Motif ID: GLI1..3.p2

Z-value: 1.690


Transcription factors associated with GLI1..3.p2:

Gene SymbolEntrez IDGene Name
GLI1 2735 glioma-associated oncogene homolog 1 (zinc finger protein)
GLI2 2736 GLI-Kruppel family member GLI2
GLI3 2737 GLI-Kruppel family member GLI3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GLI3chr7_-_422433180.721.5e-03Click!
GLI2chr2_+_1212713360.591.6e-02Click!
GLI1chr12_+_561401840.155.8e-01Click!


Activity profile for motif GLI1..3.p2.

activity profile for motif GLI1..3.p2


Sorted Z-values histogram for motif GLI1..3.p2

Sorted Z-values for motif GLI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GLI1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_2461500 2.254 NM_006181
 NTN3
netrin 3
chr11_-_118055564 2.011 NM_007180
 TREH
trehalase (brush-border membrane glycoprotein)
chr9_-_112840064 1.928 NM_001401
NM_057159
 LPAR1

lysophosphatidic acid receptor 1

chr5_-_156935283 1.712


chr5_-_168660293 1.683 NM_003062
 SLIT3
slit homolog 3 (Drosophila)
chr12_-_113330574 1.675 NM_000192
NM_080717
 TBX5

T-box 5

chr16_+_85169615 1.659 NM_005250
 FOXL1
forkhead box L1
chr19_-_6061561 1.656 NM_000635
NM_134433
 RFX2

regulatory factor X, 2 (influences HLA class II expression)

chr5_+_122452739 1.563 NM_001136239
 PRDM6
PR domain containing 6
chr16_+_85158357 1.539 NM_005251
 FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr16_-_1999796 1.535 ZNF598
zinc finger protein 598
chr16_+_85101605 1.477 NM_001451
 FOXF1
forkhead box F1
chr17_+_58058783 1.446 MRC2
mannose receptor, C type 2
chr9_+_18464090 1.431 NM_001040272
NM_052866
 ADAMTSL1

ADAMTS-like 1

chr4_+_72271218 1.424 NM_001098484
NM_001134742
 SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr22_-_26527469 1.403 NM_002430
 MN1
meningioma (disrupted in balanced translocation) 1
chr1_-_32036802 1.399 SPOCD1
SPOC domain containing 1
chr5_-_156935317 1.387 NM_033274
 ADAM19
ADAM metallopeptidase domain 19
chr6_-_166960690 1.385 NM_021135
 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr20_+_1194959 1.354 NM_014723
 SNPH
syntaphilin

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 35 entries
enrichment   p-value GO term description
2.12 2.14e-03 GO:0006813 potassium ion transport
1.62 1.26e-02 GO:0007409 axonogenesis
1.59 7.61e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.58 2.99e-02 GO:0048667 cell morphogenesis involved in neuron differentiation
1.57 3.37e-02 GO:0048812 neuron projection morphogenesis
1.54 3.71e-02 GO:0031175 neuron projection development
1.53 3.06e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.53 3.41e-02 GO:0000904 cell morphogenesis involved in differentiation
1.51 2.94e-03 GO:0010628 positive regulation of gene expression
1.48 7.33e-04 GO:0048699 generation of neurons
1.47 2.32e-02 GO:0051254 positive regulation of RNA metabolic process
1.45 7.91e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.45 3.70e-02 GO:0030182 neuron differentiation
1.44 2.80e-04 GO:0010646 regulation of cell communication
1.44 1.73e-03 GO:0022008 neurogenesis
1.44 1.67e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.44 2.74e-02 GO:0010557 positive regulation of macromolecule biosynthetic process
1.43 1.98e-07 GO:0023051 regulation of signaling
1.42 2.71e-06 GO:0009653 anatomical structure morphogenesis
1.40 4.53e-03 GO:0007154 cell communication

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
2.19 3.11e-02 GO:0008076 voltage-gated potassium channel complex
2.19 3.11e-02 GO:0034705 potassium channel complex
2.06 3.50e-03 GO:0034703 cation channel complex
1.52 2.94e-02 GO:0043005 neuron projection
1.34 1.19e-03 GO:0031226 intrinsic to plasma membrane
1.34 1.48e-03 GO:0005887 integral to plasma membrane
1.32 7.29e-07 GO:0044459 plasma membrane part
1.20 5.58e-06 GO:0071944 cell periphery
1.20 7.15e-06 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
2.21 1.02e-03 GO:0005267 potassium channel activity
2.01 9.15e-03 GO:0022843 voltage-gated cation channel activity
1.80 9.73e-04 GO:0005261 cation channel activity
1.70 2.14e-02 GO:0005096 GTPase activator activity
1.50 5.30e-04 GO:0043565 sequence-specific DNA binding
1.34 2.41e-02 GO:0001071 nucleic acid binding transcription factor activity
1.34 2.41e-02 GO:0003700 sequence-specific DNA binding transcription factor activity