Motif ID: EN1,2.p2

Z-value: 1.511


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EN1chr2_-_1193222280.421.0e-01Click!
EN2chr7_+_1549434660.312.4e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_50318801 2.470 IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr2_+_234265059 2.211 NM_205862
 UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr2_+_68855436 2.123 NM_001166276
NM_014882
 ARHGAP25

Rho GTPase activating protein 25

chr2_+_102401580 2.072 NM_003853
 IL18RAP
interleukin 18 receptor accessory protein
chr22_+_38627031 2.025 NM_004810
 GRAP2
GRB2-related adaptor protein 2
chr11_+_123639909 2.011 NM_001005198
 OR8G5
olfactory receptor, family 8, subfamily G, member 5
chr16_-_20271530 1.954 NM_001008389
NM_003361
 UMOD

uromodulin

chr2_-_158008763 1.935 NM_004288
 CYTIP
cytohesin 1 interacting protein
chr17_-_36928604 1.898 NM_002275
 KRT15
keratin 15
chr1_+_169421011 1.889 NM_001460
 FMO2
flavin containing monooxygenase 2 (non-functional)
chr1_+_159032551 1.854 NM_001033667
NM_002348
 LY9

lymphocyte antigen 9

chr11_+_59979857 1.799 NM_021950
NM_152866
 MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr13_+_112349358 1.764 NM_207440
 C13orf35
chromosome 13 open reading frame 35
chr3_-_184756101 1.709 NM_130446
 KLHL6
kelch-like 6 (Drosophila)
chr16_-_79811475 1.647 NM_001076780
NM_052892
 PKD1L2

polycystic kidney disease 1-like 2

chr6_+_32515596 1.640 NM_019111
 HLA-DRA
major histocompatibility complex, class II, DR alpha
chr2_+_234333653 1.571 NM_000463
 UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr6_+_160247962 1.568 NM_002377
 MAS1
MAS1 oncogene
chr6_+_28601767 1.567 NM_001509
NM_003996
 GPX5

glutathione peroxidase 5 (epididymal androgen-related protein)

chr1_+_246635918 1.566 NM_030904
 OR2T1
olfactory receptor, family 2, subfamily T, member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
4.82 3.94e-53 GO:0007608 sensory perception of smell
4.54 1.59e-52 GO:0007606 sensory perception of chemical stimulus
3.22 5.20e-42 GO:0007600 sensory perception
3.21 1.82e-02 GO:0034341 response to interferon-gamma
2.34 6.43e-29 GO:0050877 neurological system process
2.23 4.46e-05 GO:0045087 innate immune response
2.13 2.69e-27 GO:0003008 system process
2.07 3.10e-09 GO:0006955 immune response
1.87 2.73e-06 GO:0006952 defense response
1.69 1.78e-06 GO:0002376 immune system process
1.38 2.57e-13 GO:0032501 multicellular organismal process
1.35 5.37e-15 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
2.59 3.16e-03 GO:0009897 external side of plasma membrane
2.57 5.01e-04 GO:0005882 intermediate filament
2.44 4.82e-04 GO:0045111 intermediate filament cytoskeleton
1.63 1.23e-03 GO:0005615 extracellular space
1.62 1.97e-28 GO:0071944 cell periphery
1.62 5.69e-28 GO:0005886 plasma membrane
1.55 7.08e-09 GO:0005576 extracellular region
1.49 7.52e-03 GO:0044421 extracellular region part
1.47 3.61e-03 GO:0005887 integral to plasma membrane
1.45 2.75e-22 GO:0031224 intrinsic to membrane
1.45 1.34e-21 GO:0016021 integral to membrane
1.45 5.36e-03 GO:0031226 intrinsic to plasma membrane
1.35 4.77e-17 GO:0044425 membrane part
1.29 2.85e-02 GO:0044459 plasma membrane part
1.24 2.31e-11 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
4.98 9.05e-55 GO:0004984 olfactory receptor activity
4.04 5.50e-03 GO:0008009 chemokine activity
3.64 1.86e-02 GO:0042379 chemokine receptor binding
3.21 3.46e-44 GO:0004930 G-protein coupled receptor activity
2.68 4.68e-43 GO:0004888 transmembrane receptor activity
2.32 1.69e-38 GO:0004872 receptor activity
2.30 4.19e-03 GO:0005125 cytokine activity
2.08 2.65e-33 GO:0004871 signal transducer activity
2.08 2.65e-33 GO:0060089 molecular transducer activity