Motif ID: GTF2I.p2

Z-value: 0.878


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GTF2Ichr7_+_73709974-0.058.5e-01Click!


Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_68470585 1.937 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr19_+_60487578 1.831 BRSK1
BR serine/threonine kinase 1
chr19_-_36531958 1.777 NM_020856
TSHZ3
teashirt zinc finger homeobox 3
chr19_+_60487345 1.642 NM_032430
BRSK1
BR serine/threonine kinase 1
chr1_-_20685314 1.524 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr16_-_30929217 1.445 NM_052874
STX1B
syntaxin 1B
chr6_-_153494076 1.391 NM_012419
RGS17
regulator of G-protein signaling 17
chr7_+_128218685 1.366 CCDC136
coiled-coil domain containing 136
chr19_-_56178882 1.351 NM_139277
NM_005046
KLK7

kallikrein-related peptidase 7

chr5_-_81082699 1.280 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr17_+_58058774 1.263 MRC2
mannose receptor, C type 2
chr6_-_10520264 1.240 TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr6_-_29708647 1.223 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr5_-_81082614 1.222 SSBP2
single-stranded DNA binding protein 2
chr4_-_177950658 1.221 NM_005429
VEGFC
vascular endothelial growth factor C
chr2_-_144994038 1.205 ZEB2
zinc finger E-box binding homeobox 2
chr2_-_144994349 1.160 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr6_-_10520592 1.127 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr7_+_103756339 1.098 NM_199000
LHFPL3
lipoma HMGIC fusion partner-like 3
chr1_+_156229934 1.076 KIRREL
kin of IRRE like (Drosophila)
chr13_+_113574925 1.059 NM_001143945
GAS6
growth arrest-specific 6
chr17_+_58058479 1.029 NM_006039
MRC2
mannose receptor, C type 2
chr17_-_55824083 1.025 USP32
ubiquitin specific peptidase 32
chr6_-_42527760 1.018 NM_033502
TRERF1
transcriptional regulating factor 1
chr9_+_108665168 0.999 NM_021224
ZNF462
zinc finger protein 462
chr6_-_29708838 0.974 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr15_-_80125514 0.974 MEX3B
mex-3 homolog B (C. elegans)
chr21_-_27139563 0.968 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr19_-_1966628 0.965 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr8_-_116750427 0.950 TRPS1
trichorhinophalangeal syndrome I
chr12_+_52618815 0.946 NM_017410
HOXC13
homeobox C13
chr16_-_63713382 0.926 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr5_-_36912487 0.908 LOC646719
hypothetical LOC646719
chr21_-_27139143 0.900 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr11_+_129689536 0.881 FLJ34521
hypothetical protein LOC646383
chr22_-_44751671 0.880 NM_058238
WNT7B
wingless-type MMTV integration site family, member 7B
chr17_+_58058783 0.877 MRC2
mannose receptor, C type 2
chrX_+_73557809 0.874 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr2_+_45022540 0.855 NM_005413
SIX3
SIX homeobox 3
chr8_+_22078622 0.850 BMP1
bone morphogenetic protein 1
chr15_+_90197884 0.840 NM_001145044
NM_013272
SLCO3A1

solute carrier organic anion transporter family, member 3A1

chr4_-_158111995 0.833 NM_016205
PDGFC
platelet derived growth factor C
chrX_+_56275510 0.828 NM_007250
NM_001159296
KLF8

Kruppel-like factor 8

chr11_+_93916653 0.823 NM_002033
PIWIL4
FUT4
piwi-like 4 (Drosophila)
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr5_+_176492662 0.796 NM_172349
NSD1
nuclear receptor binding SET domain protein 1
chr19_-_48976852 0.790 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr1_-_68071635 0.787 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr11_+_12355600 0.777 NM_018222
PARVA
parvin, alpha
chrX_+_144707022 0.774 NM_001144003
NM_001144004
NM_001144005
NM_032539
SLITRK2



SLIT and NTRK-like family, member 2



chr11_+_124539814 0.774 PKNOX2
PBX/knotted 1 homeobox 2
chr3_+_152287365 0.772 NM_053002
MED12L
mediator complex subunit 12-like
chr11_-_78829342 0.766 NM_001098816
ODZ4
odz, odd Oz/ten-m homolog 4 (Drosophila)
chr11_-_66897584 0.762 NM_013246
CLCF1
cardiotrophin-like cytokine factor 1
chr5_+_176493233 0.760 NM_022455
NSD1
nuclear receptor binding SET domain protein 1
chr16_-_63713485 0.753 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr6_+_96570565 0.751 NM_006581
FUT9
fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
chr3_-_64648703 0.750 ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr1_+_199884152 0.748 NAV1
neuron navigator 1
chr15_+_41597097 0.746 NM_002373
MAP1A
microtubule-associated protein 1A
chr3_-_162572441 0.736 NM_001040100
C3orf57
chromosome 3 open reading frame 57
chr8_-_116750277 0.733 NM_014112
TRPS1
trichorhinophalangeal syndrome I
chr1_+_199884072 0.729 NM_020443
NAV1
neuron navigator 1
chr12_+_54612055 0.728 NM_201444
NM_201445
NM_201554
DGKA


diacylglycerol kinase, alpha 80kDa


chr16_+_12902955 0.728 NM_001145204
NM_001145205
SHISA9

shisa homolog 9 (Xenopus laevis)

chr1_+_26609893 0.717 LIN28A
lin-28 homolog A (C. elegans)
chr1_+_156229686 0.717 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr5_+_176493488 0.716 NSD1
nuclear receptor binding SET domain protein 1
chr6_-_33268177 0.712 NM_001163771
NM_080679
NM_080680
NM_080681
COL11A2



collagen, type XI, alpha 2



chr17_-_44058612 0.707 NM_024017
HOXB9
homeobox B9
chr16_-_63713466 0.702 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr17_+_45488356 0.699 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr6_-_29708938 0.697 NM_001470
NM_021904
GABBR1

gamma-aminobutyric acid (GABA) B receptor, 1

chr4_-_101090431 0.694 H2AFZ
H2A histone family, member Z
chr3_-_187025438 0.690 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr12_+_4253143 0.689 NM_001759
CCND2
cyclin D2
chr1_+_165865953 0.687 NM_052862
RCSD1
RCSD domain containing 1
chr7_+_121300394 0.680 NM_002851
PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr15_-_56829069 0.674 ADAM10
ADAM metallopeptidase domain 10
chr8_+_22078817 0.661 BMP1
bone morphogenetic protein 1
chr1_-_194844299 0.656 KCNT2
potassium channel, subfamily T, member 2
chr10_-_61139328 0.656 NM_194298
LOC100129721
SLC16A9
hypothetical protein LOC100129721
solute carrier family 16, member 9 (monocarboxylic acid transporter 9)
chr8_-_9045548 0.653 NM_024607
PPP1R3B
protein phosphatase 1, regulatory (inhibitor) subunit 3B
chr12_+_56284867 0.651 NM_178502
DTX3
deltex homolog 3 (Drosophila)
chr8_+_104582151 0.650 NM_001100117
RIMS2
regulating synaptic membrane exocytosis 2
chrX_+_117513899 0.641 NM_144658
DOCK11
dedicator of cytokinesis 11
chr2_-_192767494 0.635 TMEFF2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr2_+_113709553 0.634 LOC654433
hypothetical LOC654433
chr7_+_115952279 0.633 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chr1_+_221955876 0.628 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr5_+_176493752 0.623 NSD1
nuclear receptor binding SET domain protein 1
chr6_-_46246543 0.621 NM_021572
ENPP5
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
chr8_-_105670300 0.618 LRP12
low density lipoprotein receptor-related protein 12
chr4_-_140696740 0.617 NM_030648
SETD7
SET domain containing (lysine methyltransferase) 7
chr8_-_105670410 0.610 NM_001135703
NM_013437
LRP12

low density lipoprotein receptor-related protein 12

chr2_-_144991556 0.610 ZEB2
zinc finger E-box binding homeobox 2
chr8_-_11096257 0.610 NM_173683
XKR6
XK, Kell blood group complex subunit-related family, member 6
chr19_-_60573552 0.599 NM_000641
IL11
interleukin 11
chr2_-_166358792 0.595 GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr12_+_81604752 0.593 TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr11_-_122571046 0.590 CLMP
CXADR-like membrane protein
chr11_-_122571198 0.586 NM_024769
CLMP
CXADR-like membrane protein
chr4_+_145786622 0.583 NM_022475
HHIP
hedgehog interacting protein
chr15_+_90738108 0.582 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr6_+_69401660 0.582 NM_001704
BAI3
brain-specific angiogenesis inhibitor 3
chr4_-_101090505 0.580 NM_002106
H2AFZ
H2A histone family, member Z
chr17_-_39265965 0.579 NM_001932
MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr3_-_170864111 0.578 NM_004991
MECOM
MDS1 and EVI1 complex locus
chr3_-_187025501 0.574 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr8_-_22044463 0.572 NM_005144
NM_018411
HR

hairless homolog (mouse)

chr1_-_231498081 0.566 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)
chr7_+_106472243 0.564 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr7_-_140270749 0.562 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr19_-_13478037 0.559 NM_000068
NM_001127221
NM_001127222
NM_001174080
NM_023035
CACNA1A




calcium channel, voltage-dependent, P/Q type, alpha 1A subunit




chr19_+_60691671 0.559 NM_001144950
NM_001195267
SSC5D

scavenger receptor cysteine rich domain containing (5 domains)

chr6_-_75972473 0.557 COL12A1
collagen, type XII, alpha 1
chr9_+_8848130 0.548


chr12_-_6354818 0.548 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr2_+_79593679 0.548 CTNNA2
catenin (cadherin-associated protein), alpha 2
chr4_-_158111504 0.546 PDGFC
platelet derived growth factor C
chr5_+_76542461 0.545 NM_001029851
NM_001029852
NM_001029853
NM_001029854
NM_003719
PDE8B




phosphodiesterase 8B




chr15_-_80125403 0.545 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr7_+_68702252 0.544 AUTS2
autism susceptibility candidate 2
chr5_+_148766632 0.541 LOC728264
hypothetical LOC728264
chr2_-_19421852 0.538 NM_145260
OSR1
odd-skipped related 1 (Drosophila)
chr12_+_74071145 0.536 NM_152436
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr4_+_30331289 0.535 PCDH7
protocadherin 7
chr20_-_47532585 0.531 NM_004975
KCNB1
potassium voltage-gated channel, Shab-related subfamily, member 1
chr4_-_122213018 0.530 NM_024574
C4orf31
chromosome 4 open reading frame 31
chr13_-_71339313 0.530 NM_004392
NM_080759
NM_080760
DACH1


dachshund homolog 1 (Drosophila)


chr9_+_115678365 0.527 NM_133374
ZNF618
zinc finger protein 618
chr6_+_21774624 0.527 FLJ22536
hypothetical locus LOC401237
chr11_-_106394039 0.525 NM_000855
GUCY1A2
guanylate cyclase 1, soluble, alpha 2
chr3_+_121296290 0.524


chr3_-_121652183 0.520 NM_007085
FSTL1
follistatin-like 1
chr19_-_54031725 0.510 NM_016246
HSD17B14
hydroxysteroid (17-beta) dehydrogenase 14
chr4_+_30330963 0.507 NM_001173523
NM_002589
NM_032456
NM_032457
PCDH7



protocadherin 7



chr1_-_29322993 0.507 NM_001003682
TMEM200B
transmembrane protein 200B
chr22_-_15982142 0.505 NM_031890
NM_001163079
CECR6

cat eye syndrome chromosome region, candidate 6

chrX_+_109132507 0.502 NM_017698
TMEM164
transmembrane protein 164
chr9_-_16860719 0.501 NM_017637
BNC2
basonuclin 2
chrX_+_109132994 0.497 NM_032227
TMEM164
transmembrane protein 164
chr18_-_70416018 0.495 LOC400657
hypothetical LOC400657
chr8_+_22078589 0.491 NM_001199
NM_006129
BMP1

bone morphogenetic protein 1

chr1_+_158636987 0.491 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr7_-_150283794 0.490 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr12_+_92488932 0.490 SOCS2
suppressor of cytokine signaling 2
chr4_-_96689373 0.486 NM_003728
UNC5C
unc-5 homolog C (C. elegans)
chr16_+_54782751 0.483 NM_020988
NM_138736
GNAO1

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

chrX_-_153016173 0.481 MECP2
LOC728653
methyl CpG binding protein 2 (Rett syndrome)
hypothetical protein LOC728653
chr12_-_48387394 0.476 FMNL3
formin-like 3
chr5_-_137117936 0.475 NM_006805
HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr7_+_93861808 0.474 NM_000089
COL1A2
collagen, type I, alpha 2
chr21_+_38550533 0.473 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr10_-_79067296 0.469 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr7_+_90731671 0.465 NM_003505
FZD1
frizzled homolog 1 (Drosophila)
chr11_-_118167108 0.464 NM_004397
DDX6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
chr17_-_43977273 0.462 NM_002145
HOXB2
homeobox B2
chr19_-_11452439 0.460 NM_001420
NM_032281
ELAVL3

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)

chr10_+_23424383 0.460 NM_012228
MSRB2
methionine sulfoxide reductase B2
chr3_+_20056857 0.458 KAT2B
K(lysine) acetyltransferase 2B
chr11_+_102485293 0.457 NM_001080463
NM_001377
DYNC2H1

dynein, cytoplasmic 2, heavy chain 1

chr4_+_174326464 0.455 NM_017423
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr11_-_66898223 0.452 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr20_-_47618059 0.448 NM_000961
PTGIS
prostaglandin I2 (prostacyclin) synthase
chr5_+_176492629 0.448 NSD1
nuclear receptor binding SET domain protein 1
chr5_-_178704934 0.448 ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr12_+_56291484 0.446 NM_182947
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr17_+_2443652 0.444 NM_000430
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr16_-_30841938 0.444 NCRNA00095
non-protein coding RNA 95
chr9_+_130491668 0.444 SET
SET nuclear oncogene
chr5_+_137829065 0.443 EGR1
early growth response 1
chr6_-_80713589 0.440 NM_022726
ELOVL4
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
chr5_-_137906814 0.439 NM_004730
ETF1
eukaryotic translation termination factor 1
chr12_-_6354650 0.438 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr13_-_35603513 0.436 NM_004734
DCLK1
doublecortin-like kinase 1
chr9_+_138341752 0.435 NM_001145638
NM_015597
GPSM1

G-protein signaling modulator 1

chr1_-_200946038 0.435 NM_177402
SYT2
synaptotagmin II
chr7_+_32734244 0.433 LOC441208
zinc and ring finger 2 pseudogene
chr5_+_31229549 0.431 NM_004932
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr10_-_88116181 0.429 NM_017551
GRID1
glutamate receptor, ionotropic, delta 1
chr7_-_82629735 0.426 PCLO
piccolo (presynaptic cytomatrix protein)
chr5_-_64813459 0.426 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr18_+_53170718 0.425 NM_015879
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr8_-_122722674 0.425 NM_005328
HAS2
hyaluronan synthase 2
chr2_-_200030412 0.424 SATB2
SATB homeobox 2
chrX_-_151370325 0.424 NM_000808
GABRA3
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr7_+_93862137 0.421 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr15_-_69194854 0.420 NM_001102658
CT62
cancer/testis antigen 62
chr13_+_99431417 0.419


chr19_-_54958326 0.418 NM_021733
TSKS
testis-specific serine kinase substrate
chr12_+_47495567 0.416 CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr9_+_129414287 0.416 NM_001032221
NM_003165
STXBP1

syntaxin binding protein 1

chr12_-_33483847 0.415 NM_198992
SYT10
synaptotagmin X
chr12_-_51912101 0.415 NM_000966
RARG
retinoic acid receptor, gamma
chr15_+_99237527 0.415 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr14_-_90596665 0.412 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr11_-_3143051 0.411 OSBPL5
oxysterol binding protein-like 5
chr21_-_44583505 0.410 C21orf2
chromosome 21 open reading frame 2
chr1_+_55237193 0.409 NM_057176
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr15_+_99237555 0.409 ALDH1A3
aldehyde dehydrogenase 1 family, member A3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.16 9.01e-23 GO:0050794 regulation of cellular process
1.14 2.69e-19 GO:0050789 regulation of biological process
1.27 1.52e-18 GO:0048731 system development
1.13 6.81e-18 GO:0065007 biological regulation
1.38 9.40e-18 GO:0009653 anatomical structure morphogenesis
1.23 2.29e-16 GO:0007275 multicellular organismal development
1.24 4.18e-16 GO:0048856 anatomical structure development
1.21 4.46e-16 GO:0032502 developmental process
1.35 1.50e-14 GO:0007399 nervous system development
1.20 2.01e-14 GO:0023052 signaling
1.45 6.04e-14 GO:0022008 neurogenesis
1.45 1.10e-12 GO:0048699 generation of neurons
1.07 2.11e-11 GO:0009987 cellular process
1.20 2.69e-11 GO:0007165 signal transduction
1.40 9.98e-11 GO:0050793 regulation of developmental process
1.22 1.42e-10 GO:0048518 positive regulation of biological process
1.25 3.49e-10 GO:0048869 cellular developmental process
1.22 7.70e-10 GO:0048522 positive regulation of cellular process
1.25 1.28e-09 GO:0030154 cell differentiation
1.16 2.44e-09 GO:0051716 cellular response to stimulus
1.22 4.34e-09 GO:0048519 negative regulation of biological process
1.25 1.35e-08 GO:0048513 organ development
1.40 2.35e-08 GO:2000026 regulation of multicellular organismal development
1.42 3.39e-08 GO:0045595 regulation of cell differentiation
1.22 3.52e-08 GO:0048523 negative regulation of cellular process
1.41 3.64e-08 GO:0030182 neuron differentiation
1.44 5.29e-08 GO:0000902 cell morphogenesis
1.29 5.57e-08 GO:0051239 regulation of multicellular organismal process
1.47 2.98e-07 GO:0031175 neuron projection development
1.46 5.20e-07 GO:0000904 cell morphogenesis involved in differentiation
1.25 5.54e-07 GO:0023051 regulation of signaling
1.41 5.74e-07 GO:0032989 cellular component morphogenesis
1.48 1.28e-06 GO:0048812 neuron projection morphogenesis
1.41 2.21e-06 GO:0048666 neuron development
1.39 2.90e-06 GO:0030030 cell projection organization
1.44 4.49e-06 GO:0048858 cell projection morphogenesis
1.40 4.85e-06 GO:0009887 organ morphogenesis
1.43 5.96e-06 GO:0032990 cell part morphogenesis
1.30 7.47e-06 GO:0032879 regulation of localization
1.46 1.12e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
1.26 1.36e-05 GO:0009893 positive regulation of metabolic process
1.31 1.67e-05 GO:0048468 cell development
1.27 1.80e-05 GO:0010604 positive regulation of macromolecule metabolic process
1.28 1.80e-05 GO:0010646 regulation of cell communication
1.46 1.83e-05 GO:0007409 axonogenesis
1.14 3.57e-05 GO:0031323 regulation of cellular metabolic process
1.51 5.78e-05 GO:0060284 regulation of cell development
1.32 1.09e-04 GO:0007267 cell-cell signaling
1.33 1.35e-04 GO:0009790 embryo development
1.57 1.48e-04 GO:0003002 regionalization
1.14 1.53e-04 GO:0016043 cellular component organization
1.25 1.56e-04 GO:0031325 positive regulation of cellular metabolic process
1.50 1.71e-04 GO:0022603 regulation of anatomical structure morphogenesis
1.45 1.75e-04 GO:0048598 embryonic morphogenesis
1.13 1.82e-04 GO:0080090 regulation of primary metabolic process
1.22 2.09e-04 GO:0009966 regulation of signal transduction
1.14 2.19e-04 GO:0060255 regulation of macromolecule metabolic process
1.12 3.61e-04 GO:0019222 regulation of metabolic process
1.26 4.69e-04 GO:0007154 cell communication
2.12 5.04e-04 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
1.38 5.08e-04 GO:0019226 transmission of nerve impulse
1.38 5.08e-04 GO:0035637 multicellular organismal signaling
1.13 5.14e-04 GO:0071840 cellular component organization or biogenesis
1.15 5.34e-04 GO:0071842 cellular component organization at cellular level
1.40 5.71e-04 GO:0007268 synaptic transmission
1.40 5.73e-04 GO:0051094 positive regulation of developmental process
1.75 6.30e-04 GO:0010959 regulation of metal ion transport
1.25 8.39e-04 GO:0051246 regulation of protein metabolic process
1.28 9.02e-04 GO:0051128 regulation of cellular component organization
1.45 9.33e-04 GO:0007389 pattern specification process
1.28 9.50e-04 GO:0009888 tissue development
1.10 1.22e-03 GO:0032501 multicellular organismal process
1.30 1.38e-03 GO:0051049 regulation of transport
1.52 1.43e-03 GO:0050767 regulation of neurogenesis
1.18 1.53e-03 GO:0048583 regulation of response to stimulus
1.36 1.75e-03 GO:0007417 central nervous system development
1.47 1.85e-03 GO:0001944 vasculature development
1.45 1.95e-03 GO:0001501 skeletal system development
1.63 1.96e-03 GO:0009952 anterior/posterior pattern formation
1.37 2.43e-03 GO:0048646 anatomical structure formation involved in morphogenesis
1.24 2.70e-03 GO:0032268 regulation of cellular protein metabolic process
1.65 2.75e-03 GO:0001655 urogenital system development
1.47 2.77e-03 GO:0051960 regulation of nervous system development
1.25 2.96e-03 GO:0042127 regulation of cell proliferation
1.51 3.27e-03 GO:0048568 embryonic organ development
1.24 3.93e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.14 4.99e-03 GO:0071841 cellular component organization or biogenesis at cellular level
1.17 5.39e-03 GO:0007166 cell surface receptor linked signaling pathway
1.35 7.48e-03 GO:0072358 cardiovascular system development
1.35 7.48e-03 GO:0072359 circulatory system development
1.41 8.78e-03 GO:0044057 regulation of system process
1.45 1.17e-02 GO:0001568 blood vessel development
1.40 1.46e-02 GO:0007411 axon guidance
1.60 2.04e-02 GO:0043269 regulation of ion transport
1.38 2.27e-02 GO:0007420 brain development
1.27 2.57e-02 GO:0010628 positive regulation of gene expression
1.14 2.80e-02 GO:0065008 regulation of biological quality
1.42 3.28e-02 GO:0035295 tube development
1.70 3.43e-02 GO:0051924 regulation of calcium ion transport
1.24 3.64e-02 GO:0040011 locomotion
1.26 4.12e-02 GO:0019220 regulation of phosphate metabolic process
1.26 4.12e-02 GO:0051174 regulation of phosphorus metabolic process
1.30 4.46e-02 GO:0008284 positive regulation of cell proliferation
1.25 4.89e-02 GO:0010557 positive regulation of macromolecule biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.57 2.78e-07 GO:0044456 synapse part
1.48 3.30e-07 GO:0045202 synapse
1.72 1.34e-05 GO:0045211 postsynaptic membrane
1.17 2.66e-05 GO:0044459 plasma membrane part
1.33 1.01e-04 GO:0030054 cell junction
1.39 2.40e-04 GO:0043005 neuron projection
1.06 4.31e-04 GO:0005737 cytoplasm
1.86 8.11e-04 GO:0014069 postsynaptic density
1.16 9.73e-04 GO:0005829 cytosol
1.51 1.29e-03 GO:0034702 ion channel complex
1.36 2.89e-03 GO:0031012 extracellular matrix
2.72 4.28e-03 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
1.38 7.44e-03 GO:0005578 proteinaceous extracellular matrix
1.55 2.34e-02 GO:0034703 cation channel complex
1.45 3.13e-02 GO:0030425 dendrite
1.22 3.93e-02 GO:0031988 membrane-bounded vesicle
1.21 4.25e-02 GO:0031982 vesicle
1.03 4.84e-02 GO:0044424 intracellular part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 1.31e-17 GO:0005515 protein binding
1.06 5.24e-11 GO:0005488 binding
1.30 4.08e-04 GO:0043565 sequence-specific DNA binding
1.43 1.08e-03 GO:0022836 gated channel activity
1.38 1.22e-03 GO:0005216 ion channel activity
1.37 1.57e-03 GO:0015267 channel activity
1.36 1.89e-03 GO:0022803 passive transmembrane transporter activity
1.22 3.44e-03 GO:0030528 transcription regulator activity
1.36 3.72e-03 GO:0022838 substrate-specific channel activity
1.43 4.37e-03 GO:0005261 cation channel activity
1.59 2.13e-02 GO:0015276 ligand-gated ion channel activity
1.59 2.13e-02 GO:0022834 ligand-gated channel activity
1.54 3.38e-02 GO:0022843 voltage-gated cation channel activity
1.36 3.43e-02 GO:0016563 transcription activator activity