Motif ID: E2F1..5.p2

Z-value: 1.705


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
E2F4chr16_+_65783528,
chr16_+_65783599
-0.638.9e-03Click!
E2F1chr20_-_31737731-0.411.1e-01Click!
E2F3chr6_+_205100190.411.1e-01Click!
E2F5chr8_+_862871610.302.7e-01Click!
E2F2chr1_-_237298710.253.4e-01Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_135544170 6.690 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr6_+_135544214 6.571 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr6_+_135544138 5.370 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr10_+_62208256 4.716 CDK1
cyclin-dependent kinase 1
chr10_+_62208094 4.144 NM_001170406
NM_001170407
NM_001786
NM_033379
CDK1



cyclin-dependent kinase 1



chr9_-_98220482 4.094 NM_153695
ZNF367
zinc finger protein 367
chr2_+_173927783 3.707 NM_031942
NM_145810
CDCA7

cell division cycle associated 7

chr20_-_35157744 3.296 RBL1
retinoblastoma-like 1 (p107)
chr11_-_33847507 3.255 LMO2
LIM domain only 2 (rhombotin-like 1)
chr8_-_124477639 3.238 ATAD2
ATPase family, AAA domain containing 2
chr1_-_91260357 3.217 ZNF644
zinc finger protein 644
chr1_-_91260181 3.183 NM_032186
NM_201269
ZNF644

zinc finger protein 644

chr5_-_39110251 3.061 NM_152756
RICTOR
RPTOR independent companion of MTOR, complex 2
chr6_+_88356503 3.059 NM_001197259
NM_012381
NM_181837
ORC3


origin recognition complex, subunit 3


chr1_-_91260131 3.043 ZNF644
zinc finger protein 644
chr1_-_26105230 3.041 NM_203401
STMN1
stathmin 1
chr8_-_121526514 2.980 MRPL13
mitochondrial ribosomal protein L13
chr6_-_27208507 2.978 NM_021058
HIST1H2BJ
histone cluster 1, H2bj
chr1_-_36008009 2.932 NM_001190481
NM_022111
CLSPN

claspin

chr8_-_124477846 2.928 ATAD2
ATPase family, AAA domain containing 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 156 entries
enrichment   p-value GO term description
9.45 2.02e-03 GO:0002566 somatic diversification of immune receptors via somatic mutation
9.45 2.02e-03 GO:0016446 somatic hypermutation of immunoglobulin genes
9.11 7.60e-05 GO:0071897 DNA biosynthetic process
9.11 1.93e-02 GO:0000731 DNA synthesis involved in DNA repair
9.11 1.93e-02 GO:0007064 mitotic sister chromatid cohesion
7.42 5.34e-05 GO:0007062 sister chromatid cohesion
6.68 2.42e-04 GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle
6.68 2.42e-04 GO:2000104 negative regulation of DNA-dependent DNA replication
6.51 1.69e-06 GO:0006271 DNA strand elongation involved in DNA replication
6.34 1.35e-04 GO:0090329 regulation of DNA-dependent DNA replication
6.07 5.99e-06 GO:0022616 DNA strand elongation
6.07 8.69e-04 GO:0006270 DNA-dependent DNA replication initiation
6.07 3.04e-03 GO:0006298 mismatch repair
6.07 3.76e-02 GO:0006297 nucleotide-excision repair, DNA gap filling
5.75 1.88e-02 GO:0032201 telomere maintenance via semi-conservative replication
5.57 2.64e-03 GO:0031055 chromatin remodeling at centromere
5.47 3.16e-02 GO:0000722 telomere maintenance via recombination
5.21 2.06e-03 GO:0043044 ATP-dependent chromatin remodeling
4.86 7.53e-10 GO:0006261 DNA-dependent DNA replication
4.86 3.67e-02 GO:0002200 somatic diversification of immune receptors

Gene overrepresentation in compartment category:

Showing 1 to 20 of 55 entries
enrichment   p-value GO term description
10.79 7.65e-06 GO:0035098 ESC/E(Z) complex
8.10 3.36e-04 GO:0032300 mismatch repair complex
6.39 2.82e-04 GO:0031519 PcG protein complex
5.72 1.13e-02 GO:0030894 replisome
5.72 1.13e-02 GO:0043601 nuclear replisome
5.40 1.89e-02 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
4.97 1.39e-02 GO:0043596 nuclear replication fork
4.60 2.68e-04 GO:0005657 replication fork
4.31 8.99e-03 GO:0000932 cytoplasmic mRNA processing body
3.76 3.95e-08 GO:0032993 protein-DNA complex
3.72 1.31e-04 GO:0000786 nucleosome
3.60 1.85e-03 GO:0034708 methyltransferase complex
3.60 1.85e-03 GO:0035097 histone methyltransferase complex
3.59 1.52e-02 GO:0000792 heterochromatin
3.47 3.12e-03 GO:0016605 PML body
3.44 3.78e-17 GO:0000785 chromatin
3.41 4.70e-05 GO:0000790 nuclear chromatin
3.23 4.45e-04 GO:0071013 catalytic step 2 spliceosome
3.14 1.67e-09 GO:0044454 nuclear chromosome part
3.07 1.83e-25 GO:0044427 chromosomal part

Gene overrepresentation in function category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
12.14 3.02e-02 GO:0032138 single base insertion or deletion binding
6.94 2.58e-03 GO:0030983 mismatched DNA binding
5.40 2.79e-02 GO:0016538 cyclin-dependent protein kinase regulator activity
5.14 1.77e-03 GO:0003887 DNA-directed DNA polymerase activity
5.03 8.23e-04 GO:0034061 DNA polymerase activity
4.69 1.54e-07 GO:0003697 single-stranded DNA binding
3.61 3.34e-04 GO:0008094 DNA-dependent ATPase activity
3.15 1.75e-03 GO:0003729 mRNA binding
2.69 2.17e-06 GO:0043566 structure-specific DNA binding
2.66 3.03e-06 GO:0003682 chromatin binding
2.52 2.62e-03 GO:0003690 double-stranded DNA binding
1.94 1.19e-10 GO:0003723 RNA binding
1.62 4.29e-25 GO:0003676 nucleic acid binding
1.62 5.11e-16 GO:0003677 DNA binding
1.47 6.23e-09 GO:0000166 nucleotide binding
1.44 2.47e-02 GO:0030528 transcription regulator activity
1.35 1.94e-02 GO:0032559 adenyl ribonucleotide binding
1.35 2.78e-02 GO:0005524 ATP binding
1.34 2.60e-02 GO:0030554 adenyl nucleotide binding
1.32 1.29e-02 GO:0017076 purine nucleotide binding