Motif ID: FOSL2.p2

Z-value: 0.744


Transcription factors associated with FOSL2.p2:

Gene SymbolEntrez IDGene Name
FOSL2 2355 FOS-like antigen 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOSL2chr2_+_284698640.381.5e-01Click!


Activity profile for motif FOSL2.p2.

activity profile for motif FOSL2.p2


Sorted Z-values histogram for motif FOSL2.p2

Sorted Z-values for motif FOSL2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOSL2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_37022465 1.974 NM_005557
KRT16
keratin 16
chr18_+_19706979 1.748 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr5_-_141041933 1.699 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr5_-_141041982 1.672 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr1_+_17507276 1.523 NM_012387
PADI4
peptidyl arginine deiminase, type IV
chr7_-_1465487 1.500 MICALL2
MICAL-like 2
chr1_-_151788341 1.474 NM_002960
S100A3
S100 calcium binding protein A3
chr2_-_219566364 1.436 NM_005209
NM_057093
NM_057094
CRYBA2


crystallin, beta A2


chr1_-_207891264 1.350 NM_001017402
LAMB3
laminin, beta 3
chr16_+_56219802 1.297 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chrX_-_15593074 1.295 NM_020665
TMEM27
transmembrane protein 27
chr2_+_97696462 1.208 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr3_-_48607596 1.201 NM_000094
COL7A1
collagen, type VII, alpha 1
chr16_-_1086244 1.171 NM_207419
C1QTNF8
C1q and tumor necrosis factor related protein 8
chr13_-_85271329 1.147 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr11_-_65860450 1.128 NM_004292
RIN1
Ras and Rab interactor 1
chr5_+_150000394 1.120 NM_001109974
NM_007286
SYNPO

synaptopodin

chr11_+_696607 1.104 EPS8L2
EPS8-like 2
chr16_+_31274030 1.059 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr1_-_221919982 1.055 CAPN8
calpain 8
chr16_+_31273969 1.033 NM_000887
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr18_+_59593591 1.031 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr20_-_17487480 1.005 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr10_-_88720908 0.986 LOC100133190
hypothetical LOC100133190
chr17_-_36792161 0.955 NM_021013
KRT34
keratin 34
chr22_+_20899155 0.940


chr15_+_71953020 0.930 NM_153356
TBC1D21
TBC1 domain family, member 21
chr7_+_72883128 0.908 NM_001305
CLDN4
claudin 4
chr6_+_83129641 0.896 NM_006670
TPBG
trophoblast glycoprotein
chr19_-_40696393 0.886 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr8_+_10567556 0.866 NM_001040032
C8orf74
chromosome 8 open reading frame 74
chr1_-_153272859 0.863 NM_144622
DCST2
DC-STAMP domain containing 2
chr5_+_177473071 0.860 NM_015111
N4BP3
NEDD4 binding protein 3
chr12_-_46439127 0.855 NM_001098531
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr9_-_86173232 0.841 NM_022127
SLC28A3
solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
chr14_+_104218487 0.840


chr9_+_139239464 0.836 NM_199001
C9orf169
chromosome 9 open reading frame 169
chr4_-_100575313 0.834 NM_001166504
NM_000673
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr14_+_68796433 0.832 NM_001168368
NM_020692
GALNTL1

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1

chr15_+_38318528 0.828 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr6_+_41712907 0.825 MDFI
MyoD family inhibitor
chr2_-_89223666 0.820 IGKC
IGK@
immunoglobulin kappa constant
immunoglobulin kappa locus
chr11_+_696103 0.820 NM_022772
EPS8L2
EPS8-like 2
chr17_-_36409632 0.819 NM_031959
KRTAP3-2
keratin associated protein 3-2
chr10_+_134751398 0.815 NM_001083909
GPR123
G protein-coupled receptor 123
chr17_-_7962859 0.811 NM_001165960
ALOXE3
arachidonate lipoxygenase 3
chr7_-_128330615 0.802 KCP
kielin/chordin-like protein
chr19_+_43486640 0.801 NM_033520
C19orf33
chromosome 19 open reading frame 33
chr11_+_35596310 0.784 NM_014344
FJX1
four jointed box 1 (Drosophila)
chr11_+_55869996 0.783 NM_001002907
OR8K1
olfactory receptor, family 8, subfamily K, member 1
chr1_-_53972464 0.777 NM_147193
GLIS1
GLIS family zinc finger 1
chr1_+_148747208 0.777 ECM1
extracellular matrix protein 1
chr11_-_58368555 0.776 NM_145016
GLYATL2
glycine-N-acyltransferase-like 2
chr20_-_43889339 0.774 NM_003279
TNNC2
troponin C type 2 (fast)
chr6_-_36518643 0.761 NM_152990
PXT1
peroxisomal, testis specific 1
chr19_+_43971689 0.753 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr6_-_116799548 0.751 LOC100287467
hypothetical LOC100287467
chr19_-_56215084 0.748 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr11_-_57173823 0.746 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chr7_+_129720209 0.744 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr12_-_46438447 0.743 NM_001098532
NM_006105
RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3

chr1_-_115682374 0.732 NM_002506
NGF
nerve growth factor (beta polypeptide)
chr9_-_90983501 0.732 NM_016848
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr19_+_10820105 0.727 NM_001136482
C19orf38
chromosome 19 open reading frame 38
chr16_+_1773004 0.727 NUBP2
nucleotide binding protein 2 (MinD homolog, E. coli)
chr20_-_33658823 0.725 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr2_+_220200530 0.720 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr2_+_233605625 0.720 NM_005383
NEU2
sialidase 2 (cytosolic sialidase)
chr6_-_31853027 0.717 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr5_+_145297490 0.708 SH3RF2
SH3 domain containing ring finger 2
chr3_-_12775718 0.694 NM_018306
TMEM40
transmembrane protein 40
chr17_-_24068759 0.689 NM_001144942
NM_031934
RAB34

RAB34, member RAS oncogene family

chr17_+_77261440 0.689 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr4_-_7487514 0.685 NM_001085382
PSAPL1
prosaposin-like 1 (gene/pseudogene)
chr12_+_13240868 0.682 NM_001423
EMP1
epithelial membrane protein 1
chr8_-_68821131 0.668 NM_020361
CPA6
carboxypeptidase A6
chr11_-_102250876 0.662 NM_002426
MMP12
matrix metallopeptidase 12 (macrophage elastase)
chr3_-_195571748 0.659 NM_001135057
NM_130830
LRRC15

leucine rich repeat containing 15

chr11_-_6298284 0.657 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr9_-_129381086 0.655 NM_001035534
FAM129B
family with sequence similarity 129, member B
chr11_-_64133908 0.654


chr10_-_128199986 0.653 NM_001004298
C10orf90
chromosome 10 open reading frame 90
chr1_+_181421984 0.651 LAMC2
laminin, gamma 2
chr12_-_7547552 0.650 NM_004244
NM_203416
CD163

CD163 molecule

chr2_+_89849009 0.646


chr3_+_36396948 0.643 NM_003149
STAC
SH3 and cysteine rich domain
chr6_+_31190505 0.638 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr12_-_10173947 0.637 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr19_-_53935648 0.637 NM_017805
RASIP1
Ras interacting protein 1
chr1_+_199426575 0.635 NM_001164586
IGFN1
immunoglobulin-like and fibronectin type III domain containing 1
chr1_+_152644471 0.633 IL6R
interleukin 6 receptor
chr9_+_5500544 0.629 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr11_-_65186790 0.625 RELA
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr11_+_12265022 0.624 NM_032867
MICALCL
MICAL C-terminal like
chr22_+_36549334 0.620 NM_003614
GALR3
galanin receptor 3
chr17_+_77261401 0.620 NM_004712
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr15_+_38319326 0.617 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr20_+_42776888 0.617 WISP2
WNT1 inducible signaling pathway protein 2
chr1_-_120112989 0.613 NM_001166107
NM_005518
HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

chr1_-_221920023 0.610 NM_001143962
CAPN8
calpain 8
chr1_+_151240846 0.604 NM_001097589
NM_005416
SPRR3

small proline-rich protein 3

chr22_-_43040063 0.604 NM_001099294
KIAA1644
KIAA1644
chr14_+_68796621 0.603 GALNTL1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1
chr13_-_109236897 0.600 NM_003749
IRS2
insulin receptor substrate 2
chr2_+_27358800 0.599 NM_032546
NM_187841
TRIM54

tripartite motif containing 54

chr12_+_13240987 0.599 EMP1
epithelial membrane protein 1
chr22_-_28972683 0.598 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr17_+_77261457 0.596


chr2_-_85494639 0.591 CAPG
capping protein (actin filament), gelsolin-like
chr14_+_95792299 0.583 NM_000710
BDKRB1
bradykinin receptor B1
chr17_+_77261477 0.579 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chrX_-_108611940 0.575 NM_001522
GUCY2F
guanylate cyclase 2F, retinal
chr19_-_48866111 0.574 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr11_-_118571793 0.572 NM_001145018
CCDC153
coiled-coil domain containing 153
chr21_+_42492867 0.571 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr16_-_2848106 0.569 NM_022119
PRSS22
protease, serine, 22
chr11_-_119514058 0.567 NM_012101
TRIM29
tripartite motif containing 29
chr3_-_171070314 0.564 NM_024727
LRRC31
leucine rich repeat containing 31
chr3_-_48576204 0.563 NM_033199
UCN2
urocortin 2
chr3_+_57069508 0.558 NM_181727
SPATA12
spermatogenesis associated 12
chr12_+_111713931 0.557 NM_001143854
NM_014954
RPH3A

rabphilin 3A homolog (mouse)

chr10_+_88404285 0.555 NM_001030015
NM_033282
OPN4

opsin 4

chr16_+_2023279 0.553 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr11_+_55617328 0.553 NM_001003750
OR8I2
olfactory receptor, family 8, subfamily I, member 2
chr4_+_84676414 0.551 NM_032717
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr11_-_102174102 0.550 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr12_+_76749199 0.546 NM_014903
NAV3
neuron navigator 3
chr2_+_169631777 0.546 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr6_+_1556543 0.542 FOXC1
forkhead box C1
chr15_+_38923470 0.541 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr5_+_35892747 0.540 NM_002185
IL7R
interleukin 7 receptor
chr1_+_153272905 0.537 NM_001143687
NM_152494
DCST1

DC-STAMP domain containing 1

chr17_+_77910411 0.533 NM_207459
TEX19
testis expressed 19
chr10_-_49152918 0.532 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr2_-_70916412 0.528 NM_015717
CD207
CD207 molecule, langerin
chr1_+_203740306 0.527 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr2_+_113542017 0.527 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr3_-_152517204 0.527 NM_023915
GPR87
G protein-coupled receptor 87
chr11_+_384199 0.526 NM_007183
PKP3
plakophilin 3
chr1_-_17180659 0.526 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2

chr3_-_51884639 0.526 NM_001145059
IQCF5
IQ motif containing F5
chr9_-_90983195 0.526 SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr11_+_117452936 0.526 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chr1_+_86662356 0.524 NM_006536
CLCA2
chloride channel accessory 2
chr1_+_207995999 0.524 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr12_-_121224676 0.523 NM_001014336
IL31
interleukin 31
chr2_-_89400935 0.523 IGKC
immunoglobulin kappa constant
chr15_-_40089736 0.520 NM_001080490
PLA2G4E
phospholipase A2, group IVE
chr1_+_151456683 0.520 NM_001195571
PRR9
proline rich 9
chr3_-_58175437 0.518 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr1_+_201363458 0.511 NM_000674
NM_001048230
ADORA1

adenosine A1 receptor

chr11_-_66898223 0.511 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr2_+_68815416 0.510 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr22_+_20316968 0.509 NM_152612
CCDC116
coiled-coil domain containing 116
chr18_+_50646616 0.507 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr1_-_151804929 0.506 NM_005978
S100A2
S100 calcium binding protein A2
chr21_-_30836051 0.505 NM_181612
KRTAP19-6
keratin associated protein 19-6
chr20_+_42463279 0.505 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr13_+_77007809 0.503 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr1_+_152644668 0.502 IL6R
interleukin 6 receptor
chr18_+_258147 0.502


chr11_-_6148131 0.500 NM_001004052
OR52B2
olfactory receptor, family 52, subfamily B, member 2
chr3_-_12175646 0.499 NM_003256
TIMP4
TIMP metallopeptidase inhibitor 4
chr17_-_7078399 0.498 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr11_-_62213577 0.496 LRRN4CL
LRRN4 C-terminal like
chr2_-_85494664 0.493 CAPG
capping protein (actin filament), gelsolin-like
chr19_-_43955984 0.492 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr17_+_7402315 0.486 NM_001198622
NM_001198623
NM_001198624
NM_003808
NM_172087
NM_172088
TNFSF13





tumor necrosis factor (ligand) superfamily, member 13





chr2_+_113591940 0.485 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr7_+_23252915 0.480 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_23252909 0.478 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_48094750 0.478 NM_181597
UPP1
uridine phosphorylase 1
chr16_+_68765428 0.477 NM_173619
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr7_-_42243318 0.476 GLI3
GLI family zinc finger 3
chr17_-_52248248 0.475 NM_001085430
C17orf67
chromosome 17 open reading frame 67
chr2_-_224175293 0.475 SCG2
secretogranin II
chr20_-_1257782 0.474 SDCBP2
syndecan binding protein (syntenin) 2
chr5_-_149446303 0.473 CSF1R
colony stimulating factor 1 receptor
chr11_+_384238 0.470 PKP3
plakophilin 3
chr7_-_42243142 0.468 NM_000168
GLI3
GLI family zinc finger 3
chr17_+_7196151 0.466 KCTD11
potassium channel tetramerisation domain containing 11
chr1_-_108032645 0.463 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr1_+_20788027 0.462 NM_001785
CDA
cytidine deaminase
chr21_+_39951123 0.460 NM_006057
NM_033170
NM_033171
NM_033172
NM_033173
B3GALT5




UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5




chr11_+_118259684 0.460 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr1_+_148747110 0.459 NM_004425
NM_022664
ECM1

extracellular matrix protein 1

chr19_-_51097694 0.458 NM_001012643
MYPOP
Myb-related transcription factor, partner of profilin
chr1_+_152644292 0.457 NM_000565
NM_181359
IL6R

interleukin 6 receptor

chr1_+_203740391 0.455 CDK18
cyclin-dependent kinase 18
chr17_-_31231421 0.454 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr11_-_102174032 0.452 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr16_+_31312097 0.451 NM_005353
ITGAD
integrin, alpha D
chr15_+_38923914 0.449 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr9_-_115178161 0.447 NM_031219
HDHD3
haloacid dehalogenase-like hydrolase domain containing 3
chr1_+_207823667 0.447 NM_020439
CAMK1G
calcium/calmodulin-dependent protein kinase IG
chr17_-_24069299 0.446 NM_001142624
NM_001142625
NM_001144943
RAB34


RAB34, member RAS oncogene family


chr8_+_11599119 0.440 NM_002052
GATA4
GATA binding protein 4
chr13_-_40666392 0.439 KBTBD7
kelch repeat and BTB (POZ) domain containing 7
chr20_+_31132978 0.439 NM_182519
C20orf186
chromosome 20 open reading frame 186
chr11_+_67107852 0.439 GSTP1
glutathione S-transferase pi 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.48 4.71e-05 GO:0048583 regulation of response to stimulus
2.61 1.56e-04 GO:0008544 epidermis development
3.01 1.67e-04 GO:0032496 response to lipopolysaccharide
1.44 4.59e-04 GO:0048513 organ development
1.23 4.85e-04 GO:0032501 multicellular organismal process
1.62 1.18e-03 GO:0042127 regulation of cell proliferation
2.74 1.47e-03 GO:0002237 response to molecule of bacterial origin
1.33 1.77e-03 GO:0048731 system development
1.64 2.82e-03 GO:0009888 tissue development
2.24 3.06e-03 GO:0009617 response to bacterium
1.38 3.15e-03 GO:0065008 regulation of biological quality
1.65 3.84e-03 GO:0048584 positive regulation of response to stimulus
1.18 6.33e-03 GO:0050896 response to stimulus
1.91 9.24e-03 GO:0051707 response to other organism
1.44 1.58e-02 GO:0009966 regulation of signal transduction
1.27 1.67e-02 GO:0048856 anatomical structure development
1.63 1.94e-02 GO:0007155 cell adhesion
1.63 1.94e-02 GO:0022610 biological adhesion
1.76 2.11e-02 GO:0010647 positive regulation of cell communication
1.75 2.58e-02 GO:0023056 positive regulation of signaling
1.98 2.76e-02 GO:0051050 positive regulation of transport
1.76 3.66e-02 GO:0009967 positive regulation of signal transduction

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.34 1.37e-08 GO:0005886 plasma membrane
1.33 2.77e-08 GO:0071944 cell periphery
1.48 4.44e-07 GO:0005576 extracellular region
1.66 5.32e-06 GO:0044421 extracellular region part
1.40 2.98e-05 GO:0044459 plasma membrane part
1.64 5.92e-04 GO:0005615 extracellular space
1.70 2.44e-03 GO:0030054 cell junction
1.89 2.78e-03 GO:0031012 extracellular matrix
5.75 3.33e-03 GO:0001533 cornified envelope
1.93 6.84e-03 GO:0005578 proteinaceous extracellular matrix
2.61 1.01e-02 GO:0044420 extracellular matrix part
5.87 2.94e-02 GO:0005605 basal lamina
1.12 3.12e-02 GO:0016020 membrane
1.73 3.65e-02 GO:0045202 synapse

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.49 1.81e-05 GO:0004872 receptor activity
1.40 1.24e-04 GO:0004871 signal transducer activity
1.40 1.24e-04 GO:0060089 molecular transducer activity
2.04 1.55e-04 GO:0030246 carbohydrate binding
1.50 8.16e-04 GO:0004888 transmembrane receptor activity
2.30 3.40e-03 GO:0005529 sugar binding
2.40 1.54e-02 GO:0004252 serine-type endopeptidase activity