Motif ID: HAND1,2.p2

Z-value: 0.709


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HAND1chr5_-_153838013,
chr5_-_153837975		0.629.8e-03Click!
HAND2chr4_-_1746879310.391.4e-01Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_62753574 2.267 NM_199352
 SLC22A25
solute carrier family 22, member 25
chr11_+_66927976 2.206 NM_198517
 TBC1D10C
TBC1 domain family, member 10C
chr2_+_204440753 1.734 NM_001037631
NM_005214
 CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr19_+_55614006 1.585 NM_003121
 SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr17_-_8711701 1.354 NM_001010855
 PIK3R6
phosphoinositide-3-kinase, regulatory subunit 6
chr18_+_59405513 1.347 NM_012397
 SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr2_-_31293882 1.249 NM_001145122
 CAPN14
calpain 14
chr19_+_60279032 1.157 NM_133180
 EPS8L1
EPS8-like 1
chr7_+_142270634 1.132 EPHB6
EPH receptor B6
chr17_-_76897590 1.129 NM_178519
 C17orf55
chromosome 17 open reading frame 55
chr11_-_65244486 1.113 RNASEH2C
ribonuclease H2, subunit C
chr20_+_764710 1.112 NM_207121
 FAM110A
family with sequence similarity 110, member A
chr14_-_87806913 1.099 NM_138318
 KCNK10
potassium channel, subfamily K, member 10
chr11_+_55617328 1.084 NM_001003750
 OR8I2
olfactory receptor, family 8, subfamily I, member 2
chr15_+_52092392 1.082 NM_001080534
 UNC13C
unc-13 homolog C (C. elegans)
chr11_+_89032112 1.017 NM_153696
 FOLH1B
folate hydrolase 1B
chr14_-_106241445 1.002 IGHV4-31
IGHV1-69
IGHA1
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr9_+_124416768 0.959 NM_012364
 OR1Q1
olfactory receptor, family 1, subfamily Q, member 1
chr12_-_55917134 0.944 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr19_-_56163815 0.940 NM_001012964
NM_001012965
 KLK6

kallikrein-related peptidase 6


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
2.65 1.52e-09 GO:0007608 sensory perception of smell
2.48 9.66e-09 GO:0007606 sensory perception of chemical stimulus
1.94 1.62e-06 GO:0007600 sensory perception
1.67 9.36e-06 GO:0050877 neurological system process
1.58 1.59e-05 GO:0003008 system process
1.24 2.46e-03 GO:0032501 multicellular organismal process
1.20 4.44e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
1.67 2.77e-11 GO:0005576 extracellular region
1.65 2.96e-03 GO:0005615 extracellular space
1.61 6.89e-04 GO:0044421 extracellular region part
1.59 1.45e-04 GO:0005887 integral to plasma membrane
1.56 3.69e-04 GO:0031226 intrinsic to plasma membrane
1.54 3.90e-18 GO:0005886 plasma membrane
1.53 3.92e-18 GO:0071944 cell periphery
1.46 1.86e-05 GO:0044459 plasma membrane part
1.34 6.59e-11 GO:0031224 intrinsic to membrane
1.33 9.03e-10 GO:0016021 integral to membrane
1.30 8.61e-11 GO:0044425 membrane part
1.24 1.17e-09 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
5.26 2.30e-04 GO:0003823 antigen binding
2.68 4.63e-03 GO:0004252 serine-type endopeptidase activity
2.65 1.27e-09 GO:0004984 olfactory receptor activity
2.41 1.98e-02 GO:0008236 serine-type peptidase activity
2.36 2.68e-02 GO:0017171 serine hydrolase activity
2.03 3.96e-09 GO:0004930 G-protein coupled receptor activity
1.94 2.51e-12 GO:0004888 transmembrane receptor activity
1.86 2.13e-14 GO:0004872 receptor activity
1.67 3.28e-11 GO:0004871 signal transducer activity
1.67 3.28e-11 GO:0060089 molecular transducer activity