
nucleoporin 93kDa
chr6_+_167445284 0.126 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr1_+_207668787 0.125 NM_001104548
LOC642587
NPC-A-5
chr9_+_109085372 0.125 RAD23B
RAD23 homolog B (S. cerevisiae)
chr1_+_243199906 0.124 EFCAB2
EF-hand calcium binding domain 2
chr17_+_1612056 0.123 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr6_+_153113624 0.122 NM_003381
NM_194435
VIP

vasoactive intestinal peptide

chr18_-_53440024 0.121 NM_004539
NARS
asparaginyl-tRNA synthetase
chr11_+_57554977 0.121 NM_001005186
OR6Q1
olfactory receptor, family 6, subfamily Q, member 1
chr11_+_61794205 0.120 NM_002411
SCGB2A2
secretoglobin, family 2A, member 2
chr9_+_109085386 0.119 RAD23B
RAD23 homolog B (S. cerevisiae)
chr5_-_35266305 0.117 PRLR
prolactin receptor
chr16_-_68880844 0.115 AARS
alanyl-tRNA synthetase
chr17_+_75766875 0.115 NM_024110
CARD14
caspase recruitment domain family, member 14
chrX_+_48572226 0.114 NM_181532
ERAS
ES cell expressed Ras
chr20_+_11846536 0.113 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr1_-_172153024 0.113 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr11_+_47236072 0.113 NM_001130101
NM_005693
NR1H3

nuclear receptor subfamily 1, group H, member 3

chr17_+_1612031 0.113 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr19_+_13111072 0.112 NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr9_-_8723893 0.111 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr3_+_162697289 0.110 NM_001080440
OTOL1
otolin 1 homolog (zebrafish)
chr20_+_23368321 0.109 NM_138283
CSTL1
cystatin-like 1
chr16_-_21571409 0.109 IGSF6
immunoglobulin superfamily, member 6
chr6_+_28601767 0.108 NM_001509
NM_003996
GPX5

glutathione peroxidase 5 (epididymal androgen-related protein)

chr17_+_29707583 0.108 NM_005408
CCL13
chemokine (C-C motif) ligand 13
chr9_+_115382760 0.108 NM_021106
RGS3
regulator of G-protein signaling 3
chr19_+_11837843 0.108 NM_152262
ZNF439
zinc finger protein 439
chr19_-_9074981 0.107 NM_001005193
OR7G2
olfactory receptor, family 7, subfamily G, member 2
chr10_-_104201234 0.106 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr17_+_1612092 0.105 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.66 2.73e-03 GO:0071702 organic substance transport
3.64 1.31e-02 GO:0010876 lipid localization
15.06 1.55e-02 GO:0010885 regulation of cholesterol storage
3.72 1.94e-02 GO:0006869 lipid transport
9.86 3.23e-02 GO:0034367 macromolecular complex remodeling
9.86 3.23e-02 GO:0034368 protein-lipid complex remodeling
9.86 3.23e-02 GO:0034369 plasma lipoprotein particle remodeling

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.61 1.29e-03 GO:0005576 extracellular region
1.92 1.59e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
36.15 7.36e-03 GO:0060230 lipoprotein lipase activator activity