Motif ID: EGR1..3.p2

Z-value: 1.233


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EGR2chr10_-_64246080,
chr10_-_64246129		0.411.1e-01Click!
EGR3chr8_-_22606401-0.263.4e-01Click!
EGR1chr5_+_137829077-0.126.5e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_57492236 3.069 NM_144684
 ZNF480
zinc finger protein 480
chr4_-_25473528 1.777 NM_015187
 SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr2_+_42128521 1.452 NM_138370
 PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr13_+_19430906 1.429 NM_001190965
 ZMYM2
zinc finger, MYM-type 2
chr21_+_16024241 1.345 NM_013396
 USP25
ubiquitin specific peptidase 25
chr7_-_81910956 1.327 NM_000722
 CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr7_-_81910740 1.322 CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr3_-_15875932 1.291 NM_015199
 ANKRD28
ankyrin repeat domain 28
chr6_-_74420330 1.253 SLC17A5
solute carrier family 17 (anion/sugar transporter), member 5
chr12_+_129388543 1.246 PIWIL1
piwi-like 1 (Drosophila)
chr8_+_72918889 1.224


chr3_+_171558143 1.162 NM_001145098
NM_005414
 SKIL

SKI-like oncogene

chr5_-_81082699 1.108 NM_012446
 SSBP2
single-stranded DNA binding protein 2
chr13_+_19430881 1.091 ZMYM2
zinc finger, MYM-type 2
chr13_+_19430788 1.085 NM_003453
NM_197968
NM_001190964
 ZMYM2


zinc finger, MYM-type 2


chr8_+_72918772 1.043 LOC100132891
hypothetical LOC100132891
chr7_-_107883929 1.025 NM_001193582
NM_001193583
NM_001193584
NM_005010
 NRCAM



neuronal cell adhesion molecule



chr7_+_64975596 1.012 NM_173517
 VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr10_+_11099860 0.993 NM_006561
 CELF2
CUGBP, Elav-like family member 2
chr9_-_85622366 0.981 NM_001135953
NM_025211
 GKAP1

G kinase anchoring protein 1


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 111 entries
enrichment   p-value GO term description
2.83 1.82e-02 GO:0070936 protein K48-linked ubiquitination
2.30 6.17e-04 GO:0000209 protein polyubiquitination
2.17 1.67e-04 GO:0040029 regulation of gene expression, epigenetic
2.17 3.90e-02 GO:0031124 mRNA 3'-end processing
2.08 3.25e-02 GO:0031123 RNA 3'-end processing
1.92 7.99e-04 GO:0006184 GTP catabolic process
1.88 2.15e-08 GO:0032446 protein modification by small protein conjugation
1.85 1.98e-03 GO:0046039 GTP metabolic process
1.84 2.84e-09 GO:0070647 protein modification by small protein conjugation or removal
1.83 1.48e-06 GO:0016567 protein ubiquitination
1.82 3.98e-02 GO:0006403 RNA localization
1.81 7.55e-04 GO:0016569 covalent chromatin modification
1.79 1.98e-03 GO:0016570 histone modification
1.73 2.30e-02 GO:0006417 regulation of translation
1.70 1.15e-06 GO:0016568 chromatin modification
1.64 1.56e-03 GO:0010608 posttranscriptional regulation of gene expression
1.63 2.34e-02 GO:0009261 ribonucleotide catabolic process
1.63 3.01e-02 GO:0009203 ribonucleoside triphosphate catabolic process
1.63 3.01e-02 GO:0009207 purine ribonucleoside triphosphate catabolic process
1.62 9.71e-03 GO:0072523 purine-containing compound catabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 32 entries
enrichment   p-value GO term description
3.67 3.01e-04 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
2.32 4.14e-03 GO:0035770 RNA granule
2.20 4.14e-05 GO:0016585 chromatin remodeling complex
1.72 1.56e-03 GO:0031252 cell leading edge
1.57 4.65e-02 GO:0030425 dendrite
1.45 1.67e-02 GO:0048471 perinuclear region of cytoplasm
1.41 1.17e-10 GO:0005654 nucleoplasm
1.36 5.90e-12 GO:0031981 nuclear lumen
1.35 1.67e-03 GO:0044451 nucleoplasm part
1.34 6.27e-13 GO:0044428 nuclear part
1.32 7.90e-11 GO:0005829 cytosol
1.30 4.08e-02 GO:0015630 microtubule cytoskeleton
1.28 2.32e-31 GO:0005634 nucleus
1.26 6.80e-08 GO:0070013 intracellular organelle lumen
1.25 1.97e-07 GO:0031974 membrane-enclosed lumen
1.25 3.65e-07 GO:0043233 organelle lumen
1.24 6.14e-09 GO:0043234 protein complex
1.21 6.58e-09 GO:0032991 macromolecular complex
1.19 2.36e-31 GO:0043227 membrane-bounded organelle
1.19 3.92e-31 GO:0043231 intracellular membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
3.87 3.47e-02 GO:0070411 I-SMAD binding
2.73 1.10e-04 GO:0046332 SMAD binding
1.75 3.34e-05 GO:0019787 small conjugating protein ligase activity
1.70 3.42e-05 GO:0016881 acid-amino acid ligase activity
1.67 1.72e-05 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.67 6.93e-03 GO:0003682 chromatin binding
1.65 2.00e-03 GO:0004842 ubiquitin-protein ligase activity
1.57 4.51e-02 GO:0003924 GTPase activity
1.43 2.73e-02 GO:0003712 transcription cofactor activity
1.43 3.11e-02 GO:0000988 protein binding transcription factor activity
1.43 3.11e-02 GO:0000989 transcription factor binding transcription factor activity
1.40 1.04e-05 GO:0003723 RNA binding
1.40 1.65e-02 GO:0016874 ligase activity
1.32 1.15e-02 GO:0019899 enzyme binding
1.29 5.32e-10 GO:0000166 nucleotide binding
1.28 5.09e-03 GO:0030528 transcription regulator activity
1.24 1.43e-05 GO:0008270 zinc ion binding
1.24 1.19e-04 GO:0032553 ribonucleotide binding
1.24 1.19e-04 GO:0032555 purine ribonucleotide binding
1.23 4.02e-10 GO:0003676 nucleic acid binding