Motif ID: HAND1,2.p2

Z-value: 0.709


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HAND1chr5_-_153838013,
chr5_-_153837975
0.629.8e-03Click!
HAND2chr4_-_1746879310.391.4e-01Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_62753574 2.267 NM_199352
SLC22A25
solute carrier family 22, member 25
chr11_+_66927976 2.206 NM_198517
TBC1D10C
TBC1 domain family, member 10C
chr2_+_204440753 1.734 NM_001037631
NM_005214
CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr19_+_55614006 1.585 NM_003121
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr17_-_8711701 1.354 NM_001010855
PIK3R6
phosphoinositide-3-kinase, regulatory subunit 6
chr18_+_59405513 1.347 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr2_-_31293882 1.249 NM_001145122
CAPN14
calpain 14
chr19_+_60279032 1.157 NM_133180
EPS8L1
EPS8-like 1
chr7_+_142270634 1.132 EPHB6
EPH receptor B6
chr17_-_76897590 1.129 NM_178519
C17orf55
chromosome 17 open reading frame 55
chr11_-_65244486 1.113 RNASEH2C
ribonuclease H2, subunit C
chr20_+_764710 1.112 NM_207121
FAM110A
family with sequence similarity 110, member A
chr14_-_87806913 1.099 NM_138318
KCNK10
potassium channel, subfamily K, member 10
chr11_+_55617328 1.084 NM_001003750
OR8I2
olfactory receptor, family 8, subfamily I, member 2
chr15_+_52092392 1.082 NM_001080534
UNC13C
unc-13 homolog C (C. elegans)
chr11_+_89032112 1.017 NM_153696
FOLH1B
folate hydrolase 1B
chr14_-_106241445 1.002 IGHV4-31
IGHV1-69
IGHA1
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr9_+_124416768 0.959 NM_012364
OR1Q1
olfactory receptor, family 1, subfamily Q, member 1
chr12_-_55917134 0.944 NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr19_-_56163815 0.940 NM_001012964
NM_001012965
KLK6

kallikrein-related peptidase 6

chr11_-_2279642 0.931 NM_001142946
C11orf21
chromosome 11 open reading frame 21
chr19_+_60850765 0.930 NM_013301
CCDC106
coiled-coil domain containing 106
chr6_-_34632061 0.929 NM_012391
SPDEF
SAM pointed domain containing ets transcription factor
chr12_-_50502474 0.927 NM_001013690
FIGNL2
fidgetin-like 2
chr2_+_218929822 0.925 NM_198559
C2orf62
chromosome 2 open reading frame 62
chr1_+_180685878 0.901 NM_001137669
RGSL1
regulator of G-protein signaling like 1
chr6_+_37081387 0.895 NM_173558
FGD2
FYVE, RhoGEF and PH domain containing 2
chr2_-_31491057 0.894 XDH
xanthine dehydrogenase
chr11_+_71605466 0.882 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chrX_+_50044279 0.874 NM_033031
NM_033670
CCNB3

cyclin B3

chr11_+_71524403 0.872 NM_000804
FOLR3
folate receptor 3 (gamma)
chr12_+_115455579 0.864 NCRNA00173
non-protein coding RNA 173
chr1_-_158948176 0.863 NM_001778
CD48
CD48 molecule
chrX_+_128741578 0.861 SASH3
SAM and SH3 domain containing 3
chr10_-_121286034 0.861 NM_002925
RGS10
regulator of G-protein signaling 10
chrX_+_128741562 0.851 NM_018990
SASH3
SAM and SH3 domain containing 3
chr11_-_117305277 0.842 NM_001077263
TMPRSS13
transmembrane protease, serine 13
chr18_+_59571256 0.841 NM_001040147
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr20_-_29441946 0.812 NM_153289
NM_153323
NM_173460
DEFB119


defensin, beta 119


chr1_+_26358097 0.805 NM_024869
GRRP1
glycine/arginine rich protein 1
chr15_+_38318528 0.804 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr11_+_2279932 0.804 TSPAN32
tetraspanin 32
chr19_-_60360768 0.802 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr17_+_71232370 0.784 NM_001005619
ITGB4
integrin, beta 4
chr16_+_56286212 0.783 NM_032269
CCDC135
coiled-coil domain containing 135
chr11_+_55700669 0.783 NM_001005492
OR5J2
olfactory receptor, family 5, subfamily J, member 2
chr2_-_228206045 0.781 NM_001162483
NM_020161
C2orf83

chromosome 2 open reading frame 83

chr1_-_41722883 0.776 NM_001956
EDN2
endothelin 2
chr10_+_118946989 0.758 NM_181840
KCNK18
potassium channel, subfamily K, member 18
chr1_+_159943385 0.756 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr20_-_43370333 0.753 NM_003833
NM_030590
NM_030592
MATN4


matrilin 4


chr11_-_6148131 0.751 NM_001004052
OR52B2
olfactory receptor, family 52, subfamily B, member 2
chr19_-_12807221 0.751 NM_031429
RTBDN
retbindin
chr19_-_47623340 0.742 NM_005357
LIPE
lipase, hormone-sensitive
chr1_-_199348316 0.735 NM_000069
CACNA1S
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr19_-_56564068 0.730 NM_152353
CLDND2
claudin domain containing 2
chr1_+_154297588 0.726 NM_020387
RAB25
RAB25, member RAS oncogene family
chr1_+_17404206 0.723 NM_013358
PADI1
peptidyl arginine deiminase, type I
chr9_+_107464558 0.720 NM_005421
TAL2
T-cell acute lymphocytic leukemia 2
chr2_+_218954995 0.714 NM_000578
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr11_+_2279812 0.707 NM_139022
TSPAN32
tetraspanin 32
chr19_+_17047569 0.706 NM_001130065
NM_004145
MYO9B

myosin IXB

chr11_+_22316242 0.704 NM_020346
SLC17A6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr12_+_111900650 0.702 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr19_+_59927763 0.698 NM_153443
KIR3DL3
KIR2DL3
KIR3DP1
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
killer cell immunoglobulin-like receptor, three domains, pseudogene 1
chr20_+_71230 0.696 NM_030931
DEFB126
defensin, beta 126
chr3_+_99733432 0.689 NM_005290
GPR15
G protein-coupled receptor 15
chr7_-_142293382 0.686 NM_018646
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr7_+_100037817 0.684 NM_002593
PCOLCE
procollagen C-endopeptidase enhancer
chr19_-_10074332 0.683 NM_031917
ANGPTL6
angiopoietin-like 6
chrX_-_48213508 0.683 SLC38A5
solute carrier family 38, member 5
chr10_-_104201234 0.681 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr19_-_60740246 0.680 NM_001101401
SBK2
SH3-binding domain kinase family, member 2
chr8_-_27906287 0.678 NM_173833
SCARA5
scavenger receptor class A, member 5 (putative)
chr11_+_56512922 0.676 NM_001005323
OR5AK2
olfactory receptor, family 5, subfamily AK, member 2
chr12_-_52016270 0.673 NM_001173467
SP7
Sp7 transcription factor
chr19_+_41085221 0.672 NM_001007469
NM_014266
HCST

hematopoietic cell signal transducer

chrX_+_16051344 0.665 NM_005314
GRPR
gastrin-releasing peptide receptor
chr14_+_95792299 0.664 NM_000710
BDKRB1
bradykinin receptor B1
chrX_-_106033202 0.662 NM_001171706
NM_138382
RIPPLY1

ripply1 homolog (zebrafish)

chr14_+_103675194 0.658 KIF26A
kinesin family member 26A
chr11_+_6762823 0.656 NM_001004489
OR2AG1
olfactory receptor, family 2, subfamily AG, member 1
chr4_-_189263395 0.656 NM_173553
TRIML2
tripartite motif family-like 2
chr19_-_56585603 0.652 NM_001193623
LOC147646
hypothetical protein LOC147646
chr9_+_94776538 0.650 NM_033086
FGD3
FYVE, RhoGEF and PH domain containing 3
chr10_+_118340460 0.646 NM_006229
PNLIPRP1
pancreatic lipase-related protein 1
chr3_+_150675117 0.646 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr1_-_158815850 0.643 CD84
CD84 molecule
chr5_+_148766632 0.640 LOC728264
hypothetical LOC728264
chr17_+_3065661 0.639 NM_014565
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr11_+_60626505 0.639 NM_014207
CD5
CD5 molecule
chr6_-_39390073 0.637 NM_031460
NM_001135111
KCNK17

potassium channel, subfamily K, member 17

chr19_+_61624 0.637 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr2_-_31491102 0.635 NM_000379
XDH
xanthine dehydrogenase
chr14_+_23527866 0.634 NM_198083
DHRS4
DHRS4L2
dehydrogenase/reductase (SDR family) member 4
dehydrogenase/reductase (SDR family) member 4 like 2
chr2_+_95621492 0.633 NM_138800
TRIM43
tripartite motif containing 43
chr19_+_59107802 0.632 NM_031896
CACNG7
calcium channel, voltage-dependent, gamma subunit 7
chr11_-_133220578 0.632 NM_174927
SPATA19
spermatogenesis associated 19
chr8_-_145809695 0.625 NM_025251
ARHGAP39
Rho GTPase activating protein 39
chr11_+_34599227 0.623 EHF
ets homologous factor
chr17_-_37590910 0.618 NM_001524
HCRT
hypocretin (orexin) neuropeptide precursor
chr9_-_35818728 0.617 NM_001012446
C9orf128
chromosome 9 open reading frame 128
chr1_-_158815895 0.617 NM_001184879
NM_001184881
NM_001184882
NM_003874
CD84



CD84 molecule



chr12_+_53177806 0.616 NCKAP1L
NCK-associated protein 1-like
chr19_-_63715135 0.612 NM_012254
SLC27A5
solute carrier family 27 (fatty acid transporter), member 5
chr19_-_17819773 0.608 JAK3
Janus kinase 3
chr1_-_29322993 0.606 NM_001003682
TMEM200B
transmembrane protein 200B
chr1_+_159899528 0.605 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr16_-_20246309 0.600 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr5_-_149772563 0.588 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr12_+_53177789 0.583 NCKAP1L
NCK-associated protein 1-like
chr19_-_7702977 0.582 NM_198492
CLEC4G
C-type lectin domain family 4, member G
chrX_+_130505630 0.581 NM_001004486
OR13H1
olfactory receptor, family 13, subfamily H, member 1
chr22_+_23329113 0.580 NM_001032364
NM_005265
GGT1

gamma-glutamyltransferase 1

chr19_-_47261761 0.577 NM_002088
GRIK5
glutamate receptor, ionotropic, kainate 5
chr19_+_5865192 0.576 NM_004058
NM_080590
CAPS

calcyphosine

chr1_-_207892420 0.576 NM_000228
LAMB3
laminin, beta 3
chr8_+_11388918 0.573 NM_001715
BLK
B lymphoid tyrosine kinase
chr16_+_2450081 0.568 NM_025108
C16orf59
chromosome 16 open reading frame 59
chr11_-_7941617 0.567 NM_176821
NLRP10
NLR family, pyrin domain containing 10
chr19_+_11510578 0.565 NM_001299
CNN1
calponin 1, basic, smooth muscle
chr8_+_50987149 0.560 NM_018967
SNTG1
syntrophin, gamma 1
chr4_-_40326603 0.559 NM_001098634
RBM47
RNA binding motif protein 47
chr1_+_246591505 0.556 NM_001004696
OR2T4
olfactory receptor, family 2, subfamily T, member 4
chr11_-_10630408 0.550 NM_001098579
MRVI1
murine retrovirus integration site 1 homolog
chr10_-_75080784 0.548 NM_024875
SYNPO2L
synaptopodin 2-like
chr16_+_639278 0.548 NM_145294
WDR90
WD repeat domain 90
chr11_+_62813947 0.546 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr17_+_44643067 0.546 ABI3
ABI family, member 3
chr3_+_196933481 0.545 MUC20
mucin 20, cell surface associated
chr3_-_194579207 0.541 NM_198505
ATP13A5
ATPase type 13A5
chr17_-_36409632 0.540 NM_031959
KRTAP3-2
keratin associated protein 3-2
chr6_-_25940247 0.540 NM_005074
SLC17A1
solute carrier family 17 (sodium phosphate), member 1
chr22_-_16127520 0.540 CECR3
cat eye syndrome chromosome region, candidate 3
chr11_+_5558682 0.537 NM_001005162
OR52B6
olfactory receptor, family 52, subfamily B, member 6
chr8_+_1980564 0.536 NM_003970
MYOM2
myomesin (M-protein) 2, 165kDa
chr20_+_62164900 0.533 TCEA2
transcription elongation factor A (SII), 2
chr6_-_31196174 0.533 NM_001264
CDSN
corneodesmosin
chr16_+_82885821 0.531 NM_021197
WFDC1
WAP four-disulfide core domain 1
chr9_-_106705867 0.531 ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr14_-_106240998 0.529 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)
chr20_+_42776888 0.523 WISP2
WNT1 inducible signaling pathway protein 2
chr19_+_60851207 0.514 CCDC106
coiled-coil domain containing 106
chr19_-_56196611 0.513 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr19_+_458475 0.509 NM_033513
C19orf20
chromosome 19 open reading frame 20
chr7_+_75977680 0.505 NM_030570
NM_182684
UPK3B

uroplakin 3B

chr1_+_26516967 0.503 NM_001803
CD52
CD52 molecule
chr16_+_20370359 0.499 NM_001010845
ACSM2A
acyl-CoA synthetase medium-chain family member 2A
chr11_-_62233552 0.499 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr22_+_35586950 0.499 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr19_+_60691671 0.495 NM_001144950
NM_001195267
SSC5D

scavenger receptor cysteine rich domain containing (5 domains)

chr15_+_61676604 0.492 NM_203373
FBXL22
F-box and leucine-rich repeat protein 22
chr1_+_28134090 0.491 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr1_+_199519202 0.489 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr6_+_146390474 0.488 NM_000838
NM_001114329
GRM1

glutamate receptor, metabotropic 1

chr17_+_20423628 0.484 NM_001190790
CDRT15L2
CMT1A duplicated region transcript 15-like 2
chr1_+_148511806 0.484 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr21_-_42644138 0.484 NM_005423
TFF2
trefoil factor 2
chr1_+_179269766 0.480 MR1
major histocompatibility complex, class I-related
chr22_+_38296703 0.478 NM_001003406
NM_021096
CACNA1I

calcium channel, voltage-dependent, T type, alpha 1I subunit

chr19_-_56147971 0.476 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr14_+_75058518 0.473 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr1_+_151035850 0.472 NM_178352
LCE1D
late cornified envelope 1D
chr12_+_39372456 0.470 NM_001843
NM_175038
CNTN1

contactin 1

chr5_-_147266257 0.469 NM_206966
C5orf46
chromosome 5 open reading frame 46
chr1_-_53972464 0.468 NM_147193
GLIS1
GLIS family zinc finger 1
chr1_+_34098662 0.467 NM_145205
HMGB4
high-mobility group box 4
chr1_+_200358594 0.467 NM_004767
GPR37L1
G protein-coupled receptor 37 like 1
chrX_+_106030049 0.461 NM_001171092
CLDN2
claudin 2
chr1_-_150353179 0.460 NM_007113
TCHH
trichohyalin
chr17_-_9863929 0.457 GAS7
growth arrest-specific 7
chr17_+_45617676 0.456


chr3_+_51870684 0.452 NM_203424
IQCF2
IQ motif containing F2
chr22_-_29866339 0.451 NM_015715
PLA2G3
phospholipase A2, group III
chr2_-_240634161 0.447 NM_173351
OR6B3
olfactory receptor, family 6, subfamily B, member 3
chr3_+_99699137 0.445 NM_001004737
OR5K2
olfactory receptor, family 5, subfamily K, member 2
chr16_-_31054321 0.444 PRSS8
protease, serine, 8
chr8_+_134272463 0.441 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr8_-_145661545 0.439 NM_032687
NM_001129888
CYHR1

cysteine/histidine-rich 1

chr5_-_150928697 0.438 NM_001447
FAT2
FAT tumor suppressor homolog 2 (Drosophila)
chrX_+_36936352 0.436 NM_001013736
FAM47C
family with sequence similarity 47, member C
chr14_-_20694023 0.435 NM_001004731
OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chr19_-_4351470 0.432 NM_003025
SH3GL1
SH3-domain GRB2-like 1
chr6_-_55848346 0.430 BMP5
bone morphogenetic protein 5
chr3_-_48576204 0.427 NM_033199
UCN2
urocortin 2
chrX_-_48213545 0.427 NM_033518
SLC38A5
solute carrier family 38, member 5
chr12_+_53177758 0.426 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr12_+_54045161 0.426 NM_001005497
OR6C75
olfactory receptor, family 6, subfamily C, member 75
chr17_+_38166730 0.425 NM_005854
RAMP2
receptor (G protein-coupled) activity modifying protein 2
chr20_+_16676997 0.425 NM_020157
OTOR
otoraplin
chr6_+_31016755 0.423 NM_080870
DPCR1
diffuse panbronchiolitis critical region 1
chr12_-_10853940 0.422 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr14_-_106249999 0.422 IGHA1
immunoglobulin heavy constant alpha 1
chr14_-_21172837 0.421 NM_001005466
OR10G2
olfactory receptor, family 10, subfamily G, member 2
chr1_-_110949867 0.415 NM_004974
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr12_+_121218218 0.415 NM_152759
LRRC43
leucine rich repeat containing 43
chr3_-_36756355 0.404 NM_033403
DCLK3
doublecortin-like kinase 3
chr22_-_38258468 0.403 RPS19BP1
ribosomal protein S19 binding protein 1
chr11_-_111636792 0.400 NM_001145024
C11orf34
chromosome 11 open reading frame 34
chr8_+_28230567 0.399 NM_006228
PNOC
prepronociceptin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.65 1.52e-09 GO:0007608 sensory perception of smell
2.48 9.66e-09 GO:0007606 sensory perception of chemical stimulus
1.94 1.62e-06 GO:0007600 sensory perception
1.67 9.36e-06 GO:0050877 neurological system process
1.58 1.59e-05 GO:0003008 system process
1.24 2.46e-03 GO:0032501 multicellular organismal process
1.20 4.44e-03 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.54 3.90e-18 GO:0005886 plasma membrane
1.53 3.92e-18 GO:0071944 cell periphery
1.67 2.77e-11 GO:0005576 extracellular region
1.34 6.59e-11 GO:0031224 intrinsic to membrane
1.30 8.61e-11 GO:0044425 membrane part
1.33 9.03e-10 GO:0016021 integral to membrane
1.24 1.17e-09 GO:0016020 membrane
1.46 1.86e-05 GO:0044459 plasma membrane part
1.59 1.45e-04 GO:0005887 integral to plasma membrane
1.56 3.69e-04 GO:0031226 intrinsic to plasma membrane
1.61 6.89e-04 GO:0044421 extracellular region part
1.65 2.96e-03 GO:0005615 extracellular space

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.86 2.13e-14 GO:0004872 receptor activity
1.94 2.51e-12 GO:0004888 transmembrane receptor activity
1.67 3.28e-11 GO:0004871 signal transducer activity
1.67 3.28e-11 GO:0060089 molecular transducer activity
2.65 1.27e-09 GO:0004984 olfactory receptor activity
2.03 3.96e-09 GO:0004930 G-protein coupled receptor activity
5.26 2.30e-04 GO:0003823 antigen binding
2.68 4.63e-03 GO:0004252 serine-type endopeptidase activity
2.41 1.98e-02 GO:0008236 serine-type peptidase activity
2.36 2.68e-02 GO:0017171 serine hydrolase activity