Motif ID: E2F1..5.p2

Z-value: 1.705


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
E2F4chr16_+_65783528,
chr16_+_65783599
-0.638.9e-03Click!
E2F1chr20_-_31737731-0.411.1e-01Click!
E2F3chr6_+_205100190.411.1e-01Click!
E2F5chr8_+_862871610.302.7e-01Click!
E2F2chr1_-_237298710.253.4e-01Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_135544170 6.690 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr6_+_135544214 6.571 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr6_+_135544138 5.370 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr10_+_62208256 4.716 CDK1
cyclin-dependent kinase 1
chr10_+_62208094 4.144 NM_001170406
NM_001170407
NM_001786
NM_033379
CDK1



cyclin-dependent kinase 1



chr9_-_98220482 4.094 NM_153695
ZNF367
zinc finger protein 367
chr2_+_173927783 3.707 NM_031942
NM_145810
CDCA7

cell division cycle associated 7

chr20_-_35157744 3.296 RBL1
retinoblastoma-like 1 (p107)
chr11_-_33847507 3.255 LMO2
LIM domain only 2 (rhombotin-like 1)
chr8_-_124477639 3.238 ATAD2
ATPase family, AAA domain containing 2
chr1_-_91260357 3.217 ZNF644
zinc finger protein 644
chr1_-_91260181 3.183 NM_032186
NM_201269
ZNF644

zinc finger protein 644

chr5_-_39110251 3.061 NM_152756
RICTOR
RPTOR independent companion of MTOR, complex 2
chr6_+_88356503 3.059 NM_001197259
NM_012381
NM_181837
ORC3


origin recognition complex, subunit 3


chr1_-_91260131 3.043 ZNF644
zinc finger protein 644
chr1_-_26105230 3.041 NM_203401
STMN1
stathmin 1
chr8_-_121526514 2.980 MRPL13
mitochondrial ribosomal protein L13
chr6_-_27208507 2.978 NM_021058
HIST1H2BJ
histone cluster 1, H2bj
chr1_-_36008009 2.932 NM_001190481
NM_022111
CLSPN

claspin

chr8_-_124477846 2.928 ATAD2
ATPase family, AAA domain containing 2
chr17_+_54997667 2.865 NM_001166301
NM_024612
DHX40

DEAH (Asp-Glu-Ala-His) box polypeptide 40

chrX_+_24621964 2.837 POLA1
polymerase (DNA directed), alpha 1, catalytic subunit
chr11_-_33847937 2.830 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr10_+_96295511 2.804 NM_018063
HELLS
helicase, lymphoid-specific
chr8_-_124477869 2.787 NM_014109
ATAD2
ATPase family, AAA domain containing 2
chr7_+_50314801 2.770 NM_006060
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr1_-_23729871 2.675 E2F2
E2F transcription factor 2
chr1_-_26105954 2.673 NM_203399
STMN1
stathmin 1
chr11_-_33847834 2.654 LMO2
LIM domain only 2 (rhombotin-like 1)
chr7_+_120378052 2.644 NM_019071
NM_198267
ING3

inhibitor of growth family, member 3

chr11_-_33848013 2.560 LMO2
LIM domain only 2 (rhombotin-like 1)
chr9_-_98220360 2.558 ZNF367
zinc finger protein 367
chrX_+_130985316 2.535 NM_001042452
MST4
serine/threonine protein kinase MST4
chr1_-_91259601 2.526 NM_016620
ZNF644
zinc finger protein 644
chr2_+_232281491 2.507 PTMA
prothymosin, alpha
chr1_-_24179326 2.486 SRSF10
serine/arginine-rich splicing factor 10
chr6_-_52257500 2.469 NM_002388
MCM3
minichromosome maintenance complex component 3
chr1_-_23730298 2.469 NM_004091
E2F2
E2F transcription factor 2
chr17_+_27288152 2.451 NM_015355
SUZ12
suppressor of zeste 12 homolog (Drosophila)
chr17_+_27288167 2.419 SUZ12
suppressor of zeste 12 homolog (Drosophila)
chr6_+_27883877 2.406 NM_003509
HIST1H2AI
HIST1H3F
histone cluster 1, H2ai
histone cluster 1, H3f
chr2_-_136350404 2.365 MCM6
minichromosome maintenance complex component 6
chr5_-_39110235 2.348 RICTOR
RPTOR independent companion of MTOR, complex 2
chr17_+_27288253 2.344 SUZ12
suppressor of zeste 12 homolog (Drosophila)
chr5_+_56505608 2.299 GPBP1
GC-rich promoter binding protein 1
chr3_+_44778212 2.265 NM_020242
KIF15
kinesin family member 15
chr3_+_44778284 2.260 KIF15
kinesin family member 15
chr1_-_26105477 2.259 NM_001145454
NM_005563
STMN1

stathmin 1

chrX_+_24621984 2.249 NM_016937
POLA1
polymerase (DNA directed), alpha 1, catalytic subunit
chr7_+_26207569 2.245 NM_007276
CBX3
chromobox homolog 3
chr4_+_39734902 2.241 NM_018177
N4BP2
NEDD4 binding protein 2
chr4_+_154485224 2.220 NM_032117
MND1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr7_+_128861471 2.203 NM_001134336
NM_020704
FAM40B

family with sequence similarity 40, member B

chr7_+_26207854 2.191 CBX3
chromobox homolog 3
chrX_+_130984912 2.119 NM_001042453
NM_016542
MST4

serine/threonine protein kinase MST4

chr6_-_153345786 2.118 NM_012177
FBXO5
F-box protein 5
chr5_+_75414994 2.118 NM_014979
SV2C
synaptic vesicle glycoprotein 2C
chr6_+_27941012 2.117 NM_003511
HIST1H2AI
HIST1H2AL
histone cluster 1, H2ai
histone cluster 1, H2al
chr7_-_148212292 2.104 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr17_+_26183074 2.103 NM_024857
ATAD5
ATPase family, AAA domain containing 5
chr6_-_27222556 2.099 NM_080593
HIST1H2BK
histone cluster 1, H2bk
chr13_+_33290254 2.096 RFC3
replication factor C (activator 1) 3, 38kDa
chr1_-_23543330 2.095 NM_001102397
NM_001102398
NM_001102399
NM_005826
HNRNPR



heterogeneous nuclear ribonucleoprotein R



chrX_-_131451675 2.094 NM_001170704
MBNL3
muscleblind-like 3 (Drosophila)
chr20_-_35157815 2.092 NM_002895
NM_183404
RBL1

retinoblastoma-like 1 (p107)

chr17_+_27288178 2.089 SUZ12
suppressor of zeste 12 homolog (Drosophila)
chr8_-_124477850 2.061 ATAD2
ATPase family, AAA domain containing 2
chr17_+_27288374 2.059


chr22_+_18485057 2.015 RANBP1
RAN binding protein 1
chr7_-_148212310 2.007 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr7_+_138695144 1.989 NM_016019
LUC7L2
LUC7-like 2 (S. cerevisiae)
chr7_-_158190193 1.973 NM_017760
NCAPG2
non-SMC condensin II complex, subunit G2
chr7_+_93977267 1.969 CASD1
CAS1 domain containing 1
chr2_+_149118791 1.939 EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr2_+_153283381 1.928 ARL6IP6
ADP-ribosylation-like factor 6 interacting protein 6
chr7_+_26207806 1.908 NM_016587
CBX3
chromobox homolog 3
chr11_-_19219000 1.884 NM_024680
E2F8
E2F transcription factor 8
chr2_-_136350472 1.884 NM_005915
MCM6
minichromosome maintenance complex component 6
chr15_-_64436045 1.878 NM_017858
TIPIN
TIMELESS interacting protein
chr1_-_91260174 1.874 ZNF644
zinc finger protein 644
chr2_-_174538675 1.868 NM_001172712
NM_003111
SP3

Sp3 transcription factor

chr2_-_175754366 1.862 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr2_+_153283375 1.861 ARL6IP6
ADP-ribosylation-like factor 6 interacting protein 6
chr1_+_109434896 1.811 NM_020141
TMEM167B
transmembrane protein 167B
chr3_+_38363226 1.806 NM_005108
XYLB
xylulokinase homolog (H. influenzae)
chr1_+_240078167 1.800 EXO1
exonuclease 1
chr7_+_138695209 1.781 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr7_+_103756339 1.766 NM_199000
LHFPL3
lipoma HMGIC fusion partner-like 3
chr1_+_26671548 1.760 HMGN2
high-mobility group nucleosomal binding domain 2
chr1_+_240078094 1.740 NM_130398
EXO1
exonuclease 1
chr5_+_93980108 1.739 NM_032290
ANKRD32
ankyrin repeat domain 32
chr2_+_48395271 1.736 NM_002158
FOXN2
forkhead box N2
chr4_-_39655944 1.734 NM_001100399
NM_001100400
PDS5A

PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)

chrX_-_122694569 1.731 NM_001081550
THOC2
THO complex 2
chr7_+_26207897 1.728 CBX3
chromobox homolog 3
chr7_+_93976927 1.725 NM_022900
CASD1
CAS1 domain containing 1
chr3_-_150286812 1.724 NM_003071
NM_139048
HLTF

helicase-like transcription factor

chr2_+_177785667 1.710 NM_194247
HNRNPA3P1
HNRNPA3
heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
heterogeneous nuclear ribonucleoprotein A3
chr7_+_64136078 1.707 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr14_-_54438913 1.703 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr6_-_27914095 1.698 NM_003510
HIST1H2AK
histone cluster 1, H2ak
chr1_-_47552238 1.686 NM_001048166
NM_003035
STIL

SCL/TAL1 interrupting locus

chr2_+_10180304 1.679 NM_001034
RRM2
ribonucleotide reductase M2
chr5_+_36912656 1.679 NIPBL
Nipped-B homolog (Drosophila)
chr7_-_151764004 1.679 NM_170606
MLL3
myeloid/lymphoid or mixed-lineage leukemia 3
chr2_+_47483750 1.672 NM_000251
MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
chrX_+_122923236 1.668 NM_001042750
NM_001042751
NM_006603
STAG2


stromal antigen 2


chr2_-_219141199 1.666 NM_020935
USP37
ubiquitin specific peptidase 37
chr8_-_95976599 1.659 NM_057749
CCNE2
cyclin E2
chr15_+_30694982 1.658 NM_014783
NM_199357
ARHGAP11A

Rho GTPase activating protein 11A

chr2_+_177965734 1.636 AGPS
alkylglycerone phosphate synthase
chr3_+_38363299 1.622 XYLB
xylulokinase homolog (H. influenzae)
chr11_-_19219720 1.616 E2F8
E2F transcription factor 8
chr15_+_42507123 1.607 CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr3_+_5138929 1.598 NM_018184
ARL8B
ADP-ribosylation factor-like 8B
chr2_+_149119029 1.593 NM_015630
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr7_-_148212312 1.593 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr3_+_140148765 1.581 NM_001040061
C3orf72
chromosome 3 open reading frame 72
chr4_+_152240182 1.575 NM_001006
RPS3A
ribosomal protein S3A
chr10_+_75580914 1.575 NM_006721
ADK
adenosine kinase
chr8_+_121526823 1.570 NM_022045
MTBP
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
chr2_+_47483795 1.570 MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
chr6_-_35764588 1.562 FKBP5
FK506 binding protein 5
chr5_-_79986063 1.558 DHFR
dihydrofolate reductase
chr2_+_47483694 1.553 MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
chr16_-_46052254 1.552 ITFG1
integrin alpha FG-GAP repeat containing 1
chr7_-_148212230 1.534 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr9_+_85785456 1.534 NM_024945
RMI1
RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)
chr6_-_111911106 1.530 NM_002912
REV3L
REV3-like, catalytic subunit of DNA polymerase zeta (yeast)
chr1_-_33275071 1.527 NM_013411
AK2
adenylate kinase 2
chr17_-_53439513 1.519 SRSF1
serine/arginine-rich splicing factor 1
chr20_-_39199936 1.518


chr2_+_10180145 1.511 NM_001165931
RRM2
ribonucleotide reductase M2
chr1_-_28113817 1.502 NM_002946
RPA2
replication protein A2, 32kDa
chr1_-_203985780 1.499 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr11_-_62379788 1.497 SNHG1
small nucleolar RNA host gene 1 (non-protein coding)
chr13_-_29938029 1.496 NM_002128
HMGB1
high-mobility group box 1
chr6_+_24883133 1.495 NM_015895
GMNN
geminin, DNA replication inhibitor
chr2_-_174538197 1.480 SP3
Sp3 transcription factor
chr8_+_38208322 1.477 NM_001164232
DDHD2
DDHD domain containing 2
chr2_+_232281470 1.474 NM_001099285
NM_002823
PTMA

prothymosin, alpha

chr2_-_70848621 1.470 NM_001185055
NM_001617
NM_017482
NM_017488
ADD2



adducin 2 (beta)



chr7_-_94123413 1.465 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr1_-_12599934 1.456 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr1_+_220952681 1.448 BROX
BRO1 domain and CAAX motif containing
chr1_-_203985896 1.443 NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr7_-_44854222 1.439 NM_012412
NM_138635
NM_201436
NM_201516
NM_201517
H2AFV




H2A histone family, member V




chrX_-_122694562 1.438 THOC2
THO complex 2
chr1_-_223682324 1.435 LBR
lamin B receptor
chr11_-_85053807 1.433 NM_001039618
CREBZF
CREB/ATF bZIP transcription factor
chrX_-_53466335 1.422 NM_006306
SMC1A
structural maintenance of chromosomes 1A
chr8_+_38208165 1.421 NM_001164234
NM_015214
DDHD2

DDHD domain containing 2

chr22_+_18485068 1.411 RANBP1
RAN binding protein 1
chr5_+_138657317 1.407 NM_001194955
NM_001194956
MATR3

matrin 3

chr16_-_23515104 1.406 NM_005003
NDUFAB1
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
chr7_+_32734244 1.404 LOC441208
zinc and ring finger 2 pseudogene
chr6_-_17814596 1.400 NM_005124
NUP153
nucleoporin 153kDa
chr4_+_178467973 1.397 NM_018248
NEIL3
nei endonuclease VIII-like 3 (E. coli)
chr9_-_122679387 1.396 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr6_-_27968906 1.394 NM_003514
HIST1H2AM
histone cluster 1, H2am
chr1_+_93317374 1.391 NM_001164391
NM_001164392
NM_001164393
NM_007358
MTF2



metal response element binding transcription factor 2



chr7_+_138695241 1.390 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr5_+_79986049 1.388 NM_002439
MSH3
mutS homolog 3 (E. coli)
chr6_-_160130679 1.386 TCP1
t-complex 1
chr11_+_4072499 1.384 NM_001033
RRM1
ribonucleotide reductase M1
chrX_+_122923279 1.381 STAG2
stromal antigen 2
chr16_+_46052667 1.377 NM_000293
NM_001031835
PHKB

phosphorylase kinase, beta

chr5_+_130627600 1.375 NM_001038702
NM_020240
CDC42SE2

CDC42 small effector 2

chr5_+_138657229 1.368 NM_018834
MATR3
matrin 3
chr7_-_44854188 1.366 H2AFV
H2A histone family, member V
chr17_-_16197433 1.366 NM_181716
CENPV
centromere protein V
chr5_-_36187710 1.361 NM_001007527
LMBRD2
LMBR1 domain containing 2
chr5_+_56505412 1.361 NM_022913
GPBP1
GC-rich promoter binding protein 1
chr3_+_38363292 1.357 XYLB
xylulokinase homolog (H. influenzae)
chr17_+_35697660 1.351 NM_001254
CDC6
cell division cycle 6 homolog (S. cerevisiae)
chr9_-_122679283 1.348 PHF19
PHD finger protein 19
chr2_-_144991556 1.348 ZEB2
zinc finger E-box binding homeobox 2
chr14_+_35365266 1.345 NM_032352
BRMS1L
breast cancer metastasis-suppressor 1-like
chr9_+_70509925 1.344 NM_003558
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr7_+_138695236 1.343 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr6_-_27548438 1.337 NM_007149
ZNF184
zinc finger protein 184
chr11_-_95162333 1.333 FAM76B
family with sequence similarity 76, member B
chr16_-_46052482 1.330 NM_030790
ITFG1
integrin alpha FG-GAP repeat containing 1
chr16_-_46052596 1.324 ITFG1
integrin alpha FG-GAP repeat containing 1
chr16_-_48960186 1.322 NM_001173984
NM_013263
BRD7

bromodomain containing 7

chr7_+_64975778 1.315 VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr15_+_42506870 1.315 NM_016396
CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr1_-_24179419 1.309 NM_001191005
NM_001191006
NM_001191007
NM_001191009
NM_006625
NM_054016
SRSF10





serine/arginine-rich splicing factor 10





chr11_-_95162288 1.306 FAM76B
family with sequence similarity 76, member B
chr7_-_151763857 1.305 MLL3
myeloid/lymphoid or mixed-lineage leukemia 3
chr21_-_32026276 1.297 NM_001145444
NM_001145445
NM_020706
SCAF4


SR-related CTD-associated factor 4


chr5_-_79986104 1.292 DHFR
dihydrofolate reductase
chr6_-_35764655 1.290 NM_001145776
NM_001145777
NM_004117
FKBP5


FK506 binding protein 5


chr2_+_85619802 1.288 MAT2A
methionine adenosyltransferase II, alpha
chr1_-_54291378 1.286 TMEM59
transmembrane protein 59
chr12_-_109665019 1.286 PPP1CC
protein phosphatase 1, catalytic subunit, gamma isozyme
chrX_+_118592568 1.285 UBE2A
ubiquitin-conjugating enzyme E2A (RAD6 homolog)
chr4_-_175986952 1.282 NM_001042543
NM_006529
GLRA3

glycine receptor, alpha 3

chr1_+_220952518 1.273 NM_144695
BROX
BRO1 domain and CAAX motif containing
chr1_-_227761038 1.273 NM_012089
ABCB10
ATP-binding cassette, sub-family B (MDR/TAP), member 10

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.99 3.68e-34 GO:0090304 nucleic acid metabolic process
1.84 3.87e-33 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.55 4.80e-33 GO:0007049 cell cycle
1.59 6.62e-31 GO:0044260 cellular macromolecule metabolic process
2.82 1.94e-28 GO:0022403 cell cycle phase
2.61 3.24e-27 GO:0022402 cell cycle process
1.68 2.97e-26 GO:0034641 cellular nitrogen compound metabolic process
1.65 2.70e-25 GO:0006807 nitrogen compound metabolic process
2.84 3.10e-24 GO:0000278 mitotic cell cycle
2.76 7.53e-24 GO:0051276 chromosome organization
1.46 1.01e-22 GO:0043170 macromolecule metabolic process
1.37 1.85e-20 GO:0044237 cellular metabolic process
2.67 2.06e-20 GO:0006259 DNA metabolic process
1.34 1.37e-18 GO:0044238 primary metabolic process
3.21 3.62e-17 GO:0051325 interphase
3.18 2.09e-16 GO:0051329 interphase of mitotic cell cycle
1.79 2.12e-16 GO:0016070 RNA metabolic process
3.84 4.89e-16 GO:0006260 DNA replication
2.51 3.88e-15 GO:0016071 mRNA metabolic process
2.53 7.56e-15 GO:0006974 response to DNA damage stimulus
1.78 1.33e-14 GO:0006996 organelle organization
1.27 9.15e-14 GO:0008152 metabolic process
1.74 9.15e-14 GO:0034645 cellular macromolecule biosynthetic process
2.84 2.02e-13 GO:0006281 DNA repair
2.52 2.36e-13 GO:0006325 chromatin organization
1.72 3.57e-13 GO:0009059 macromolecule biosynthetic process
2.29 4.29e-13 GO:0051726 regulation of cell cycle
2.57 5.11e-13 GO:0000279 M phase
1.68 5.87e-13 GO:0010467 gene expression
3.84 3.64e-12 GO:0000082 G1/S transition of mitotic cell cycle
1.55 1.19e-11 GO:0044249 cellular biosynthetic process
4.08 3.50e-11 GO:0071824 protein-DNA complex subunit organization
1.14 4.29e-11 GO:0009987 cellular process
4.09 7.73e-11 GO:0051320 S phase
2.15 1.15e-10 GO:0006396 RNA processing
4.09 1.71e-10 GO:0065004 protein-DNA complex assembly
2.51 1.87e-10 GO:0006397 mRNA processing
4.05 2.36e-10 GO:0000084 S phase of mitotic cell cycle
1.50 2.87e-10 GO:0009058 biosynthetic process
3.51 2.94e-10 GO:0071103 DNA conformation change
2.74 3.64e-10 GO:0000280 nuclear division
2.74 3.64e-10 GO:0007067 mitosis
1.41 4.16e-10 GO:0071840 cellular component organization or biogenesis
4.86 7.53e-10 GO:0006261 DNA-dependent DNA replication
2.56 7.91e-10 GO:0010564 regulation of cell cycle process
1.41 9.27e-10 GO:0016043 cellular component organization
3.55 1.39e-09 GO:0006333 chromatin assembly or disassembly
2.66 1.42e-09 GO:0000087 M phase of mitotic cell cycle
4.01 1.58e-09 GO:0034728 nucleosome organization
2.65 1.67e-09 GO:0048285 organelle fission
4.09 1.84e-09 GO:0031497 chromatin assembly
1.46 1.87e-09 GO:0071841 cellular component organization or biogenesis at cellular level
3.61 2.99e-09 GO:0006323 DNA packaging
1.91 7.64e-09 GO:0033554 cellular response to stress
1.98 1.73e-08 GO:0065003 macromolecular complex assembly
3.42 1.83e-08 GO:0006310 DNA recombination
1.45 2.03e-08 GO:0071842 cellular component organization at cellular level
2.39 3.27e-08 GO:0034622 cellular macromolecular complex assembly
1.71 3.46e-08 GO:0044085 cellular component biogenesis
2.53 4.57e-08 GO:0008380 RNA splicing
3.92 7.00e-08 GO:0006334 nucleosome assembly
1.85 8.64e-08 GO:0043933 macromolecular complex subunit organization
2.80 1.50e-07 GO:0000075 cell cycle checkpoint
2.75 1.80e-07 GO:0071156 regulation of cell cycle arrest
2.12 2.45e-07 GO:0034621 cellular macromolecular complex subunit organization
2.33 3.63e-07 GO:0051301 cell division
1.72 4.18e-07 GO:0022607 cellular component assembly
1.36 4.81e-07 GO:0060255 regulation of macromolecule metabolic process
2.29 6.24e-07 GO:0016568 chromatin modification
1.43 6.37e-07 GO:2000112 regulation of cellular macromolecule biosynthetic process
6.51 1.69e-06 GO:0006271 DNA strand elongation involved in DNA replication
1.33 1.70e-06 GO:0031323 regulation of cellular metabolic process
1.40 2.20e-06 GO:0031326 regulation of cellular biosynthetic process
2.72 2.52e-06 GO:0000375 RNA splicing, via transesterification reactions
2.73 3.60e-06 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.73 3.60e-06 GO:0000398 nuclear mRNA splicing, via spliceosome
1.38 4.43e-06 GO:0009889 regulation of biosynthetic process
1.40 5.45e-06 GO:0010556 regulation of macromolecule biosynthetic process
6.07 5.99e-06 GO:0022616 DNA strand elongation
3.39 7.08e-06 GO:0007059 chromosome segregation
1.72 8.61e-06 GO:0010605 negative regulation of macromolecule metabolic process
1.32 8.66e-06 GO:0080090 regulation of primary metabolic process
3.19 9.93e-06 GO:0050657 nucleic acid transport
3.19 9.93e-06 GO:0050658 RNA transport
3.19 9.93e-06 GO:0051236 establishment of RNA localization
1.39 1.05e-05 GO:0010468 regulation of gene expression
1.29 1.24e-05 GO:0019222 regulation of metabolic process
1.78 1.60e-05 GO:0071844 cellular component assembly at cellular level
3.26 1.83e-05 GO:0051028 mRNA transport
4.52 2.06e-05 GO:0051053 negative regulation of DNA metabolic process
3.09 2.36e-05 GO:0006403 RNA localization
1.66 3.39e-05 GO:0009892 negative regulation of metabolic process
7.42 5.34e-05 GO:0007062 sister chromatid cohesion
1.84 5.93e-05 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.35 6.70e-05 GO:0051171 regulation of nitrogen compound metabolic process
9.11 7.60e-05 GO:0071897 DNA biosynthetic process
3.58 9.77e-05 GO:0000216 M/G1 transition of mitotic cell cycle
1.68 1.02e-04 GO:0006351 transcription, DNA-dependent
2.84 1.21e-04 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
3.66 1.25e-04 GO:0006338 chromatin remodeling
6.34 1.35e-04 GO:0090329 regulation of DNA-dependent DNA replication
3.86 1.92e-04 GO:0031124 mRNA 3'-end processing
1.65 2.05e-04 GO:0031324 negative regulation of cellular metabolic process
6.68 2.42e-04 GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle
6.68 2.42e-04 GO:2000104 negative regulation of DNA-dependent DNA replication
3.06 2.48e-04 GO:0006401 RNA catabolic process
4.79 3.18e-04 GO:0008156 negative regulation of DNA replication
1.76 4.59e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
2.16 4.71e-04 GO:0006366 transcription from RNA polymerase II promoter
1.33 5.49e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.59 6.29e-04 GO:0032774 RNA biosynthetic process
1.72 7.43e-04 GO:0031327 negative regulation of cellular biosynthetic process
1.36 8.08e-04 GO:0051252 regulation of RNA metabolic process
6.07 8.69e-04 GO:0006270 DNA-dependent DNA replication initiation
3.40 1.00e-03 GO:0031123 RNA 3'-end processing
1.82 1.07e-03 GO:0044265 cellular macromolecule catabolic process
4.34 1.48e-03 GO:0006369 termination of RNA polymerase II transcription
1.74 1.49e-03 GO:0009057 macromolecule catabolic process
3.22 1.51e-03 GO:0006402 mRNA catabolic process
3.31 1.62e-03 GO:0000956 nuclear-transcribed mRNA catabolic process
3.71 1.68e-03 GO:0006406 mRNA export from nucleus
1.33 1.77e-03 GO:0044267 cellular protein metabolic process
1.69 1.85e-03 GO:0009890 negative regulation of biosynthetic process
9.45 2.02e-03 GO:0002566 somatic diversification of immune receptors via somatic mutation
9.45 2.02e-03 GO:0016446 somatic hypermutation of immunoglobulin genes
5.21 2.06e-03 GO:0043044 ATP-dependent chromatin remodeling
5.57 2.64e-03 GO:0031055 chromatin remodeling at centromere
6.07 3.04e-03 GO:0006298 mismatch repair
1.72 3.42e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.35 4.01e-03 GO:0048523 negative regulation of cellular process
1.32 4.91e-03 GO:0048519 negative regulation of biological process
1.70 5.59e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.33 8.39e-03 GO:0006355 regulation of transcription, DNA-dependent
3.31 1.02e-02 GO:0006405 RNA export from nucleus
4.27 1.04e-02 GO:0051318 G1 phase
2.41 1.20e-02 GO:0000226 microtubule cytoskeleton organization
1.52 1.29e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
2.67 1.70e-02 GO:0007126 meiosis
2.67 1.70e-02 GO:0051327 M phase of meiotic cell cycle
5.75 1.88e-02 GO:0032201 telomere maintenance via semi-conservative replication
2.29 1.92e-02 GO:0006913 nucleocytoplasmic transport
9.11 1.93e-02 GO:0000731 DNA synthesis involved in DNA repair
9.11 1.93e-02 GO:0007064 mitotic sister chromatid cohesion
1.14 1.95e-02 GO:0050794 regulation of cellular process
2.96 1.96e-02 GO:0051168 nuclear export
2.65 2.01e-02 GO:0051321 meiotic cell cycle
3.78 2.28e-02 GO:0000819 sister chromatid segregation
4.29 2.33e-02 GO:0000080 G1 phase of mitotic cell cycle
2.26 2.47e-02 GO:0051169 nuclear transport
5.47 3.16e-02 GO:0000722 telomere maintenance via recombination
4.45 3.64e-02 GO:0007131 reciprocal meiotic recombination
4.86 3.67e-02 GO:0002200 somatic diversification of immune receptors
4.86 3.67e-02 GO:0043486 histone exchange
6.07 3.76e-02 GO:0006297 nucleotide-excision repair, DNA gap filling
3.29 3.77e-02 GO:0000079 regulation of cyclin-dependent protein kinase activity
2.38 4.72e-02 GO:0051052 regulation of DNA metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.64 1.62e-56 GO:0005634 nucleus
1.36 3.01e-54 GO:0043226 organelle
1.36 6.54e-54 GO:0043229 intracellular organelle
1.40 2.27e-52 GO:0043227 membrane-bounded organelle
1.40 7.33e-52 GO:0043231 intracellular membrane-bounded organelle
2.16 9.47e-48 GO:0044428 nuclear part
1.26 4.32e-46 GO:0044424 intracellular part
1.25 2.44e-44 GO:0005622 intracellular
2.19 2.25e-41 GO:0031981 nuclear lumen
2.01 4.88e-39 GO:0070013 intracellular organelle lumen
1.99 6.48e-38 GO:0043233 organelle lumen
1.97 1.49e-37 GO:0031974 membrane-enclosed lumen
2.36 1.09e-36 GO:0005654 nucleoplasm
1.51 4.42e-36 GO:0044446 intracellular organelle part
1.50 1.69e-35 GO:0044422 organelle part
3.04 7.35e-30 GO:0005694 chromosome
3.07 1.83e-25 GO:0044427 chromosomal part
1.54 1.48e-20 GO:0032991 macromolecular complex
1.58 3.03e-17 GO:0043228 non-membrane-bounded organelle
1.58 3.03e-17 GO:0043232 intracellular non-membrane-bounded organelle
2.29 3.54e-17 GO:0044451 nucleoplasm part
3.44 3.78e-17 GO:0000785 chromatin
2.95 4.66e-10 GO:0000228 nuclear chromosome
1.06 8.41e-10 GO:0044464 cell part
2.87 8.64e-10 GO:0016604 nuclear body
1.06 8.79e-10 GO:0005623 cell
3.14 1.67e-09 GO:0044454 nuclear chromosome part
1.41 2.51e-09 GO:0043234 protein complex
2.13 4.27e-09 GO:0030529 ribonucleoprotein complex
3.76 3.95e-08 GO:0032993 protein-DNA complex
10.79 7.65e-06 GO:0035098 ESC/E(Z) complex
2.80 1.77e-05 GO:0000775 chromosome, centromeric region
1.14 2.32e-05 GO:0005737 cytoplasm
1.88 3.53e-05 GO:0005730 nucleolus
3.41 4.70e-05 GO:0000790 nuclear chromatin
3.72 1.31e-04 GO:0000786 nucleosome
4.60 2.68e-04 GO:0005657 replication fork
6.39 2.82e-04 GO:0031519 PcG protein complex
8.10 3.36e-04 GO:0032300 mismatch repair complex
2.65 4.11e-04 GO:0005681 spliceosomal complex
3.23 4.45e-04 GO:0071013 catalytic step 2 spliceosome
2.52 1.24e-03 GO:0000793 condensed chromosome
3.60 1.85e-03 GO:0034708 methyltransferase complex
3.60 1.85e-03 GO:0035097 histone methyltransferase complex
2.59 2.32e-03 GO:0016607 nuclear speck
3.47 3.12e-03 GO:0016605 PML body
1.60 3.86e-03 GO:0015630 microtubule cytoskeleton
2.02 6.30e-03 GO:0005635 nuclear envelope
4.31 8.99e-03 GO:0000932 cytoplasmic mRNA processing body
5.72 1.13e-02 GO:0030894 replisome
5.72 1.13e-02 GO:0043601 nuclear replisome
2.15 1.24e-02 GO:0005819 spindle
4.97 1.39e-02 GO:0043596 nuclear replication fork
3.59 1.52e-02 GO:0000792 heterochromatin
5.40 1.89e-02 GO:0030530 heterogeneous nuclear ribonucleoprotein complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.62 4.29e-25 GO:0003676 nucleic acid binding
1.29 9.85e-19 GO:0005515 protein binding
1.62 5.11e-16 GO:0003677 DNA binding
1.13 3.19e-13 GO:0005488 binding
1.94 1.19e-10 GO:0003723 RNA binding
1.47 6.23e-09 GO:0000166 nucleotide binding
4.69 1.54e-07 GO:0003697 single-stranded DNA binding
2.69 2.17e-06 GO:0043566 structure-specific DNA binding
2.66 3.03e-06 GO:0003682 chromatin binding
3.61 3.34e-04 GO:0008094 DNA-dependent ATPase activity
5.03 8.23e-04 GO:0034061 DNA polymerase activity
3.15 1.75e-03 GO:0003729 mRNA binding
5.14 1.77e-03 GO:0003887 DNA-directed DNA polymerase activity
6.94 2.58e-03 GO:0030983 mismatched DNA binding
2.52 2.62e-03 GO:0003690 double-stranded DNA binding
1.32 1.29e-02 GO:0017076 purine nucleotide binding
1.32 1.32e-02 GO:0032553 ribonucleotide binding
1.32 1.32e-02 GO:0032555 purine ribonucleotide binding
1.35 1.94e-02 GO:0032559 adenyl ribonucleotide binding
1.31 2.13e-02 GO:0035639 purine ribonucleoside triphosphate binding
1.44 2.47e-02 GO:0030528 transcription regulator activity
1.34 2.60e-02 GO:0030554 adenyl nucleotide binding
1.35 2.78e-02 GO:0005524 ATP binding
5.40 2.79e-02 GO:0016538 cyclin-dependent protein kinase regulator activity
12.14 3.02e-02 GO:0032138 single base insertion or deletion binding