Motif ID: EP300.p2

Z-value: 2.245


Transcription factors associated with EP300.p2:

Gene SymbolEntrez IDGene Name
EP300 2033 E1A binding protein p300

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EP300chr22_+_398177330.253.5e-01Click!


Activity profile for motif EP300.p2.

activity profile for motif EP300.p2


Sorted Z-values histogram for motif EP300.p2

Sorted Z-values for motif EP300.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EP300.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_6179736 2.199 NM_001769
CD9
CD9 molecule
chr1_+_156229934 2.116 KIRREL
kin of IRRE like (Drosophila)
chr14_-_104515738 1.862 NM_138420
AHNAK2
AHNAK nucleoprotein 2
chr13_+_113546841 1.821 NM_000820
GAS6
growth arrest-specific 6
chr21_+_44941514 1.726 NM_198699
KRTAP10-12
keratin associated protein 10-12
chr13_+_113546897 1.466 GAS6
growth arrest-specific 6
chr3_+_113061218 1.445 NM_001134439
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr3_-_51971915 1.444 NM_033010
PCBP4
poly(rC) binding protein 4
chr1_+_156229686 1.393 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr3_+_113061330 1.326 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr19_-_61324456 1.315 NM_001002836
ZNF787
zinc finger protein 787
chr16_-_65818401 1.298 NM_001004055
LRRC29
leucine rich repeat containing 29
chr8_-_23077392 1.259 NM_003840
TNFRSF10D
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
chr19_+_10900502 1.199 C19orf52
chromosome 19 open reading frame 52
chr16_-_30992574 1.183 ZNF668
zinc finger protein 668
chr5_+_174084137 1.170 NM_002449
MSX2
msh homeobox 2
chr13_+_113546912 1.169 GAS6
growth arrest-specific 6
chr16_-_30993004 1.152 NM_024706
ZNF668
zinc finger protein 668
chrX_-_140098941 1.143 LDOC1
leucine zipper, down-regulated in cancer 1
chr10_+_102782156 1.120 SFXN3
sideroflexin 3
chr12_+_51727076 1.103 NM_198316
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr5_-_33927724 1.096 NM_030955
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr17_-_24068759 1.079 NM_001144942
NM_031934
RAB34

RAB34, member RAS oncogene family

chr9_-_116920232 1.051 NM_002160
TNC
tenascin C
chr22_+_40800193 1.037 NM_001002034
FAM109B
family with sequence similarity 109, member B
chr12_-_47468985 1.034 NM_020983
ADCY6
adenylate cyclase 6
chr22_+_40800213 1.032 FAM109B
family with sequence similarity 109, member B
chr19_+_951295 1.030 NM_138690
GRIN3B
glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
chr15_-_21483503 1.028 NM_002487
NDN
necdin homolog (mouse)
chr4_-_177950658 1.024 NM_005429
VEGFC
vascular endothelial growth factor C
chr12_-_57600564 1.021 LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr3_+_113061296 1.019 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr11_+_35116961 1.001 NM_000610
NM_001001389
NM_001001390
NM_001001391
NM_001001392
CD44




CD44 molecule (Indian blood group)




chr5_-_149515502 0.999 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr13_+_113546943 0.998 GAS6
growth arrest-specific 6
chr19_+_52451642 0.978 CCDC9
coiled-coil domain containing 9
chr11_-_64247230 0.975 NM_015080
NM_138732
NRXN2

neurexin 2

chr14_+_92049396 0.972 NM_024832
RIN3
Ras and Rab interactor 3
chr12_+_6808025 0.970 LEPREL2
leprecan-like 2
chr17_+_76988134 0.967 NM_001080519
BAHCC1
BAH domain and coiled-coil containing 1
chr14_+_105028614 0.962 NM_001134875
NM_001134876
C14orf80

chromosome 14 open reading frame 80

chr21_+_46226072 0.939 NM_001848
COL6A1
collagen, type VI, alpha 1
chr15_-_21483457 0.932 NDN
necdin homolog (mouse)
chr19_-_1125263 0.920 NM_014963
SBNO2
strawberry notch homolog 2 (Drosophila)
chr12_-_26169074 0.915 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr19_-_1125201 0.912


chr22_-_43040063 0.908 NM_001099294
KIAA1644
KIAA1644
chr1_-_94779727 0.895 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr3_+_160964574 0.894 SCHIP1
schwannomin interacting protein 1
chr11_+_47386621 0.890 NM_001128225
NM_152264
SLC39A13

solute carrier family 39 (zinc transporter), member 13

chr11_+_124539814 0.886 PKNOX2
PBX/knotted 1 homeobox 2
chr8_-_122722674 0.879 NM_005328
HAS2
hyaluronan synthase 2
chrX_+_71047344 0.875 NM_001013627
NHSL2
NHS-like 2
chr5_-_149515331 0.874 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chrX_-_140098959 0.866 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chr1_-_16355013 0.863 NM_004431
EPHA2
EPH receptor A2
chr19_-_1125257 0.863 SBNO2
strawberry notch homolog 2 (Drosophila)
chr11_-_46678691 0.859 NM_004308
ARHGAP1
Rho GTPase activating protein 1
chr17_+_58058783 0.853 MRC2
mannose receptor, C type 2
chr11_+_47386707 0.853 SLC39A13
solute carrier family 39 (zinc transporter), member 13
chr11_-_2881750 0.848 NM_007105
SLC22A18AS
solute carrier family 22 (organic cation transporter), member 18 antisense
chr14_-_68515791 0.845 NM_001102
NM_001130004
NM_001130005
ACTN1


actinin, alpha 1


chr11_+_35117226 0.841 CD44
CD44 molecule (Indian blood group)
chr19_+_46417117 0.840 AXL
AXL receptor tyrosine kinase
chr11_-_46678736 0.833 ARHGAP1
Rho GTPase activating protein 1
chr2_-_189752575 0.830 NM_000393
COL5A2
collagen, type V, alpha 2
chr15_-_80125514 0.829 MEX3B
mex-3 homolog B (C. elegans)
chr13_-_39075304 0.826 LHFP
lipoma HMGIC fusion partner
chr11_+_46678892 0.814 NM_024741
ZNF408
zinc finger protein 408
chr11_+_124539768 0.813 NM_022062
PKNOX2
PBX/knotted 1 homeobox 2
chr10_-_126839546 0.809 NM_001083914
CTBP2
C-terminal binding protein 2
chr7_+_128257698 0.807 NM_001127487
NM_001458
FLNC

filamin C, gamma

chr3_+_113060716 0.804 NM_001134438
NM_145753
PHLDB2

pleckstrin homology-like domain, family B, member 2

chr11_+_44742551 0.801 NM_130783
TSPAN18
tetraspanin 18
chr15_-_81743198 0.791 BNC1
basonuclin 1
chr11_+_46679140 0.783 NM_001184751
ZNF408
zinc finger protein 408
chr2_+_109112428 0.780 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chrX_-_140099014 0.771 LDOC1
leucine zipper, down-regulated in cancer 1
chr9_-_128924706 0.769 ANGPTL2
angiopoietin-like 2
chr4_-_5761194 0.759 NM_147127
EVC2
Ellis van Creveld syndrome 2
chr9_+_108665168 0.753 NM_021224
ZNF462
zinc finger protein 462
chr14_-_68515761 0.749 ACTN1
actinin, alpha 1
chr12_-_57600336 0.746 NM_153377
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr9_-_128924782 0.744 ANGPTL2
angiopoietin-like 2
chr14_-_68515731 0.742 ACTN1
actinin, alpha 1
chr9_-_4290028 0.737 NM_001042413
GLIS3
GLIS family zinc finger 3
chr11_-_127897271 0.731 NM_001162422
NM_005238
ETS1

v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

chr8_-_145085616 0.729 NM_201384
PLEC
plectin
chr1_-_154913712 0.722 NM_006617
NES
nestin
chr10_-_49483002 0.705 NM_021226
ARHGAP22
Rho GTPase activating protein 22
chr14_-_100420936 0.703 NM_001134888
RTL1
retrotransposon-like 1
chr18_-_33399997 0.699 NM_001025087
NM_001025088
NM_001025089
NM_020180
CELF4



CUGBP, Elav-like family member 4



chr19_+_10900419 0.698 NM_138358
C19orf52
chromosome 19 open reading frame 52
chr14_-_68515742 0.697 ACTN1
actinin, alpha 1
chr6_+_43151922 0.697 NM_002821
NM_152880
NM_152881
NM_152882
PTK7



PTK7 protein tyrosine kinase 7



chr13_-_113151453 0.693 NM_199162
ADPRHL1
ADP-ribosylhydrolase like 1
chr19_+_52451570 0.691 NM_015603
CCDC9
coiled-coil domain containing 9
chr14_-_68515727 0.689 ACTN1
actinin, alpha 1
chr19_-_6061491 0.684 RFX2
regulatory factor X, 2 (influences HLA class II expression)
chr14_-_68515525 0.676 ACTN1
actinin, alpha 1
chr3_+_113060826 0.673 PHLDB2
pleckstrin homology-like domain, family B, member 2
chr7_-_45927263 0.673 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr1_+_179148935 0.667 NM_020950
KIAA1614
KIAA1614
chr12_-_46439127 0.662 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr7_-_5519831 0.661 NM_024963
FBXL18
F-box and leucine-rich repeat protein 18
chr12_-_6354650 0.656 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr14_+_104523660 0.655 NM_174891
C14orf79
chromosome 14 open reading frame 79
chr12_+_69046241 0.655 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr19_-_10166536 0.652 DNMT1
DNA (cytosine-5-)-methyltransferase 1
chr17_-_77422561 0.651 NM_001185078
NM_004309
ARHGDIA

Rho GDP dissociation inhibitor (GDI) alpha

chr11_+_129823667 0.650 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr16_+_85158357 0.646 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr11_+_696607 0.644 EPS8L2
EPS8-like 2
chr1_-_151852128 0.643 NM_080388
S100A16
S100 calcium binding protein A16
chr9_+_119506428 0.638 TLR4
toll-like receptor 4
chr16_+_2145765 0.629 NM_032271
TRAF7
TNF receptor-associated factor 7
chr14_-_68515701 0.628 ACTN1
actinin, alpha 1
chr7_+_115952074 0.621 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chr20_+_9236446 0.621 NM_000933
PLCB4
phospholipase C, beta 4
chr19_+_18803742 0.621 NM_002911
UPF1
UPF1 regulator of nonsense transcripts homolog (yeast)
chr5_-_171813960 0.621 SH3PXD2B
SH3 and PX domains 2B
chr19_+_18803786 0.620 UPF1
UPF1 regulator of nonsense transcripts homolog (yeast)
chr15_-_66511488 0.619 NM_001004439
ITGA11
integrin, alpha 11
chr3_+_156280497 0.612 MME
membrane metallo-endopeptidase
chr17_-_77422400 0.612


chr8_+_104222052 0.612 NM_001024372
NM_024812
BAALC

brain and acute leukemia, cytoplasmic

chr8_+_22078622 0.604 BMP1
bone morphogenetic protein 1
chr10_-_105202139 0.602 NM_015916
CALHM2
calcium homeostasis modulator 2
chr1_-_40009513 0.600 NM_022120
OXCT2
3-oxoacid CoA transferase 2
chr10_-_75352540 0.596 NM_001001791
C10orf55
chromosome 10 open reading frame 55
chr3_+_156280539 0.594 MME
membrane metallo-endopeptidase
chr17_+_40594046 0.593 NM_144608
HEXIM2
hexamthylene bis-acetamide inducible 2
chr16_+_30993223 0.591 NM_014699
ZNF646
zinc finger protein 646
chr22_+_22907443 0.586 NM_019601
SUSD2
sushi domain containing 2
chr8_+_22513043 0.585 NM_001013842
NM_001198827
NM_173686
C8orf58


chromosome 8 open reading frame 58


chr11_+_12355600 0.583 NM_018222
PARVA
parvin, alpha
chr19_-_18913017 0.583 HOMER3
homer homolog 3 (Drosophila)
chr11_-_46678715 0.582 ARHGAP1
Rho GTPase activating protein 1
chr6_+_30018287 0.579 NM_002116
HLA-A
major histocompatibility complex, class I, A
chr3_-_31998241 0.579 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr16_+_3447957 0.577 NM_001083600
NM_024845
NAT15

N-acetyltransferase 15 (GCN5-related, putative)

chr17_-_72045218 0.576 NM_134268
CYGB
cytoglobin
chr10_-_80875097 0.575 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr8_-_23317577 0.572 LOXL2
lysyl oxidase-like 2
chr11_+_1925075 0.571 NM_021134
MRPL23
mitochondrial ribosomal protein L23
chr17_+_76003574 0.570 FLJ35220
hypothetical protein FLJ35220
chr18_+_19973445 0.570 NM_138644
CABYR
calcium binding tyrosine-(Y)-phosphorylation regulated
chr9_-_4289915 0.569 GLIS3
GLIS family zinc finger 3
chr19_-_18749728 0.568


chr16_+_30993252 0.568 ZNF646
zinc finger protein 646
chr19_-_18913011 0.566 HOMER3
homer homolog 3 (Drosophila)
chr1_+_182622751 0.565 NM_030806
C1orf21
chromosome 1 open reading frame 21
chr10_-_49534304 0.565 ARHGAP22
Rho GTPase activating protein 22
chr1_-_120413798 0.562 NM_024408
NOTCH2
notch 2
chr16_-_65818221 0.560 NM_012163
LRRC29
leucine rich repeat containing 29
chr3_-_51976428 0.559 NM_020418
NM_001174100
NM_033008
PCBP4


poly(rC) binding protein 4


chr22_+_36286350 0.558 NM_152243
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr2_-_40532651 0.558 SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr3_+_156280129 0.555 NM_000902
MME
membrane metallo-endopeptidase
chr5_+_140747586 0.555 NM_003736
NM_032098
PCDHGB4

protocadherin gamma subfamily B, 4

chr22_-_27405708 0.555 NM_001145418
TTC28
tetratricopeptide repeat domain 28
chr6_-_72187168 0.553 C6orf155
chromosome 6 open reading frame 155
chr8_-_119192985 0.550 NM_000127
EXT1
exostosin 1
chr14_-_88090641 0.549 NM_007039
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr8_-_23317571 0.549 LOXL2
lysyl oxidase-like 2
chr19_+_12966970 0.549 NM_002501
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr19_-_18913032 0.547 NM_004838
HOMER3
homer homolog 3 (Drosophila)
chr6_+_46763570 0.547 NM_001010870
NM_001168359
TDRD6

tudor domain containing 6

chr15_-_84139021 0.546 KLHL25
kelch-like 25 (Drosophila)
chr1_+_182622850 0.545 C1orf21
chromosome 1 open reading frame 21
chr9_+_129509088 0.545 NM_001012502
C9orf117
chromosome 9 open reading frame 117
chr1_-_56817717 0.543 PPAP2B
phosphatidic acid phosphatase type 2B
chr16_+_639278 0.543 NM_145294
WDR90
WD repeat domain 90
chr10_+_114699953 0.542 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chr1_-_93919789 0.541 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr18_-_20231709 0.540 OSBPL1A
oxysterol binding protein-like 1A
chr5_+_119827797 0.540 PRR16
proline rich 16
chr1_-_1233109 0.540 NM_030649
ACAP3
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
chr8_+_22492198 0.539 NM_021630
PDLIM2
PDZ and LIM domain 2 (mystique)
chr1_-_199613427 0.538 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr2_+_28469275 0.537 NM_005253
FOSL2
FOS-like antigen 2
chr1_+_182622809 0.536 C1orf21
chromosome 1 open reading frame 21
chr1_+_23990228 0.533 NM_007260
LYPLA2
lysophospholipase II
chr6_-_112682459 0.532 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr7_+_115952279 0.527 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chr8_-_23317536 0.527 LOXL2
lysyl oxidase-like 2
chr22_+_22907417 0.526 SUSD2
sushi domain containing 2
chr18_-_20231783 0.521 NM_080597
OSBPL1A
oxysterol binding protein-like 1A
chr19_+_4255590 0.520 NM_024333
FSD1
fibronectin type III and SPRY domain containing 1
chr8_-_26427304 0.519 NM_007257
PNMA2
paraneoplastic antigen MA2
chr10_+_134060681 0.518 NM_001098637
NM_138499
PWWP2B

PWWP domain containing 2B

chr19_-_8485026 0.516 NM_001146175
NM_032370
ZNF414

zinc finger protein 414

chrX_+_152684150 0.516 PLXNB3
plexin B3
chr15_-_80125403 0.516 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr1_+_112852892 0.515 NM_024494
WNT2B
wingless-type MMTV integration site family, member 2B
chr14_-_104333060 0.514 AKT1
v-akt murine thymoma viral oncogene homolog 1
chr1_+_53300410 0.513 NM_153703
PODN
podocan
chr10_+_102782151 0.512 SFXN3
sideroflexin 3
chr17_-_68819713 0.511 NM_012121
CDC42EP4
CDC42 effector protein (Rho GTPase binding) 4
chr2_-_218843109 0.510 NM_001087
AAMP
angio-associated, migratory cell protein

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.35 3.20e-06 GO:0023051 regulation of signaling
1.37 4.78e-06 GO:0009966 regulation of signal transduction
1.22 1.59e-04 GO:0048731 system development
1.21 2.73e-04 GO:0048856 anatomical structure development
1.56 4.08e-04 GO:0009967 positive regulation of signal transduction
1.22 4.25e-04 GO:0048518 positive regulation of biological process
1.23 5.02e-04 GO:0048522 positive regulation of cellular process
1.18 6.20e-04 GO:0023052 signaling
1.37 6.90e-04 GO:0010646 regulation of cell communication
1.19 8.77e-04 GO:0007275 multicellular organismal development
1.30 1.18e-03 GO:0009653 anatomical structure morphogenesis
1.25 1.33e-03 GO:0030154 cell differentiation
1.17 1.38e-03 GO:0032502 developmental process
1.26 1.80e-03 GO:0048583 regulation of response to stimulus
1.51 2.89e-03 GO:0023056 positive regulation of signaling
1.50 3.52e-03 GO:0010647 positive regulation of cell communication
1.24 4.53e-03 GO:0048869 cellular developmental process
1.56 4.80e-03 GO:0007409 axonogenesis
1.29 5.05e-03 GO:0007399 nervous system development
1.50 6.97e-03 GO:0000904 cell morphogenesis involved in differentiation
1.53 8.82e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
1.57 9.40e-03 GO:0010627 regulation of intracellular protein kinase cascade
1.43 1.33e-02 GO:0030030 cell projection organization
1.52 1.44e-02 GO:0046903 secretion
1.64 3.43e-02 GO:0010740 positive regulation of intracellular protein kinase cascade
1.10 3.47e-02 GO:0050794 regulation of cellular process
1.49 3.56e-02 GO:0048812 neuron projection morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.93 2.57e-04 GO:0070161 anchoring junction
2.22 2.99e-04 GO:0005925 focal adhesion
2.14 4.53e-04 GO:0030055 cell-substrate junction
1.94 6.69e-04 GO:0005912 adherens junction
2.11 1.24e-03 GO:0005924 cell-substrate adherens junction
1.81 1.95e-03 GO:0031252 cell leading edge
2.14 3.91e-03 GO:0001726 ruffle
1.20 7.80e-03 GO:0044459 plasma membrane part
1.40 8.14e-03 GO:0030054 cell junction
1.58 9.57e-03 GO:0015629 actin cytoskeleton
1.32 1.66e-02 GO:0042995 cell projection
1.22 3.99e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.54 5.10e-05 GO:0008092 cytoskeletal protein binding
1.11 3.98e-04 GO:0005515 protein binding
1.59 3.92e-03 GO:0003779 actin binding
1.05 8.43e-03 GO:0005488 binding
1.35 3.63e-02 GO:0043565 sequence-specific DNA binding
1.29 4.33e-02 GO:0030528 transcription regulator activity