Motif ID: ETS1,2.p2

Z-value: 0.916


Transcription factors associated with ETS1,2.p2:

Gene SymbolEntrez IDGene Name
ETS1 2113 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
ETS2 2114 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ETS1chr11_-_1278972710.647.6e-03Click!
ETS2chr21_+_391170640.495.6e-02Click!


Activity profile for motif ETS1,2.p2.

activity profile for motif ETS1,2.p2


Sorted Z-values histogram for motif ETS1,2.p2

Sorted Z-values for motif ETS1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ETS1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_88707299 3.115 NM_024756
MMRN2
multimerin 2
chr3_-_184756101 2.531 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr3_-_123223658 2.362 NM_175924
ILDR1
immunoglobulin-like domain containing receptor 1
chr19_-_61324456 2.195 NM_001002836
ZNF787
zinc finger protein 787
chr4_+_2783764 2.089 SH3BP2
SH3-domain binding protein 2
chr1_+_155130146 1.974 NM_001080471
PEAR1
platelet endothelial aggregation receptor 1
chr17_+_7549138 1.970 NM_001406
EFNB3
ephrin-B3
chr5_+_180582905 1.961 NM_033549
NM_201627
TRIM41

tripartite motif containing 41

chr14_-_37795290 1.919 NM_175060
CLEC14A
C-type lectin domain family 14, member A
chr18_+_21967813 1.881 NM_001025096
NM_001025097
NM_144662
PSMA8


proteasome (prosome, macropain) subunit, alpha type, 8


chr19_+_52451570 1.818 NM_015603
CCDC9
coiled-coil domain containing 9
chr22_+_35586950 1.805 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr10_+_129595289 1.785 NM_006504
PTPRE
protein tyrosine phosphatase, receptor type, E
chr12_-_6103945 1.761 NM_000552
VWF
von Willebrand factor
chr19_+_52451642 1.753 CCDC9
coiled-coil domain containing 9
chr10_+_129595349 1.741 PTPRE
protein tyrosine phosphatase, receptor type, E
chr16_+_2145810 1.732 TRAF7
TNF receptor-associated factor 7
chr16_-_65818401 1.684 NM_001004055
LRRC29
leucine rich repeat containing 29
chr1_-_1300680 1.648 NM_017900
AURKAIP1
aurora kinase A interacting protein 1
chr3_+_120799411 1.538 NM_015900
PLA1A
phospholipase A1 member A
chr1_-_153213483 1.530 NM_001130041
NM_003029
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr17_-_42621626 1.517 CDC27
cell division cycle 27 homolog (S. cerevisiae)
chr11_+_2378559 1.515 TSSC4
tumor suppressing subtransferable candidate 4
chr15_-_68971665 1.496 NM_020147
THAP10
THAP domain containing 10
chr11_+_46679140 1.450 NM_001184751
ZNF408
zinc finger protein 408
chr7_-_3049872 1.446 NM_032415
CARD11
caspase recruitment domain family, member 11
chr17_-_4783943 1.443 NM_001165417
NM_001165418
NM_003562
SLC25A11


solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11


chr21_-_45165302 1.435 NM_000211
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr17_+_4784097 1.421 RNF167
ring finger protein 167
chr16_-_30993004 1.387 NM_024706
ZNF668
zinc finger protein 668
chr17_+_4784330 1.386 NM_015528
RNF167
ring finger protein 167
chr5_+_180582880 1.366 TRIM41
tripartite motif containing 41
chr22_+_25398690 1.364 LOC388889
hypothetical LOC388889
chr8_-_38153369 1.356 LSM1
LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr3_-_150533948 1.351 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr15_-_40236061 1.329 NM_213600
PLA2G4F
phospholipase A2, group IVF
chr1_+_43539239 1.309 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr11_-_67528103 1.299 NM_030930
UNC93B1
unc-93 homolog B1 (C. elegans)
chr17_+_4283967 1.290 NM_182538
SPNS3
spinster homolog 3 (Drosophila)
chr19_+_47079147 1.288 ARHGEF1
Rho guanine nucleotide exchange factor (GEF) 1
chr11_-_46678715 1.275 ARHGAP1
Rho GTPase activating protein 1
chr22_+_42908548 1.264 PARVG
parvin, gamma
chr11_-_66967481 1.261 CORO1B
coronin, actin binding protein, 1B
chr11_-_46678736 1.256 ARHGAP1
Rho GTPase activating protein 1
chr15_-_21444085 1.236 NM_019066
MAGEL2
MAGE-like 2
chr16_+_2145765 1.235 NM_032271
TRAF7
TNF receptor-associated factor 7
chr11_+_46678892 1.230 NM_024741
ZNF408
zinc finger protein 408
chr22_+_36008465 1.228 CYTH4
cytohesin 4
chr3_+_47004457 1.211 NBEAL2
neurobeachin-like 2
chr12_+_88268845 1.204 LOC100131490
hypothetical LOC100131490
chr1_+_12108542 1.198 NM_152942
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr19_+_17495109 1.194 NM_001098524
NM_173544
FAM129C

family with sequence similarity 129, member C

chr19_+_19487535 1.193 NDUFA13
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
chr11_-_3104413 1.186 OSBPL5
oxysterol binding protein-like 5
chr11_-_66967528 1.184 NM_020441
CORO1B
coronin, actin binding protein, 1B
chr12_-_6668787 1.182 NM_001039918
NM_133476
ZNF384

zinc finger protein 384

chr19_+_47079089 1.167 NM_004706
NM_198977
ARHGEF1

Rho guanine nucleotide exchange factor (GEF) 1

chr1_-_31003260 1.163 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr7_-_44985175 1.156 MYO1G
myosin IG
chr9_+_263025 1.149 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr19_-_59276445 1.149 NM_001135686
TARM1
T cell-interacting, activating receptor on myeloid cells 1
chr17_-_42621535 1.147 CDC27
cell division cycle 27 homolog (S. cerevisiae)
chr1_-_1300416 1.139 NM_001127230
NM_001127229
AURKAIP1

aurora kinase A interacting protein 1

chr17_+_4784524 1.126 RNF167
ring finger protein 167
chr1_-_153213454 1.102 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr1_-_40496161 1.095


chr10_+_49562866 1.092 WDFY4
WDFY family member 4
chr8_-_38153325 1.092 LSM1
LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr1_+_159899528 1.088 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr7_-_97719372 1.077 NM_015395
TECPR1
tectonin beta-propeller repeat containing 1
chr1_-_153213425 1.076 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr1_-_208024491 1.074 NM_152485
C1orf74
chromosome 1 open reading frame 74
chr3_+_11242666 1.074 NM_001098211
HRH1
histamine receptor H1
chr2_-_96174865 1.072 NM_004418
DUSP2
dual specificity phosphatase 2
chr17_+_29606408 1.070 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr15_+_68971835 1.066 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr14_-_37795001 1.062 CLEC14A
C-type lectin domain family 14, member A
chr1_-_149385556 1.061 NM_001178061
NM_001178062
NM_030913
SEMA6C


sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C


chr18_-_70415788 1.041 LOC400657
hypothetical LOC400657
chr12_-_6668680 1.035 ZNF384
zinc finger protein 384
chr15_-_38387410 1.033 NM_004573
PLCB2
phospholipase C, beta 2
chr9_-_90983501 1.030 NM_016848
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr16_-_49272617 1.018 SNX20
sorting nexin 20
chr6_+_41714171 1.003 NM_005586
MDFI
MyoD family inhibitor
chr11_-_10672079 1.003 NM_001100163
NM_130385
MRVI1

murine retrovirus integration site 1 homolog

chr7_-_44985202 1.002 NM_033054
MYO1G
myosin IG
chr10_+_129735796 0.998 NM_130435
PTPRE
protein tyrosine phosphatase, receptor type, E
chr19_-_41196942 0.993 ALKBH6
alkB, alkylation repair homolog 6 (E. coli)
chr6_-_119137923 0.982 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr20_-_34005799 0.977 NM_016558
NM_033630
SCAND1

SCAN domain containing 1

chr1_-_159306273 0.976 ARHGAP30
Rho GTPase activating protein 30
chr5_-_138842408 0.976 TMEM173
transmembrane protein 173
chr8_-_29262240 0.973 NM_057158
DUSP4
dual specificity phosphatase 4
chr14_+_60045621 0.972 NM_007374
SIX6
SIX homeobox 6
chr4_+_2783743 0.954 NM_001145855
SH3BP2
SH3-domain binding protein 2
chr19_+_52940604 0.954 NM_015710
GLTSCR2
glioma tumor suppressor candidate region gene 2
chr12_-_6668880 0.952 NM_001039917
NM_001039919
NM_001039920
NM_001135734
ZNF384



zinc finger protein 384



chr14_+_75521806 0.948 NM_001102564
NM_052873
C14orf179

chromosome 14 open reading frame 179

chrX_-_128616594 0.947 NM_017413
APLN
apelin
chr16_+_29373365 0.940 NM_001014999
NM_001015000
NM_024044
NM_178044
SLX1A-SULT1A3
SLX1A

SLX1B

SLX1A-SULT1A3 read-through transcript
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)

SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)

chr4_+_8251818 0.936 NM_018986
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr6_+_33347833 0.935 RPS18
ribosomal protein S18
chr22_-_36212160 0.929 NM_001166343
NM_002405
MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr9_-_132759045 0.925 NM_198180
QRFP
pyroglutamylated RFamide peptide
chr19_+_60878238 0.921 NM_001130072
NM_013333
EPN1

epsin 1

chr6_+_33347776 0.921 NM_022551
RPS18
ribosomal protein S18
chr14_+_105024576 0.919 CRIP1
cysteine-rich protein 1 (intestinal)
chr11_-_118394242 0.915 NM_001028
RPS25
ribosomal protein S25
chr12_-_53044495 0.909 NM_020370
GPR84
G protein-coupled receptor 84
chr1_+_226420437 0.908 C1orf69
chromosome 1 open reading frame 69
chr19_+_60878392 0.906 EPN1
epsin 1
chr7_-_5535726 0.904 ACTB
actin, beta
chr1_+_38046073 0.902 C1orf122
chromosome 1 open reading frame 122
chr11_-_64641700 0.899 NM_014205
ZNHIT2
zinc finger, HIT-type containing 2
chr19_+_17723285 0.896 NM_001161359
NM_015122
FCHO1

FCH domain only 1

chr5_-_496168 0.894 NM_138464
C5orf55
chromosome 5 open reading frame 55
chr19_+_60878422 0.893 EPN1
epsin 1
chr16_+_3295433 0.889 NM_153028
ZNF75A
zinc finger protein 75a
chr22_+_36008511 0.883 CYTH4
cytohesin 4
chr5_-_99898788 0.882


chr17_-_40865987 0.874 SH3D20
SH3 domain containing 20
chr19_-_1125201 0.865


chr8_-_120033240 0.859 NM_002546
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr1_+_199975271 0.857 NAV1
neuron navigator 1
chr22_+_36008369 0.849 NM_013385
CYTH4
cytohesin 4
chr14_+_104462260 0.846 PLD4
phospholipase D family, member 4
chr5_+_180583315 0.844 TRIM41
tripartite motif containing 41
chr19_-_1125263 0.843 NM_014963
SBNO2
strawberry notch homolog 2 (Drosophila)
chr17_-_40866062 0.841 NM_174919
SH3D20
SH3 domain containing 20
chr20_+_30019465 0.840 NM_001011718
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr15_-_38387164 0.838 PLCB2
phospholipase C, beta 2
chr2_+_85834111 0.837 NM_032827
ATOH8
atonal homolog 8 (Drosophila)
chr1_-_79244948 0.828 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr1_+_43410587 0.824 NM_001167965
NM_152498
NM_001167966
WDR65


WD repeat domain 65


chr13_-_76358370 0.821 KCTD12
potassium channel tetramerisation domain containing 12
chrX_+_67830215 0.819 STARD8
StAR-related lipid transfer (START) domain containing 8
chr1_+_38046005 0.817 C1orf122
chromosome 1 open reading frame 122
chr1_+_15955719 0.815 FBLIM1
filamin binding LIM protein 1
chr19_-_18891190 0.815 COPE
coatomer protein complex, subunit epsilon
chr19_-_1125257 0.815 SBNO2
strawberry notch homolog 2 (Drosophila)
chr2_+_109112428 0.815 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr11_+_66580884 0.815 RHOD
ras homolog gene family, member D
chrX_+_67830204 0.808 NM_001142504
STARD8
StAR-related lipid transfer (START) domain containing 8
chr4_-_153820535 0.802 NM_152680
TMEM154
transmembrane protein 154
chr15_+_79080341 0.800 NM_022566
MESDC1
mesoderm development candidate 1
chr7_-_149960218 0.798 GIMAP6
GTPase, IMAP family member 6
chr5_+_35892747 0.798 NM_002185
IL7R
interleukin 7 receptor
chr9_-_129656413 0.796 ENG
endoglin
chr4_-_122063118 0.793 NM_018699
PRDM5
PR domain containing 5
chr17_-_8220709 0.793 KRBA2
KRAB-A domain containing 2
chr10_-_105835609 0.789 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr17_-_10682123 0.785 NM_001101387
PIRT
phosphoinositide-interacting regulator of transient receptor potential channels
chr15_-_38387317 0.784 PLCB2
phospholipase C, beta 2
chr11_-_66967838 0.784 NM_001018070
CORO1B
coronin, actin binding protein, 1B
chr22_-_35875890 0.770 NM_000878
IL2RB
interleukin 2 receptor, beta
chr3_-_186752952 0.768 NM_139248
LIPH
lipase, member H
chr1_-_155788775 0.768 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr10_-_131652007 0.767 NM_001005463
EBF3
early B-cell factor 3
chr2_+_31310485 0.765 EHD3
EH-domain containing 3
chr9_-_136949531 0.765 NM_002003
FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr19_-_18891197 0.763 NM_007263
NM_199442
NM_199444
COPE


coatomer protein complex, subunit epsilon


chr11_-_62146144 0.762 B3GAT3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr19_+_60878381 0.761 EPN1
epsin 1
chrX_-_15782792 0.756 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr2_+_174968751 0.755 SCRN3
secernin 3
chr13_-_45654327 0.752 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr5_-_149360314 0.750 NM_030953
LOC728287
TIGD6
hypothetical protein LOC728287
tigger transposable element derived 6
chr14_+_23937766 0.750 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr11_-_46678691 0.750 NM_004308
ARHGAP1
Rho GTPase activating protein 1
chr4_-_15549047 0.748 NM_005130
FGFBP1
fibroblast growth factor binding protein 1
chr6_-_112682573 0.747 LAMA4
laminin, alpha 4
chr5_+_99898922 0.744 NM_198507
FAM174A
family with sequence similarity 174, member A
chr12_+_92595281 0.742 NM_003805
CRADD
CASP2 and RIPK1 domain containing adaptor with death domain
chr9_+_35739276 0.742 NM_001080496
RGP1
RGP1 retrograde golgi transport homolog (S. cerevisiae)
chr7_-_44985084 0.741 MYO1G
myosin IG
chr4_+_30330963 0.740 NM_001173523
NM_002589
NM_032456
NM_032457
PCDH7



protocadherin 7



chr15_+_79376295 0.738 NM_004513
IL16
interleukin 16 (lymphocyte chemoattractant factor)
chr1_+_38046404 0.738 C1orf122
chromosome 1 open reading frame 122
chr8_+_144711619 0.737 NM_024736
GSDMD
gasdermin D
chr11_+_36354110 0.737 NM_001160168
NM_024841
PRR5L

proline rich 5 like

chr7_+_150065594 0.737 GIMAP5
GTPase, IMAP family member 5
chr11_-_62145952 0.736 NM_012200
B3GAT3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr1_-_2312850 0.735 NM_024848
MORN1
MORN repeat containing 1
chr16_+_28413421 0.734 NM_018690
APOBR
apolipoprotein B receptor
chr9_-_139043035 0.734 NM_212533
ABCA2
ATP-binding cassette, sub-family A (ABC1), member 2
chr10_-_121292139 0.733 NM_001005339
RGS10
regulator of G-protein signaling 10
chr19_-_17349096 0.731 NM_031310
PLVAP
plasmalemma vesicle associated protein
chr21_-_45165249 0.728 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr12_+_120055013 0.728 NM_002562
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7
chr22_-_30018329 0.726 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr10_+_91051685 0.721 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr19_-_13074973 0.721 NM_005583
LYL1
lymphoblastic leukemia derived sequence 1
chr6_+_110119190 0.719 FIG4
FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
chr6_-_137857213 0.719 NM_175747
OLIG3
oligodendrocyte transcription factor 3
chr16_-_65525766 0.719 NM_016062
FAM96B
family with sequence similarity 96, member B
chr15_+_88035031 0.718 NM_020212
WDR93
WD repeat domain 93
chr3_+_44665220 0.718 NM_003420
ZNF35
zinc finger protein 35
chr14_+_99912481 0.711 NM_001161476
NM_024515
WDR25

WD repeat domain 25

chr19_-_5631910 0.710 NM_205767
C19orf70
chromosome 19 open reading frame 70
chr11_+_128751044 0.710 NM_003658
BARX2
BARX homeobox 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.44 1.32e-07 GO:0002376 immune system process
1.32 2.06e-06 GO:0048583 regulation of response to stimulus
1.53 2.67e-06 GO:0006955 immune response
1.62 3.09e-05 GO:0001775 cell activation
2.39 1.91e-04 GO:0050851 antigen receptor-mediated signaling pathway
1.47 4.48e-04 GO:0002682 regulation of immune system process
2.23 8.30e-04 GO:0002768 immune response-regulating cell surface receptor signaling pathway
2.21 2.39e-03 GO:0002429 immune response-activating cell surface receptor signaling pathway
1.18 2.78e-03 GO:0007165 signal transduction
1.55 3.58e-03 GO:0002684 positive regulation of immune system process
1.55 3.73e-03 GO:0050776 regulation of immune response
1.75 4.67e-03 GO:0002694 regulation of leukocyte activation
1.73 4.85e-03 GO:0050865 regulation of cell activation
1.75 6.32e-03 GO:0030168 platelet activation
1.76 1.16e-02 GO:0051249 regulation of lymphocyte activation
1.28 1.54e-02 GO:0009966 regulation of signal transduction
2.27 2.64e-02 GO:0050852 T cell receptor signaling pathway
3.70 3.48e-02 GO:0050853 B cell receptor signaling pathway

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.45 1.89e-02 GO:0030695 GTPase regulator activity
1.44 2.38e-02 GO:0060589 nucleoside-triphosphatase regulator activity