Motif ID: EOMES.p2

Z-value: 0.915


Transcription factors associated with EOMES.p2:

Gene SymbolEntrez IDGene Name
EOMES 8320 eomesodermin

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EOMESchr3_-_27738788-0.165.5e-01Click!


Activity profile for motif EOMES.p2.

activity profile for motif EOMES.p2


Sorted Z-values histogram for motif EOMES.p2

Sorted Z-values for motif EOMES.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EOMES.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_2465252 0.934 NM_080751
TMC2
transmembrane channel-like 2
chr14_+_94148466 0.817 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr2_+_171280944 0.776 SP5
Sp5 transcription factor
chr12_+_54760211 0.774 ERBB3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr2_-_74606819 0.733 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr6_-_137857213 0.707 NM_175747
OLIG3
oligodendrocyte transcription factor 3
chr2_+_171280046 0.606 NM_001003845
SP5
Sp5 transcription factor
chr2_+_228386800 0.580 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr12_-_88270128 0.544 DUSP6
dual specificity phosphatase 6
chr17_-_20311411 0.543 NM_001042685
LGALS9B
lectin, galactoside-binding, soluble, 9B
chr14_-_22516271 0.540 NM_198086
JUB
jub, ajuba homolog (Xenopus laevis)
chr12_-_88270375 0.531 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr20_+_42776888 0.531 WISP2
WNT1 inducible signaling pathway protein 2
chr12_-_88270369 0.501 DUSP6
dual specificity phosphatase 6
chr1_-_155053124 0.494 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr11_-_2138984 0.486 NM_000207
NM_001185097
NM_001185098
NM_001042376
INS


INS-IGF2
insulin


INS-IGF2 readthrough transcript
chr16_+_30293598 0.475 NM_013292
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr14_+_54104099 0.433 SAMD4A
sterile alpha motif domain containing 4A
chr10_+_4995597 0.427 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr1_-_44255583 0.423 NM_006934
NM_201649
SLC6A9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr17_+_8154864 0.421 NM_025014
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chr2_+_218954995 0.418 NM_000578
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr17_-_71535076 0.415 NM_001988
EVPL
envoplakin
chr10_-_123346148 0.413 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr5_-_44424423 0.399 NM_004465
FGF10
fibroblast growth factor 10
chr12_-_55134692 0.398 NM_012064
MIP
major intrinsic protein of lens fiber
chr1_+_224477941 0.384 NM_031944
MIXL1
Mix1 homeobox-like 1 (Xenopus laevis)
chr7_+_27248688 0.381 NM_001989
EVX1
even-skipped homeobox 1
chr7_-_111216180 0.378 DOCK4
dedicator of cytokinesis 4
chr3_+_10832867 0.367 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr3_-_69381995 0.366 FRMD4B
FERM domain containing 4B
chr1_+_17719405 0.364 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr4_+_124537334 0.343 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr1_-_203557379 0.335 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr20_+_42463279 0.335 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr20_-_22513050 0.334 NM_021784
FOXA2
forkhead box A2
chr14_-_23107106 0.333 NM_003917
AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr1_+_110795271 0.329 NM_032414
PROK1
prokineticin 1
chr6_-_29431950 0.326 NM_030876
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr17_-_59349867 0.323 NM_000515
NM_022559
NM_022560
NM_022561
NM_022562
GH1




growth hormone 1




chr8_-_146173531 0.322 ZNF252
zinc finger protein 252
chr17_-_10393664 0.322 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr2_+_65070030 0.320 SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr6_+_108722752 0.314 NM_145315
LACE1
lactation elevated 1
chr7_-_123460722 0.312 NM_001136002
TMEM229A
transmembrane protein 229A
chr12_-_51173238 0.309 NM_005554
KRT6A
keratin 6A
chr15_-_88095363 0.309 NM_018670
MESP1
mesoderm posterior 1 homolog (mouse)
chr2_+_218992053 0.302 NM_007127
VIL1
villin 1
chr2_+_152900076 0.300 FMNL2
formin-like 2
chr1_-_110949867 0.298 NM_004974
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr3_-_48446405 0.295 NM_001130082
PLXNB1
plexin B1
chrX_-_106033202 0.295 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr2_+_65069986 0.292 NM_003038
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr11_+_20000938 0.287 NAV2
neuron navigator 2
chr4_-_186815116 0.286 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr11_+_60727559 0.286 NM_001079807
PGA3
PGA4
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr16_-_66523255 0.286 NM_001907
CTRL
chymotrypsin-like
chr16_-_51139214 0.286 NM_001146188
TOX3
TOX high mobility group box family member 3
chr2_+_176680251 0.284 NM_021192
HOXD11
homeobox D11
chr21_-_30786145 0.284 NM_181609
KRTAP19-3
keratin associated protein 19-3
chr1_+_210848592 0.281 NM_001040619
NM_001674
ATF3

activating transcription factor 3

chr3_+_38322430 0.278 NM_004803
SLC22A14
solute carrier family 22, member 14
chr19_+_53559468 0.275 NM_012451
SYNGR4
synaptogyrin 4
chr11_-_46364681 0.275 NM_000741
CHRM4
cholinergic receptor, muscarinic 4
chr17_+_22982278 0.274 NM_002308
NM_009587
LGALS9

lectin, galactoside-binding, soluble, 9

chr20_+_32926452 0.273 ACSS2
acyl-CoA synthetase short-chain family member 2
chr3_-_71625318 0.272 FOXP1
forkhead box P1
chr12_-_8706637 0.272 NM_003480
MFAP5
microfibrillar associated protein 5
chr14_-_65550379 0.272


chr1_+_210848726 0.270 ATF3
activating transcription factor 3
chr17_-_36469869 0.269 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr5_-_1935764 0.266 NM_016358
IRX4
iroquois homeobox 4
chr3_-_188946168 0.265 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr2_+_171280182 0.263


chr14_+_20537253 0.262 NM_014579
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr15_+_88120592 0.261 NM_001039958
MESP2
mesoderm posterior 2 homolog (mouse)
chr12_+_123339662 0.261 NM_181709
FAM101A
family with sequence similarity 101, member A
chr7_-_27191287 0.261 NM_005523
HOXA11
homeobox A11
chr19_+_13848949 0.261 NM_001098622
NANOS3
nanos homolog 3 (Drosophila)
chr11_-_55460451 0.258 NM_006637
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chr14_-_23106779 0.257 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr3_+_195336631 0.256 HES1
hairy and enhancer of split 1, (Drosophila)
chr6_+_132915522 0.255 NM_053278
TAAR8
trace amine associated receptor 8
chr5_+_140573692 0.253 NM_018933
PCDHB13
protocadherin beta 13
chr4_-_186969202 0.253 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr20_-_2589476 0.248 IDH3B
isocitrate dehydrogenase 3 (NAD+) beta
chr3_-_147696411 0.248 NM_020359
PLSCR2
phospholipid scramblase 2
chr6_-_130224108 0.240 NM_001010876
C6orf191
chromosome 6 open reading frame 191
chr11_+_55899675 0.240 NM_001005204
NM_001013356
OR8U1
OR8U8
olfactory receptor, family 8, subfamily U, member 1
olfactory receptor, family 8, subfamily U, member 8
chr5_-_35974493 0.238 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr11_+_36354110 0.236 NM_001160168
NM_024841
PRR5L

proline rich 5 like

chr9_-_35962454 0.235 YBX1
Y box binding protein 1
chr4_-_186969041 0.235 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr10_-_15453060 0.232 NM_001010924
FAM171A1
family with sequence similarity 171, member A1
chr7_-_36730525 0.232 NM_001177506
NM_001177507
NM_001637
AOAH


acyloxyacyl hydrolase (neutrophil)


chr1_+_31814672 0.232 NM_022164
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr5_-_16795336 0.231 MYO10
myosin X
chr1_+_210848763 0.225 ATF3
activating transcription factor 3
chr14_-_23106372 0.224 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr10_-_92670764 0.222 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr16_+_31105579 0.221


chr17_+_18320822 0.221 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr11_+_6237541 0.221 NM_176875
CCKBR
cholecystokinin B receptor
chr1_-_12599934 0.218 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr16_-_79668304 0.212 NM_001100873
NM_152337
C16orf46

chromosome 16 open reading frame 46

chr14_+_54104383 0.210 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr9_+_17124974 0.210 NM_001114395
NM_017738
CNTLN

centlein, centrosomal protein

chr17_-_71534906 0.207 EVPL
envoplakin
chr22_-_14829803 0.206 NM_001005239
OR11H1
olfactory receptor, family 11, subfamily H, member 1
chr12_-_1791146 0.205 CACNA2D4
calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr5_-_34078991 0.204 NM_030945
NM_181435
C1QTNF3

C1q and tumor necrosis factor related protein 3

chr11_-_5178505 0.204 NM_001004760
OR51V1
olfactory receptor, family 51, subfamily V, member 1
chr1_-_75849350 0.204 NM_001130058
NM_152697
SLC44A5

solute carrier family 44, member 5

chr10_+_24538094 0.204 KIAA1217
KIAA1217
chr7_-_71440143 0.203 NM_001017440
CALN1
calneuron 1
chr17_+_38014883 0.200 NM_001070
TUBG1
tubulin, gamma 1
chr3_-_197726587 0.199 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr1_-_35143570 0.199 NM_001080418
DLGAP3
discs, large (Drosophila) homolog-associated protein 3
chr8_+_21956335 0.199 NM_003867
FGF17
fibroblast growth factor 17
chr7_-_50740491 0.199 NM_001001550
GRB10
growth factor receptor-bound protein 10
chr1_+_31814712 0.197 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr12_+_32546243 0.196 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr8_+_22075112 0.193 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr5_-_134899537 0.193 NM_006161
NEUROG1
neurogenin 1
chr6_+_84619703 0.190 NM_001009994
RIPPLY2
ripply2 homolog (zebrafish)
chr1_+_61697209 0.190 NFIA
nuclear factor I/A
chr19_-_7896974 0.188 NM_206833
CTXN1
cortexin 1
chr18_-_54447168 0.187 NM_052947
ALPK2
alpha-kinase 2
chr19_+_55405635 0.187 MYH14
myosin, heavy chain 14, non-muscle
chr15_+_63701322 0.185 NM_004727
SLC24A1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr10_+_74323344 0.185 NM_152635
OIT3
oncoprotein induced transcript 3
chr1_+_69806543 0.183


chr6_-_36915195 0.183 NM_020939
CPNE5
copine V
chr5_-_49772973 0.181 NM_198449
EMB
embigin
chr5_-_50714836 0.181 LOC642366
hypothetical LOC642366
chr12_-_14024187 0.180 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr6_+_55300225 0.179 NM_207410
GFRAL
GDNF family receptor alpha like
chr9_-_112010233 0.178 NM_001012993
C9orf152
chromosome 9 open reading frame 152
chr3_-_49701085 0.177 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr20_-_218957 0.177 C20orf96
chromosome 20 open reading frame 96
chr11_+_73037382 0.176 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr1_+_158317967 0.174 NM_004983
KCNJ9
potassium inwardly-rectifying channel, subfamily J, member 9
chr12_+_6424293 0.174 NM_001242
CD27
CD27 molecule
chr6_+_30402986 0.174 NM_172016
TRIM39
tripartite motif containing 39
chr11_+_89032112 0.172 NM_153696
FOLH1B
folate hydrolase 1B
chr13_-_31784088 0.171 NM_001136571
ZAR1L
zygote arrest 1-like
chr11_+_66580884 0.171 RHOD
ras homolog gene family, member D
chr17_+_40280804 0.171 NM_016438
HIGD1B
HIG1 hypoxia inducible domain family, member 1B
chr1_-_167822248 0.170 F5
coagulation factor V (proaccelerin, labile factor)
chr11_+_122214415 0.170 NM_019604
CRTAM
cytotoxic and regulatory T cell molecule
chr20_-_54013418 0.169 NM_080617
CBLN4
cerebellin 4 precursor
chr22_-_36809094 0.169 NM_013356
SLC16A8
solute carrier family 16, member 8 (monocarboxylic acid transporter 3)
chr2_+_241213334 0.169 NM_005301
GPR35
G protein-coupled receptor 35
chr17_+_22982383 0.166 LGALS9
lectin, galactoside-binding, soluble, 9
chr1_+_559129 0.164


chr2_-_63518589 0.163 NM_001042692
WDPCP
WD repeat containing planar cell polarity effector
chr8_-_38577891 0.163


chr6_+_30402599 0.162 NM_021253
TRIM39
tripartite motif containing 39
chr3_-_173010921 0.162 NM_001130081
NM_002662
PLD1

phospholipase D1, phosphatidylcholine-specific

chr11_-_44928803 0.161 NM_001076787
NM_006034
TP53I11

tumor protein p53 inducible protein 11

chrX_+_69418746 0.161 NM_001032726
RAB41
RAB41, member RAS oncogene family
chr17_+_22982319 0.160 LGALS9
lectin, galactoside-binding, soluble, 9
chr5_+_150020595 0.160 NM_001122853
NM_133371
MYOZ3

myozenin 3

chr10_+_24537725 0.160 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr5_+_140714951 0.159 NM_018917
NM_032053
PCDHGA4

protocadherin gamma subfamily A, 4

chr17_+_22982372 0.159 LGALS9
lectin, galactoside-binding, soluble, 9
chr1_-_10964680 0.159 NM_001170754
C1orf127
chromosome 1 open reading frame 127
chr2_+_27652892 0.159 NM_032266
C2orf16
chromosome 2 open reading frame 16
chr15_+_73803351 0.159 NM_175881
ODF3L1
outer dense fiber of sperm tails 3-like 1
chr10_+_114125955 0.158 ACSL5
acyl-CoA synthetase long-chain family member 5
chr16_-_73839638 0.157 NM_001170719
BCAR1
breast cancer anti-estrogen resistance 1
chr17_+_44263370 0.157 NM_005831
CALCOCO2
calcium binding and coiled-coil domain 2
chr1_-_13350155 0.156 NM_001099850
NM_001099790
PRAMEF18
PRAMEF19
PRAME family member 18
PRAME family member 19
chrX_-_99778340 0.156 NM_003270
TSPAN6
tetraspanin 6
chr17_+_22982344 0.155 LGALS9
lectin, galactoside-binding, soluble, 9
chr17_-_36807322 0.155 NM_002277
KRT31
keratin 31
chr2_+_28469850 0.153 FOSL2
FOS-like antigen 2
chr12_+_121885246 0.149 HIP1R
huntingtin interacting protein 1 related
chr2_+_152899837 0.148 NM_052905
FMNL2
formin-like 2
chr6_-_31728121 0.146 NM_001098534
BAG6
BCL2-associated athanogene 6
chr3_+_130744746 0.146 NM_153833
H1FOO
H1 histone family, member O, oocyte-specific
chr2_-_233586164 0.145 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr10_-_92671005 0.145 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr17_-_36475652 0.145 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr2_-_27446816 0.144 NM_001034116
NM_015636
EIF2B4

eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa

chr1_-_180908639 0.144 NM_001102450
NM_033345
RGS8

regulator of G-protein signaling 8

chr7_-_96471544 0.143 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chr6_+_131508153 0.142 NM_016377
AKAP7
A kinase (PRKA) anchor protein 7
chr12_-_55730125 0.141 NM_005379
MYO1A
myosin IA
chr22_-_16127520 0.141 CECR3
cat eye syndrome chromosome region, candidate 3
chr5_+_176446425 0.140 NM_002011
NM_213647
FGFR4

fibroblast growth factor receptor 4

chr9_+_123544884 0.140 NM_138709
DAB2IP
DAB2 interacting protein
chr20_+_42463350 0.140 HNF4A
hepatocyte nuclear factor 4, alpha
chr8_-_124818754 0.139 NM_001003954
NM_004306
ANXA13

annexin A13

chr21_-_38792173 0.138 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr2_+_233112680 0.138 NM_005199
CHRNG
cholinergic receptor, nicotinic, gamma
chr17_+_56109940 0.138 NM_001099432
NM_017679
BCAS3

breast carcinoma amplified sequence 3

chr17_+_8154280 0.138 NM_173728
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chr7_+_97199206 0.138 NM_003182
NM_013996
NM_013997
NM_013998
TAC1



tachykinin, precursor 1



chr9_-_98656206 0.137 NM_001001662
ZNF782
zinc finger protein 782

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.22 2.67e-03 GO:0032501 multicellular organismal process
1.26 1.65e-02 GO:0023052 signaling
7.65 2.54e-02 GO:0010632 regulation of epithelial cell migration

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.29 1.38e-05 GO:0005886 plasma membrane
1.29 1.55e-05 GO:0071944 cell periphery
1.39 4.21e-04 GO:0005576 extracellular region
1.33 6.98e-03 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.56 2.18e-03 GO:0005102 receptor binding