Motif ID: EGR1..3.p2

Z-value: 1.233


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EGR2chr10_-_64246080,
chr10_-_64246129
0.411.1e-01Click!
EGR3chr8_-_22606401-0.263.4e-01Click!
EGR1chr5_+_137829077-0.126.5e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_57492236 3.069 NM_144684
ZNF480
zinc finger protein 480
chr4_-_25473528 1.777 NM_015187
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr2_+_42128521 1.452 NM_138370
PKDCC
protein kinase domain containing, cytoplasmic homolog (mouse)
chr13_+_19430906 1.429 NM_001190965
ZMYM2
zinc finger, MYM-type 2
chr21_+_16024241 1.345 NM_013396
USP25
ubiquitin specific peptidase 25
chr7_-_81910956 1.327 NM_000722
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr7_-_81910740 1.322 CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr3_-_15875932 1.291 NM_015199
ANKRD28
ankyrin repeat domain 28
chr6_-_74420330 1.253 SLC17A5
solute carrier family 17 (anion/sugar transporter), member 5
chr12_+_129388543 1.246 PIWIL1
piwi-like 1 (Drosophila)
chr8_+_72918889 1.224


chr3_+_171558143 1.162 NM_001145098
NM_005414
SKIL

SKI-like oncogene

chr5_-_81082699 1.108 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr13_+_19430881 1.091 ZMYM2
zinc finger, MYM-type 2
chr13_+_19430788 1.085 NM_003453
NM_197968
NM_001190964
ZMYM2


zinc finger, MYM-type 2


chr8_+_72918772 1.043 LOC100132891
hypothetical LOC100132891
chr7_-_107883929 1.025 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr7_+_64975596 1.012 NM_173517
VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr10_+_11099860 0.993 NM_006561
CELF2
CUGBP, Elav-like family member 2
chr9_-_85622366 0.981 NM_001135953
NM_025211
GKAP1

G kinase anchoring protein 1

chr5_+_89806436 0.979 NM_006467
POLR3G
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr7_+_128257698 0.979 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr22_+_18081968 0.961 NM_002688
SEPT5
septin 5
chr1_+_234372454 0.955 NM_003272
GPR137B
G protein-coupled receptor 137B
chr10_-_74925753 0.947 NM_001142353
NM_001142354
NM_021132
PPP3CB


protein phosphatase 3, catalytic subunit, beta isozyme


chr22_+_38183262 0.938 NM_002409
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr6_+_135544170 0.932 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr5_-_114660139 0.930 NM_001040440
CCDC112
coiled-coil domain containing 112
chr1_+_35507145 0.928 NM_005095
ZMYM4
zinc finger, MYM-type 4
chr1_-_32574185 0.919 NM_023009
MARCKSL1
MARCKS-like 1
chr10_+_11100075 0.917 CELF2
CUGBP, Elav-like family member 2
chr12_-_95317928 0.903 CDK17
cyclin-dependent kinase 17
chr5_-_137116746 0.897 HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr21_-_39642808 0.895 HMGN1
high-mobility group nucleosome binding domain 1
chr16_-_19803606 0.882 NM_016235
GPRC5B
G protein-coupled receptor, family C, group 5, member B
chr6_-_85530617 0.880 NM_001080508
TBX18
T-box 18
chr3_+_171558188 0.870 SKIL
SKI-like oncogene
chr3_+_171558215 0.861 SKIL
SKI-like oncogene
chr2_-_210744158 0.858 NM_152519
C2orf67
chromosome 2 open reading frame 67
chr18_+_12937972 0.856 NM_001013437
NM_031216
SEH1L

SEH1-like (S. cerevisiae)

chr6_+_133604181 0.855 NM_004100
NM_172103
NM_172105
EYA4


eyes absent homolog 4 (Drosophila)


chr10_+_93160066 0.853 NM_173497
NM_182765
HECTD2

HECT domain containing 2

chr10_-_74925653 0.850 PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr1_+_224317044 0.821 H3F3A
LOC440926
H3 histone, family 3A
H3 histone, family 3A pseudogene
chr3_-_184180985 0.804 NM_020640
DCUN1D1
DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
chr1_+_78126787 0.802 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr2_+_191222077 0.801 NM_005966
NAB1
NGFI-A binding protein 1 (EGR1 binding protein 1)
chr10_-_74925724 0.800 PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr17_-_44010543 0.787 NM_024015
HOXB4
homeobox B4
chr6_+_18263514 0.779 NM_153042
KDM1B
lysine (K)-specific demethylase 1B
chr10_-_33286792 0.776 NM_133376
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr21_+_16024157 0.775 USP25
ubiquitin specific peptidase 25
chr19_-_54314090 0.773 NM_018111
C19orf73
chromosome 19 open reading frame 73
chr6_+_111911226 0.772 LOC643749
hypothetical LOC643749
chr1_+_65763978 0.769 LEPR
leptin receptor
chr17_+_63252668 0.766 BPTF
bromodomain PHD finger transcription factor
chr3_-_172660545 0.761 NM_001161560
NM_001161561
NM_001161562
NM_001161563
NM_001161564
NM_001161565
NM_001161566
NM_015028
TNIK







TRAF2 and NCK interacting kinase







chr1_+_65763945 0.752 NM_001198687
NM_001198688
NM_001198689
LEPR


leptin receptor


chr1_+_177261627 0.751 FAM20B
family with sequence similarity 20, member B
chr2_-_144991386 0.750 ZEB2
zinc finger E-box binding homeobox 2
chr6_+_135544138 0.744 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr5_-_88215034 0.738 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr10_+_89613399 0.729 PTEN
phosphatase and tensin homolog
chr11_+_46359878 0.721 NM_001012333
MDK
midkine (neurite growth-promoting factor 2)
chr17_+_63252704 0.720 BPTF
bromodomain PHD finger transcription factor
chr5_+_176493233 0.718 NM_022455
NSD1
nuclear receptor binding SET domain protein 1
chr9_-_15500209 0.708 NM_021144
PSIP1
PC4 and SFRS1 interacting protein 1
chr9_-_100510657 0.706 NM_005458
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr7_-_140270749 0.701 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr10_+_94598204 0.700 NM_019053
EXOC6
exocyst complex component 6
chr12_+_19484044 0.699 AEBP2
AE binding protein 2
chr1_+_39229474 0.698 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr5_+_176493488 0.697 NSD1
nuclear receptor binding SET domain protein 1
chr7_-_27206249 0.694 NM_000522
HOXA13
homeobox A13
chr6_+_133604203 0.692 EYA4
eyes absent homolog 4 (Drosophila)
chr2_+_181553333 0.685 NM_182678
NM_006357
UBE2E3

ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)

chr3_-_88190737 0.682 NM_001008390
NM_003663
CGGBP1

CGG triplet repeat binding protein 1

chr5_+_76542461 0.679 NM_001029851
NM_001029852
NM_001029853
NM_001029854
NM_003719
PDE8B




phosphodiesterase 8B




chr2_-_174537021 0.678 NM_001017371
SP3
Sp3 transcription factor
chr13_+_77170470 0.676 NM_001040153
SLAIN1
SLAIN motif family, member 1
chr12_-_122415327 0.676 SBNO1
strawberry notch homolog 1 (Drosophila)
chr10_+_49184658 0.662 MAPK8
mitogen-activated protein kinase 8
chrX_-_153952447 0.660 NM_001018024
NM_001018025
MTCP1NB
MTCP1
mature T-cell proliferation 1 neighbor
mature T-cell proliferation 1
chr17_+_63252087 0.655 NM_004459
NM_182641
BPTF

bromodomain PHD finger transcription factor

chr9_+_130491668 0.654 SET
SET nuclear oncogene
chr8_+_57286875 0.652 CHCHD7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr5_-_81082614 0.648 SSBP2
single-stranded DNA binding protein 2
chr2_+_56264627 0.645 NM_001080433
CCDC85A
coiled-coil domain containing 85A
chr16_+_65620536 0.640 NM_001755
NM_022845
CBFB

core-binding factor, beta subunit

chr22_+_42751487 0.640 NM_013327
PARVB
parvin, beta
chr2_+_198377561 0.639 NM_006226
PLCL1
phospholipase C-like 1
chr19_+_60487578 0.636 BRSK1
BR serine/threonine kinase 1
chr6_+_143423723 0.635 AIG1
androgen-induced 1
chr21_-_39642935 0.634 HMGN1
high-mobility group nucleosome binding domain 1
chr6_-_46566969 0.632 RCAN2
regulator of calcineurin 2
chr5_+_86599800 0.627 RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr21_+_46473494 0.627 MCM3AP-AS1
MCM3AP antisense RNA 1 (non-protein coding)
chr8_+_16929116 0.623 NM_181723
EFHA2
EF-hand domain family, member A2
chr2_-_219141199 0.620 NM_020935
USP37
ubiquitin specific peptidase 37
chr20_-_30636535 0.614 LOC284804
hypothetical protein LOC284804
chr12_+_102982365 0.612 NM_013320
HCFC2
host cell factor C2
chr10_+_89613071 0.610 NM_000314
PTEN
phosphatase and tensin homolog
chr16_+_51722285 0.607 CHD9
chromodomain helicase DNA binding protein 9
chr12_+_19484387 0.604 AEBP2
AE binding protein 2
chr6_+_76368337 0.604 NM_001100409
NM_015571
SENP6

SUMO1/sentrin specific peptidase 6

chr3_+_20056857 0.603 KAT2B
K(lysine) acetyltransferase 2B
chr7_+_119700924 0.602 NM_012281
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr8_+_17058377 0.600 ZDHHC2
zinc finger, DHHC-type containing 2
chr8_-_74821610 0.597 STAU2
LOC729696
staufen, RNA binding protein, homolog 2 (Drosophila)
hypothetical protein LOC729696
chr11_+_107304344 0.597 NM_017516
RAB39
RAB39, member RAS oncogene family
chr18_-_802268 0.595 NM_005433
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr14_-_52327895 0.591 GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chrX_-_16798383 0.588 NM_002893
RBBP7
retinoblastoma binding protein 7
chr9_+_130491291 0.584 NM_003011
SET
SET nuclear oncogene
chr6_+_84799969 0.582 NM_138409
MRAP2
melanocortin 2 receptor accessory protein 2
chr8_+_26204997 0.581 PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr10_+_93160033 0.580


chr10_-_43082372 0.579 NM_145313
RASGEF1A
RasGEF domain family, member 1A
chr21_-_39642712 0.578 HMGN1
high-mobility group nucleosome binding domain 1
chr1_-_93199586 0.577 NM_001006605
FAM69A
family with sequence similarity 69, member A
chrX_-_16798363 0.573 RBBP7
retinoblastoma binding protein 7
chr12_+_75682016 0.572 ZDHHC17
zinc finger, DHHC-type containing 17
chr14_-_22840249 0.571


chr8_-_74821636 0.571 NM_001164380
NM_001164381
NM_001164382
NM_001164383
NM_001164385
NM_014393
STAU2





staufen, RNA binding protein, homolog 2 (Drosophila)





chr15_+_73922838 0.570 UBE2Q2
ubiquitin-conjugating enzyme E2Q family member 2
chr5_-_40834232 0.569 PRKAA1
protein kinase, AMP-activated, alpha 1 catalytic subunit
chr3_-_38666122 0.568 NM_000335
NM_001099404
NM_001099405
NM_198056
NM_001160160
NM_001160161
SCN5A





sodium channel, voltage-gated, type V, alpha subunit





chr12_+_129388385 0.566 NM_001190971
NM_004764
PIWIL1

piwi-like 1 (Drosophila)

chr6_-_153494076 0.565 NM_012419
RGS17
regulator of G-protein signaling 17
chr7_+_106472243 0.565 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr1_+_35507197 0.564 ZMYM4
zinc finger, MYM-type 4
chr3_-_25680723 0.563 NM_001068
TOP2B
topoisomerase (DNA) II beta 180kDa
chr1_-_115433570 0.561 NM_005725
TSPAN2
tetraspanin 2
chr9_+_130491370 0.560 SET
SET nuclear oncogene
chr5_-_137396677 0.558 NM_001101800
NM_001101801
NM_016603
FAM13B


family with sequence similarity 13, member B


chr7_+_35807352 0.552 SEPT7
septin 7
chr15_+_73923047 0.551 UBE2Q2
ubiquitin-conjugating enzyme E2Q family member 2
chrX_-_16798096 0.550 RBBP7
retinoblastoma binding protein 7
chrX_-_135161185 0.550 NM_001173517
NM_024597
MAP7D3

MAP7 domain containing 3

chr10_-_64248932 0.550 NM_001136178
EGR2
early growth response 2
chr6_+_19945578 0.547 NM_001546
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr9_-_15500899 0.546 NM_001128217
NM_033222
PSIP1

PC4 and SFRS1 interacting protein 1

chr1_-_166171838 0.545 NM_015415
BRP44
brain protein 44
chr7_+_35807139 0.545 NM_001011553
NM_001788
SEPT7

septin 7

chr17_-_60345364 0.543 NM_199340
LRRC37A3
leucine rich repeat containing 37, member A3
chr11_+_32870935 0.540 NM_001076786
QSER1
glutamine and serine rich 1
chr5_-_167938875 0.539 PANK3
pantothenate kinase 3
chr6_-_79844618 0.539 PHIP
pleckstrin homology domain interacting protein
chr12_+_75682146 0.539 ZDHHC17
zinc finger, DHHC-type containing 17
chr7_+_64136078 0.537 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr1_+_210525885 0.536 PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr14_-_101623139 0.536 NM_005348
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr12_+_50271283 0.535 NM_014191
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr3_+_23822481 0.533 UBE2E1
ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)
chr7_-_120823556 0.532 FAM3C
family with sequence similarity 3, member C
chr12_+_49444509 0.531 ATF1
activating transcription factor 1
chr18_+_12938010 0.529 SEH1L
SEH1-like (S. cerevisiae)
chr2_-_225615556 0.523 NM_014689
DOCK10
dedicator of cytokinesis 10
chr6_+_76367944 0.522 SENP6
SUMO1/sentrin specific peptidase 6
chr12_-_99060590 0.520 UHRF1BP1L
UHRF1 binding protein 1-like
chr7_+_64975778 0.518 VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr14_-_101623097 0.518 HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr1_-_181871473 0.517 ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr13_+_24844084 0.516 NM_016529
ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chr8_+_172199 0.514 NM_173539
NM_001042415
NM_001042416
ZNF596


zinc finger protein 596


chr4_-_71924052 0.513 NM_001098477
GRSF1
G-rich RNA sequence binding factor 1
chr2_+_102602579 0.512 NM_003048
SLC9A2
solute carrier family 9 (sodium/hydrogen exchanger), member 2
chr1_-_224441024 0.511 NM_022735
ACBD3
acyl-CoA binding domain containing 3
chr1_-_58784967 0.510 NM_145243
OMA1
OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
chr2_+_207016525 0.510 NM_003812
ADAM23
ADAM metallopeptidase domain 23
chr15_+_73922676 0.510 NM_173469
UBE2Q2
ubiquitin-conjugating enzyme E2Q family member 2
chr7_+_102502852 0.508 ARMC10
armadillo repeat containing 10
chr1_+_67168470 0.506 NM_001077701
NM_001077704
MIER1

mesoderm induction early response 1 homolog (Xenopus laevis)

chr9_-_126945536 0.506 NM_001144877
NM_173690
SCAI

suppressor of cancer cell invasion

chr12_+_69046241 0.505 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr13_-_40533072 0.504 ELF1
E74-like factor 1 (ets domain transcription factor)
chr6_+_76368462 0.504 SENP6
SUMO1/sentrin specific peptidase 6
chr2_+_181553613 0.503 UBE2E3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr5_-_114659863 0.503 NM_152549
CCDC112
coiled-coil domain containing 112
chr4_+_108965167 0.502 NM_001136258
SGMS2
sphingomyelin synthase 2
chr1_-_182273114 0.501 GLT25D2
glycosyltransferase 25 domain containing 2
chr4_+_154606900 0.501 NM_001131007
NM_015196
KIAA0922

KIAA0922

chr6_-_79844606 0.498 PHIP
pleckstrin homology domain interacting protein
chr12_-_116983276 0.497 NM_018639
WSB2
WD repeat and SOCS box containing 2
chr14_-_57688560 0.492 NM_001001872
C14orf37
chromosome 14 open reading frame 37
chr7_-_120823591 0.491 NM_001040020
NM_014888
FAM3C

family with sequence similarity 3, member C

chr12_-_99060771 0.490 NM_001006947
NM_015054
UHRF1BP1L

UHRF1 binding protein 1-like

chrX_-_19918958 0.490 LOC729609
hypothetical LOC729609
chr2_+_135392857 0.489 NM_001241
NM_058241
CCNT2

cyclin T2

chr1_-_181871416 0.487 ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr9_-_134220179 0.486 NM_015046
SETX
senataxin
chr1_-_181871462 0.485 ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr10_+_89613347 0.484 PTEN
phosphatase and tensin homolog
chrX_+_9392980 0.483 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr12_+_75681973 0.481 NM_015336
ZDHHC17
zinc finger, DHHC-type containing 17
chr10_+_64951114 0.479 NM_001001330
REEP3
receptor accessory protein 3
chr7_+_35807369 0.478 SEPT7
septin 7
chr1_-_224441023 0.477 ACBD3
acyl-CoA binding domain containing 3
chr10_+_94439658 0.476 NM_002729
HHEX
hematopoietically expressed homeobox
chr14_+_66777578 0.476 NM_022474
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.22 1.07e-20 GO:0044237 cellular metabolic process
1.28 5.89e-20 GO:0044260 cellular macromolecule metabolic process
1.11 2.42e-17 GO:0009987 cellular process
1.23 2.98e-15 GO:0043170 macromolecule metabolic process
1.19 3.79e-15 GO:0044238 primary metabolic process
1.32 6.02e-14 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.16 4.07e-13 GO:0008152 metabolic process
1.16 5.08e-13 GO:0050794 regulation of cellular process
1.32 1.64e-12 GO:0044267 cellular protein metabolic process
1.27 1.96e-12 GO:0006807 nitrogen compound metabolic process
1.25 3.48e-12 GO:0031323 regulation of cellular metabolic process
1.38 3.63e-12 GO:0006464 protein modification process
1.27 4.00e-12 GO:0034641 cellular nitrogen compound metabolic process
1.15 8.34e-12 GO:0050789 regulation of biological process
1.14 1.22e-11 GO:0065007 biological regulation
1.26 3.45e-11 GO:0060255 regulation of macromolecule metabolic process
1.35 5.32e-11 GO:0043412 macromolecule modification
1.29 2.20e-10 GO:0010468 regulation of gene expression
1.22 2.39e-10 GO:0019222 regulation of metabolic process
1.24 4.97e-10 GO:0080090 regulation of primary metabolic process
1.84 2.84e-09 GO:0070647 protein modification by small protein conjugation or removal
1.28 5.23e-09 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.28 9.94e-09 GO:0010556 regulation of macromolecule biosynthetic process
1.88 2.15e-08 GO:0032446 protein modification by small protein conjugation
1.24 2.97e-08 GO:0019538 protein metabolic process
1.28 3.96e-08 GO:0051252 regulation of RNA metabolic process
1.25 7.63e-08 GO:0031326 regulation of cellular biosynthetic process
1.25 8.48e-08 GO:0009889 regulation of biosynthetic process
1.32 1.66e-07 GO:0016070 RNA metabolic process
1.28 1.78e-07 GO:0090304 nucleic acid metabolic process
1.24 5.90e-07 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.70 1.15e-06 GO:0016568 chromatin modification
1.83 1.48e-06 GO:0016567 protein ubiquitination
1.23 1.55e-06 GO:0051171 regulation of nitrogen compound metabolic process
1.26 4.42e-06 GO:0006355 regulation of transcription, DNA-dependent
1.23 1.07e-05 GO:0071842 cellular component organization at cellular level
1.35 2.30e-05 GO:0044248 cellular catabolic process
1.52 3.33e-05 GO:0016071 mRNA metabolic process
1.42 5.91e-05 GO:0046907 intracellular transport
1.51 6.63e-05 GO:0044265 cellular macromolecule catabolic process
1.28 7.62e-05 GO:0006996 organelle organization
1.18 1.01e-04 GO:0016043 cellular component organization
1.20 1.20e-04 GO:0071841 cellular component organization or biogenesis at cellular level
2.17 1.67e-04 GO:0040029 regulation of gene expression, epigenetic
1.37 2.14e-04 GO:0022008 neurogenesis
1.31 2.44e-04 GO:0051641 cellular localization
1.43 4.10e-04 GO:0007167 enzyme linked receptor protein signaling pathway
1.17 4.35e-04 GO:0071840 cellular component organization or biogenesis
1.51 4.96e-04 GO:0006325 chromatin organization
1.28 5.28e-04 GO:0007399 nervous system development
1.61 6.12e-04 GO:0019941 modification-dependent protein catabolic process
2.30 6.17e-04 GO:0000209 protein polyubiquitination
1.60 6.87e-04 GO:0051603 proteolysis involved in cellular protein catabolic process
1.81 7.55e-04 GO:0016569 covalent chromatin modification
1.61 7.87e-04 GO:0006511 ubiquitin-dependent protein catabolic process
1.92 7.99e-04 GO:0006184 GTP catabolic process
1.60 8.84e-04 GO:0043632 modification-dependent macromolecule catabolic process
1.59 9.85e-04 GO:0009259 ribonucleotide metabolic process
1.58 1.04e-03 GO:0044257 cellular protein catabolic process
1.45 1.23e-03 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
1.36 1.48e-03 GO:0048699 generation of neurons
1.64 1.56e-03 GO:0010608 posttranscriptional regulation of gene expression
1.55 1.83e-03 GO:0030163 protein catabolic process
1.79 1.98e-03 GO:0016570 histone modification
1.85 1.98e-03 GO:0046039 GTP metabolic process
1.46 2.03e-03 GO:0006753 nucleoside phosphate metabolic process
1.46 2.03e-03 GO:0009117 nucleotide metabolic process
1.50 2.17e-03 GO:0072521 purine-containing compound metabolic process
1.41 2.56e-03 GO:0009057 macromolecule catabolic process
1.52 2.66e-03 GO:0006163 purine nucleotide metabolic process
1.30 3.26e-03 GO:0051649 establishment of localization in cell
1.32 3.63e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.57 3.73e-03 GO:0009150 purine ribonucleotide metabolic process
1.31 5.78e-03 GO:0032268 regulation of cellular protein metabolic process
1.18 6.87e-03 GO:0009058 biosynthetic process
1.39 7.57e-03 GO:0051276 chromosome organization
1.19 7.67e-03 GO:0048522 positive regulation of cellular process
1.19 8.58e-03 GO:0044249 cellular biosynthetic process
1.20 9.31e-03 GO:0048523 negative regulation of cellular process
1.19 9.59e-03 GO:0048519 negative regulation of biological process
1.62 9.71e-03 GO:0072523 purine-containing compound catabolic process
1.56 9.86e-03 GO:0009141 nucleoside triphosphate metabolic process
1.56 1.07e-02 GO:0009144 purine nucleoside triphosphate metabolic process
1.49 1.13e-02 GO:0006397 mRNA processing
1.32 1.14e-02 GO:0006351 transcription, DNA-dependent
1.15 1.20e-02 GO:0051179 localization
1.56 1.22e-02 GO:0009205 purine ribonucleoside triphosphate metabolic process
1.62 1.25e-02 GO:0006195 purine nucleotide catabolic process
1.56 1.44e-02 GO:0009199 ribonucleoside triphosphate metabolic process
1.21 1.79e-02 GO:0010467 gene expression
2.83 1.82e-02 GO:0070936 protein K48-linked ubiquitination
1.59 1.89e-02 GO:0009166 nucleotide catabolic process
1.22 1.89e-02 GO:0023051 regulation of signaling
1.50 1.90e-02 GO:0018193 peptidyl-amino acid modification
1.73 2.30e-02 GO:0006417 regulation of translation
1.63 2.34e-02 GO:0009261 ribonucleotide catabolic process
1.27 2.63e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.28 2.69e-02 GO:0007049 cell cycle
1.63 3.01e-02 GO:0009203 ribonucleoside triphosphate catabolic process
1.63 3.01e-02 GO:0009207 purine ribonucleoside triphosphate catabolic process
1.62 3.20e-02 GO:0009143 nucleoside triphosphate catabolic process
1.62 3.20e-02 GO:0009154 purine ribonucleotide catabolic process
2.08 3.25e-02 GO:0031123 RNA 3'-end processing
1.62 3.63e-02 GO:0009146 purine nucleoside triphosphate catabolic process
1.23 3.79e-02 GO:0009056 catabolic process
2.17 3.90e-02 GO:0031124 mRNA 3'-end processing
1.82 3.98e-02 GO:0006403 RNA localization
1.27 4.84e-02 GO:0051246 regulation of protein metabolic process
1.40 4.84e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.28 4.90e-02 GO:0006793 phosphorus metabolic process
1.28 4.90e-02 GO:0006796 phosphate metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.17 1.57e-47 GO:0044424 intracellular part
1.16 2.20e-47 GO:0005622 intracellular
1.18 1.20e-34 GO:0043226 organelle
1.18 1.69e-34 GO:0043229 intracellular organelle
1.28 2.32e-31 GO:0005634 nucleus
1.19 2.36e-31 GO:0043227 membrane-bounded organelle
1.19 3.92e-31 GO:0043231 intracellular membrane-bounded organelle
1.16 3.44e-21 GO:0005737 cytoplasm
1.34 6.27e-13 GO:0044428 nuclear part
1.36 5.90e-12 GO:0031981 nuclear lumen
1.05 6.12e-11 GO:0044464 cell part
1.05 6.64e-11 GO:0005623 cell
1.32 7.90e-11 GO:0005829 cytosol
1.41 1.17e-10 GO:0005654 nucleoplasm
1.15 1.48e-09 GO:0044444 cytoplasmic part
1.24 6.14e-09 GO:0043234 protein complex
1.21 6.58e-09 GO:0032991 macromolecular complex
1.15 1.26e-08 GO:0044446 intracellular organelle part
1.15 4.24e-08 GO:0044422 organelle part
1.26 6.80e-08 GO:0070013 intracellular organelle lumen
1.25 1.97e-07 GO:0031974 membrane-enclosed lumen
1.25 3.65e-07 GO:0043233 organelle lumen
2.20 4.14e-05 GO:0016585 chromatin remodeling complex
3.67 3.01e-04 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
1.72 1.56e-03 GO:0031252 cell leading edge
1.35 1.67e-03 GO:0044451 nucleoplasm part
1.16 2.69e-03 GO:0043228 non-membrane-bounded organelle
1.16 2.69e-03 GO:0043232 intracellular non-membrane-bounded organelle
2.32 4.14e-03 GO:0035770 RNA granule
1.45 1.67e-02 GO:0048471 perinuclear region of cytoplasm
1.30 4.08e-02 GO:0015630 microtubule cytoskeleton
1.57 4.65e-02 GO:0030425 dendrite

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.21 3.51e-27 GO:0005515 protein binding
1.11 2.00e-21 GO:0005488 binding
1.23 4.02e-10 GO:0003676 nucleic acid binding
1.29 5.32e-10 GO:0000166 nucleotide binding
1.23 3.38e-06 GO:0003677 DNA binding
1.40 1.04e-05 GO:0003723 RNA binding
1.24 1.43e-05 GO:0008270 zinc ion binding
1.67 1.72e-05 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.75 3.34e-05 GO:0019787 small conjugating protein ligase activity
1.70 3.42e-05 GO:0016881 acid-amino acid ligase activity
2.73 1.10e-04 GO:0046332 SMAD binding
1.24 1.19e-04 GO:0032553 ribonucleotide binding
1.24 1.19e-04 GO:0032555 purine ribonucleotide binding
1.15 1.29e-04 GO:0046872 metal ion binding
1.23 1.32e-04 GO:0017076 purine nucleotide binding
1.15 1.70e-04 GO:0043167 ion binding
1.15 2.14e-04 GO:0043169 cation binding
1.23 2.39e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.20 2.83e-04 GO:0046914 transition metal ion binding
1.65 2.00e-03 GO:0004842 ubiquitin-protein ligase activity
1.28 5.09e-03 GO:0030528 transcription regulator activity
1.67 6.93e-03 GO:0003682 chromatin binding
1.32 1.15e-02 GO:0019899 enzyme binding
1.21 1.37e-02 GO:0030554 adenyl nucleotide binding
1.21 1.43e-02 GO:0032559 adenyl ribonucleotide binding
1.40 1.65e-02 GO:0016874 ligase activity
1.43 2.73e-02 GO:0003712 transcription cofactor activity
1.43 3.11e-02 GO:0000988 protein binding transcription factor activity
1.43 3.11e-02 GO:0000989 transcription factor binding transcription factor activity
3.87 3.47e-02 GO:0070411 I-SMAD binding
1.20 4.25e-02 GO:0005524 ATP binding
1.10 4.27e-02 GO:0003824 catalytic activity
1.57 4.51e-02 GO:0003924 GTPase activity