Motif ID: FOXO1,3,4.p2

Z-value: 0.826


Transcription factors associated with FOXO1,3,4.p2:

Gene SymbolEntrez IDGene Name
FOXO1 2308 forkhead box O1
FOXO3 2309 forkhead box O3
FOXO4 4303 forkhead box O4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXO4chrX_+_70232362-0.282.9e-01Click!
FOXO3chr6_+_108988797-0.214.3e-01Click!
FOXO1chr13_-_40138607-0.058.6e-01Click!


Activity profile for motif FOXO1,3,4.p2.

activity profile for motif FOXO1,3,4.p2


Sorted Z-values histogram for motif FOXO1,3,4.p2

Sorted Z-values for motif FOXO1,3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXO1,3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_94226380 1.215 NM_005014
OMD
osteomodulin
chr7_-_94902149 0.755 NM_000305
NM_001018161
PON2

paraoxonase 2

chr1_+_86707113 0.691 NM_001285
CLCA1
chloride channel accessory 1
chr9_+_119506274 0.665 NM_138554
TLR4
toll-like receptor 4
chr2_-_192419896 0.657 SDPR
serum deprivation response
chr9_+_119506428 0.646 TLR4
toll-like receptor 4
chr2_-_215951161 0.620 FN1
fibronectin 1
chr9_+_119506446 0.618 TLR4
toll-like receptor 4
chr5_-_59100194 0.613 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_-_58497913 0.613 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr10_-_52315390 0.607 A1CF
APOBEC1 complementation factor
chr9_+_74956614 0.606 ANXA1
annexin A1
chr4_-_186934059 0.584 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr10_-_52315436 0.573 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr3_+_171621721 0.568 NM_001185056
CLDN11
claudin 11
chr4_-_100431093 0.565 NM_000667
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr12_+_32578513 0.562 FGD4
FYVE, RhoGEF and PH domain containing 4
chr4_-_159311959 0.547 FAM198B
family with sequence similarity 198, member B
chr4_-_155731288 0.543 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr12_-_7487989 0.534 NM_174941
CD163L1
CD163 molecule-like 1
chr7_+_134114957 0.530 CALD1
caldesmon 1
chr5_-_58607673 0.524 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_-_56817823 0.521 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr2_-_215955206 0.519 FN1
fibronectin 1
chr2_-_192420168 0.516 NM_004657
SDPR
serum deprivation response
chr7_+_116151411 0.509 MET
met proto-oncogene (hepatocyte growth factor receptor)
chr3_+_23904086 0.508 UBE2E1
ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)
chr1_+_92318449 0.505 NM_183242
BTBD8
BTB (POZ) domain containing 8
chr7_+_120415958 0.500 NM_024913
C7orf58
chromosome 7 open reading frame 58
chr3_-_71262426 0.492 FOXP1
forkhead box P1
chr4_+_41309690 0.481 LIMCH1
LIM and calponin homology domains 1
chr6_-_152744143 0.480 SYNE1
spectrin repeat containing, nuclear envelope 1
chr7_+_120416103 0.478 C7orf58
chromosome 7 open reading frame 58
chr4_+_26194643 0.476 NM_018317
TBC1D19
TBC1 domain family, member 19
chr1_-_56817717 0.473 PPAP2B
phosphatidic acid phosphatase type 2B
chr2_-_40510923 0.469 NM_001112800
NM_001112801
NM_021097
SLC8A1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr4_-_152368492 0.461 SH3D19
SH3 domain containing 19
chr3_-_187309442 0.457 NM_004454
ETV5
ets variant 5
chr16_+_54070302 0.441 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr2_-_160765008 0.439 ITGB6
integrin, beta 6
chr6_-_127705244 0.439 NM_001139510
ECHDC1
enoyl CoA hydratase domain containing 1
chr5_-_64955905 0.433 NM_001656
NM_033227
NM_033228
TRIM23


tripartite motif containing 23


chr1_-_47428310 0.433 NM_005764
PDZK1IP1
PDZK1 interacting protein 1
chr4_+_124540114 0.425 NM_005841
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr12_+_7348194 0.416 NM_001080454
ACSM4
acyl-CoA synthetase medium-chain family member 4
chr11_-_104274606 0.412 NM_001191016
CASP12
caspase 12 (gene/pseudogene)
chr20_-_19984685 0.412 NM_016652
CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr4_-_139382672 0.407 NM_014331
SLC7A11
solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
chr2_+_215885053 0.401 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr9_+_74956601 0.396 ANXA1
annexin A1
chr7_+_134114912 0.392 CALD1
caldesmon 1
chr3_+_156280604 0.392 NM_007288
MME
membrane metallo-endopeptidase
chr11_-_121492010 0.390 NM_001001786
BLID
BH3-like motif containing, cell death inducer
chr10_+_111975618 0.387 NM_005962
MXI1
MAX interactor 1
chr7_-_87180499 0.385 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr11_-_56101772 0.384 NM_001004741
OR5M10
olfactory receptor, family 5, subfamily M, member 10
chr7_+_20621769 0.382 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr4_-_111339201 0.379 NM_001130721
NM_024090
ELOVL6

ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)

chr14_-_60260211 0.376 NM_017420
SIX4
SIX homeobox 4
chr9_+_66293049 0.375 MGC21881
hypothetical locus MGC21881
chr8_-_13178399 0.372 DLC1
deleted in liver cancer 1
chr15_-_53349775 0.371 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr18_+_31488530 0.370 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr3_-_158703821 0.369 NM_001167911
NM_001167912
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr1_+_181421796 0.369 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr4_-_164754106 0.365 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr2_+_61243132 0.364 NM_001143959
C2orf74
chromosome 2 open reading frame 74
chr6_+_101953581 0.362 NM_001166247
NM_021956
NM_175768
GRIK2


glutamate receptor, ionotropic, kainate 2


chr4_-_107508040 0.361 NM_001195138
LOC100507096
GTPase IMAP family member-like
chr6_-_117853710 0.359 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr3_-_129777618 0.356 NM_007354
C3orf27
chromosome 3 open reading frame 27
chr5_-_58688428 0.349 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_+_75892187 0.349 NM_001110354
ZP3
zona pellucida glycoprotein 3 (sperm receptor)
chr8_-_62764839 0.343 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr1_+_92405196 0.342 NM_015237
KIAA1107
KIAA1107
chr7_-_27668882 0.341 HIBADH
3-hydroxyisobutyrate dehydrogenase
chr3_+_156280539 0.335 MME
membrane metallo-endopeptidase
chr2_+_135526304 0.330 NM_001172435
NM_012233
RAB3GAP1

RAB3 GTPase activating protein subunit 1 (catalytic)

chr5_+_66160359 0.330 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr2_+_169367345 0.328 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr2_-_162808123 0.327 NM_004460
FAP
fibroblast activation protein, alpha
chr6_+_123152044 0.327 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr2_-_160764819 0.327 NM_000888
ITGB6
integrin, beta 6
chr10_-_37931864 0.326 NM_001190489
MTRNR2L7
MT-RNR2-like 7
chr2_-_174968595 0.321 NM_004882
CIR1
corepressor interacting with RBPJ, 1
chr3_-_102714663 0.318 NM_001077203
NM_020654
SENP7

SUMO1/sentrin specific peptidase 7

chr2_+_174968701 0.311 NM_001193528
NM_024583
SCRN3

secernin 3

chr9_+_696744 0.310 NM_153186
KANK1
KN motif and ankyrin repeat domains 1
chr9_+_74956494 0.308 NM_000700
ANXA1
annexin A1
chr4_-_174774368 0.306 NM_006792
MORF4
mortality factor 4
chr11_+_55319607 0.302 NM_001004735
OR5D14
olfactory receptor, family 5, subfamily D, member 14
chr4_+_91035025 0.300 NM_007351
MMRN1
multimerin 1
chr2_+_108571336 0.300 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr6_-_41823056 0.299 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr6_+_131498540 0.299 AKAP7
A kinase (PRKA) anchor protein 7
chr4_+_87070449 0.297 NM_031305
ARHGAP24
Rho GTPase activating protein 24
chr4_-_21559471 0.296 NM_147182
KCNIP4
Kv channel interacting protein 4
chrX_+_102498035 0.296 NM_001006612
NM_001006613
NM_001006614
NM_016303
WBP5



WW domain binding protein 5



chr2_+_215884923 0.296 NM_004044
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr14_-_54720101 0.295 DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr4_+_86918870 0.294 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr11_+_113436438 0.293 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr2_+_190248955 0.293 NM_144708
ANKAR
ankyrin and armadillo repeat containing
chr1_-_47428190 0.291 PDZK1IP1
PDZK1 interacting protein 1
chr5_-_39400319 0.290 NM_001737
C9
complement component 9
chr2_-_20390601 0.290 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr5_+_54434230 0.287 NM_006144
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr5_-_64955856 0.287 TRIM23
tripartite motif containing 23
chr4_+_146623405 0.286 NM_001003688
SMAD1
SMAD family member 1
chr2_+_86998248 0.286 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr12_+_50342814 0.286 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr2_+_108571177 0.285 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr6_+_112481970 0.284 NM_003880
NM_198239
WISP3

WNT1 inducible signaling pathway protein 3

chr15_+_53398697 0.284 PIGB
phosphatidylinositol glycan anchor biosynthesis, class B
chr15_-_40173949 0.282 NM_178034
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chr4_-_81212737 0.280 ANTXR2
anthrax toxin receptor 2
chr11_-_57883117 0.279 NM_001005489
OR5B17
olfactory receptor, family 5, subfamily B, member 17
chr11_+_60765219 0.279 NM_014224
PGA5
pepsinogen 5, group I (pepsinogen A)
chr1_+_25537372 0.278 NM_014313
TMEM50A
transmembrane protein 50A
chr8_+_144802972 0.274 NM_014789
ZNF623
zinc finger protein 623
chr10_+_111957292 0.274 NM_130439
MXI1
MAX interactor 1
chr2_+_215885063 0.273 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr3_-_170347019 0.272 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr21_-_18697829 0.271 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr2_-_112729072 0.271 NM_032494
ZC3H8
zinc finger CCCH-type containing 8
chr10_+_104995633 0.271 NM_001143909
LOC729020
rcRPE
chr2_+_47483694 0.270 MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
chr14_-_68424653 0.269 ACTN1
actinin, alpha 1
chr18_+_6824431 0.269 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chr6_-_48186868 0.269 C6orf138
chromosome 6 open reading frame 138
chr16_-_28528780 0.268 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr3_+_156280772 0.267 NM_007289
MME
membrane metallo-endopeptidase
chr2_-_153282104 0.267 NM_017892
PRPF40A
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr6_-_80303822 0.266 NM_001122769
NM_181714
LCA5

Leber congenital amaurosis 5

chr4_-_177353707 0.265 NM_144644
SPATA4
spermatogenesis associated 4
chr6_-_122807439 0.265 SERINC1
serine incorporator 1
chr11_-_17147863 0.264 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr4_+_41309482 0.264 LIMCH1
LIM and calponin homology domains 1
chr2_+_108571209 0.264 LIMS1
LIM and senescent cell antigen-like domains 1
chr10_+_70517823 0.264 NM_002727
SRGN
serglycin
chr2_+_138438277 0.263 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr2_+_196229715 0.263 NM_001127257
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr3_-_15814678 0.263 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr6_-_105734535 0.262 NM_022361
POPDC3
popeye domain containing 3
chr5_-_10360873 0.262 CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr8_-_18585721 0.262 PSD3
pleckstrin and Sec7 domain containing 3
chr2_+_236067424 0.262 NM_001037131
NM_014914
AGAP1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

chrX_-_153698930 0.260 HMGN1P37
high-mobility group nucleosome binding domain 1 pseudogene 37
chr2_-_225078931 0.260 CUL3
cullin 3
chr7_+_113513828 0.259 FOXP2
forkhead box P2
chr1_+_149877955 0.259 SNX27
sorting nexin family member 27
chr4_+_86968069 0.258 ARHGAP24
Rho GTPase activating protein 24
chr12_+_50633430 0.258 NM_020327
ACVR1B
activin A receptor, type IB
chr1_+_97033103 0.257


chr3_-_168854395 0.257 WDR49
WD repeat domain 49
chr2_+_207115060 0.256 ADAM23
ADAM metallopeptidase domain 23
chr6_-_109521969 0.255 NM_014454
SESN1
sestrin 1
chr4_+_41309668 0.255 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr1_-_184684478 0.255 NM_022576
PDC
phosducin
chr13_-_35842289 0.255 NM_001142294
SPG20
spastic paraplegia 20 (Troyer syndrome)
chr11_+_86710076 0.255 TMEM135
transmembrane protein 135
chr2_-_165133239 0.254 GRB14
growth factor receptor-bound protein 14
chr6_+_127940011 0.254 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr19_-_14800275 0.253 NM_017506
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr6_+_62341966 0.253 NM_001190706
MTRNR2L9
MT-RNR2-like 9
chr3_+_133798770 0.253 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr6_-_150099352 0.253 NUP43
nucleoporin 43kDa
chr6_-_152744022 0.251 SYNE1
spectrin repeat containing, nuclear envelope 1
chr11_-_85115105 0.251 NM_206927
NM_206928
SYTL2

synaptotagmin-like 2

chr11_-_106833715 0.251 NM_152434
CWF19L2
CWF19-like 2, cell cycle control (S. pombe)
chr4_+_184602778 0.251 NM_017632
CDKN2AIP
CDKN2A interacting protein
chr2_+_174968751 0.251 SCRN3
secernin 3
chr2_-_138762909 0.249


chr1_+_161308318 0.248 NM_001113380
RGS4
regulator of G-protein signaling 4
chr17_-_62793129 0.248 NM_002816
NM_174871
PSMD12

proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

chr3_-_28365510 0.247 NM_001134432
NM_001134433
NM_022461
AZI2


5-azacytidine induced 2


chr11_+_17289030 0.247


chr1_+_144236398 0.247 ITGA10
integrin, alpha 10
chr12_+_21570457 0.245 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr17_-_36719030 0.245 NM_001146182
KRTAP16-1
keratin associated protein 16-1
chr9_-_14076901 0.245 NFIB
nuclear factor I/B
chr18_+_606671 0.244 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr6_+_49539049 0.243 NM_018132
CENPQ
centromere protein Q
chr4_+_184602784 0.243 CDKN2AIP
CDKN2A interacting protein
chr5_+_65475760 0.242 NM_001077199
SREK1
splicing regulatory glutamine/lysine-rich protein 1
chr10_+_111959978 0.242 NM_001008541
MXI1
MAX interactor 1
chr22_+_31526801 0.242 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr19_-_63353956 0.242 NM_024620
ZNF329
zinc finger protein 329
chrX_+_77889861 0.241 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr5_-_131160589 0.240 FNIP1
folliculin interacting protein 1
chr10_+_123912930 0.240 TACC2
transforming, acidic coiled-coil containing protein 2
chr11_+_77209807 0.239 NM_024684
C11orf67
chromosome 11 open reading frame 67
chr10_-_93992982 0.239 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr5_+_55098469 0.239 NM_001166534
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr6_-_31622599 0.239 NM_130463
NM_138282
ATP6V1G2

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2

chr2_-_215957927 0.239 FN1
fibronectin 1
chr5_+_72287509 0.238 NM_001146032
NM_138782
FCHO2

FCH domain only 2

chr11_+_76491532 0.238 NM_006189
OMP
olfactory marker protein
chr16_+_2749934 0.236


chr1_+_146910634 0.235 NM_001144032
PPIAL4E
peptidylprolyl isomerase A (cyclophilin A)-like 4E

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.70 3.12e-02 GO:0005604 basement membrane

Nothing significant found in function category.