Motif ID: GATA6.p2

Z-value: 1.545


Transcription factors associated with GATA6.p2:

Gene SymbolEntrez IDGene Name
GATA6 2627 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GATA6chr18_+_18003401-0.126.7e-01Click!


Activity profile for motif GATA6.p2.

activity profile for motif GATA6.p2


Sorted Z-values histogram for motif GATA6.p2

Sorted Z-values for motif GATA6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_52975777 4.172 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr10_-_48036698 4.049 NM_016204
GDF2
growth differentiation factor 2
chr1_-_156923111 3.815 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr7_-_142369534 3.406 NM_000420
KEL
Kell blood group, metallo-endopeptidase
chr9_-_99740243 3.281 NM_197978
HEMGN
hemogen
chr7_-_142369519 3.184 KEL
Kell blood group, metallo-endopeptidase
chrX_+_65152004 3.137


chr12_-_52975823 3.118 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr12_-_68291208 3.046 NM_201550
LRRC10
leucine rich repeat containing 10
chr16_-_87570716 2.969 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr6_-_46155937 2.729 NM_001114086
CLIC5
chloride intracellular channel 5
chr6_-_49712483 2.571 NM_000324
RHAG
Rh-associated glycoprotein
chr1_+_152560179 2.232 NM_080429
AQP10
aquaporin 10
chr7_-_100077072 2.227 NM_003227
TFR2
transferrin receptor 2
chr17_-_59437782 2.174 NM_000873
ICAM2
intercellular adhesion molecule 2
chr19_-_12858956 2.160 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr17_-_53764867 1.888


chr1_-_30969016 1.865 NM_002379
MATN1
matrilin 1, cartilage matrix protein
chr8_+_124264054 1.832 FAM83A
family with sequence similarity 83, member A
chrX_-_55074125 1.758 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr9_+_263025 1.711 NM_001190458
NM_001193536
DOCK8

dedicator of cytokinesis 8

chr12_+_70618892 1.689 NM_173353
TPH2
tryptophan hydroxylase 2
chr1_-_46789473 1.649 NM_001097611
KNCN
kinocilin
chr1_-_206125877 1.616


chr11_-_5419358 1.615 NM_001005288
OR51I1
olfactory receptor, family 51, subfamily I, member 1
chr8_+_124263932 1.615 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr2_+_169465995 1.585 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr1_+_87368044 1.584 LOC339524
hypothetical LOC339524
chr12_+_8557402 1.568 NM_080387
CLEC4D
C-type lectin domain family 4, member D
chr10_+_118340460 1.536 NM_006229
PNLIPRP1
pancreatic lipase-related protein 1
chr11_-_5099422 1.490 NM_001005222
OR52A4
olfactory receptor, family 52, subfamily A, member 4
chr19_-_60241424 1.490 NM_001083899
NM_016363
GP6

glycoprotein VI (platelet)

chr7_+_150321771 1.457 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr6_+_31782618 1.430 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr3_-_185912240 1.419 NM_022149
MAGEF1
melanoma antigen family F, 1
chr11_-_26700121 1.382 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr7_+_129807467 1.344 NM_001868
CPA1
carboxypeptidase A1 (pancreatic)
chr6_-_30236667 1.339 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr1_-_148124738 1.333 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr16_+_55456619 1.333 NM_000339
NM_001126107
NM_001126108
SLC12A3


solute carrier family 12 (sodium/chloride transporters), member 3


chr2_+_27573206 1.331 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr19_-_60360768 1.325 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr19_+_7647934 1.321 NM_174918
C19orf59
chromosome 19 open reading frame 59
chr16_+_70117523 1.312 NM_005769
NM_001166395
CHST4

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

chr18_-_62422195 1.290 NM_021153
CDH19
cadherin 19, type 2
chr2_+_170742900 1.283 NM_001083615
NM_001171642
NM_138995
MYO3B


myosin IIIB


chr7_-_87774130 1.282 NM_024636
STEAP4
STEAP family member 4
chr1_+_50347188 1.272 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr16_+_24765052 1.268 NM_052944
SLC5A11
solute carrier family 5 (sodium/glucose cotransporter), member 11
chr11_+_71605466 1.250 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr19_+_16860807 1.249 NM_003950
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr17_-_39822366 1.235 NM_000419
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr12_+_121218218 1.221 NM_152759
LRRC43
leucine rich repeat containing 43
chr11_+_59027624 1.204 NM_001004706
OR4D11
olfactory receptor, family 4, subfamily D, member 11
chr11_-_5766621 1.189 NM_001001913
OR52N1
olfactory receptor, family 52, subfamily N, member 1
chr19_+_16860871 1.161 F2RL3
coagulation factor II (thrombin) receptor-like 3
chr7_+_142459538 1.154 NM_001001667
OR6V1
olfactory receptor, family 6, subfamily V, member 1
chr21_+_42697058 1.146 NM_001001895
NM_018961
UBASH3A

ubiquitin associated and SH3 domain containing A

chr1_+_22176004 1.146 NM_007352
CELA3A
CELA3B
chymotrypsin-like elastase family, member 3A
chymotrypsin-like elastase family, member 3B
chr1_+_246290586 1.144 NM_001004687
OR2L3
olfactory receptor, family 2, subfamily L, member 3
chr19_-_13074513 1.127 LYL1
lymphoblastic leukemia derived sequence 1
chr16_+_31446703 1.118 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr1_-_26266571 1.102 NM_032588
TRIM63
tripartite motif containing 63
chr12_-_14740694 1.087 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr19_-_11355882 1.084 NM_000121
EPOR
erythropoietin receptor
chr21_-_38792173 1.075 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr9_-_124431634 1.050 NM_001004450
OR1B1
olfactory receptor, family 1, subfamily B, member 1
chr13_-_45654327 1.049 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_-_175207521 1.035 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr9_-_205892 1.033 NM_152569
C9orf66
chromosome 9 open reading frame 66
chr13_-_45654296 1.032 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr7_+_106293112 1.021 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr12_-_23628774 1.007 NM_178010
SOX5
SRY (sex determining region Y)-box 5
chr10_+_98054074 0.973 NM_001017520
NM_004088
DNTT

deoxynucleotidyltransferase, terminal

chr12_+_54132264 0.968 NM_054105
OR6C2
olfactory receptor, family 6, subfamily C, member 2
chr17_+_54188205 0.965 PPM1E
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr22_+_33792125 0.946 NM_001008494
ISX
intestine-specific homeobox
chr5_-_131907071 0.946 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chrX_+_65299352 0.944 HEPH
hephaestin
chr1_+_195503956 0.942 NM_001193640
NM_201253
CRB1

crumbs homolog 1 (Drosophila)

chr7_+_129693938 0.941 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chr6_+_135558572 0.937


chr9_-_70780574 0.933


chr11_-_67047374 0.928 NM_016366
NM_031204
CABP2

calcium binding protein 2

chr9_-_113977285 0.922 NM_022486
SUSD1
sushi domain containing 1
chr5_-_176868483 0.921 DOK3
docking protein 3
chr7_-_122627235 0.917 NM_022444
SLC13A1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr8_-_72431274 0.911 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr12_-_51383513 0.910 NM_175078
KRT77
keratin 77
chr8_-_86477585 0.902 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr1_+_198263352 0.902 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr6_-_29451042 0.887 NM_030959
OR12D3
olfactory receptor, family 12, subfamily D, member 3
chr10_-_134449467 0.882 NM_177400
NKX6-2
NK6 homeobox 2
chr12_+_52105131 0.881 AMHR2
anti-Mullerian hormone receptor, type II
chr5_-_96504194 0.879 LIX1
Lix1 homolog (chicken)
chr11_+_5399916 0.877 NM_001004757
OR51Q1
olfactory receptor, family 51, subfamily Q, member 1
chr17_-_44400952 0.871 NM_004123
GIP
gastric inhibitory polypeptide
chr8_-_20084892 0.865 NM_001135691
NM_001142324
NM_001142325
NM_003053
SLC18A1



solute carrier family 18 (vesicular monoamine), member 1



chr3_+_115099007 0.858 NM_001172105
GRAMD1C
GRAM domain containing 1C
chrX_-_78509367 0.855 ITM2A
integral membrane protein 2A
chr1_+_173303616 0.855 NM_022093
TNN
tenascin N
chrX_+_34870833 0.854 NM_152631
FAM47B
family with sequence similarity 47, member B
chr12_-_51298599 0.845 NM_175068
KRT73
keratin 73
chr11_-_123816190 0.844 NM_012378
OR8B8
olfactory receptor, family 8, subfamily B, member 8
chr18_-_39111243 0.836 NM_020783
SYT4
synaptotagmin IV
chr4_+_111616630 0.829 NM_001977
ENPEP
glutamyl aminopeptidase (aminopeptidase A)
chr2_+_102294393 0.819 NM_016232
IL18R1
IL1RL1
interleukin 18 receptor 1
interleukin 1 receptor-like 1
chr7_+_139175420 0.818 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr3_-_57209319 0.806 NM_003865
HESX1
HESX homeobox 1
chrX_+_44588192 0.800 NM_022076
DUSP21
dual specificity phosphatase 21
chr19_-_53239030 0.788 NM_019855
CABP5
calcium binding protein 5
chr14_+_75058518 0.788 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr6_-_29503468 0.783 NM_013937
OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr5_+_140481763 0.783 NM_018938
PCDHB4
protocadherin beta 4
chr1_-_153537810 0.780 NM_000298
PKLR
pyruvate kinase, liver and RBC
chr13_-_45654292 0.779 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr7_+_20621769 0.776 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr12_-_16321885 0.771 NM_001170798
SLC15A5
solute carrier family 15, member 5
chr14_+_19681734 0.770 NM_001004724
OR4N5
olfactory receptor, family 4, subfamily N, member 5
chr6_+_167624792 0.769 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr13_+_31211678 0.756 NM_001166058
NM_130806
RXFP2

relaxin/insulin-like family peptide receptor 2

chrX_+_65299157 0.755 NM_138737
HEPH
hephaestin
chr11_-_16387001 0.753 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr1_-_27113018 0.751 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr11_+_91724909 0.749 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr2_-_68952006 0.746 NM_014482
BMP10
bone morphogenetic protein 10
chr4_+_120276386 0.741 NM_016599
MYOZ2
myozenin 2
chr19_+_9984861 0.736 NM_015725
RDH8
retinol dehydrogenase 8 (all-trans)
chr6_+_135558744 0.735 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr9_+_101628829 0.727 NM_173200
NR4A3
nuclear receptor subfamily 4, group A, member 3
chr11_-_56914668 0.721 NM_002728
PRG2
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
chr17_-_45196516 0.719 NM_030802
FAM117A
family with sequence similarity 117, member A
chr1_-_204179169 0.719 NM_052934
NM_134325
SLC26A9

solute carrier family 26, member 9

chr10_-_21226536 0.719 NM_006393
NEBL
nebulette
chr17_-_3766441 0.703 P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr5_-_135318420 0.695 NM_002302
LECT2
leukocyte cell-derived chemotaxin 2
chr6_+_41118214 0.685 NM_001010873
NM_001159726
TSPO2

translocator protein 2

chr10_-_7722747 0.683 ITIH5
inter-alpha (globulin) inhibitor H5
chr3_-_139333813 0.682 NM_016161
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr2_+_69055208 0.681 NM_019617
GKN1
gastrokine 1
chr13_-_27441290 0.679 NM_001265
CDX2
caudal type homeobox 2
chr6_+_54281161 0.678 NM_014464
TINAG
tubulointerstitial nephritis antigen
chr5_-_39255335 0.662 NM_001465
NM_199335
FYB

FYN binding protein

chr2_+_220087135 0.661 NM_018674
NM_182847
ACCN4

amiloride-sensitive cation channel 4, pituitary

chr8_-_72437020 0.658 NM_000503
EYA1
eyes absent homolog 1 (Drosophila)
chr17_+_65612589 0.657 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr17_-_53761119 0.656 NM_004758
NM_024418
BZRAP1

benzodiazapine receptor (peripheral) associated protein 1

chr6_-_118103062 0.655


chr11_+_59612712 0.649 NM_000139
MS4A2
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
chr17_-_29714293 0.644 NM_002981
CCL1
chemokine (C-C motif) ligand 1
chr21_-_14840506 0.641 NM_022136
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr4_+_78651929 0.634 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr1_-_166149867 0.631 NM_001167749
NM_018417
ADCY10

adenylate cyclase 10 (soluble)

chr6_-_49820030 0.631 NM_001190986
NM_006061
CRISP3

cysteine-rich secretory protein 3

chr8_-_41774296 0.630 NM_000037
NM_020475
NM_020476
NM_020477
ANK1



ankyrin 1, erythrocytic



chr1_-_109651140 0.629 NM_001010985
MYBPHL
myosin binding protein H-like
chr3_+_46370578 0.621 CCR2
chemokine (C-C motif) receptor 2
chr8_-_124818754 0.621 NM_001003954
NM_004306
ANXA13

annexin A13

chr8_+_12847521 0.617 NM_020844
KIAA1456
KIAA1456
chr5_+_131424245 0.616 NM_000588
IL3
interleukin 3 (colony-stimulating factor, multiple)
chr19_+_10258642 0.615 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr6_-_123999640 0.611 NM_006073
TRDN
triadin
chr17_-_45196465 0.608 FAM117A
family with sequence similarity 117, member A
chr20_-_29524476 0.602 NM_001037500
DEFB124
defensin, beta 124
chr2_-_49235059 0.597 NM_000145
NM_181446
FSHR

follicle stimulating hormone receptor

chr22_+_21559959 0.591 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr7_+_143287952 0.589 NM_012369
OR2F1
olfactory receptor, family 2, subfamily F, member 1
chr14_+_75058591 0.588 BATF
basic leucine zipper transcription factor, ATF-like
chrX_+_119379967 0.588 NM_001142447
NM_012069
ATP1B4

ATPase, Na+/K+ transporting, beta 4 polypeptide

chr19_-_13074669 0.588 LYL1
lymphoblastic leukemia derived sequence 1
chr6_+_49575629 0.585 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr18_-_26996742 0.585 NM_004948
NM_024421
DSC1

desmocollin 1

chr11_+_1064869 0.582 NM_002457
MUC2
mucin 2, oligomeric mucus/gel-forming
chr16_+_142853 0.580 NM_005332
HBZ
hemoglobin, zeta
chr19_+_40824486 0.578 NM_014209
ETV2
ets variant 2
chr7_+_127020924 0.576 NM_020369
FSCN3
fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)
chr12_+_98565663 0.575 NM_153364
FAM71C
family with sequence similarity 71, member C
chr4_+_75393053 0.567 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr2_-_219558517 0.566 NM_017521
FEV
FEV (ETS oncogene family)
chr2_+_166137091 0.563 NM_024969
CSRNP3
cysteine-serine-rich nuclear protein 3
chr3_+_129124591 0.560 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr6_-_46997579 0.558 NM_001098518
GPR116
G protein-coupled receptor 116
chr8_+_120148604 0.555 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr2_-_144711375 0.555 NM_024659
GTDC1
glycosyltransferase-like domain containing 1
chrX_-_70248022 0.555 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr5_-_34020445 0.553 NM_001012509
NM_016180
SLC45A2

solute carrier family 45, member 2

chr3_+_133518900 0.553 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr22_-_48865864 0.550 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr1_+_213245507 0.550 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr3_-_3127057 0.545 NM_000564
NM_175724
NM_175725
NM_175726
NM_175727
NM_175728
IL5RA





interleukin 5 receptor, alpha





chr5_+_32824701 0.544 NM_024563
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr2_+_234191029 0.542 NM_019076
UGT1A8
UDP glucuronosyltransferase 1 family, polypeptide A8
chrX_+_15435351 0.536 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr15_-_91078307 0.535 FAM174B
family with sequence similarity 174, member B
chr11_+_56705796 0.534 NM_001005210
LRRC55
leucine rich repeat containing 55
chr8_-_93144366 0.531 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr7_-_112515068 0.530 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr10_-_48010879 0.529 NM_002900
RBP3
retinol binding protein 3, interstitial
chr1_-_153537362 0.528 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr15_-_41300316 0.527 EPB42
erythrocyte membrane protein band 4.2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
4.07 2.79e-22 GO:0007608 sensory perception of smell
1.60 3.57e-21 GO:0032501 multicellular organismal process
3.74 1.52e-20 GO:0007606 sensory perception of chemical stimulus
2.17 7.62e-18 GO:0003008 system process
2.81 9.51e-18 GO:0007600 sensory perception
2.24 2.93e-15 GO:0050877 neurological system process
1.40 7.89e-12 GO:0050896 response to stimulus
1.66 3.12e-07 GO:0065008 regulation of biological quality
3.03 6.73e-05 GO:0008202 steroid metabolic process
1.82 2.08e-03 GO:0009611 response to wounding
3.89 2.55e-03 GO:0007586 digestion
1.96 6.66e-03 GO:0048878 chemical homeostasis
2.08 7.51e-03 GO:0001775 cell activation
2.00 8.02e-03 GO:0050878 regulation of body fluid levels
2.63 8.47e-03 GO:0030168 platelet activation
2.76 1.21e-02 GO:0003013 circulatory system process
2.76 1.21e-02 GO:0008015 blood circulation
2.04 1.46e-02 GO:0007599 hemostasis
2.01 2.79e-02 GO:0007596 blood coagulation
2.01 2.79e-02 GO:0050817 coagulation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.67 8.26e-21 GO:0071944 cell periphery
1.67 1.67e-20 GO:0005886 plasma membrane
1.43 1.17e-12 GO:0031224 intrinsic to membrane
1.42 6.77e-12 GO:0016021 integral to membrane
1.80 7.90e-12 GO:0005576 extracellular region
1.37 1.57e-11 GO:0044425 membrane part
1.25 6.02e-07 GO:0016020 membrane
1.53 3.00e-05 GO:0044459 plasma membrane part
1.81 4.06e-05 GO:0044421 extracellular region part
1.72 4.86e-05 GO:0005887 integral to plasma membrane
1.71 6.01e-05 GO:0031226 intrinsic to plasma membrane
1.91 7.88e-05 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.35 7.61e-25 GO:0004872 receptor activity
2.54 5.67e-23 GO:0004888 transmembrane receptor activity
2.95 4.95e-22 GO:0004930 G-protein coupled receptor activity
4.04 2.56e-21 GO:0004984 olfactory receptor activity
2.03 4.87e-19 GO:0004871 signal transducer activity
2.03 4.87e-19 GO:0060089 molecular transducer activity