Motif ID: ESRRA.p2

Z-value: 1.170


Transcription factors associated with ESRRA.p2:

Gene SymbolEntrez IDGene Name
ESRRA 2101 estrogen-related receptor alpha

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESRRAchr11_+_638296160.136.4e-01Click!


Activity profile for motif ESRRA.p2.

activity profile for motif ESRRA.p2


Sorted Z-values histogram for motif ESRRA.p2

Sorted Z-values for motif ESRRA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESRRA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_29086206 1.412 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr1_+_29086156 1.409 NM_001166005
NM_001166007
NM_004437
NM_203342
NM_203343
 EPB41




erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)




chr10_+_80777248 0.973 PPIF
peptidylprolyl isomerase F
chr10_+_80777265 0.940 PPIF
peptidylprolyl isomerase F
chr19_+_540849 0.859 NM_001194
 HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr5_+_271428 0.827 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr20_+_36867708 0.798 NM_001172735
NM_015568
 PPP1R16B

protein phosphatase 1, regulatory (inhibitor) subunit 16B

chr14_+_87560646 0.788 LOC283587
hypothetical protein LOC283587
chr9_-_129929809 0.785 PTGES2
prostaglandin E synthase 2
chr5_-_1647617 0.777 SDHAP3
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 3
chr19_-_44518465 0.754 GMFG
glia maturation factor, gamma
chr19_-_12773591 0.754 NM_005809
NM_181738
 PRDX2

peroxiredoxin 2

chr3_+_196870099 0.742 SDHAP2
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 2
chr2_+_119905812 0.706 NM_183240
 TMEM37
transmembrane protein 37
chr5_+_271441 0.685 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr5_+_271355 0.674 NM_004168
 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr7_+_2409731 0.673 NM_018641
 CHST12
carbohydrate (chondroitin 4) sulfotransferase 12
chr1_+_29113589 0.670 NM_001166006
 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr5_-_63293301 0.664 NM_000524
 HTR1A
5-hydroxytryptamine (serotonin) receptor 1A
chrX_+_48934831 0.664



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
6.72 5.64e-08 GO:0042773 ATP synthesis coupled electron transport
6.72 5.64e-08 GO:0042775 mitochondrial ATP synthesis coupled electron transport
6.39 2.05e-05 GO:0006120 mitochondrial electron transport, NADH to ubiquinone
6.37 4.88e-08 GO:0006119 oxidative phosphorylation
6.07 3.59e-15 GO:0022904 respiratory electron transport chain
5.98 5.66e-04 GO:0009060 aerobic respiration
5.39 5.18e-16 GO:0045333 cellular respiration
4.83 4.95e-02 GO:0006084 acetyl-CoA metabolic process
4.75 1.21e-12 GO:0022900 electron transport chain
3.79 1.61e-03 GO:0006839 mitochondrial transport
3.22 2.78e-10 GO:0015980 energy derivation by oxidation of organic compounds
2.91 1.78e-11 GO:0006091 generation of precursor metabolites and energy
2.72 3.62e-02 GO:0007005 mitochondrion organization
2.45 3.03e-02 GO:0006979 response to oxidative stress
2.19 6.07e-12 GO:0055114 oxidation-reduction process
1.51 8.36e-09 GO:0006810 transport
1.49 4.18e-08 GO:0051234 establishment of localization
1.43 1.37e-02 GO:0044281 small molecule metabolic process
1.40 1.44e-06 GO:0051179 localization
1.21 1.63e-03 GO:0044237 cellular metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
6.47 1.11e-12 GO:0070469 respiratory chain
6.47 1.35e-11 GO:0005746 mitochondrial respiratory chain
6.32 1.27e-06 GO:0005747 mitochondrial respiratory chain complex I
6.32 1.27e-06 GO:0030964 NADH dehydrogenase complex
6.32 1.27e-06 GO:0045271 respiratory chain complex I
5.25 7.04e-16 GO:0044455 mitochondrial membrane part
3.93 3.76e-22 GO:0005743 mitochondrial inner membrane
3.71 3.89e-21 GO:0019866 organelle inner membrane
3.43 4.53e-23 GO:0031966 mitochondrial membrane
3.36 6.47e-23 GO:0005740 mitochondrial envelope
3.05 1.83e-26 GO:0044429 mitochondrial part
2.93 1.32e-02 GO:0005741 mitochondrial outer membrane
2.62 2.71e-18 GO:0031967 organelle envelope
2.60 3.41e-18 GO:0031975 envelope
2.58 4.83e-02 GO:0031968 organelle outer membrane
2.55 2.37e-05 GO:0005759 mitochondrial matrix
2.26 1.09e-22 GO:0005739 mitochondrion
1.55 1.03e-07 GO:0031090 organelle membrane
1.49 2.57e-02 GO:0000267 cell fraction
1.42 4.32e-04 GO:0005829 cytosol

Gene overrepresentation in function category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
6.85 3.68e-04 GO:0004129 cytochrome-c oxidase activity
6.85 3.68e-04 GO:0015002 heme-copper terminal oxidase activity
6.85 3.68e-04 GO:0016675 oxidoreductase activity, acting on a heme group of donors
6.85 3.68e-04 GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
6.22 8.83e-06 GO:0003954 NADH dehydrogenase activity
6.22 8.83e-06 GO:0008137 NADH dehydrogenase (ubiquinone) activity
6.22 8.83e-06 GO:0050136 NADH dehydrogenase (quinone) activity
5.35 8.03e-05 GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
4.52 1.12e-02 GO:0003823 antigen binding
3.65 5.69e-05 GO:0015078 hydrogen ion transmembrane transporter activity
3.21 1.81e-02 GO:0016651 oxidoreductase activity, acting on NADH or NADPH
2.71 8.36e-04 GO:0009055 electron carrier activity
2.32 3.19e-02 GO:0015077 monovalent inorganic cation transmembrane transporter activity
2.24 9.89e-03 GO:0022890 inorganic cation transmembrane transporter activity
2.21 3.23e-10 GO:0016491 oxidoreductase activity
1.30 2.47e-07 GO:0003824 catalytic activity
1.16 3.87e-03 GO:0005515 protein binding