Motif ID: GTF2A1,2.p2

Z-value: 2.013


Transcription factors associated with GTF2A1,2.p2:

Gene SymbolEntrez IDGene Name
GTF2A1 2957 general transcription factor IIA, 1, 19/37kDa
GTF2A2 2958 general transcription factor IIA, 2, 12kDa

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GTF2A1chr14_-_80757327-0.514.6e-02Click!
GTF2A2chr15_-_57736828-0.312.4e-01Click!


Activity profile for motif GTF2A1,2.p2.

activity profile for motif GTF2A1,2.p2


Sorted Z-values histogram for motif GTF2A1,2.p2

Sorted Z-values for motif GTF2A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_129823667 4.962 NM_139055
ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
chr7_-_41709191 3.787 NM_002192
INHBA
inhibin, beta A
chr8_+_37672427 3.563 NM_025069
ZNF703
zinc finger protein 703
chr15_-_73792234 3.197 NM_001897
CSPG4
chondroitin sulfate proteoglycan 4
chr15_-_73792150 3.082 CSPG4
chondroitin sulfate proteoglycan 4
chr2_+_27154938 2.862 NM_007046
EMILIN1
elastin microfibril interfacer 1
chr2_+_242146791 2.542 NM_032515
BOK
BCL2-related ovarian killer
chr9_+_35528890 2.526 RUSC2
RUN and SH3 domain containing 2
chr17_-_77602493 2.506 RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr3_+_141879555 2.456 NM_152616
TRIM42
tripartite motif containing 42
chrX_-_139414890 2.387 NM_005634
SOX3
SRY (sex determining region Y)-box 3
chr2_+_27155197 2.249 EMILIN1
elastin microfibril interfacer 1
chr12_+_13240868 2.246 NM_001423
EMP1
epithelial membrane protein 1
chr12_-_7136147 2.204 NM_001733
C1R
complement component 1, r subcomponent
chr12_-_7136189 2.164 C1R
complement component 1, r subcomponent
chr17_+_45488330 2.162 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr1_-_245988330 2.156 NM_012353
OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr16_+_54072969 2.139 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr2_+_28469275 2.109 NM_005253
FOSL2
FOS-like antigen 2
chr5_+_60663842 2.049 NM_020928
ZSWIM6
zinc finger, SWIM-type containing 6
chr17_+_45488356 2.010 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr17_-_45633986 1.972 NM_000088
COL1A1
collagen, type I, alpha 1
chr19_-_50601406 1.962 NM_001142502
PPP1R13L
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr12_+_50342814 1.927 NM_001177984
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr19_+_46417117 1.926 AXL
AXL receptor tyrosine kinase
chr14_-_72430545 1.908 NM_012074
DPF3
D4, zinc and double PHD fingers, family 3
chr17_-_77602938 1.898 NM_002917
RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chrX_-_139694248 1.847 NM_004065
CDR1
cerebellar degeneration-related protein 1, 34kDa
chr1_-_56817717 1.834 PPAP2B
phosphatidic acid phosphatase type 2B
chr17_-_36456949 1.832 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr7_+_100557098 1.831 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr3_-_62334229 1.830 NM_018008
FEZF2
FEZ family zinc finger 2
chr20_+_32610161 1.818 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr2_+_28469850 1.815 FOSL2
FOS-like antigen 2
chr22_-_36998615 1.801 NM_001195071
TMEM184B
transmembrane protein 184B
chr19_-_48723150 1.800 NM_014297
ETHE1
ethylmalonic encephalopathy 1
chr22_-_36998912 1.792 NM_001195072
NM_012264
TMEM184B

transmembrane protein 184B

chr19_+_10083196 1.775 NM_002566
P2RY11
purinergic receptor P2Y, G-protein coupled, 11
chr1_-_56817823 1.764 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr16_+_3102556 1.758 NM_001042428
NM_003456
ZNF205

zinc finger protein 205

chr19_-_1827133 1.749


chr1_-_202402043 1.747 NM_000537
REN
renin
chr16_+_82544327 1.734 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr9_+_35528628 1.705 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr22_-_36998889 1.692 TMEM184B
transmembrane protein 184B
chr8_-_145119627 1.687 NM_201378
PLEC
plectin
chr4_+_9094611 1.676 NM_001040071
LOC650293
seven transmembrane helix receptor
chr19_+_46416975 1.663 AXL
AXL receptor tyrosine kinase
chr10_+_101532450 1.654 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr2_+_28469199 1.646 FOSL2
FOS-like antigen 2
chr11_+_64448628 1.637 NM_006244
PPP2R5B
protein phosphatase 2, regulatory subunit B', beta
chr19_+_46416971 1.628 AXL
AXL receptor tyrosine kinase
chr19_-_51690989 1.625 NM_020709
PNMAL2
PNMA-like 2
chr17_-_36436979 1.625 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr17_-_39340638 1.621 NM_005374
MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr22_+_29817315 1.615 SMTN
smoothelin
chrX_+_16051344 1.612 NM_005314
GRPR
gastrin-releasing peptide receptor
chr19_+_46417099 1.609 AXL
AXL receptor tyrosine kinase
chr22_+_28032950 1.588 NM_006478
NM_152236
NM_152237
GAS2L1


growth arrest-specific 2 like 1


chr17_+_9420668 1.564 NM_001080556
NM_145054
WDR16

WD repeat domain 16

chr1_+_22011344 1.561 NM_001013693
LDLRAD2
low density lipoprotein receptor class A domain containing 2
chr1_-_16355013 1.556 NM_004431
EPHA2
EPH receptor A2
chr17_-_45633873 1.551 COL1A1
collagen, type I, alpha 1
chr12_+_108061584 1.540 NM_001093
ACACB
acetyl-CoA carboxylase beta
chr9_+_115303527 1.523 NM_130795
RGS3
regulator of G-protein signaling 3
chr7_+_99537065 1.512 NM_004722
AP4M1
adaptor-related protein complex 4, mu 1 subunit
chr2_+_28469864 1.508 FOSL2
FOS-like antigen 2
chr11_-_85074848 1.494 NM_152723
CCDC89
coiled-coil domain containing 89
chr3_+_42675841 1.470 ZBTB47
zinc finger and BTB domain containing 47
chr12_+_51777715 1.444 IGFBP6
insulin-like growth factor binding protein 6
chr17_-_24940728 1.441 NM_001085454
NM_014030
GIT1

G protein-coupled receptor kinase interacting ArfGAP 1

chr1_-_31942206 1.432 NM_001856
COL16A1
collagen, type XVI, alpha 1
chr1_+_201729893 1.432 NM_014359
OPTC
opticin
chr17_-_1335763 1.406 NM_001080950
MYO1C
myosin IC
chr17_-_59342319 1.404 NM_001318
NM_022579
NM_022580
NM_022581
CSHL1



chorionic somatomammotropin hormone-like 1



chr22_+_22445035 1.397 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr16_-_2970474 1.393 NM_004203
NM_182687
PKMYT1

protein kinase, membrane associated tyrosine/threonine 1

chr3_+_38282301 1.380 NM_004256
SLC22A13
solute carrier family 22 (organic anion transporter), member 13
chr12_+_6768934 1.368 NM_001195014
NM_001195015
NM_001195016
NM_001195017
CD4



CD4 molecule



chr1_+_163084707 1.364 PBX1
pre-B-cell leukemia homeobox 1
chr20_-_3610635 1.360 NM_025220
NM_153202
ADAM33

ADAM metallopeptidase domain 33

chr3_+_195887903 1.359 NM_153690
FAM43A
family with sequence similarity 43, member A
chr9_+_130620540 1.356 NM_004435
ENDOG
endonuclease G
chr17_-_21097170 1.356 NM_152914
C17orf103
chromosome 17 open reading frame 103
chr19_+_3523903 1.348 NM_006339
HMG20B
high-mobility group 20B
chr19_+_17691302 1.347 NM_018174
MAP1S
microtubule-associated protein 1S
chr19_+_53520439 1.340 NM_001425
EMP3
epithelial membrane protein 3
chr22_+_36334811 1.337 GGA1
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr1_-_56817568 1.331 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_-_155336223 1.331 NM_001004341
ETV3L
ets variant 3-like
chr15_-_84139182 1.330 NM_022480
KLHL25
kelch-like 25 (Drosophila)
chr12_+_50750013 1.329 NM_001098673
NM_021934
C12orf44

chromosome 12 open reading frame 44

chr19_+_13767207 1.323 NM_023072
ZSWIM4
zinc finger, SWIM-type containing 4
chr11_+_65781322 1.321 NM_001134775
KLC2
kinesin light chain 2
chr19_-_51319769 1.320 NM_207393
IGFL3
IGF-like family member 3
chr15_-_88150823 1.314 ANPEP
alanyl (membrane) aminopeptidase
chr4_+_77829743 1.314 SHROOM3
shroom family member 3
chr21_-_27139563 1.311 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr2_+_218929822 1.310 NM_198559
C2orf62
chromosome 2 open reading frame 62
chr3_+_50217692 1.305 NM_006841
SLC38A3
solute carrier family 38, member 3
chr15_-_84139021 1.294 KLHL25
kelch-like 25 (Drosophila)
chr19_+_3523950 1.289 HMG20B
high-mobility group 20B
chr19_+_50150441 1.289 NM_001294
CLPTM1
cleft lip and palate associated transmembrane protein 1
chr16_+_30843396 1.285 NM_001099784
FBXL19
F-box and leucine-rich repeat protein 19
chr14_+_74815233 1.281 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr9_+_91409746 1.275 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr6_-_35873034 1.274 NM_001832
CLPS
colipase, pancreatic
chr19_+_50150486 1.270 CLPTM1
cleft lip and palate associated transmembrane protein 1
chr1_-_238842011 1.269 GREM2
gremlin 2
chr19_+_4353658 1.268 NM_005483
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr22_+_34107087 1.256 HMOX1
heme oxygenase (decycling) 1
chr11_+_65781646 1.245 NM_001134776
NM_001134774
NM_022822
KLC2


kinesin light chain 2


chr22_-_37598115 1.244 CBX6
chromobox homolog 6
chr2_-_218516950 1.243 NM_022648
TNS1
tensin 1
chr1_-_56817802 1.243 PPAP2B
phosphatidic acid phosphatase type 2B
chr22_-_37598160 1.238 CBX6
chromobox homolog 6
chr8_-_22582526 1.236 NM_018688
BIN3
bridging integrator 3
chr1_-_31942142 1.234 COL16A1
collagen, type XVI, alpha 1
chr20_+_59260847 1.230 NM_001794
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr12_+_108452117 1.226 UBE3B
ubiquitin protein ligase E3B
chr2_+_176737050 1.222 NM_006898
HOXD3
homeobox D3
chr12_-_123617962 1.221 NM_001077261
NM_006312
NCOR2

nuclear receptor corepressor 2

chr17_-_39340414 1.210 MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr3_-_50333859 1.208 HYAL2
hyaluronoglucosaminidase 2
chr12_+_6768966 1.196 CD4
CD4 molecule
chr2_+_28469172 1.192 FOSL2
FOS-like antigen 2
chrX_+_134383533 1.191 NCRNA00086
non-protein coding RNA 86
chr22_+_34107051 1.181 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr1_+_204710409 1.180 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr1_+_84540921 1.178 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr12_-_51047521 1.172 NM_002283
KRT85
keratin 85
chr11_-_67032125 1.166 CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr14_+_99859427 1.165 NM_207117
SLC25A47
solute carrier family 25, member 47
chr7_+_72720093 1.160 NM_001077621
VPS37D
vacuolar protein sorting 37 homolog D (S. cerevisiae)
chr19_+_2173415 1.153 DOT1L
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
chr1_+_203740391 1.152 CDK18
cyclin-dependent kinase 18
chr7_-_7541974 1.149 NM_001037763
COL28A1
collagen, type XXVIII, alpha 1
chr20_+_62266270 1.147 NM_004535
MYT1
myelin transcription factor 1
chr16_-_727889 1.147 NARFL
nuclear prelamin A recognition factor-like
chr12_+_51777684 1.147 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr17_+_76549658 1.144 RPTOR
regulatory associated protein of MTOR, complex 1
chr4_-_111763655 1.143 NM_000325
PITX2
paired-like homeodomain 2
chr19_+_17691283 1.139 MAP1S
microtubule-associated protein 1S
chr16_+_30569558 1.138 PRR14
proline rich 14
chr22_+_36412277 1.130 NM_024313
NOL12
nucleolar protein 12
chr3_-_71262405 1.128 FOXP1
forkhead box P1
chr17_+_74542066 1.125 NM_198593
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr1_-_68470585 1.122 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr20_-_43889339 1.118 NM_003279
TNNC2
troponin C type 2 (fast)
chr6_+_43247168 1.113 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr2_+_73973640 1.113 ACTG2
actin, gamma 2, smooth muscle, enteric
chr22_+_31526801 1.110 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr21_-_32879617 1.108 NM_144659
TCP10L
t-complex 10 (mouse)-like
chr1_+_31655607 1.107 NM_001199037
SERINC2
serine incorporator 2
chr5_+_150000394 1.107 NM_001109974
NM_007286
SYNPO

synaptopodin

chr15_-_72282452 1.102 STRA6
stimulated by retinoic acid gene 6 homolog (mouse)
chr3_+_50279993 1.099 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr5_+_150008030 1.099 SYNPO
synaptopodin
chr19_-_5854991 1.095 NM_001193375
NM_175614
NDUFA11

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa

chr11_-_1549719 1.092 NM_004420
DUSP8
dual specificity phosphatase 8
chr1_-_151848039 1.085 S100A16
S100 calcium binding protein A16
chr1_+_204710453 1.080 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr1_+_53300410 1.080 NM_153703
PODN
podocan
chr12_+_6768960 1.076 CD4
CD4 molecule
chr17_+_38259620 1.076 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr1_-_20179495 1.075 NM_000300
NM_001161727
NM_001161728
PLA2G2A


phospholipase A2, group IIA (platelets, synovial fluid)


chr16_-_48418418 1.071 NM_015069
ZNF423
zinc finger protein 423
chr1_+_150749943 1.063 NM_178438
LCE5A
late cornified envelope 5A
chr17_-_24940521 1.056 GIT1
G protein-coupled receptor kinase interacting ArfGAP 1
chr5_+_15553288 1.052 NM_012304
FBXL7
F-box and leucine-rich repeat protein 7
chr22_+_20068039 1.052 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr7_+_68701704 1.044 NM_001127231
NM_001127232
NM_015570
AUTS2


autism susceptibility candidate 2


chr10_+_101532544 1.038 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr2_+_94900904 1.035 NM_144705
TEKT4
tektin 4
chr19_+_41085221 1.027 NM_001007469
NM_014266
HCST

hematopoietic cell signal transducer

chr7_+_72720256 1.027 VPS37D
vacuolar protein sorting 37 homolog D (S. cerevisiae)
chr8_+_42247978 1.018 IKBKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr1_+_203740306 1.016 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr1_+_204710208 1.014 NM_001193321
NM_001193322
NM_014002
IKBKE


inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon


chr1_+_149520601 1.005 ZNF687
zinc finger protein 687
chr17_+_7151653 1.003 EIF5A
eukaryotic translation initiation factor 5A
chr19_+_46416938 1.000 NM_001699
NM_021913
AXL

AXL receptor tyrosine kinase

chr21_+_46367216 1.000 COL6A2
collagen, type VI, alpha 2
chr12_+_79634820 0.999 NM_005593
MYF5
myogenic factor 5
chr16_-_2970390 0.997 PKMYT1
protein kinase, membrane associated tyrosine/threonine 1
chr5_+_145296313 0.997 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr22_-_40856821 0.995 NM_000106
NM_001025161
CYP2D6

cytochrome P450, family 2, subfamily D, polypeptide 6

chr22_-_39362569 0.995 MKL1
megakaryoblastic leukemia (translocation) 1
chr19_-_1430194 0.993 C19orf25
chromosome 19 open reading frame 25
chr17_+_7196151 0.988 KCTD11
potassium channel tetramerisation domain containing 11
chr10_+_114700775 0.988 TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr1_+_154351162 0.988 LMNA
lamin A/C
chr16_+_29915003 0.987 NM_173618
INO80E
INO80 complex subunit E
chr19_+_53520632 0.980 EMP3
epithelial membrane protein 3
chr19_-_51081147 0.978 NM_015649
IRF2BP1
interferon regulatory factor 2 binding protein 1
chr22_-_29015452 0.977 NM_001037666
GATSL3
GATS protein-like 3
chr22_+_36334400 0.973 NM_001001560
NM_001001561
NM_001172687
NM_013365
GGA1



golgi-associated, gamma adaptin ear containing, ARF binding protein 1



chr4_+_1330957 0.971 NM_020894
KIAA1530
KIAA1530
chr15_-_87239745 0.971 NM_178232
HAPLN3
hyaluronan and proteoglycan link protein 3
chr22_+_29817218 0.970 SMTN
smoothelin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.24 1.86e-04 GO:0032502 developmental process
1.27 3.41e-04 GO:0048856 anatomical structure development
1.37 4.09e-04 GO:0048583 regulation of response to stimulus
1.43 5.11e-04 GO:0009966 regulation of signal transduction
1.28 9.82e-04 GO:0048731 system development
1.38 1.12e-03 GO:0023051 regulation of signaling
1.24 1.74e-03 GO:0007275 multicellular organismal development
1.32 4.38e-03 GO:0030154 cell differentiation
1.12 5.23e-03 GO:0065007 biological regulation
1.21 5.99e-03 GO:0023052 signaling
1.70 8.07e-03 GO:0072358 cardiovascular system development
1.70 8.07e-03 GO:0072359 circulatory system development
1.17 8.92e-03 GO:0032501 multicellular organismal process
1.30 9.03e-03 GO:0048869 cellular developmental process
1.36 1.18e-02 GO:0009653 anatomical structure morphogenesis
1.90 1.19e-02 GO:0040012 regulation of locomotion
2.29 1.21e-02 GO:0034330 cell junction organization
2.83 1.30e-02 GO:0002576 platelet degranulation
1.92 1.49e-02 GO:0001568 blood vessel development
1.85 1.64e-02 GO:0022603 regulation of anatomical structure morphogenesis
1.51 2.32e-02 GO:0007155 cell adhesion
1.51 2.32e-02 GO:0022610 biological adhesion
1.86 2.60e-02 GO:0001944 vasculature development
1.90 3.32e-02 GO:0030334 regulation of cell migration
1.85 4.56e-02 GO:0061061 muscle structure development
1.87 4.65e-02 GO:2000145 regulation of cell motility
1.46 4.72e-02 GO:0009888 tissue development
1.60 4.72e-02 GO:0023056 positive regulation of signaling

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.43 1.83e-08 GO:0005576 extracellular region
1.63 4.00e-08 GO:0044421 extracellular region part
1.54 3.26e-04 GO:0005615 extracellular space
1.31 3.36e-04 GO:0044459 plasma membrane part
1.79 8.50e-04 GO:0031012 extracellular matrix
3.19 3.92e-03 GO:0031983 vesicle lumen
1.56 4.11e-03 GO:0030054 cell junction
1.79 4.38e-03 GO:0005578 proteinaceous extracellular matrix
3.03 4.89e-03 GO:0031091 platelet alpha granule
1.17 8.55e-03 GO:0005886 plasma membrane
3.12 1.81e-02 GO:0031093 platelet alpha granule lumen
1.17 1.82e-02 GO:0071944 cell periphery
3.05 2.39e-02 GO:0034774 secretory granule lumen
1.89 3.06e-02 GO:0030141 stored secretory granule
2.93 4.04e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.52 2.60e-02 GO:0005198 structural molecule activity