Motif ID: EWSR1-FLI1.p2

Z-value: 0.732


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EWSR1chr22_+_279983670.401.3e-01Click!
FLI1chr11_+_1280692030.126.7e-01Click!


Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_156819604 0.997 NM_001099287
NM_001172292
 NIPAL4

NIPA-like domain containing 4

chr20_+_42807901 0.931 NM_022358
 KCNK15
potassium channel, subfamily K, member 15
chr5_+_156819782 0.876 NIPAL4
NIPA-like domain containing 4
chr1_-_6468600 0.809 NM_001042665
 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr1_-_68071635 0.802 NM_018841
 GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr14_-_53493198 0.801 NM_001202
NM_130850
 BMP4

bone morphogenetic protein 4

chr1_-_68470585 0.793 NM_001002292
NM_001193334
NM_024911
 WLS


wntless homolog (Drosophila)


chr6_-_10520264 0.789 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr6_-_10520592 0.763 NM_001032280
 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr17_+_45488356 0.760 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr17_+_45488330 0.742 NM_002204
NM_005501
 ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr6_-_132314004 0.730 NM_001901
 CTGF
connective tissue growth factor
chr12_-_47464143 0.688 NM_015270
 ADCY6
adenylate cyclase 6
chr11_+_101485946 0.684 NM_001130145
NM_001195044
NM_006106
 YAP1


Yes-associated protein 1


chr2_+_113532685 0.662 NM_173170
 IL1F5
interleukin 1 family, member 5 (delta)
chrX_-_148394570 0.652 NM_000202
NM_001166550
NM_006123
 IDS


iduronate 2-sulfatase


chr19_-_1966628 0.580 NM_017797
 BTBD2
BTB (POZ) domain containing 2
chr1_-_231498081 0.577 NM_014801
 PCNXL2
pecanex-like 2 (Drosophila)
chrX_-_107569256 0.554 NM_001847
 COL4A6
collagen, type IV, alpha 6
chr5_-_148422799 0.547 NM_024577
 SH3TC2
SH3 domain and tetratricopeptide repeats 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 25 entries
enrichment   p-value GO term description
13.49 3.26e-02 GO:0030501 positive regulation of bone mineralization
3.09 1.08e-02 GO:0007409 axonogenesis
3.05 7.67e-03 GO:0051094 positive regulation of developmental process
2.98 1.81e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
2.93 2.33e-02 GO:0048812 neuron projection morphogenesis
2.88 1.11e-02 GO:0000904 cell morphogenesis involved in differentiation
2.86 1.28e-02 GO:0048858 cell projection morphogenesis
2.83 1.46e-02 GO:0032990 cell part morphogenesis
2.78 3.01e-02 GO:0031175 neuron projection development
2.75 6.24e-03 GO:0000902 cell morphogenesis
2.63 3.01e-02 GO:0048666 neuron development
2.61 1.58e-02 GO:0032989 cellular component morphogenesis
2.55 1.01e-02 GO:0030182 neuron differentiation
2.53 1.13e-03 GO:0048699 generation of neurons
2.39 4.07e-03 GO:0022008 neurogenesis
2.17 2.36e-04 GO:0009653 anatomical structure morphogenesis
2.06 2.50e-03 GO:0007399 nervous system development
1.90 3.29e-03 GO:0048583 regulation of response to stimulus
1.77 1.94e-02 GO:0048869 cellular developmental process
1.75 3.59e-02 GO:0030154 cell differentiation

Gene overrepresentation in compartment category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
10.23 2.55e-02 GO:0034704 calcium channel complex

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
3.15 3.68e-02 GO:0005261 cation channel activity